Veterinary Medicine Commons^™

Deep Sequencing And Genome-Wide Analysis Reveals The Expansion Of Microrna Genes In The Gall Midge Mayetiola Destructor, Chitvan Khajuria, Christie E. Williams, Mustapha El Bouhssini, R. Jeff Whitworth, Stephen Richards, Jeffrey J. Stuart, Ming-Shun Chen

School of Veterinary and Biomedical Sciences: Faculty Publications

Background: MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in regulating post transcriptional gene expression. Gall midges encompass a large group of insects that are of economic importance and also possess fascinating biological traits. The gall midge Mayetiola destructor, commonly known as the Hessian fly, is a destructive pest of wheat and model organism for studying gall midge biology and insect – host plant interactions.

Results: In this study, we systematically analyzed miRNAs from the Hessian fly. Deep-sequencing a Hessian fly larval transcriptome led to the identification of 89 miRNA species that are either identical or very …

Development And Evaluation Of A Replicon Particle Vaccine Expressing The E2 Glycoprotein Of Bovine Viral Diarrhea Virus (Bvdv) In Cattle, John Dustin Loy, Jill Gander, Mark Mogler, Ryan Vander Veen, Julia Ridpath, Delbert Hank Harris, Kurt Kamrud

School of Veterinary and Biomedical Sciences: Faculty Publications

Background: Bovine viral diarrhea virus is one of the most significant and costly viral pathogens of cattle worldwide. Alphavirus-derived replicon particles have been shown to be safe and highly effective vaccine vectors against a variety of human and veterinary pathogens. Replicon particles are non-propagating, DIVA compatible, and can induce both humoral and cell mediated immune responses. This is the first experiment to demonstrate that Alphavirus-based replicon particles can be utilized in a standard prime/boost vaccination strategy in calves against a commercially significant bovine pathogen.

Findings: Replicon particles that express bovine viral diarrhea virus sub-genotype 1b E2 glycoprotein were …

Mutation From Arginine To Lysine At The Position 189 Of Hemagglutinin Contributes To The Antigenic Drift In H3n2 Swine Influenza Viruses, Jianqiang Ye, Yifei Xu, Jillian Harris, Hailiang Sun, Andrew S. Bowman, Fred L. Cunningham, Carol Cardona, Kyoungjin J. Yoon, Richard D. Slemons, Xiu-Feng Wan

United States Department of Agriculture Wildlife Services: Staff Publications

Two distinct antigenic clusters were previously identified among the H3N2 swine influenza A viruses (IAVs) and were designated H3N2SIV-alpha and H3N2SIV-beta (Feng et al., 2013. Journal of Virology 87(13), 7655–7667). A consistent mutation was observed at the position 189 of hemagglutinin (R189K) between H3N2SIV-alpha and H3N2SIV-beta fair isolates. To evaluate the contribution of R189K mutation to the antigenic drift from H3N2SIV-alpha to H3N2SIV-beta, four reassortant viruses with189R or189K were generated. The antigenic cartography demonstrated that the R189K mutation in the hemagglutinin of H3N2IAV contributed to the antigenicdrift, separating these viruses into H3N2SIV-alpha to H3N2SIV- beta. This R189K mutation was also …

Herpes Simplex Virus Type 1 Glycoprotein Gm And The Membrane Associated Protein Ul11 Are Required For Virus-Induced Cell Fusion And Efficient Virus Entry, In Joong Kim

LSU Doctoral Dissertations

HSV-1 facilitates virus entry into cells and cell-to-cell spread by mediating fusion of the viral envelope with cellular membranes and fusion of adjacent cellular membranes. Although virus strains isolated from herpetic lesions cause limited cell fusion in cell culture, clinical herpetic lesions typically contain large syncytia, underscoring the importance of cell-to-cell fusion in virus spread in infected tissues. Certain mutations in gB, gK, UL20 and other viral genes, drastically enhance virus-induced cell fusion in vitro and in vivo. Recent work has suggested that gB is the sole fusogenic glycoprotein, which is regulated by interactions with viral glycoproteins gD, gH/gL, gK, …

Characterization, Prevalence, And Risk Factors Of Spontaneous And Experimental Atherosclerosis And Vascular Imaging In Psittaciformes, Hugues Beaufrère

LSU Doctoral Dissertations

Atherosclerosis is a degenerative and inflammatory vascular disease characterized by the accumulation of inflammatory cells, lipids, calcium, and formation of large fibrofatty lesions within the intima of arteries resulting in the disorganization of the arterial wall and stenosis of the lumen. Despite the importance of atherosclerosis in psittacine cardiology, there are few pathologic, clinical, and experimental investigations in psittaciformes. In order to expand the knowledge on psittacine atherosclerosis and provide fundamental observational information for future research, a series of studies was conducted on psittaciformes: 1) psittacine atherosclerotic lesions were characterized and categorized based on histopathology, histochemistry, transmission (TEM), and scanning …

General Reproductive Properties In Pigs, İrfan Tur

Turkish Journal of Veterinary & Animal Sciences

Pig breeding is usually undertaken for fat and meat production, but different sectors (cosmetics industry, pharmaceutical industry, medical sector, etc.) can also use pigs for alternate purposes. Pork is evaluated based on the status of an amended law regarding butchers' meat in Turkey. There have been 25 pig farms registered in Turkey since 7 July 2006 in the framework of compliance with the European Union. On average, a sow has 2.3 farrowings per year, producing 9.5 to 12.5 piglets per litter. It is important that high proportions of selected replacement gilts reach puberty at an early age in order to …

Prevention Of Embryonic Death Using Different Hormonal Treatments In Ewes, Mehmet Bozkurt Ataman, Mehmet Aköz, Mustafa Kemal Saribay, Hüseyi̇n Erdem, Mustafa Numan Bucak

Turkish Journal of Veterinary & Animal Sciences

The purpose of this study was to evaluate different treatment protocols to prevent embryonic death in ewes. A total of 180 Akkaraman crossbred ewes and 10 healthy rams were used as material. The ewes were divided into 3 equal groups, with each of the 3 groups then separated into 3 subgroups. Ewes in estrus, determined with teaser rams, were exposed to mating. Three different treatment protocols of gonadotropin-releasing hormone (GnRH) analog (buserelin, intramuscularly) at a dose of 20 µg, vaginal sponges containing 30 mg fluorogestone acetate (FGA), and saline at a dose of 1 mL (control, intramuscularly) were applied on …

Microsatellite Analysis For Parentage Testing Of The Arabian Horse Breed From Syria, Anas Mahmoud Khanshour, Eleanore Kathleen Conant, Rytis Juras, Ernest Gus Cothran

Turkish Journal of Veterinary & Animal Sciences

Parentage testing is very important for genetically determining the accuracy of the pedigree of domestic animals. The Arabian horse population in Syria might be expected to have a high level of homozygosity because the traditional method of breeding results in such a small population. For this reason, using a set of highly polymorphic markers such as microsatellites is required for parentage testing. The purpose of this study was to analyze the usefulness of 16 STR markers for routine parentage testing in 94 samples from registered and nonregistered horses collected from Syria. The mean number of alleles was 5.69 per locus …

Effect Of Different Transport Temperatures On In Vitro Maturation Of Oocytes Collected From Frozen-Thawed Sheep Ovaries, Özen Banu Özdaş, Alper Baran, Muzaffer Taş, Ümüt Ci̇ri̇t, Kamber Demi̇r, Süleyman Bacinoğlu, Serhat Pabuccuoğlu, Kemal Ak

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to determine the effects of 2 different transport temperatures on the in vitro maturation of oocytes collected from frozen-thawed sheep ovaries. Sheep ovaries were transferred into saline at temperatures of 4 °C and 32 °C. After the 2 experimental groups (A: fresh cortex, B: frozen-thawed cortex) were formed, each group was divided into 2 subgroups (group A1: 4 °C, group A2: 32 °C [control]; group B1: 4 °C, group B2: 32 °C). The cortexes were dissected into slices 1-3 mm thick and pieces of 0.5 cm2. For groups B1 and B2, 1-2 cortex pieces …

Effect Of Oocyte Quality And Activation Protocols On Bovine Embryo Development Following Intracytoplasmic Sperm Injection, Ömer Korkmaz, Şükrü Küplülü, Yüksel Ağca, İbrahi̇m Mert Polat

Turkish Journal of Veterinary & Animal Sciences

The purpose of this study was to investigate the effects of oocyte quality and activation protocols on the in vitro developmental competence of bovine embryos after intracytoplasmic sperm injection (ICSI). Bovine oocytes were grouped as being of excellent, good, and poor quality. All of the oocytes were activated using a calcium ionophore only, ethanol only, and 6-dimethylaminopurine (6-DMAP) following calcium ionophore. For the excellent quality oocytes, cleavage rates after ICSI were 70% in the Ca ionophore + 6-DMAP activation group, 47% in the ethanol activation group, 41.82% in the Ca ionophore group, and 30% in the nontreated control group. Cleavage …

Seroepidemiology Of Canine Brucellosis In Beijing, China, Fu Xiang, Zhaofei Xia, Qingming Wu, Yanyun Chen, Jinhau Yu, Jianging Wan

Turkish Journal of Veterinary & Animal Sciences

A seroepidemiological survey of canine brucellosis was carried out in Beijing, China. Serum samples were taken from dogs admitted to the Beijing Companion Animal Hospital for immigration and emigration inspection, including dogs from 4 breeding farms and stray dogs (n = 1200, 14 districts), between January 2008 and April 2009. All of the sera were first tested and preselected by Rose Bengal plate agglutination test (RBAT), and the positive samples by RBAT were determined by tube agglutination test (TAT) again. Of the 1200 dogs studied, 60 (5%) were positive by RBAT, 21 (51.7%) of which were confirmed by TAT. The …

Changes In The Bioactive Protein Concentrations In The Bovine Colostrum Of Jersey And Polish Holstein–Friesian Cows, Monika Sobczuk-Szul, Zofia Wielgosz-Groth, Marek Wronski, Arkadiusz Rzemieniewski

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to determine changes in the bioactive protein concentrations in the bovine colostrum of Jersey and Polish Holstein-Friesian (PHF) cows. Double colostrum samples were collected from 16 Jersey and PHF cows, during 8 successive milking runs after calving. A total of 256 colostrum samples were analyzed to determine the pH, density, percentage share, and content of selected bioactive proteins, including the percentage share of casein fractions (\alpha_s-, \beta-, \gamma-, and \kappa-) in the total casein, and the concentrations of \alpha-lactalbumin (\alpha-LA), \beta-lactoglobulin (\beta-LG), lactoferrin (LF), interleukin-1\beta, interleukin-6, and tumor necrosis factor-alpha. The concentrations of the …

A Retrospective Study Of Tetralogy Of Fallot In Dogs, Urszula Paslawska, Agnieszka Noszczyk-Nowak, Alicja Cepiel, Maciej Staszczyk, Adrian Janiszewski

Turkish Journal of Veterinary & Animal Sciences

Tetralogy of Fallot is a rare congenital heart defect; however, it is the most common cyanotic heart malformation in humans and animals. It consists of a ventricular septal defect, pulmonic stenosis, displacement of the aortic root, and hypertrophy of the right ventricle. At the Department of Internal Medicine Clinic of Diseases of Horses, Dogs, and Cats at the Wroclaw University of Environmental and Life Sciences, patients with Fallot syndrome constituted 4.44% of all patients with congenital heart diseases. There was no breed predisposition found. The most common clinical signs were exercise intolerance, dyspnea, and cyanosis of the mucous membranes, but …

The Effect Of Selenized Yeast Supplementation On Some Performance Parameters In Sheep, Bogumila Pilarczyk, Agnieszka Tomza-Marciniak, Zbigniew Dobrzanski, Malgorzata Szewczuk, Tomasz Stankiewicz, Dariusz Gaczarzewicz, Wlodzimierz Lachowski

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to determine the levels of serum selenium in coarse-haired Pomeranian sheep and to evaluate the effect of the oral supplementation of selenized yeast on selected performance parameters in such sheep. The sheep were divided into 2 groups, with 53 ewes forming the experimental group and 34 ewes forming the control group. The concentration of serum selenium in all 87 sheep from the 2 groups was analyzed. The sheep in the experimental group received selenized yeast for the 3 days before and 3 days after mating (1 g preparation/animal daily, with 1 g of preparation …

Whole-Blood Thrombelastography Using Calcium Chloride Activation In Healthy Cats, Ramazan Çöl, Alicia Montgomery, Maria Cristina Iazbik, Ashley Defelice, Poulo Vilar Saavedra, Guillermo Couto

Turkish Journal of Veterinary & Animal Sciences

Thrombelastography (TEG, Haemoscope Corp., Niles, IL, USA) allows for a global evaluation of the hemostatic system; while conventional coagulation tests typically evaluate only one part of the coagulation system, TEG simultaneously examines the interaction between platelets, clotting factors, the fibrinolytic system, and clot retraction mechanisms. Since its development, TEG has been widely employed in human clinical medicine and research, but has only recently gained popularity in veterinary medicine. The purpose of this study was to establish TEG reference ranges in healthy cats using the citrated native technique. In this study, 31 clinically healthy cats were evaluated. We sampled healthy adult …

A Pilot Study On The Epidemiological Status Of Equine Infectious Anaemia, Equine Viral Arteritis, Glanders, And Dourine In Turkey, Maria Luisa Marenzoni, Vincenzo Cuteri, Francesca De Parri, Maria Luisa Danzetta, Zeki̇ Yilmaz, Cagla Parkan Yaramis, Engi̇n Kennerman, Mehmet Erman Or, Silvia Marchi, Cristina Casciari, Gian Mario De Mia, Carlo Valente, Silva Costarelli

Turkish Journal of Veterinary & Animal Sciences

A serological investigation of equine infectious anaemia (EIA), equine viral arteritis (EAV), glanders, and dourine was conducted on the sera of 346 Turkish horses using a combination of tests in series (ELISA and agar gel immunodiffusion) for EIA, virus neutralisation for EAV, and complement fixation (CF) for glanders and dourine. Forty-nine sera showed anticomplementary reactions and were not assessable in the CF test for glanders and dourine. No positive samples were detected for EIA, dourine, and glanders. Fifty-seven sera were positive for EAV. A systematic review of the distribution of these diseases in Turkey was conducted to describe their epidemiological …

Determination Of Newcastle Disease Virus Among Wild Bird Populations In Lake Van Basin, Turkey, Banur Boynukara, Ti̇mur Gülhan, Fethi̇ye Çöven, İlhami̇ Ki̇zi̇roğlu, Ati̇lla Durmuş

Turkish Journal of Veterinary & Animal Sciences

In this study, 540 feces samples taken from a total of 22 bird species, including transit migrant, winter visitor, migratory, and resident bird species, in Lake Van basin were examined by real-time polymerase chain reaction (RT-PCR) with respect to the Newcastle disease virus (NDV). All of the feces samples were cultured in specific pathogen-free embryonated chicken eggs (ECEs) for NDV isolation. The NDV isolates were analyzed for virulent fusion (F) protein by RT reverse transcription PCR (RRT-PCR). Of the 540 examined feces samples, 28 (5.18%) were found to be positive by RT-PCR. The same samples were cultured in ECEs and, …

Susceptibility Of Prototheca Zopfii Strains Isolated From Cows With Mastitis To Chlorhexidine And Iodine, Henryk Krukowski, Andrzej Lisowski, Bozena Nowakowicz-Debek, Lukasz Wlazlo

Turkish Journal of Veterinary & Animal Sciences

Bovine mastitis caused by Prototheca spp. can assume high significance because of economic losses and the potential risk to public health. The aim of our study was to evaluate the effect of chlorhexidine and iodine on Prototheca zopfii strains isolated from bovine milk. For this study, 15 Prototheca zopfii isolates previously obtained from cows with clinical and subclinical mastitis in Poland were used. The in vitro susceptibility tests to chlorhexidine and iodine of the strains of Prototheca zopfii for the determination of their minimal microbicidal concentrations (MMCs) were performed using the tube dilution method in Sabouraud dextrose broth and the …

Financial Losses From Foot Diseases In Cattle Farms In Kars Province, Pinar Demi̇r, Sadik Yayla, Özgür Aksoy, İsa Özaydin

Turkish Journal of Veterinary & Animal Sciences

This study was performed via a survey conducted of a total of 112 cattle operations in Kars and the vicinity and included a total of 2317 head, of which 280 were determined to have foot problems. The financial loss incurred per operation was calculated in accordance with the data obtained. As a result, the prevalence of foot disease encountered in cattle in the region in 2010 was determined to be 12.08%, and although it varied depending on the severity of the foot diseases, the animals were healed in an average of 46.5 days. Live weights declined by an average of …

Multiple Jaw Fractures And Hiatus Linguae In A Dog, İbrahi̇m Akin, Murat Sarierler, Nuh Kiliç, Ali̇ Belge

Turkish Journal of Veterinary & Animal Sciences

The case of a 3.5-year-old male Norwegian Elkhound crossbreed dog, seen the day after a traffic accident, is reported. Fractures in the symphysis mandibulae and the right corpus mandibulae were diagnosed. The apex linguae hung down laterally; a 2-cm cut wound was present on the right side. Two more cut wounds (6 cm long on the ventral surface and 3 cm long on the dorsal aspect) of the tongue in a direction oblique to its long axis were connected by a cut through the entire thickness of the tongue. Tooth 103 was broken at the gingival line and 104 under …

Shepherd Dogs As A Common Source For Salmonella Enterica Serovar Reading In Garmsar, Iran, Taghi Zahraei Salehi, Mahdi Askari Badouei, Omid Madadgar, Seyed Reza Ghiasi, Iradj Ashrafi Tamai

Turkish Journal of Veterinary & Animal Sciences

Salmonella infection is one of the most important diseases that affect all animal species and is the leading cause of foodborne infections worldwide. One of the challenges in the control and prevention of salmonellosis is the recognition of potential carriers. To assess the potential role of shepherd dogs in the epidemiology of salmonellosis, fecal samples were taken from 38 shepherd dogs in Garmsar Province. Salmonella strains were isolated from 4 dogs (10.5%) related to 3 sheep flocks. All of the strains were confirmed at the genus level using invA virulence gene PCR. Serotyping confirmed all of the strains as Salmonella …

Comparative Imaging Of The Vesicular Glands In New Zealand White Rabbits (Oryctolagus Cuniculus), Rosen Dimitrov, Kamelia Stamatova, Dimitar Kostov

Turkish Journal of Veterinary & Animal Sciences

This study investigated the morphological topographic features of the vesicular glands (gll. vesiculosae) in 10 sexually mature and clinically healthy male New Zealand White rabbits, aged 12 months, with body weights from 2.8 kg to 3.2 kg. The glands were observed by ultrasonography in 2 planes, transversal and sagittal. The approach was percutaneous transabdominal prepubic. The rabbit vesicular glands were visualized as a solid heterogeneous echoic finding. Using computed tomography, we scanned the pelvis in the transversal plane through the first sacral vertebra, at a cut thickness of 3 mm. The vesicular glands were visualized as transversally ovoid, homogeneous, and …

Treatment Of A Distal Radius And Ulna Fracture In A Young Llama With A Combination Of External And Internal Fixation, Özlem Güzel, Di̇lek Olğun Erdi̇kmen, Serhat Özsoy, Büşra İnal

Turkish Journal of Veterinary & Animal Sciences

The case consisted of a 1-month-old female llama with a left distal diaphyseal forearm fracture caused by trauma. Clinical and radiographic examination confirmed the presence of a distal fracture of the left radius and ulna. Treatment was carried out by combining internal and external fixation techniques. Successful fracture healing was achieved without any complications using this method of treatment, which has not been reported before.

Effects Of Feeding Dry Fat And Yeast Culture On Broiler Chicken Performance, Mutassim Mohamed Abdelrahman

Turkish Journal of Veterinary & Animal Sciences

A feeding trial with 400 male broilers (Ross) was conducted to investigate the effect of using dry fat and 2 levels of yeast culture (Saccharomyces cerevisiae) on performance, blood glucose, cholesterol, calcium, phosphorus, cobalt, copper, magnesium, manganese, and zinc. One-day-old broilers were distributed among 4 treatments, with 4 replicates and 25 chicks/replicate. The treatments were: diet 1 (basal diet with maize oil, group T1), diet 2 (basal diet with dry fat, group T2), diet 3 (basal diet with dry fat + 2 kg of yeast culture/t diet, group T3), and diet 4 (basal diet with dry fat + 3 kg …

Animal Skeletal Remains Of The Theodosius Harbor: General Overview, Vedat Onar, Gülsün Pazvant, Hasan Alpak, Nazan Gezer İnce, Altan Armutak, Zeynep Sevi̇m Kiziltan

Turkish Journal of Veterinary & Animal Sciences

Archaeological excavations at the site of Yenikapı, the most important main station for Metro and Marmaray projects on the European side of İstanbul, were started in 2004 with the discovery of numerous shipwrecks, amphorae, and skeletal remains belonging to animals. The findings from the excavations conducted by the İstanbul Archaeological Museums of the General Directorate of Cultural Heritage and Museums proved that this site, known in the Ottoman period as 'Langa Bostanları', was actually the ancient harbor of Theodosius. The archeological material and animal skeletal residues, mostly of horse origin, were found side by side in excavations initiated in 2004 …

Isolation Of Streptococcus Species From The Tonsils Of Slaughtered Pigs, Arzu Funda Bağcigi̇l, Serkan İki̇z, Kemal Meti̇ner, Naci̇ye Yakut Özgür, Seyyal Ak, Ahmet Ati̇la Ilgaz

Turkish Journal of Veterinary & Animal Sciences

The palatine tonsils of 220 pigs were examined for the occurrence of Streptococcus suis and other Streptococcus species. Samples were cultured onto Colombia agar plates with 5% defibrinated horse blood and selective antibiotic supplement and were incubated at 37 °C for 24-48 h aerobically. Presumptive colonies were identified using API20 Strep (bioMérieux). S. suis was not detected in any of the 220 palatine tonsils examined. S. porcinus was the most common streptococcus recovered and was isolated from 68 (31%) pigs. From the samples, S. agalactiae was isolated from 19 (8.6%), S. equi subsp. zooepidemicus from 10 (4.5%), S. uberis from …

Effects Of Parity And Litter Size On The Energy Contents And Immunoglobulin G Concentrations Of Awassi Ewe Colostrum, Shogo Higaki, Masashi Nagano, Seiji Katagiri, Yoshiyuki Takahashi

Turkish Journal of Veterinary & Animal Sciences

This study determined the energy content and immunoglobulin G (IgG) concentration of Awassi ewe colostrum and examined the effects of parity and litter size on them. Colostral samples were collected from 57 ewes from the 1st to 7th parities with a litter size of 1 or 2, within 12 h after lambing. Concentrations of colostral fat, lactose, and protein were measured as energy sources, and IgG was measured as representative of the immunoglobulin content of the colostrum. Mean values obtained from analyses of the ewe colostrum samples were 7.4 ± 2.1 kJ/g for the energy value and 60.9 ± 21.4 …

Patellar Fracture And Patellar Tendon Rupture In A Dog, Murat Sarierler, İbrahi̇m Akin, Ali̇ Belge, Nuh Kiliç

Turkish Journal of Veterinary & Animal Sciences

The case of a patellar fracture in a 2-year-old male Chow Chow dog was reported. Clinical examination showed a few superficial wounds, erythema, a slight edema on the lateral aspect of the knee joint, and mild to moderate limping in the right hind leg. The patella was palpated more proximally than expected, while an acute ridge was felt at its distal pole. X-ray examination indicated that it had been fractured into 3 fragments. Following routine surgical preparation and inhalation anesthesia, the right knee joint was accessed through a lateral parapatellar incision. Spongious bone tissue was visible in the articular space …

Intrascrotal Testicular Torsion And Seminoma In A Dog With Chronic Renal Failure, Leandro Zuccolotto Crivellenti, Tathiana Ferguson Motheo, Ricardo Lima Salomão, Daniel Kan Honsho, Cladia Momo

Turkish Journal of Veterinary & Animal Sciences

A 10-year-old mongrel dog was presented with signs of vomiting, prostration, anorexia, abdominal pain, dyspnea, dysuria, and enhanced scrotal volume. Clinical, laboratory, and radiological examinations showed intrascrotal testicular pathology and chronic renal failure. Emergency treatment was carried out; however, the patient died. Necropsy diagnosed an intrascrotal testicular torsion and seminoma. The aim of the present report is to describe an intrascrotal testicular torsion associated with chronic renal failure in a dog.

Histological Changes In The Bone Structure Induced At 12 Weeks By Experimental Administration Of Bisphosphonates, Horea Artimoniu Almaşan, Mihaela Baciut, Oana Cristina Almaşan, Simion Bran, Grigore Baciut

Turkish Journal of Veterinary & Animal Sciences

Histological changes in bone structure were induced at 12 weeks by experimental administration of bisphosphonates, which have been associated with osteonecrosis of the jaws. The purpose of this study was to determine the effect of local administration of bisphosphonate on bone formation in rats. Surgically created bone defects were evaluated at 12 weeks by histological examination after bisphosphonate administration. Fifteen Wistar rats that underwent surgery to create a bone defect at the right femur were divided in 3 groups: 2 experimental groups and a control group. The 1st experimental group received bisphosphonate as a single 1-mL dose into the bone …