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LSU Doctoral Dissertations

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Full-Text Articles in Veterinary Pathology and Pathobiology

Genetics And Functions Of Herpes Simplex Virus Type 1 Membrane Proteins In Virus-Induced Cell Fusion, Virion Morphogenesis And Egress, Jeffrey Michael Melancon Jan 2004

Genetics And Functions Of Herpes Simplex Virus Type 1 Membrane Proteins In Virus-Induced Cell Fusion, Virion Morphogenesis And Egress, Jeffrey Michael Melancon

LSU Doctoral Dissertations

The Herpes Simplex Virus life cycle contains a number of membrane fusion events that must function properly to ensure a productive infection, including: virus attachment and entry into susceptible cells, de-envelopment at the outer nuclear lamellae, and virus-induced cell-to-cell fusion. A virus-free cell fusion assay was recently developed in order to attempt to understand the underlying mechanisms that are responsible for viral fusion events and was utilized in order to investigate the effect of mutations targeted to the carboxyl terminus of gB. We showed that the predicted alpha helical domain H17b within the carboxyl-terminus of gB is involved in both …

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Isolation And Characterization Of Carbonic Anhydrase From Ostertagia Ostertagi, Andrew Allan Derosa Jan 2004

Isolation And Characterization Of Carbonic Anhydrase From Ostertagia Ostertagi, Andrew Allan Derosa

LSU Doctoral Dissertations

The first event in the infection process of Ostertagia ostertagi in cattle is the process of exsheathment. Before trichostrongylid nematodes can transition from a free-living infective stage larva (L3) on pasture to a parasitic existence within the ruminant host, it must first undergo exsheathment. Exsheathment is the process whereby the L2 cuticle retained from the previous molt is cast from the L3. Exsheathment enables the developmental transition from a free-living stage on pasture to a parasitic existence in the bovine host. For those species with a predilection site in the abomasum, such as O. ostertagi, …

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Equine Immunity To Cyathostome Infections, Marie Alexandra Baudena Jan 2003

Equine Immunity To Cyathostome Infections, Marie Alexandra Baudena

LSU Doctoral Dissertations

To study the protective responses of cyathostome-infected ponies, two challenges were performed employing animals with different histories of exposure to these parasites. The hypothesis developed and to be tested in these experiments was that ponies that had longer exposure to cyathostome contaminated pastures would express acquired resistance to infection. The assumption behind this hypothesis was that helminth-naïve ponies infected with cyathostomes would eliminate the infection using only innate immune responses. Whereas previously exposed ponies would eliminate the infection with acquired immune responses, and these would be more effective in ponies with longer exposure to cyathostomes. Thus, helminth-naïve animals would acquire …

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Immunological, Hematological, And Serum Biochemical Effects Of High Level Dietary Fish Oil And Vitamin E Supplementation In The Dog, Casey J. Leblanc Jan 2003

Immunological, Hematological, And Serum Biochemical Effects Of High Level Dietary Fish Oil And Vitamin E Supplementation In The Dog, Casey J. Leblanc

LSU Doctoral Dissertations

Inflammation is a component of the innate immune response. However, severe or prolonged inflammation can be detrimental. Dietary n-3 fatty acid supplementation has proven clinical benefits in chronic inflammatory diseases, most likely due to reduced synthesis of inflammatory mediators and inhibition of lymphocyte proliferation and function. The purposes of this study were to characterize alterations in inflammatory mediator production, and lymphocyte proliferation, in dogs fed a diet consisting of 0.65% n-3 fatty acids (DMB) with an n-6:n-3 fatty acid ratio of 3.4:1. Fifteen dogs were randomly assigned to one of three dietary groups for twelve weeks. Group Sunflower oil received …

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Development Of The Neonatal Rat As A Model For Sudden Infant Death Syndrome: Cardiorespiratory Effects Of Ethanol, Rhett Whitman Stout Jan 2003

Development Of The Neonatal Rat As A Model For Sudden Infant Death Syndrome: Cardiorespiratory Effects Of Ethanol, Rhett Whitman Stout

LSU Doctoral Dissertations

The current pathogenesis of Sudden Infant Death Syndrome (SIDS) is unknown. Elevated endogenous ethanol production by gastrointestinal yeast has been proposed as a possible mechanism for SIDS. To investigate the role of ethanol in SIDS, three studies were undertaken. In the first study, transcutaneous blood gas technology was evaluated for repeated monitoring of arterial blood gases. The second study identified the cardiorespiratory responses to inhaled CO2 challenge in juvenile rats, to determine the age corresponding to the age range of peak incidence of SIDS in human infants. Finally, utilizing the optimized juvenile rat model, the cardiorespiratory responses to ethanol and …

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Characterization Of Protein Secretion In Mycobacterium Leprae Using Phoa Fusions In Escherichia Coli And Mycobacterium Smegmatis, Marina Noemi Torrero Jan 2003

Characterization Of Protein Secretion In Mycobacterium Leprae Using Phoa Fusions In Escherichia Coli And Mycobacterium Smegmatis, Marina Noemi Torrero

LSU Doctoral Dissertations

Complete sequencing and annotation of the M. leprae genome has provided new information related to proteins constituting its hypothetical proteome. Since M. leprae can not be grown in vitro, novel approaches are needed to determine which proteins are expressed during infection and whether these proteins are related to pathogenesis. Secreted proteins represent a distinct group of protein with respect to their structure and function, contribution to virulence and are of particular importance for vaccine development because they are often immunogenic and have the potential to be recognized early in infection. The objectives of this study were: 1) to identify putatively …

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Pathogenic Mechanisms Of Photobacterium Damselae Subspecies Piscicida In Hybrid Striped Bass, Ahmad A. Elkamel Jan 2002

Pathogenic Mechanisms Of Photobacterium Damselae Subspecies Piscicida In Hybrid Striped Bass, Ahmad A. Elkamel

LSU Doctoral Dissertations

Photobacterium damselae subspecies piscicida, previously known as Pasteurella piscicida, is an important pathogen of hybrid striped bass and many fish species cultured in brackish water in the United States, Japan, Europe, and the Mediterranean. The purpose of this study is to investigate virulence mechanisms that contribute to the pathogenesis of this organism. The ability of P. damselae to survive/replicate within hybrid striped bass macrophages was evaluated with an in vitro killing assay. Results indicated that the numbers of bacteria recovered from macrophages at 3, 6, 12, and 18 hours of incubation increased significantly over time. In contrast, the numbers of …

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