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A Two-Hit Model Of Executive Dysfunction: Simulated Galactic Cosmic Radiation Primes Latent Deficits Revealed By Sleep Fragmentation, Richard A. Britten, Ella N. Tamgue, Paola Arriaga Alvarado, Arriyam S. Fesshaye, Larry D. Sanford
A Two-Hit Model Of Executive Dysfunction: Simulated Galactic Cosmic Radiation Primes Latent Deficits Revealed By Sleep Fragmentation, Richard A. Britten, Ella N. Tamgue, Paola Arriaga Alvarado, Arriyam S. Fesshaye, Larry D. Sanford
Department Radiation Oncology & Biophysics Faculty Publications
Future Artemis-class missions to Mars will expose astronauts to prolonged space radiation (SR), sleep disruption, and operational demands requiring greater autonomy, placing decision making and executive function at heightened risk. Both SR and sleep fragmentation (SF) independently impair cognition, yet their combined effects remain poorly understood. Using the Associative Recognition Memory and Interference (ARMIT) task, we assessed cognitive performance in male rats exposed to 10 cGy of Galactic Cosmic Ray simulation (GCRsim), SF, or both. Under well-rested conditions, GCRsim-exposed rats exhibited overt deficits in the C.1.2 stage, performing at chance when reinforcement contingencies shifted, consistent with impaired cognitive flexibility. In …