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Full-Text Articles in Veterinary Medicine
Clastogenic And Anticlastogenic Potential Of Neem Flower Extract Evaluated By Rat Liver Micronucleus Assay, Piengchai Kupradinun, Yaninee Jarratwisarutporn, Rawiwan Wongpoomchai, Hathaitip Sritanaudomchai, Mati Rienkitjakarn
Clastogenic And Anticlastogenic Potential Of Neem Flower Extract Evaluated By Rat Liver Micronucleus Assay, Piengchai Kupradinun, Yaninee Jarratwisarutporn, Rawiwan Wongpoomchai, Hathaitip Sritanaudomchai, Mati Rienkitjakarn
The Thai Journal of Veterinary Medicine
Clastogenic and anticlastogenic effects of neem flower (Azadirachta indica A. Juss) extract were determined using a rat liver micronucleus assay. Methanol extracts of neem flowers (MENF) in 15% Tween 80 at 100 and 500 mg/kg body weight were orally given to male Sprague Dawley rats daily for 6 weeks (2 weeks prior to and 4 weeks during repeated administration of diethylnitrosamine (DEN). All rats were anesthetized and their livers were collected. Hepatocytes were isolated from the livers using a collagenase solution without performing liver perfusion, then stained with 4’, 6-diamidino-2-phenylindole dihydrochloride (DAPI). Incidence of the micronucleated hepatocytes was evaluated by …
Comparison Of Gentamicin Impregnated Polymethlymetacrylate Bead, Gentamicin Coated Native Calcium Sulfate Bead And Gentamicin Coated High Porous Calcium Sulfate Bead On Osteomyelitis Management In A Rat Model, Chaiyakorn Thitiyanaporn, Pareeya Udomkusonsri, Naris Thengchaisri
Comparison Of Gentamicin Impregnated Polymethlymetacrylate Bead, Gentamicin Coated Native Calcium Sulfate Bead And Gentamicin Coated High Porous Calcium Sulfate Bead On Osteomyelitis Management In A Rat Model, Chaiyakorn Thitiyanaporn, Pareeya Udomkusonsri, Naris Thengchaisri
The Thai Journal of Veterinary Medicine
Three types of gentamicin beads were compared in a rat osteomyelitis model. The gentamicin beads were prepared in cylinder shape (diameter 2 mm x height 4 mm). Gentamicin impregnated polymethylmethacrylate (GIPMMA) beads were fabricated according to manufacturer’s instructions. Gentamicin coated native calcium sulfate (GNCS) bead and gentamicin coated high porous calcium sulfate (G-HPCS) bead were prepared in laboratory. Osteomyelitis was induced in the rat’s tibias by using methicillin resistance Staphylococcus aureus (MRSA). After 3 weeks of infection, the infected tibias were implanted with GI-PMMA bead, G-NCS bead, G-HPCS bead or sham treatment (control). Radiographic change, white blood cell count and …
Acute To Subchronic Toxicity And Reproductive Effects Of Aqueous Ethanolic Extract Of Rhizomes Of Lasia Spinosa Thw. In Male Rats, Theerayuth Kaewamatawong, Wanwipa Suthikrai, Anong Bintvihok, Wijit Banlunara
Acute To Subchronic Toxicity And Reproductive Effects Of Aqueous Ethanolic Extract Of Rhizomes Of Lasia Spinosa Thw. In Male Rats, Theerayuth Kaewamatawong, Wanwipa Suthikrai, Anong Bintvihok, Wijit Banlunara
The Thai Journal of Veterinary Medicine
Acute and subchronic tests on the toxicity and reproductive effects of aqueous ethanolic extract of rhizomes of Lasia spinosa Thw. was studied in male rats. In the acute test, oral administration of 5, 10, 20, 40 g/kg of the extract showed no mortality or behavioral changes. In the subchronic test, administration of 5 or 20 g/kg of the extract for 28 days revealed no mortality of the animals. No differences in hematological parameters were observed in either control or treatment groups of both tests. For blood chemistry analysis in both tests, triglycerides in treatment rats were significantly decreased compared to …
Histological Changes In The Bone Structure Induced At 12 Weeks By Experimental Administration Of Bisphosphonates, Horea Artimoniu Almaşan, Mihaela Baciut, Oana Cristina Almaşan, Simion Bran, Grigore Baciut
Histological Changes In The Bone Structure Induced At 12 Weeks By Experimental Administration Of Bisphosphonates, Horea Artimoniu Almaşan, Mihaela Baciut, Oana Cristina Almaşan, Simion Bran, Grigore Baciut
Turkish Journal of Veterinary & Animal Sciences
Histological changes in bone structure were induced at 12 weeks by experimental administration of bisphosphonates, which have been associated with osteonecrosis of the jaws. The purpose of this study was to determine the effect of local administration of bisphosphonate on bone formation in rats. Surgically created bone defects were evaluated at 12 weeks by histological examination after bisphosphonate administration. Fifteen Wistar rats that underwent surgery to create a bone defect at the right femur were divided in 3 groups: 2 experimental groups and a control group. The 1st experimental group received bisphosphonate as a single 1-mL dose into the bone …
The Protective And Therapeutic Effect Of Phenoxy-2-Methyl-2-Propionic Acid On Experimental Fatty Liver In Rats, Ümmügülsüm Gümüş, Gülbi̇n Şennazli, Utku Bakirel
The Protective And Therapeutic Effect Of Phenoxy-2-Methyl-2-Propionic Acid On Experimental Fatty Liver In Rats, Ümmügülsüm Gümüş, Gülbi̇n Şennazli, Utku Bakirel
Turkish Journal of Veterinary & Animal Sciences
In this study, the potential protective and therapeutic effect of phenoxy-2-methyl-2-propionic acid (PMPA) was investigated in rats with experimental hepatic steatosis induced by a carbon tetrachloride and paraffin liquid mixture (1:1). Forty Wistar albino rats were allocated to 4 groups with 10 rats in each. Group 1 was administered a saline solution; group 2 was administered the carbon tetrachloride and paraffin liquid mixture; group 3 was administered the carbon tetrachloride and paraffin liquid mixture and PMPA for 7 days; and in group 4, hepatic steatosis was created with the carbon tetrachloride and paraffin liquid mixture during the first 7 days, …