Health Services Research Commons^™

Assessment Of Condylar Morphology In Various Facial Types-Cbct Study, Dr.Shruti Patil

Annual Research Symposium

Mandibular condyle being part of the TMJ complex, its volume and shape play a pivotal role in treatment stability and outcomes in orthodontic and orthognathic patients over long term periods. Different loading patterns would result in different morphology of the TMJ. The association with different facial types and understanding the relationship between condylar position, morphology and jaw base divergence is limited. This study’s objective is to assess the condylar structure which includes condylar height, width and height of the fossa in different jaw base divergences.

A cross-sectional study was conducted in which 90 patients undergoing Orthodontic treatment were selected and …

Clearing The Air: Innovations In Imaging For Early Detection And Management Of Chronic Obstructive Pulmonary Disease, Francesca Polverino

Faculty, Staff and Students Publications

No abstract provided.

Multi-Omics Analysis Reveals Immune Features Associated With Immunotherapy Benefit In Patients With Squamous Cell Lung Cancer From Phase Iii Lung-Map S1400i Trial, Edwin Roger Parra, Jiexin Zhang, Dzifa Yawa Duose, Edgar Gonzalez-Kozlova, Mary W Redman, Hong Chen, Ganiraju C Manyam, Gayatri Kumar, Jianhua Zhang, Xingzhi Song, Rossana Lazcano, Mario L Marques-Piubelli, Caddie Laberiano-Fernandez, Frank Rojas, Baili Zhang, Len Taing, Aashna Jhaveri, Jacob Geisberg, Jennifer Altreuter, Franziska Michor, James Provencher, Joyce Yu, Ethan Cerami, Radim Moravec, Kasthuri Kannan, Rajyalakshmi Luthra, Gheath Alatrash, Hsin-Hui Huang, Hui Xie, Manishkumar Patel, Kai Nie, Jocelyn Harris, Kimberly Argueta, James Lindsay, Roshni Biswas, Stephen Van Nostrand, Seunghee Kim-Schulze, Jhanelle E Gray, Roy S Herbst, Ignacio I Wistuba, Scott Gettinger, Karen Kelly, Lyudmila Bazhenova, Sacha Gnjatic, J Jack Lee, Jianjun Zhang, Cara Haymaker

Faculty, Staff and Student Publications

PURPOSE: Identifying molecular and immune features to guide immune checkpoint inhibitor (ICI)-based regimens remains an unmet clinical need.

EXPERIMENTAL DESIGN: Tissue and longitudinal blood specimens from phase III trial S1400I in patients with metastatic squamous non-small cell carcinoma (SqNSCLC) treated with nivolumab monotherapy (nivo) or nivolumab plus ipilimumab (nivo+ipi) were subjected to multi-omics analyses including multiplex immunofluorescence (mIF), nCounter PanCancer Immune Profiling Panel, whole-exome sequencing, and Olink.

RESULTS: Higher immune scores from immune gene expression profiling or immune cell infiltration by mIF were associated with response to ICIs and improved survival, except regulatory T cells, which were associated with worse …

Detecting The 2-Micron Plasmid In Saccharomyces Cerevisiae, Caitlin C. Allen, Eric T. Gillock

SACAD: Scholarly Activities

This research is a continuation of work started by a previous student, Camryn Greving. Camryn was screening for the presence of the 2-micron plasmid using PCR primers specific for the REP2 gene, devised by Nakayashiki et al. In this research, we confirmed the presence of the plasmid by using primers specific for the RAF1 gene, which were designed by Strope et al.

An Ot Needs Assessment For Children And Families Residing In Shelters, Jessie Siono, Susan Macdermott

Spring 2024 Virtual OTD Capstone Symposium

This study created a needs assessment is to determine the unique occupational deficits of children and their families in California experiencing homelessness within a shelter setting via recording their lived experiences. A local family shelter was analyzed via observation and interviews with staff and residents of the shelter. The results were compiled into a facility assessment to identify supports and barriers to occupation. Results were also utilized to complete an occupational needs assessment for families and children living in homeless shelters. The study determined the occupational needs and occurrences of occupational deficits that were experienced by residents of the family …

The Dearth Of Knowledge Of Health Insurance Literacy Within The United States, Katherine A. Conzet

Honors Thesis

This literature review and cross-comparison were conducted to combine resources that bring to light the lack of knowledge on health insurance, the impact of this low health insurance literacy (HIL), and the lack of research being done in this subject field. This thesis analyzes and compares different research that measures HIL levels and compares these findings. At the same time, this thesis presents the complex history of health insurance and how this understanding can contribute to lower population HIL and proposes different ways to accurately measure HIL. The purpose is to show the necessity for more research into the field …

Evaluation Of Four Computed Tomography Reconstruction Algorithms Using A Coronary Artery Phantom, Shungo Sawamura, Shingo Kato, Yoshinori Funama, Seitaro Oda, Harumi Mochizuki, Sayuri Inagaki, Yuka Takeuchi, Tsubasa Morioka, Toshiharu Izumi, Yoichiro Ota, Hironori Kawagoe, Shihyao Cheng, Naoki Nakayama, Kazuki Fukui, Takashi Tsutsumi, Tae Iwasawa, Daisuke Utsunomiya

Faculty, Staff and Student Publications

BACKGROUND: Despite advancements in coronary computed tomography angiography (CTA), challenges in positive predictive value and specificity remain due to limited spatial resolution. The purpose of this experimental study was to investigate the effect of 2nd generation deep learning-based reconstruction (DLR) on the quantitative and qualitative image quality in coronary CTA.

METHODS: A vessel model with stepwise non-calcified plaque was scanned using 320-detector CT. Image reconstruction was performed using four techniques: hybrid iterative reconstruction (HIR), model-based iterative reconstruction (MBIR), DLR, and 2nd generation DLR. The luminal peak CT number, contrast-to-noise ratio (CNR), and edge rise slope (ERS) were quantitatively evaluated via …

Analisis Spasial Faktor Risiko Difteri Di Provinsi Lampung Tahun 2022 Dan 2023, Nada Izzata Kamilla, Feranita Utama, Noviani Noviani

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Difteri merupakan penyakit menular yang disebabkan oleh bakteri Corynebacterium diphtheriae. Bila ditemukan satu kasus difteri di suatu wilayah maka dapat ditetapkan sebagai KLB. Provinsi Lampung terus mengalami kenaikan kasus dan suspek difteri sejak 2020 dan turut menyumbang angka kematian akibat difteri pada tahun 2023. Kasus difteri dipengaruhi oleh beberapa faktor risiko. Penelitian ini bertujuan untuk mendapatkan gambaran distribusi dan faktor risiko kasus difteri di Provinsi Lampung dengan memetakan kabupaten/kota berdasarkan persebaran dan faktor risikonya. Penelitian ini menggunakan desain studi ekologi dengan metode deskriptif analitik dengan aplikasi Quantum GIS versi 3.28.3. Hasil menunjukan distribusi kejadian difteri di Provinsi …

Hubungan Berat Derajat Merokok Terhadap Kelainan Fungsi Paru Pada Sopir Angkutan Umum Di Terminal Kampung Melayu, Rizaldi Ridwan, Fajaria Nurcandra, Chandrayani Simanjorang, Dyah Utari, Balqis Hiri Bahasoan

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Di Indonesia, terdapat sebanyak 9,2 juta jiwa penyakit kelainan fungsi paru. Sopir angkutan umum yang merokok berisiko mengalami kelainan fungsi paru yang diakibatkan oleh rokok. Penelitian ini bertujuan untuk menganalisis hubungan berat derajat merokok terhadap gejala kelainan fungsi paru pada sopir angkutan umum di Terminal Kampung Melayu. Penelitian ini dilaksanakan pada bulan Mei tahun 2023 di Terminal Kampung Melayu dengan desain cross-sectional pada 102 sopir angkutan umum sebagai sampel. Sampel dipilih menggunakan teknik purposive sampling dengan kriteria inklusi sopir angkutan umum dan bersedia diwawancara. Wawancara langsung dilakukan menggunakan kuesioner dan spirometri untuk mengukur fungsi paru. Data dianalisis menggunakan uji Cox …

Measuring The Impact Of Primary Care Team Composition On Patient Activation Utilizing Electronic Health Record Big Data Analytics, Kristen K. Will, Yue Liang, Chih-Lin Chi, Gerri Lamb, Michael Todd, Connie Delaney

Journal of Patient-Centered Research and Reviews

Purpose

Team-based care has been linked to key outcomes associated with the Quadruple Aim and a key driver of high-value patient-centered care. Use of the electronic health record (EHR) and machine learning have significant potential to overcome previous barriers to studying the impact of teams, including delays in accessing data to improve teamwork and optimize patient outcomes.

Methods

This study utilized a large EHR dataset (n = 316,542) from an urban health system to explore the relationship between team composition and patient activation, a key driver of patient engagement. Teams were operationalized using consensus definitions of teamwork from the literature. …

Research Frameworks: Critical Components For Reporting Qualitative Health Care Research, Ann Z. George

Journal of Patient-Centered Research and Reviews

Qualitative health care research can provide insights into health care practices that quantitative studies cannot. However, the potential of qualitative research to improve health care is undermined by reporting that does not explain or justify the research questions and design. The vital role of research frameworks for designing and conducting quality research is widely accepted, but despite many articles and books on the topic, confusion persists about what constitutes an adequate underpinning framework, what to call it, and how to use one. This editorial clarifies some of the terminology and reinforces why research frameworks are essential for good-quality reporting of …

Sistem Monitoring Dan Evaluasi Serta Perkembangan Program Pencegahan Dan Pengendalian Penyakit Tuberkulosis Di Dinas Kesehatan Kota Depok, Supriyanti Supriyanti, Tiur Febrina Pohan, Kemal N. Siregar

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Beban kasus TB tertinggi tahun 2021 terjadi di Provinsi Jawa Barat, Jawa Timur, Jawa Tengah, Sumatera Utara, dan DKI Jakarta. Kota Depok merupakan salah satu penyumbang beban TB di Jawa Barat. Dari data estimasi beban TB se-Provinsi Jawa Barat, Kota Depok berada di urutan ke-7 dengan estimasi jumlah kasus sebanyak 3853 kasus. Menurut indikator angka keberhasilan pengobatan pasien TB, semua kasus tahun 2018-2021 masih dibawah target 90%. Tujuan penelitian ini untuk mengetahui hasil monitoring dan evaluasi program TB yang telah berjalan di Seksi Pencegahan dan Pengendalian Penyakit Menular serta perkembangan program TB dilihat dari capaian indikator TB di Dinas Kesehatan …

Analysis Of User Satisfaction Of Telemedicine Services During Covid-19 Self-Isolation Among Fph Students At The Universitas Indonesia, Fathiya Nissa Mulyaningrum, Nadya Raihanny

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Telemedicine has become a new paradigm in the world of health since its popular use to assist the Ministry of Health in monitoring self-isolating patients during the COVID-19 pandemic. This study aims to analyze service quality variables related to user satisfaction with telemedicine services during COVID-19 self-isolation among students in FPH UI. This research is quantitative research with a cross-sectional approach. The results show that the platform most widely used for telemedicine services during the COVID-19 pandemic was platform H by 25 people. The average satisfaction of telemedicine users during self-isolation tends to be high, namely 3.8 with the lowest …

Persepsi Masyarakat Perdesaan Terhadap Penerimaan Vaksinasi Covid-19 Tahap Iii (Booster), Irma Irma, Yusuf Sabilu, Besse Amelia

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Penerimaan vaksinasi COVID-19 tahap III (booster) tiap kabupaten/kota di Provinsi Sulawesi Selatan memperoleh cakupan yang berbeda-beda. Jika dibandingkan dengan kabupaten/kota lainnya, Kabupaten Wajo memperoleh cakupan vaksin COVID-19 tahap III (booster) masih rendah yaitu 14.06%, dimana Desa Watan Rumpia memiliki persentase cakupan vaksinasi COVID-19 tahap III (booster) terendah per 16 Agustus 2022. Hal ini disebabkan karena persepsi dari masyarakat itu sendiri dalam menanggapi penerimaan vaksinasi COVID-19 tahap III (booster). Penelitian ini bertujuan untuk mengetahui hubungan antara persepsi masyarakat mengenai kerentanan, keparahan, manfaat dengan penerimaan vaksinasi COVID-19 tahap III (booster) di Desa …

Adult Development And Associated Health Risks, Elizabeth C. Halloran

Journal of Patient-Centered Research and Reviews

Much has been learned about adult development in recent decades. Adults go through stages of development (emerging adulthood, young adulthood, middle adulthood, post-retirement, and very old age) with certain challenges at each stage. Viewing patients through a developmental lens is part of providing patient-centered care. Knowing the prominent issues, stressors, and risks at each stage of development is important in understanding patients. This knowledge can help customize medical advice to patients regarding obesity, disability, sleep, substance use, relationships, and age-related declines. This paper summarizes an updated view of adult development and discusses its relevance to health risks and patient-centered care …

A Systematic Review: Mirror Neurons & Schizophrenia, Yashesvi Sharma, Surajit Dey

Annual Research Symposium

This research project establishes a link between Mirror Neuron System (MNS) activity and this information's implications in treating and understanding schizophrenia, specifically, schizophrenic patients with negative symptoms.

Voices, Stories And Experiences Of Black Women Phase Ii: Community Engagement Activity Report Informing The Establishment Of A Trenton-Based Maternal & Infant Health Innovation Center, John S. Watson Institute For Urban Policy And Research, Tirzah Spencer, Phd, Mph, Barbara George Johnson

Center for Urban Policy Research

As an extension of our 2022 study Voices, Stories and Experiences of Black Women (Phase 1), the John S. Watson Institute for Urban Policy and Research at Kean University’s Maternal and Child Health Equity Team was asked to share information about the planned Maternal and Infant Health Innovation Center (MIHIC) with Trenton residents as a part of Nurture NJ’s community engagement efforts. The Team implemented the following community engagement activities: Communication: Community engagement through social media outreach and in-person outreach were used as approaches to inform Trenton residents about the MIHIC. Dissemination of Findings: Community cafés were designed to share …

Health And Healthcare: Designing For The Social Determinants Of Health And Blue Zones In North Nashville, Rebecca Tonguis, Honor Thomas, Olivia Hobbs

[Archive] Belmont University Research Symposium (BURS)

Owned by North Nashville’s First Community Church, a now empty site in the Osage-North Fisk neighborhood of North Nashville has been identified as a potential site for a new location of The Store, in addition to a community-centric architectural development based on the social determinants of health and informed by the principles behind Blue Zones, the locations with the highest lifespans in the world. Opened by Brad Paisley and Kimberly Williams-Paisley, The Store is a free grocery store that “allow[s] people to shop for their basic needs in a way that protects dignity and fosters hope”, for which North Nashville …

Developing A Health Equity-Minded Curriculum: The Impacts Of Cancer Care, Leanna Ross, Camille Ashley, Julianne Luttrell, Krismae Jimenez

Articles, Abstracts, and Reports

No abstract provided.

Los Determinantes Sociales Y El Acceso A La Salud De Las Mujeres Migrantes: Desde La Perspectiva De Las Usuarias Y Los Trabajadores De Salud, Vanessa Gutiérrez

Independent Study Project (ISP) Collection

For the past few years, Chile has developed laws and programs, such as the Program for Access to Healthcare for Immigrants, Decree N° 67, and recently Law N° 21.235, to improve the access that migrants have, however, there has been a failure to comply with these regulations. In this qualitative and descriptive investigation, the main objective is to find out how accessible, adequate, and effective the health resources offered by clinics are for migrant women. In order to carry out the investigation, eight semi-structured interviews were held with five primary healthcare workers who frequently work with the migrant population and …

Acceso A La Salud De Mujeres Migrantes Venezolanas En La Ciudad Autónoma De Buenos Aires (2024) / Female Venezuelan Migrants’ Access To Healthcare In Autonomous City Of Buenos Aires (2024), Karen Gonzalez

Independent Study Project (ISP) Collection

Esta investigación se enfoca en indagar y describir el acceso al sector de salud en la población de mujeres migrantes venezolanas con trabajos como monotributistas que residen en la Ciudad Autónoma de Buenos Aires (CABA). En la última década, Venezuela se ha enfrentado a una crisis económica y humanitaria. Esta crisis ha provocado una ola de migración sin precedentes por todo el mundo. Dentro del Cono Sur, Argentina se cataloga como el sexto país receptor de migrantes venezolanos. Considerando las leyes de migración y el sistema de salud universal en Argentina, me propuse describir las barreras de acceso a la …

The Ethicality Of Gene Alteration In Human Embryos, Alyssa Scudder

Augustana Center for the Study of Ethics Essay Contest

No abstract provided.

Salud Integral De Las Personas En Situación De Calle Abordada Desde Los Distintos Programas Sociales De La Ciudad De Arica, Chile, Maya Trujillo

Independent Study Project (ISP) Collection

Homelessness as a public health phenomenon is a humanitarian crisis present across nations around the world. Instances of homelessness are rooted in public social and economic failures. Complex challenges like this require multifaceted and holistic initiatives such as those proposed by the Integrative Family Health Model in Chile. This project describes current interdisciplinary programs (social services) and how they collaborate to provide integrated services to people experiencing homelessness. We also consider the patient perspective on how these interventions affect their well-being. Through observational data, interviews, and surveys, we describe the physical, social, and cultural aspects of homelessness in Arica, Chile …

Research On Key Influencing Factors Of Elderly Health Information Avoidance Behavior In Public Health Emergencies, Lihui Peng, Tang Linjun, Xidan Li

Journal of Scientific Information Research

[Purpose/significance]To focus on the health information avoidance behavior of the elderly under public health emergencies, identify the key influencing factors of health information avoidance behavior of the elderly, and provide decision-making reference for epidemic prevention and health management of the elderly. [Method/process]Based on MOA theory, an index system of key influencing factors of information avoidance behavior of the elderly under public health emergencies was established. The triangular fuzzy number Dematel method was used to establish the causal relationship between factors, and DANP method was used to quantify the weight of the identified key influencing factors. [Result/conclusion]Emotional regulation and intergenerational considerations（M）; …

Non-Urgent Use Of Emergency Departments By Rural And Urban Adults, Erika Ziller Phd, Carly Milkowski, Zachariah Croll, Yvonne Jonk Phd

Access / Insurance

This study, conducted by researchers at the Maine Rural Health Research Center, provides updated information and addresses gaps in knowledge about rural non-urgent ED use. Understanding the rates of non-urgent ED use among rural adults and the factors associated with this use can inform policy and practice efforts to reduce unnecessary and inappropriate use of EDs in rural communities.

Hospital emergency departments (EDs) serve a vital role in the US health care system, providing lifesaving, around-the-clock care to patients in acute health situations. However, use of the ED for non-urgent care is costly and reflects a suboptimal care setting, with …

A Mutation In Tbxt Causes Congenital Vertebral Malformations In Humans And Mice, Shuxia Chen, Yunping Lei, Yajun Yang, Chennan Liu, Lele Kuang, Li Jin, Richard H Finnell, Xueyan Yang, Hongyan Wang

Faculty, Staff and Students Publications

T-box transcription factor T (TBXT; T) is required for mesodermal formation and axial skeletal development. Although it has been extensively studied in various model organisms, human congenital vertebral malformations (CVMs) involving T are not well established. Here, we report a family with 15 CVM patients distributed across 4 generations. All affected individuals carry a heterozygous mutation, T c.596A>G (p.Q199R), which is not found in unaffected family members, indicating co-segregation of the genotype and phenotype. In vitro assays show that T p.Q199R increases the nucleocytoplasmic ratio and enhances its DNA-binding affinity, but reduces its transcriptional activity compared to the wild-type. …

Re-Evaluation Of The Methodology For Estimating The Us Specialty Physician Workforce, W Stephen Black-Schaffer, David J Gross, Zakia Nouri, Aidan Delisle, Michael Dill, Jason Y Park, James M Crawford, Michael B Cohen, Rebecca L Johnson, Donald S Karcher, Thomas M Wheeler, Stanley J Robboy

Faculty, Staff and Students Publications

Increasing pursuit of subspecialized training has quietly revolutionized physician training, but the potential impact on physician workforce estimates has not previously been recognized. The Physicians Specialty Data Reports of the Association of American Medical Colleges, derived from specialty designations in the American Medical Association (AMA) Physician Professional Data (PPD), are the reference source for US physician workforce estimates; by 2020, the report for pathologists was an undercount of 39% when compared with the PPD. Most of the difference was due to the omission of pathology subspecialty designations. The rest resulted from reliance on only the first of the AMA PPD's …

Load703, An Oncolytic Virus-Based Immunostimulatory Gene Therapy, Combined With Chemotherapy For Unresectable Or Metastatic Pancreatic Cancer (Lokon001): Results From Arm 1 Of A Non-Randomised, Single-Centre, Phase 1/2 Study, Benjamin L Musher, Eric K Rowinsky, Brandon G Smaglo, Wasif Abidi, Mohamed Othman, Kalpesh Patel, Salmaan Jawaid, James Jing, Amanda Brisco, Ann M Leen, Mengfen Wu, Linda C Sandin, Jessica Wenthe, Emma Eriksson, Gustav J Ullenhag, Bambi Grilley, Justyna Leja-Jarblad, Susan G Hilsenbeck, Malcolm K Brenner, Angelica S I Loskog

Faculty, Staff and Students Publications

Background: Pancreatic ductal adenocarcinoma is characterised by low immunogenicity and an immunosuppressive tumour microenvironment. LOAd703, an oncolytic adenovirus with transgenes encoding TMZ-CD40L and 4-1BBL, lyses cancer cells selectively, activates cytotoxic T cells, and induces tumour regression in preclinical models. The aim of this study was to evaluate the safety and feasibility of combining LOAd703 with chemotherapy for advanced pancreatic ductal adenocarcinoma.

Methods: LOKON001 was a non-randomised, phase 1/2 study conducted at the Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA, and consisted of two arms conducted sequentially; the results of arm 1 are presented here. …

Alveolar Epithelial Cell Dysfunction In Idiopathic Pulmonary Fibrosis Linked To Lipid Alterations: Therapeutic Implications, Francesca Polverino, Ana Mora

Faculty, Staff and Students Publications

No abstract provided.

An Oocyte-Specific Cas9-Expressing Mouse For Germline Crispr/Cas9-Mediated Genome Editing, Denise G Lanza, Jianqiang Mao, Isabel Lorenzo, Lan Liao, John R Seavitt, M Cecilia Ljungberg, Elizabeth M Simpson, Francesco J Demayo, Jason D Heaney

Faculty, Staff and Students Publications

Cas9 transgenes can be employed for genome editing in mouse zygotes. However, using transgenic instead of exogenous Cas9 to produce gene-edited animals creates unique issues including ill-defined transgene integration sites, the potential for prolonged Cas9 expression in transgenic embryos, and increased genotyping burden. To overcome these issues, we generated mice harboring an oocyte-specific, Gdf9 promoter driven, Cas9 transgene (Gdf9-Cas9) targeted as a single copy into the Hprt1 locus. The X-linked Hprt1 locus was selected because it is a defined integration site that does not influence transgene expression, and breeding of transgenic males generates obligate transgenic females to serve as embryo …