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2020

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Articles 121 - 150 of 592

Full-Text Articles in Epidemiology

Gerakan Nusantara Program On Children’S Nutrition Practices, Syilga Cahya Gemily, Sandra Fikawati, Ahmad Syafiq Aug 2020

Gerakan Nusantara Program On Children’S Nutrition Practices, Syilga Cahya Gemily, Sandra Fikawati, Ahmad Syafiq

Kesmas

Gerakan Nusantara is a nutrition education program that aims to change the nutrition knowledge, attitudes, and practices of elementary school children in Indonesia. The program was implemented in 2015–2018 in Jakarta, Bandung, Surabaya, Makassar, Medan, Yogyakarta, Pontianak, East Nusa Tenggara, Pekanbaru, Padang, Jambi, and Sorong. The present study sought to determine the effects of Gerakan Nusantara on the nutrition practices of school-aged children and describe the extent of changes in each nutrition practice component covered by the program. This study used secondary data on Nutrition and Health Knowledge, Attitudes, and Practices studies collected from students participating in the program and …


Education Through Whatsapp Media In Changing Of Smoking Behavior Among Senior High School Students, Yusriani Yusriani, Joel Rey U. Acob Aug 2020

Education Through Whatsapp Media In Changing Of Smoking Behavior Among Senior High School Students, Yusriani Yusriani, Joel Rey U. Acob

Kesmas

Teenagers, who are considerably susceptible to smoking, must be educated to prevent smoking behavior that can cause health problems and even death. The aim of this study was to assess the effect of education through social media such as WhatsApp in the modification of smoking behaviors among senior high school students in Pangkep District, Indonesia. It employed a quasi-experimental, pretest-posttest-only control group design. The experimental group received education in the use of WhatsApp social media, while the control group was provided with leaflets. Data were collected through observation and interviews with a total of 180 students in both groups, with …


Effect Of The Covid-19 Pandemic On Eating Habits And Food Purchasing Behaviors Of University Students, Hacı Ömer Yilmaz, Ramazan Aslan, Cihan Unal Aug 2020

Effect Of The Covid-19 Pandemic On Eating Habits And Food Purchasing Behaviors Of University Students, Hacı Ömer Yilmaz, Ramazan Aslan, Cihan Unal

Kesmas

COVID-19 disease, which spread rapidly all over the world after the first case was detected, became the primary agenda of the countries. Radical measures have been taken by governments to prevent the spread of the disease. Precautions and warnings to prevent disease caused some changes on daily life activities of people. University students who have to stop education are among the groups most affected by this disease sociologically, psychologically and physiologically. The aim of this study was planned and conducted to determine the effect of COVID-19 on university students' eating habits and food purchasing behavior. The study was completed with …


Evaluation Of Anthropometric Parameters Of Central Obesity Among Professional Drivers: A Receiver Operating Characteristic Analysis, Muhammad Asif, Muhammad Aslam, Saima Altaf, Abdul Majid, Saima Atif Aug 2020

Evaluation Of Anthropometric Parameters Of Central Obesity Among Professional Drivers: A Receiver Operating Characteristic Analysis, Muhammad Asif, Muhammad Aslam, Saima Altaf, Abdul Majid, Saima Atif

Kesmas

Different anthropometric parameters have been proposed for assessing central obesity. The diagnostic performance of these anthropometric parameters and their ability to correctly measure central obesity for the professional community, like drivers, is questionable and needs to be assessed. The study aimed to examine the diagnostic performance of anthropometric parameters as indicators of central obesity in drivers as measured by waist circumference (WC) and to determine the best cut-off values for these parameters that would identify obese drivers. Anthropometric measurements from a cross-sectional sample of 197 professional drivers were taken under standard protocol. Receiver operating characteristics (ROC) analysis was used to …


Relationship Between Spirituality And Acceptance Of Illness Level In Bipolar Patients, Olga Putri Atsira, Erikavitri Yuliati, Atika Atika, Abdurachman Abdurachman, Margarita Maria Maramis Aug 2020

Relationship Between Spirituality And Acceptance Of Illness Level In Bipolar Patients, Olga Putri Atsira, Erikavitri Yuliati, Atika Atika, Abdurachman Abdurachman, Margarita Maria Maramis

Kesmas

Bipolar disorder is a chronic mental condition that affects patients’ quality of life. The management process is affected by acceptance of illness. The ability to accept the illness is related to the spirituality level which is something that is held strongly by Indonesian people. There has been very little research related to the relationship between spirituality with bipolar disorder. This study aimed to analyze relationship between spirituality levels with acceptance of illness in patients with bipolar disorder. This study is a correlational study using questionnaire from bipolar disorder patients contacted through Harmony in Diversity online community as a sample. Samples …


Vitamin D And Reduced Academic Stress Of Health Students, Yuni Kusmiyati, Emy Suryani, Lucky Herawati, Amalia Firdausi Aug 2020

Vitamin D And Reduced Academic Stress Of Health Students, Yuni Kusmiyati, Emy Suryani, Lucky Herawati, Amalia Firdausi

Kesmas

Stress conditions can reduce academic ability, influencing student grade point averages and encouraging negative behaviors. The object of this research was to discern the influence of vitamin D in the reduction of academic stress of health students. The study used a randomized controlled trial (RCT). The population was midwifery students who lived in the Health Polytechnic dormitory, Ministry of Health, Yogyakarta, in 2017. Samples were 77 students of midwifery who did not suffer from any chronic disease, nor did they experience academic stress. They all agreed to become research subjects. Samples were 39 respondents in a treatment group who were …


Family Planning Communication Between Wives And Husbands: Insights From The 2017 Indonesia Demographic And Health Survey, Dian Kristiani Irawaty, Suziana Mat Yasin, Hadi Pratomo Aug 2020

Family Planning Communication Between Wives And Husbands: Insights From The 2017 Indonesia Demographic And Health Survey, Dian Kristiani Irawaty, Suziana Mat Yasin, Hadi Pratomo

Kesmas

Frequent inter-spousal communication is regarded as an indicator of safe family planning practice. Nevertheless, communication about family planning within couples in Indonesia is still largely unexplored. This study assessed the levels of inter-spousal communication about family planning and its associated determinants, using cross-sectional and nationally representative data from the 2017 Indonesia Demographic and Health Survey (IDHS), from a randomly selected cohort of 8,925 currently-married couples. Data on sociodemographic characteristics, inter-spousal communication behaviors, and attitudes regarding family planning were collected. The dependent variable in this study is how frequently couples discuss family planning, based on wives’ responses. The analyses were stratified …


Physiological Factors And Physical Activity Contribute To The Incidence Of Type 2 Diabetes Mellitus In Indonesia, Demsa Simbolon, Afriyana Siregar, Ruzita Abd Talib Aug 2020

Physiological Factors And Physical Activity Contribute To The Incidence Of Type 2 Diabetes Mellitus In Indonesia, Demsa Simbolon, Afriyana Siregar, Ruzita Abd Talib

Kesmas

Type 2 diabetes mellitus (T2DM) is the sixth highest cause of death in Indonesia. Thus, it must be prevented and overcome with appropriate management. This study aimed to determine the contribution of physiological factors and physical activities to the incidence of T2DM. The study used a cohort retrospective design using secondary data from the Indonesian Family Life Survey (IFLS) from 2007 to 2014, which included a sample of 14,517 people involved for more than 20 years. Data analysis was performed using multiple logistic regressions. The results revealed a 3.8% incidence of T2DM in Indonesia. Record of hypertension risk increased the …


A Novel Methodology To Identify The Primary Topics Contained Within The Covid-19 Research Corpus, Allen Crane, Brock Freidrich, William Fehlman, Igor Frolow, Daniel W. Engels Aug 2020

A Novel Methodology To Identify The Primary Topics Contained Within The Covid-19 Research Corpus, Allen Crane, Brock Freidrich, William Fehlman, Igor Frolow, Daniel W. Engels

SMU Data Science Review

In this paper, we present a novel framework and system for the identification of primary research topics from within a corpus of related publications, the classification of individual publications according to these topics, and the results of the application of our framework and system to the COVID-19 Open Research Dataset (CORD-19). CORD-19 is a corpus of published peer reviewed and pre-peer reviewed articles related to the coronavirus that causes COVID-19. Using machine learning techniques, such as Non-negative Matrix Factorization for Natural Language Processing and a Bayesian classifier, we developed a novel framework and system that automatically extracts sparse and meaningful …


Gaining A “Foothold” On The Diagnosis Of Leishmaniasis, Brent M. Troy, Rebecca Hart, Navjyot Vidwan, Bethany Hodge Aug 2020

Gaining A “Foothold” On The Diagnosis Of Leishmaniasis, Brent M. Troy, Rebecca Hart, Navjyot Vidwan, Bethany Hodge

Journal of Refugee & Global Health

Pediatric refugees and immigrants may present with unusual diagnoses due to their extensive migration and potential harsh conditions in travel. Trauma and family separation add to the difficulty of obtaining a history of exposures. We report a case of one of the more commonly neglected tropical diseases, Leishmaniasis. A 15-year-old male refugee patient presented to the hospital with ulcerative lesions to his legs. His migration history was extensive, starting in Central Africa with travel to South America, followed by migration through Central America to Texas. The patient developed ulcerative lesions on his legs, and he was brought to the children’s …


Factors Associated With Binge Drinking During The Transition Into Adulthood: Exploring Associations Within Two Distinct Young Adult Age Ranges, Tamara Leech, Sarah Jacobs, Denis Watson Aug 2020

Factors Associated With Binge Drinking During The Transition Into Adulthood: Exploring Associations Within Two Distinct Young Adult Age Ranges, Tamara Leech, Sarah Jacobs, Denis Watson

Department of Public Health Scholarship and Creative Works

Background:

Binge drinking among young adults aged 18-21 years has declined over the past decade, but binge drinking rates among people 22-25 years old have remained largely the same. This steady trend in later years represents a departure from the traditional course of maturing out of risky alcohol use, perhaps because young adults are delaying the transition into adulthood.

Aims:

This paper explores the relationship between binge drinking and aspects of the transition into adulthood that could inform interventions targeting these two distinct groups of young adults.

Methods:

We use survey data on 1,081 young adults aged 18-25 living in …


The Incidence Of Common Respiratory Viruses During The Covid-19 Pandemic: Results From The Louisville Covid-19 Epidemiology Study, Brian C. Bohn Pharmd, Bcidp, Ashley M. Wilde Pharmd, Bcps-Aq Id, Sarah E. Moore Pharmd, Matthew Song Pharmd, Bcidp, Clayton J. Patross Pharmd, Bcps, Alan D. Junkins Phd, D(Abmm), Paul Schulz Md, Julio A. Ramirez Md Facp Aug 2020

The Incidence Of Common Respiratory Viruses During The Covid-19 Pandemic: Results From The Louisville Covid-19 Epidemiology Study, Brian C. Bohn Pharmd, Bcidp, Ashley M. Wilde Pharmd, Bcps-Aq Id, Sarah E. Moore Pharmd, Matthew Song Pharmd, Bcidp, Clayton J. Patross Pharmd, Bcps, Alan D. Junkins Phd, D(Abmm), Paul Schulz Md, Julio A. Ramirez Md Facp

The University of Louisville Journal of Respiratory Infections

Introduction: Social distancing has been utilized during the COVID-19 pandemic to reduce the spread of SARS-CoV-2; it is also expected to reduce the spread of common respiratory viruses.

Methods: This retrospective, descriptive study assessed the rate of positivity of common respiratory viruses from a commercially available respiratory pathogen panel across a five-hospital health system during four-week periods within March to April of 2019 and 2020.

Results: During the four-week period in 2019, the percent positivity of common respiratory viruses from week 1 to week 4 decreased from 6 to 32% among the four included viruses. In the comparator period in …


Pterygium Recurrence And Corneal Stabilization Point After Pterygium Excision Using The Controlled Partial Avulsion Fibrin Glue Technique, Mohd Radzi Hilmi, Khairidzan Mohd Kamal, Mohd Zulfaezal Che Azemin Aug 2020

Pterygium Recurrence And Corneal Stabilization Point After Pterygium Excision Using The Controlled Partial Avulsion Fibrin Glue Technique, Mohd Radzi Hilmi, Khairidzan Mohd Kamal, Mohd Zulfaezal Che Azemin

Makara Journal of Health Research

Background: This study aimed to evaluate the pterygium recurrence rate and corneal stabilization point after pterygium excision via the controlled partial avulsion fibrin glue technique using multiple corneal parameters.

Methods: One hundred eyes of 100 patients who had undergone primary pterygium excision surgery via the controlled partial avulsion fibrin glue technique were retrospectively reviewed. Corneal stabilization points were determined over four follow-up sessions (i.e., the 1st, 3rd, 6th, and 12th months after surgery) based on changes in Simulated-K, corneal irregularity measurement, shape factor, and toric mean keratometry. Post-operative courses were followed for 12 months after surgery. Recurrence was …


Effects Of L-Fucose Supplementation On The Viability Of Cancer Cell Lines, Muhammad Alif Mazlan, Afzan Mat Yusof, Muhammad Lokman Md Isa Aug 2020

Effects Of L-Fucose Supplementation On The Viability Of Cancer Cell Lines, Muhammad Alif Mazlan, Afzan Mat Yusof, Muhammad Lokman Md Isa

Makara Journal of Health Research

Background: Fucose is a deoxyhexose sugar. While the biological roles of L-fucose remain unclear, the sugar is known to accelerate the malignant potential of cancer cells. Therefore, this study aimed to evaluate the viability pattern of human cancer and normal cell lines treated with fucose.

Methods: The human gingival fibroblast (HGF-1), colorectal adenocarcinoma (HT-29) and skin malignant melanoma (A375) cell lines were cultured and treated with fucose at three concentrations of 1, 5, and 10 mg/ml. Cell viability was then measured using (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay. The data were analyzed using Statistical Package for the Social …


Health-Related Quality Of Life And Work Ability Of Smallholder Rice Farm Workers In San Jose, Occidental Mindoro, Philippines, Artemio Morado Gonzales Jr, Ryan Mark Aloro Ambong, Leoniel Salibio Bais, Lendon Perez Macaspac Aug 2020

Health-Related Quality Of Life And Work Ability Of Smallholder Rice Farm Workers In San Jose, Occidental Mindoro, Philippines, Artemio Morado Gonzales Jr, Ryan Mark Aloro Ambong, Leoniel Salibio Bais, Lendon Perez Macaspac

Makara Journal of Health Research

Background: Health is an integral form of human capital that can positively influence agricultural worker productivity in the physical, mental, and social domains. Poor health usually represents a burden to farm workers because a failure to meet scheduled tasks on the farm can later affect the dependents who rely on it for food nourishment and sustained livelihood. This study aims to determine the association between health and the work capabilities of smallholder rice farm workers in San Jose, Occidental Mindoro, Philippines.

Methods: A cross sectional study was conducted among 100 farm workers. The SF-36 (HRQoL) and Work Ability …


Perceived Need And Utilization Of Dental Health Care Services In Indonesia: A Secondary Analysis Using The National Socioeconomic Data, Normaliza Ab Malik, Robbykha Rosalien, Nadine Khalissya, Iwany Amalliah Badruddin, Diah Ayu Maharani Aug 2020

Perceived Need And Utilization Of Dental Health Care Services In Indonesia: A Secondary Analysis Using The National Socioeconomic Data, Normaliza Ab Malik, Robbykha Rosalien, Nadine Khalissya, Iwany Amalliah Badruddin, Diah Ayu Maharani

Makara Journal of Health Research

Background: Perceived needs and utilization of oral health services are important to ensure improvements in oral health outcomes and to allocate resources for the continuous provision of the services. This study aimed to determine the factors influencing the perceived needs and utilization of oral health services in Indonesia.

Methods: Secondary data from the 2013 Indonesian National Socioeconomic Survey (n = 260,925) was used. Descriptive analysis and logistic regression were employed to describe the relationship between perceived needs and utilization of oral health services.

Results: The proportions of Indonesians who had a perceived need for oral health services and …


Organizational Empowerment Among Nursing Faculty In The Northwestern Region Of Saudi Arabia, Salman Hamdan Alsaqri, Eddieson Pasay-An, Liza Villacorte, Fredezwinda Madjid, Carmencita Pacis, Ahmad Khalil Ahmad Al-Sadi Aug 2020

Organizational Empowerment Among Nursing Faculty In The Northwestern Region Of Saudi Arabia, Salman Hamdan Alsaqri, Eddieson Pasay-An, Liza Villacorte, Fredezwinda Madjid, Carmencita Pacis, Ahmad Khalil Ahmad Al-Sadi

Makara Journal of Health Research

Background: This study aimed to determine the differences in the workplace empowerment of nursing faculty as it relates to their demographic information.

Methods: A comparative cross-sectional study was conducted among 65 nurse educators at the College of Nursing, University of Hail, Saudi Arabia. The data were collected through a survey questionnaire between January and March 2019.

Results: Significant differences were found regarding gender and opportunity (p < 0.017), support (p < 0.020), resources (p < 0.022), job activities scale (JAS; p < 0.005), organizational relationship scale (ORS; p < 0.011), and marital status on resources (p < 0.031). In comparison, gender to information and all of the other demographic variables such as marital status (except resources), years of experience, age, nationality, educational qualifications, and specialization were found insignificant to opportunity, support, resources, information, JAS, and ORS, where all of their p-values were more than 0.05.

Conclusion: Male nursing faculty were found to be more empowered in terms of opportunity, support, resources, JAS, and …


Effect Of The Sims Program On Oral Hygiene Levels Of 5–6-Year-Old Children In The Kampar District, Malaysia: A Cluster-Randomized Controlled Trial, Nurul Hayati Anwar, Nor Azlida Mohd Nor, Zamros Yuzadi Mohd Yusof Aug 2020

Effect Of The Sims Program On Oral Hygiene Levels Of 5–6-Year-Old Children In The Kampar District, Malaysia: A Cluster-Randomized Controlled Trial, Nurul Hayati Anwar, Nor Azlida Mohd Nor, Zamros Yuzadi Mohd Yusof

Makara Journal of Health Research

Background: This study evaluated the effect of the “Senyuman Indah Milik Semua” program (SIMSP) versus the existing preschool oral healthcare program (POHP) on children’s oral health and parents’ oral health literacy (OHL) in Kampar district, Malaysia.

Methods: This was a cluster-randomized, matched pair, examiner-blind, controlled trial. Using computer-generated random tables, 14 preschools were allocated to the SIMSP intervention over 6 months and another 14 were allocated to the POHP, which was concealed at the cluster level. Healthy 5–6-year-old children and parents who understood the Malay language were recruited. The SIMSP was comprised of preschool visits by dental …


Association Between Sociodemographic Factors And Estrogen Receptor-Positive, Progesterone Receptor-Positive Breast Cancer Subtypes: A Cross-Sectional Study, Vinodkumar Mugada, Raj Kiran Kolakota, Varsha Mahato Aug 2020

Association Between Sociodemographic Factors And Estrogen Receptor-Positive, Progesterone Receptor-Positive Breast Cancer Subtypes: A Cross-Sectional Study, Vinodkumar Mugada, Raj Kiran Kolakota, Varsha Mahato

Makara Journal of Health Research

Background: The presence of risk factors have a high risk of developing breast cancer. Our study aimed to find an association between sociodemographic factors and the risk of estrogen receptor (ER)-positive, progesterone receptor (PR)-positive breast cancer among women.

Methods: A cross-sectional study was conducted on 200 women with breast cancer. Association between sociodemographic factors and hormone receptor subtypes of breast cancer was found using the Chi-square test. Multiple logistic regression analysis was used to know the strong predictors of hormone receptor subtypes.

Results: The mean age was 50.08 (10.67) years. Comorbidities had a statistically significant association with …


Limbic-Predominant Age-Related Tdp-43 Encephalopathy Differs From Frontotemporal Lobar Degeneration, John L. Robinson, Sílvia Porta, Filip G. Garrett, Panpan Zhang, Sharon X. Xie, Eunran Suh, Vivianna M. Van Deerlin, Erin L. Abner, Gregory A. Jicha, Justin M. Barber, Virginia M-Y Lee, Edward B. Lee, John Q. Trojanowski, Peter T. Nelson Aug 2020

Limbic-Predominant Age-Related Tdp-43 Encephalopathy Differs From Frontotemporal Lobar Degeneration, John L. Robinson, Sílvia Porta, Filip G. Garrett, Panpan Zhang, Sharon X. Xie, Eunran Suh, Vivianna M. Van Deerlin, Erin L. Abner, Gregory A. Jicha, Justin M. Barber, Virginia M-Y Lee, Edward B. Lee, John Q. Trojanowski, Peter T. Nelson

Epidemiology and Environmental Health Faculty Publications

TAR-DNA binding protein-43 (TDP-43) proteinopathy is seen in multiple brain diseases. A standardized terminology was recommended recently for common age-related TDP-43 proteinopathy: limbic-predominant, age-related TDP-43 encephalopathy (LATE) and the underlying neuropathological changes, LATE-NC. LATE-NC may be co-morbid with Alzheimer’s disease neuropathological changes (ADNC). However, there currently are ill-defined diagnostic classification issues among LATE-NC, ADNC, and frontotemporal lobar degeneration with TDP-43 (FTLD-TDP). A practical challenge is that different autopsy cohorts are composed of disparate groups of research volunteers: hospital- and clinic-based cohorts are enriched for FTLD-TDP cases, whereas community-based cohorts have more LATE-NC cases. Neuropathological methods also differ across laboratories. Here, …


Impact Of 2012 Spanish Health Care Reform On Hiv-Positive Immigrants: A Mixed Methods Approach, Megi Gogishvili Aug 2020

Impact Of 2012 Spanish Health Care Reform On Hiv-Positive Immigrants: A Mixed Methods Approach, Megi Gogishvili

Dissertations and Theses

Background: The financial crisis of 2008 hit Spain hard. As a consequence, the government took multiple austerity measures, including reforms in the healthcare system in 2012. Specifically, the government reduced the budget for health and social services by 13.7% in 2012.The reduction was further followed with structural changes via the 2012 Royal Decree Law (RDL) and Royal Decree (RD).The 2012 RDL and RD entailed broad areas of action,but most importantly the Spanish National Health System (SNS) no longer covered undocumented immigrants. The 2012 RDL and RD excluded approximately 500,000 undocumented immigrants from SNS.

The number of immigrants in Spain has …


Urban Warfare: Emerging Geopolitical Conundrum, Bert Chapman Aug 2020

Urban Warfare: Emerging Geopolitical Conundrum, Bert Chapman

Libraries Faculty and Staff Presentations

Urban warfare is as old as human history. It is becoming increasingly important in international political and military planning due to increasing global urbanization and the presence of megacities (urban areas with populations exceeding 10 million) in many global regions and being in areas of recent and potential military conflict. 2018 World Bank data notes that approximately 56% of the world's population lives in urban areas which is up from 34% in 1960. Many of these megacities, including New York City, Los Angeles, Sao Paulo, Mumbai, Shanghai, and Manila are adjacent to oceanic waters and vulnerable to trade and supply …


Egfr Testing And Erlotinib Use In Non-Small Cell Lung Cancer Patients In Kentucky, Kara L. Larson, Bin Huang, Quan Chen, Thomas C. Tucker, Marissa Schuh, Susanne M. Arnold, Jill M. Kolesar Aug 2020

Egfr Testing And Erlotinib Use In Non-Small Cell Lung Cancer Patients In Kentucky, Kara L. Larson, Bin Huang, Quan Chen, Thomas C. Tucker, Marissa Schuh, Susanne M. Arnold, Jill M. Kolesar

Markey Cancer Center Faculty Publications

This study determined the frequency and factors associated with EGFR testing rates and erlotinib treatment as well as associated survival outcomes in patients with non small cell lung cancer in Kentucky. Data from the Kentucky Cancer Registry (KCR) linked with health claims from Medicaid, Medicare and private insurance groups were evaluated. EGFR testing and erlotinib prescribing were identified using ICD-9 procedure codes and national drug codes in claims, respectively. Logistic regression analysis was performed to determine factors associated with EGFR testing and erlotinib prescribing. Cox-regression analysis was performed to determine factors associated with survival. EGFR mutation testing rates rose from …


Ua3/10/3 Convocation, Timothy Caboni Aug 2020

Ua3/10/3 Convocation, Timothy Caboni

WKU Administration Documents

Convocation speech given by WKU president Timothy Caboni regarding COVID-19, diversity, student recruitment, enrollment, retention and graduation; budget, and economic growth.


Understanding Covid-19: From Origin To Potential Therapeutics, Muhammad Moazzam, Muhammad Imran Sajid, Hamza Shahid, Jahanzaib Butt, Irfan Bashir, Muhammad Jamshaid, Amir Nasrolahi Shirazi, Rakesh Kumar Tiwari Aug 2020

Understanding Covid-19: From Origin To Potential Therapeutics, Muhammad Moazzam, Muhammad Imran Sajid, Hamza Shahid, Jahanzaib Butt, Irfan Bashir, Muhammad Jamshaid, Amir Nasrolahi Shirazi, Rakesh Kumar Tiwari

Pharmacy Faculty Articles and Research

Currently, a global pandemic era of public health concerns is going on with the Coronavirus Disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The first case of COVID-19 was reported from Wuhan’s Huanan seafood market in China late December 2019. Bats, pangolins, and snakes have been nominated as salient carriers of the virus. Thanks to its high pathogenicity, it can cause severe respiratory infections. Fever, dry cough, sore throat, pneumonia, septic shock, and ground-glass opacities are the foremost clinical manifestations of COVID-19. Immunocompromised patients are at high risk for COVID-19 infection and may lead to …


Reducing Adverse Outcomes In Hepatocellular Carcinoma Patients Undergoing Hepatectomies, Yongyue Qi Aug 2020

Reducing Adverse Outcomes In Hepatocellular Carcinoma Patients Undergoing Hepatectomies, Yongyue Qi

Theses & Dissertations

The incidence and mortality of liver cancers are increasing in the United States. In addition to the classic risk factors of hepatic viral infection and high alcohol consumption, non-alcoholic Fatty Liver Disease (NAFLD), has emerged as a risk factor for hepatocellular carcinoma (HCC). The most effective curative treatment for HCC is liver resection (hepatectomy), however, hepatectomy is a major operation with potential risks of mortality, hospital readmission and other adverse outcomes such as postoperative complications and longer hospital stay. The reported 90-day mortality and 30-day readmission rates following a hepatectomy vary widely across studies, most of which have limitations due …


Targeting Pd-L1 In Non-Small Cell Lung Cancer Using Car T Cells, Ming Liu, Xu Wang, Wei Li, Xinfang Yu, Pedro Flores-Villanueva, Zijun Y Xu-Monette, Ling Li, Mingzhi Zhang, Ken H Young, Xiaodong Ma, Yong Li Aug 2020

Targeting Pd-L1 In Non-Small Cell Lung Cancer Using Car T Cells, Ming Liu, Xu Wang, Wei Li, Xinfang Yu, Pedro Flores-Villanueva, Zijun Y Xu-Monette, Ling Li, Mingzhi Zhang, Ken H Young, Xiaodong Ma, Yong Li

Faculty, Staff and Students Publications

Antibodies against programmed cell death protein 1 (PD-1) and its ligand (PD-L1) have dramatically changed the landscape of therapies for non-small cell lung carcinoma (NSCLC); however, the majority of patients do not respond to these agents. In addition, hyperprogressive disease (HPD) develops in a larger portion of NSCLC patients treated with PD-1/PD-L1 inhibitors than in patients treated with standard chemotherapy. The use of chimeric antigen receptor (CAR) T cells has been successful to treat blood cancers but not for solid tumors like NSCLC. In this work, we constructed CAR T cells that target PD-L1 and evaluated their efficacy in NSCLC …


Particulate Matter Pollution And Its Effect On Covid-19, Aída Fica Conejeros Aug 2020

Particulate Matter Pollution And Its Effect On Covid-19, Aída Fica Conejeros

International Programs

Growing research supports the significant effects of particulate matter on COVID-19. This air pollutant has been identified before as responsible for serious respiratory diseases. Studies on the differences in high and low polluted cities confirmed that COVID-19 not only correlates to the number of infections but also, increases of 1 ��g/m3 can cause a mortality rate to rise by 8% and the hospital admissions by 4.4%. However, laboratory studies are still needed to support these findings.


Risk Of New Bloodstream Infections And Mortality Among People Who Inject Drugs With Infective Endocarditis., Charlie Tan, Esfandiar Shojaei, Joshua C. Wiener, Meera Shah, Sharon Koivu, Michael Silverman Aug 2020

Risk Of New Bloodstream Infections And Mortality Among People Who Inject Drugs With Infective Endocarditis., Charlie Tan, Esfandiar Shojaei, Joshua C. Wiener, Meera Shah, Sharon Koivu, Michael Silverman

Epidemiology and Biostatistics Publications

IMPORTANCE: People who inject drugs (PWID) who are being treated for infective endocarditis remain at risk of new bloodstream infections (BSIs) due to ongoing intravenous drug use (IVDU).

OBJECTIVES: To characterize new BSIs in PWID receiving treatment for infective endocarditis, to determine the clinical factors associated with their development, and to determine whether new BSIs and treatment setting are associated with mortality.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study was performed at 3 tertiary care hospitals in London, Ontario, Canada, from April 1, 2007, to March 31, 2018. Participants included a consecutive sample of all PWID 18 years or …


The Impact Of Improved Access To After-Hours Primary Care On Emergency Department And Primary Care Utilization: A Systematic Review., Michael Hong, Amardeep Thind, Gregory S Zaric, Sisira Sarma Aug 2020

The Impact Of Improved Access To After-Hours Primary Care On Emergency Department And Primary Care Utilization: A Systematic Review., Michael Hong, Amardeep Thind, Gregory S Zaric, Sisira Sarma

Epidemiology and Biostatistics Publications

Access to after-hours primary care is problematic in many developed countries, leading patients to instead visit the emergency department for non-urgent conditions. However, emergency department utilization for conditions treatable in primary care settings may contribute to emergency department overcrowding and increased health system costs. This systematic review examines the impact of various initiatives by developed countries to improve access to after-hours primary care on emergency department and primary care utilization. We performed a systematic review on the impact of improved access to after-hours primary and searched CINAHL, EMBASE, MEDLINE, and Scopus. We identified 20 studies that examined the impact of …