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2025

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Articles 2551 - 2580 of 3533

Full-Text Articles in Public Health

Interim Estimates Of 2024-2025 Seasonal Influenza Vaccine Effectiveness - Four Vaccine Effectiveness Networks, United States, October 2024-February 2025, Aaron M Frutos, Seana Cleary, Emily L Reeves, Haris M Ahmad, Ashley M Price, Wesley H Self, Yuwei Zhu, Basmah Safdar, Ithan D Peltan, Kevin W Gibbs, Matthew C Exline, Adam S Lauring, Sarah W Ball, Malini Desilva, Sara Y Tartof, Kristin Dascomb, Stephanie A Irving, Nicola P Klein, Brian E Dixon, Toan C Ong, Ivana A Vaughn, Stacey L House, Kiran A Faryar, Mary Patricia Nowalk, Manjusha Gaglani, Karen J Wernli, Vel Murugan, Olivia L Williams, Rangaraj Selvarangan, Geoffrey A Weinberg, Mary A Staat, Natasha B Halasa, Leila C Sahni, Marian G Michaels, Janet A Englund, Marie K Kirby, Diya Surie, Fatimah S Dawood, Benjamin R Clopper, Heidi L Moline, Ruth Link-Gelles, Amanda B Payne, Elizabeth Harker, Kristina Wielgosz, Zachary A Weber, Duck-Hye Yang, Nathaniel M Lewis, Jennifer Decuir, Samantha M Olson, Jessie R Chung, Brendan Flannery, Lisa A Grohskopf, Carrie Reed, Shikha Garg, Sascha Ellington, Cdc Influenza Vaccine Effectiveness Collaborators Feb 2025

Interim Estimates Of 2024-2025 Seasonal Influenza Vaccine Effectiveness - Four Vaccine Effectiveness Networks, United States, October 2024-February 2025, Aaron M Frutos, Seana Cleary, Emily L Reeves, Haris M Ahmad, Ashley M Price, Wesley H Self, Yuwei Zhu, Basmah Safdar, Ithan D Peltan, Kevin W Gibbs, Matthew C Exline, Adam S Lauring, Sarah W Ball, Malini Desilva, Sara Y Tartof, Kristin Dascomb, Stephanie A Irving, Nicola P Klein, Brian E Dixon, Toan C Ong, Ivana A Vaughn, Stacey L House, Kiran A Faryar, Mary Patricia Nowalk, Manjusha Gaglani, Karen J Wernli, Vel Murugan, Olivia L Williams, Rangaraj Selvarangan, Geoffrey A Weinberg, Mary A Staat, Natasha B Halasa, Leila C Sahni, Marian G Michaels, Janet A Englund, Marie K Kirby, Diya Surie, Fatimah S Dawood, Benjamin R Clopper, Heidi L Moline, Ruth Link-Gelles, Amanda B Payne, Elizabeth Harker, Kristina Wielgosz, Zachary A Weber, Duck-Hye Yang, Nathaniel M Lewis, Jennifer Decuir, Samantha M Olson, Jessie R Chung, Brendan Flannery, Lisa A Grohskopf, Carrie Reed, Shikha Garg, Sascha Ellington, Cdc Influenza Vaccine Effectiveness Collaborators

Faculty, Staff and Students Publications

Annual influenza vaccination is recommended for all persons aged ≥6 months in the United States. Interim influenza vaccine effectiveness (VE) was calculated among patients with acute respiratory illness–associated outpatient visits and hospitalizations from four VE networks during the 2024–25 influenza season (October 2024–February 2025). Among children and adolescents aged <18 years, VE against any influenza was 32%, 59%, and 60% in the outpatient setting in three networks, and against influenza-associated hospitalization was 63% and 78% in two networks. Among adults aged ≥18 years, VE in the outpatient setting was 36% and 54% in two networks and was 41% and 55% against hospitalization in two networks. Preliminary estimates indicate that receipt of the 2024–2025 influenza vaccine reduced the likelihood of medically attended influenza and influenza-associated hospitalization. CDC recommends annual receipt of an age-appropriate influenza vaccine by all eligible persons aged ≥6 months as long as influenza viruses continue to circulate locally.


Jc Polyomavirus Pooled Seropositivity Prevalence In Healthy Subjects, Lenka J. Kimla Feb 2025

Jc Polyomavirus Pooled Seropositivity Prevalence In Healthy Subjects, Lenka J. Kimla

Walden Dissertations and Doctoral Studies

JC polyomavirus (JCV) causes progressive multifocal leukoencephalopathy in immunocompromised individuals and has been linked to cancer development. To-date, no information is available about the JCV seroprevalence in the healthy (nondiseased) population or whether this virus is ecologically connected to humans. The aim of this systematic literature review and meta-analysis was to the estimate the overall seroprevalence of JCV in the healthy human population by age, region, and testing method. A meta-analysis conducted on 24 studies revealed a pooled JCV seroprevalence of 60% (95% CI, 55% - 65%) with statistically significant effect size (z = 32.93, p < 0.001). Meta-regression and subgroup analyses with STATA18 showed that age and region had a strong positive predictive value on prevalence (R = .578, R2 = 0.334, F(2,52) = 12.543, p < 0.001) whereas the testing method had no significant effect on prevalence. The theories that grounded this study were the ecological model and the systems theory, which support the study result that JCV appears to be ubiquitous in the human population with JCV being acquired very early in life. The results of the systematic literature review indicated that JCV is transmitted via fecal-oral and respiratory routes within and outside of families. Most infants are infected with JCV by the age of 6 months and JCV seronegativity may not be indicative of a lack of an underlying JCV infection. JCV seropositivity increases with age, which is most probably by viral reactivation due to immune senescence. These findings have positive social change implications with JCV treatment, screening, and vaccine development.


Improving Financial Sustainability Through A 990n-Sized Charity’S Fundraising-Activity Audit, Eileen Callejas Feb 2025

Improving Financial Sustainability Through A 990n-Sized Charity’S Fundraising-Activity Audit, Eileen Callejas

Walden Dissertations and Doctoral Studies

Current scholarly literature has asserted that large non-profit organizations benefit from conducting fundraising-activity audit portfolio analyses. However, suitable techniques and tools that ultra-small nonprofits (990N-sized charities) can use to improve their fundraising-activity analyses have not been clearly established. The research problem was in modifying tools that work efficiently for hyper-localized charities to compare the effectiveness of their fundraising-activities. Preferred tools were needed to reinforce ideation and align improvements within the charities’ known constraints. The purpose of this study was to explore three suitably modified instruments that could be used for fundraising-activity auditing. Based on Ostrom’s institutional analysis and development framework, …


Implementing A Comprehensive Care Model To Improve Diabetes Management In Underserved Communities, Hector Trejo, Leticia Rodriguez Feb 2025

Implementing A Comprehensive Care Model To Improve Diabetes Management In Underserved Communities, Hector Trejo, Leticia Rodriguez

MEDI 9331 Scholarly Activities Clinical Years

Diabetes is a major public health issue, particularly in underserved communities with limited healthcare access. This study evaluates the effectiveness of the Comprehensive Care Model (CCM) in improving diabetes management at three Area Health Education Center (AHEC) sites in the Rio Grande Valley (RGV). A retrospective analysis was conducted on 858 patients, categorized as prediabetic (A1C 5.7-6.4) or diabetic (A1C ≥6.5). Of these, 54 patients in each group had confirmed follow-up A1C values after a minimum of three months. The study assessed the impact of three core CCM interventions—Primary Health Services (PHS), Diabetes Education (DE), and Community Health Worker (CHW) …


Associations Of Parental Perceived Health With Child Movement Behaviors Within Two-Parent Households, You Fu, Hayley Almes, Nora Constantino, Doria Schmidt, Ryan D. Burns Feb 2025

Associations Of Parental Perceived Health With Child Movement Behaviors Within Two-Parent Households, You Fu, Hayley Almes, Nora Constantino, Doria Schmidt, Ryan D. Burns

International Journal of Physical Activity and Health

This study aimed to examine how perceived parental mental and physical health status was associated with child physical activity, screen time, and sleep. Participants were 6- to 17-year-old minors (N = 20,156; 47.9% female) from the 2022 US National Survey of Children’s Health. Dependent variables were children’s physical activity frequency, screen time, and sleep. Independent variables were parents’ physical and mental health status. Using the Actor-Partner Interdependence Model, two adjusted path models were constructed. One for parent mental health associating with parental physical health, another for parent physical health associating with parental mental health–both further associating with child movement behaviors. …


Survey Of Mosquito Larval Habitats At The Ksu Field Station, Rose Sofia, Eli Lovvorn, Aspen Hartman, Andrew Haddow Feb 2025

Survey Of Mosquito Larval Habitats At The Ksu Field Station, Rose Sofia, Eli Lovvorn, Aspen Hartman, Andrew Haddow

Symposium of Student Scholars

The greater Atlanta metropolitan area hosts numerous mosquito species that are nuisance biters and can transmit arthropod-borne diseases to humans. We surveyed the Kennesaw State University (KSU) Field Station – an incredibly biodiverse location – where student, staff, and faculty-led groups engage in outdoor research and teaching activities. The KSU Field Station located in Cobb County, GA is a heavily trafficked 25-acre property that may attract various mosquito species capable of transmitting pathogens to humans and animals alike. On August 27th, 2024, our team investigated the KSU Field Station to quantify and record potential water-holding containers that serve as mosquito …


Relationship Between Prevalence Of Disability And Receiving The Covid-19 Vaccine Abstract, Brady Beard, Michael Treichler, Kevin Gittner Feb 2025

Relationship Between Prevalence Of Disability And Receiving The Covid-19 Vaccine Abstract, Brady Beard, Michael Treichler, Kevin Gittner

Symposium of Student Scholars

COVID-19 vaccines were developed to reduce the spread and severity of the virus, particularly among vulnerable populations. People with disabilities are at higher risk of severe outcomes from COVID-19 due to underlying health conditions, limited access to healthcare, and potential barriers to preventive measures like social distancing. Despite their vulnerability, disabled individuals may face challenges in accessing vaccines, such as physical barriers, transportation issues, or a lack of tailored information. Additionally, vaccine hesitancy may be influenced by concerns about potential side effects harming existing disabilities. This study investigates the research question: "Is there a relationship between receiving the COVID-19 vaccine …


Statistical Analysis Of Sex And Adolescent E-Vapor Product Use, Madison Caroline Weeks, Anna Kate Lane, Kevin Gittner Feb 2025

Statistical Analysis Of Sex And Adolescent E-Vapor Product Use, Madison Caroline Weeks, Anna Kate Lane, Kevin Gittner

Symposium of Student Scholars

This study aims to examine the relationship between sex and electronic vapor product use among adolescent high school students aged 12 to 17. As the use of electronic vapor products, commonly known as e-cigarettes or vapes, continues to rise among youth, understanding demographic trends is crucial for the creation of public health interventions. A quantitative approach was utilized to create appropriate visuals and analyze the data, providing a clear representation of the patterns observed. This study utilizes the Centers for Disease Control and Prevention’s (CDC) Youth Risk Behavior Surveillance System (YRBSS). The sample size of the dataset being used in …


Addressing Obesity In Cancer Survivorship: Referral Gaps And Patient Engagement In Nutrition And Lifestyle Interventions, Brian Dinh, Kelly Nguyen, Whittney Thoman, Katherine Gilmore, Ying Qiao, Kathy Carpenter, Zayed Razouki, David Santos, Michael Roth Feb 2025

Addressing Obesity In Cancer Survivorship: Referral Gaps And Patient Engagement In Nutrition And Lifestyle Interventions, Brian Dinh, Kelly Nguyen, Whittney Thoman, Katherine Gilmore, Ying Qiao, Kathy Carpenter, Zayed Razouki, David Santos, Michael Roth

Cancer Survivorship Research Retreat

No abstract provided.


Pitavastatin Is Well-Tolerated With No Detrimental Effects On Physical Function, Kristine M Erlandson, Triin Umbleja, Heather J Ribaudo, Jennifer A Schrack, Edgar T Overton, Carl J Fichtenbaum, Kathleen V Fitch, Jhoanna C Roa, Marissa R Diggs, Kenneth Wood, Markella V Zanni, Gerald S Bloomfield, Carlos Malvestutto, Judith A Aberg, Maria C Rodriguez-Barradas, Rosalba Gomez Morones, Katherine Breaux, Pamela S Douglas, Steven K Grinspoon, Todd T Brown Feb 2025

Pitavastatin Is Well-Tolerated With No Detrimental Effects On Physical Function, Kristine M Erlandson, Triin Umbleja, Heather J Ribaudo, Jennifer A Schrack, Edgar T Overton, Carl J Fichtenbaum, Kathleen V Fitch, Jhoanna C Roa, Marissa R Diggs, Kenneth Wood, Markella V Zanni, Gerald S Bloomfield, Carlos Malvestutto, Judith A Aberg, Maria C Rodriguez-Barradas, Rosalba Gomez Morones, Katherine Breaux, Pamela S Douglas, Steven K Grinspoon, Todd T Brown

Faculty, Staff and Students Publications

Background: Little is known about the potential benefits or harms of statins on physical function among people with human immunodeficiency virus (PWH).

Methods: REPRIEVE was a double-blind randomized controlled trial evaluating pitavastatin for primary prevention of major adverse cardiovascular events in PWH. Time to complete 10 chair rises, 4-m gait speed, grip strength, and a modified short physical performance test were assessed annually for up to 5 years in the ancillary study PREPARE and analyzed using linear mixed models.

Findings: Of 602 PWH, 52% were randomized to pitavastatin and 48% to placebo. Median age was 51 years; 18% were female …


Hurricane Irma's Impact On Mortality Among The Chronically Ill Populations In Florida, Cody Ray Thornton Feb 2025

Hurricane Irma's Impact On Mortality Among The Chronically Ill Populations In Florida, Cody Ray Thornton

Walden Dissertations and Doctoral Studies

Natural disasters pose significant risks to individuals with chronic diseases, exacerbating health disparities through disruptions in healthcare access and systemic vulnerabilities. This study investigated the association between chronic disease-related mortality occurring within 2 months of Hurricane Irma, and whether demographic variables, including age, sex, race, Hispanic ethnicity, poverty, urbanicity, and educational attainment, modified this relationship. This cross-sectional study used the social-ecological model to analyze secondary mortality data from the National Vital Statistics System. Bivariate and multivariate logistic regression revealed that deaths from chronic illnesses, occurring between September 2017 and October 2017, were 2.694 times higher, compared to the same period …


Association Between The Lack Of Health Insurance, Income, And The Severity Of Negative Perinatal Outcomes Among Native Spanish- And English-Speaking Women Living In Florida, Khadijeh Ashktorab Feb 2025

Association Between The Lack Of Health Insurance, Income, And The Severity Of Negative Perinatal Outcomes Among Native Spanish- And English-Speaking Women Living In Florida, Khadijeh Ashktorab

Walden Dissertations and Doctoral Studies

Evidence indicates that non-English-speaking mothers, particularly Spanish-only speakers, experience worse maternal health outcomes compared to their mainstream counterparts. Language barriers often hinder communication and negatively affect perinatal care. This study used data from the Centers for Disease Control and Prevention Pregnancy Risk Assessment Monitoring System from Florida (2019–2020) to examine associations between health insurance, income, and perinatal outcomes among Spanish and English-speaking women. Krieger’s eco-social theory guided this cross-sectional, quantitative analysis. Chi-square tests were used for bivariable analysis, and multivariable models were used to adjust for confounders. Results showed that native language alone significantly predicted specific outcomes such as large-for-gestational-age …


Analisis Faktor Penyebab Komplain Pasien Pada Pelayanan Rawat Inap: Studi Kasus Di Rumah Sakit X Tahun 2024, Tasmiati Manzilah, Risky Kusuma Hartono Feb 2025

Analisis Faktor Penyebab Komplain Pasien Pada Pelayanan Rawat Inap: Studi Kasus Di Rumah Sakit X Tahun 2024, Tasmiati Manzilah, Risky Kusuma Hartono

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Complaints from patients are often used as an indicator of the quality of health services. The causes of complaints from inpatients are related to factors that cause dissatisfaction or discomfort experienced by patients during their hospitalization. This study aims to see the causes of patient complaints about inpatient services. In addition, researchers also examine the relationship between several variables and complaints and analyze further to determine the main factors causing complaints from patients about inpatient services. This study uses a sequential explanatory approach. The study design is cross-sectional for inpatients at Hospital X who are willing to be respondents and …


A Disparities Analysis Of Cancer Patients’ Access To Depression Treatment By Health Insurance Status And Type, Stephanie Minbiole-Snider Feb 2025

A Disparities Analysis Of Cancer Patients’ Access To Depression Treatment By Health Insurance Status And Type, Stephanie Minbiole-Snider

Walden Dissertations and Doctoral Studies

Research has demonstrated that comorbid conditions like depression in cancer patients reduce quality of life, prolong recovery, and reduce survival time of the cancer patient. Although other studies have investigated the issue of depression among cancer patients, there is a dearth of studies looking at differences in taking depression medication with health insurance as a source of disparity. Using survey data from the National Health Interview Survey (NHIS), and the health belief model as the theoretical framework, this study had two purposes. The first was to determine if there were differences in the likelihood of taking medication for depression based …


The Mutational Landscape And Functional Effects Of Noncoding Ultraconserved Elements In Human Cancers, Recep Bayraktar, Yitao Tang, Mihnea P Dragomir, Cristina Ivan, Xinxin Peng, Linda Fabris, Jianhua Zhang, Alessandro Carugo, Serena Aneli, Jintan Liu, Mei-Ju M Chen, Sanjana Srinivasan, Iman Sahnoune, Emine Bayraktar, Kadir C Akdemir, Meng Chen, Pranav Narayanan, Wilson Huang, Leonie Florence Ott, Agda Karina Eterovic, Oscar Eduardo Villarreal, Mohammad Moustaf Mohammad, Michael D Peoples, Danielle M Walsh, Jon Andrew Hernandez, Margaret B Morgan, Kenna R Shaw, Jennifer S Davis, David Menter, Constantine S Tam, Paul Yeh, Sarah-Jane Dawson, Laura Z Rassenti, Thomas J Kipps, Tanja Kunej, Zeev Estrov, Simon A Joosse, Luca Pagani, Catherine Alix-Panabières, Klaus Pantel, Alessandra Ferajoli, Andrew Futreal, Ignacio I Wistuba, Milan Radovich, Scott Kopetz, Michael J Keating, Giulio F Draetta, John S Mattick, Han Liang, George A Calin Feb 2025

The Mutational Landscape And Functional Effects Of Noncoding Ultraconserved Elements In Human Cancers, Recep Bayraktar, Yitao Tang, Mihnea P Dragomir, Cristina Ivan, Xinxin Peng, Linda Fabris, Jianhua Zhang, Alessandro Carugo, Serena Aneli, Jintan Liu, Mei-Ju M Chen, Sanjana Srinivasan, Iman Sahnoune, Emine Bayraktar, Kadir C Akdemir, Meng Chen, Pranav Narayanan, Wilson Huang, Leonie Florence Ott, Agda Karina Eterovic, Oscar Eduardo Villarreal, Mohammad Moustaf Mohammad, Michael D Peoples, Danielle M Walsh, Jon Andrew Hernandez, Margaret B Morgan, Kenna R Shaw, Jennifer S Davis, David Menter, Constantine S Tam, Paul Yeh, Sarah-Jane Dawson, Laura Z Rassenti, Thomas J Kipps, Tanja Kunej, Zeev Estrov, Simon A Joosse, Luca Pagani, Catherine Alix-Panabières, Klaus Pantel, Alessandra Ferajoli, Andrew Futreal, Ignacio I Wistuba, Milan Radovich, Scott Kopetz, Michael J Keating, Giulio F Draetta, John S Mattick, Han Liang, George A Calin

Faculty, Staff and Student Publications

The mutational landscape of phylogenetically ultraconserved elements (UCEs), especially those in noncoding DNAs (ncUCEs), and their functional relevance in cancers remain poorly characterized. Here, we perform a systematic analysis of whole-genome and in-house targeted UCE sequencing datasets from more than 3000 patients with cancer of 13,736 UCEs and demonstrate that ncUCE somatic alterations are common. Using a multiplexed CRISPR knockout screen in colorectal cancer cells, we show that the loss of several altered ncUCEs significantly affects cell proliferation. In-depth functional studies in vitro and in vivo further reveal that specific ncUCEs can be enhancers of tumor suppressors (such as ARID1B) …


Invasion And Metastasis In Cancer: Molecular Insights And Therapeutic Targets, Yongxing Li, Fengshuo Liu, Qingjin Cai, Lijun Deng, Qin Ouyang, Xiang H-F Zhang, Ji Zheng Feb 2025

Invasion And Metastasis In Cancer: Molecular Insights And Therapeutic Targets, Yongxing Li, Fengshuo Liu, Qingjin Cai, Lijun Deng, Qin Ouyang, Xiang H-F Zhang, Ji Zheng

Faculty, Staff and Students Publications

The progression of malignant tumors leads to the development of secondary tumors in various organs, including bones, the brain, liver, and lungs. This metastatic process severely impacts the prognosis of patients, significantly affecting their quality of life and survival rates. Research efforts have consistently focused on the intricate mechanisms underlying this process and the corresponding clinical management strategies. Consequently, a comprehensive understanding of the biological foundations of tumor metastasis, identification of pivotal signaling pathways, and systematic evaluation of existing and emerging therapeutic strategies are paramount to enhancing the overall diagnostic and treatment capabilities for metastatic tumors. However, current research is …


A Comprehensive Study On Clinical Management Of Hypertension Among The Patients From Selected Suburban Region Of Tirupati, Jyothi Basini, Prasanna Rajy Y, Jagadeesh M, Anusha K, Asiya S, Chandrakala G, Nivetha D, Navyasree K, Amarnath Reddy B Feb 2025

A Comprehensive Study On Clinical Management Of Hypertension Among The Patients From Selected Suburban Region Of Tirupati, Jyothi Basini, Prasanna Rajy Y, Jagadeesh M, Anusha K, Asiya S, Chandrakala G, Nivetha D, Navyasree K, Amarnath Reddy B

International Journal of Health and Allied Sciences

Background: Hypertension (HTN) is the major public health concern and non communicable disease affects 29% of global population by 2025.

Aim: This is study was aimed to explore the awareness and knowledge of hypertension and clinical symptoms among adult hypertensive patients in and around suburban/rural region of Tirupati Municipality.

Method: The assessment study was conducted with aid of informed consent, patient demographic and questionnaire forms. Both male and female participants about 250 at the age above 18 years were included. The study was performed in off-line and on-line mode.

Results: Out of 250 study population 106 …


Legal Residency Status And Its Relationship With Health Indicators Among Syrian Refugees In Lebanon: A Nested Cross-Sectional Study, Marie-Elizabeth Ragi, Hala Ghattas Ph.D., Berthe Abi Zeid, Hazar Shamas, Noura Joseph El Salibi, Sawsan Abdulrahim, Jocelyn Dejong, Stephen J. Mccall, The Caep Study Group Feb 2025

Legal Residency Status And Its Relationship With Health Indicators Among Syrian Refugees In Lebanon: A Nested Cross-Sectional Study, Marie-Elizabeth Ragi, Hala Ghattas Ph.D., Berthe Abi Zeid, Hazar Shamas, Noura Joseph El Salibi, Sawsan Abdulrahim, Jocelyn Dejong, Stephen J. Mccall, The Caep Study Group

Faculty Publications

Background Failure to possess or renew legal residency permits increases the burden on a vulnerable refugee population. It risks detention or deportation, and hinders access to basic services including healthcare. This study aimed to examine the association between legal residency status and health of Syrian refugees living in Lebanon.

Methods Data were from two independent nested cross-sectional studies collected in 2022 through telephone surveys. In the first study, all Syrian refugees aged 50 years or older from households that received humanitarian assistance were invited to participate. The second included all adult Syrian refugees residing in a suburb of Beirut. The …


Semaglutide And Nonarteritic Anterior Ischemic Optic Neuropathy, Cindy X Cai, Michelle Hribar, Sally Baxter, Kerry Goetz, Swarup S Swaminathan, Alexis Flowers, Eric N Brown, Brian Toy, Benjamin Xu, John Chen, Aiyin Chen, Sophia Wang, Cecilia Lee, Theodore Leng, Joshua R Ehrlich, Andrew Barkmeier, Karen R Armbrust, Michael V Boland, David Dorr, Danielle Boyce, Thamir Alshammari, Joel Swerdel, Marc A Suchard, Martijn Schuemie, Fan Bu, Anthony G Sena, George Hripcsak, Akihiko Nishimura, Paul Nagy, Thomas Falconer, Scott L Duvall, Michael Matheny, Benjamin Viernes, William O'Brien, Linying Zhang, Benjamin Martin, Erik Westlund, Nestoras Mathioudakis, Ruochong Fan, Adam Wilcox, Albert Lai, Jacqueline C Stocking, Sahar Takkouche, Lok Hin Lee, Yangyiran Xie, Izabelle Humes, David B Mccoy, Mohammad Adibuzzaman, Raymond G Areaux, William Rojas-Carabali, James Brash, David A Lee, Nicole G Weiskopf, Louise Mawn, Rupesh Agrawal, Hannah Morgan-Cooper, Priya Desai, Patrick B Ryan Feb 2025

Semaglutide And Nonarteritic Anterior Ischemic Optic Neuropathy, Cindy X Cai, Michelle Hribar, Sally Baxter, Kerry Goetz, Swarup S Swaminathan, Alexis Flowers, Eric N Brown, Brian Toy, Benjamin Xu, John Chen, Aiyin Chen, Sophia Wang, Cecilia Lee, Theodore Leng, Joshua R Ehrlich, Andrew Barkmeier, Karen R Armbrust, Michael V Boland, David Dorr, Danielle Boyce, Thamir Alshammari, Joel Swerdel, Marc A Suchard, Martijn Schuemie, Fan Bu, Anthony G Sena, George Hripcsak, Akihiko Nishimura, Paul Nagy, Thomas Falconer, Scott L Duvall, Michael Matheny, Benjamin Viernes, William O'Brien, Linying Zhang, Benjamin Martin, Erik Westlund, Nestoras Mathioudakis, Ruochong Fan, Adam Wilcox, Albert Lai, Jacqueline C Stocking, Sahar Takkouche, Lok Hin Lee, Yangyiran Xie, Izabelle Humes, David B Mccoy, Mohammad Adibuzzaman, Raymond G Areaux, William Rojas-Carabali, James Brash, David A Lee, Nicole G Weiskopf, Louise Mawn, Rupesh Agrawal, Hannah Morgan-Cooper, Priya Desai, Patrick B Ryan

Faculty, Staff and Student Publications

Importance

Semaglutide, a glucagonlike peptide-1 receptor agonist (GLP-1RA), has recently been implicated in cases of nonarteritic anterior ischemic optic neuropathy (NAION), raising safety concerns in the treatment of type 2 diabetes (T2D).

Objective

To investigate the potential association between semaglutide and NAION in the Observational Health Data Sciences and Informatics (OHDSI) network.

Design, Setting, and Participants

This was a retrospective study across 14 databases (6 administrative claims and 8 electronic health records). Included were adults with T2D taking semaglutide, other GLP-1RA (dulaglutide, exenatide), or non–GLP-1RA medications (empagliflozin, sitagliptin, glipizide) from December 1, 2017, to December 31, 2023. The incidence proportion …


Does Adiponectin Inform Cardiovascular Risk In Older Adults?: The Aric Study, Layla A Abushamat, Xiaoming Jia, Lu Xu, Chao Cheng, Chiadi E Ndumele, Caroline Sun, B Gwen Windham, Kunihiro Matsushita, Bing Yu, Vijay Nambi, Biykem Bozkurt, Jane E B Reusch, Casey M Rebholz, Elizabeth Selvin, Christie M Ballantyne, Ron C Hoogeveen Feb 2025

Does Adiponectin Inform Cardiovascular Risk In Older Adults?: The Aric Study, Layla A Abushamat, Xiaoming Jia, Lu Xu, Chao Cheng, Chiadi E Ndumele, Caroline Sun, B Gwen Windham, Kunihiro Matsushita, Bing Yu, Vijay Nambi, Biykem Bozkurt, Jane E B Reusch, Casey M Rebholz, Elizabeth Selvin, Christie M Ballantyne, Ron C Hoogeveen

Faculty, Staff and Student Publications

BACKGROUND: Adiponectin, an atheroprotective adipokine, is associated with adverse outcomes in older age. It is unclear whether this is due to overlapping pathophysiological pathways with N-terminal pro-B-type natriuretic peptide (NT-proBNP).

OBJECTIVES: The authors investigated adiponectin's associations with cardiovascular disease (CVD) risk in older adults.

METHODS: Among Atherosclerosis Risk in Communities prospective cohort study participants without baseline CVD at visit 5 (n = 4,729, mean age 75), adiponectin and adiponectin/NT-proBNP category associations with incident CVD events (heart failure [HF], atherosclerotic cardiovascular disease, and death during median follow-up of 5.5 years) and echocardiographic parameters were assessed. Metabolomic signatures of adiponectin/NT-proBNP categories were …


Erythritol, Erythronate, And Cardiovascular Outcomes In Older Adults In The Aric Study, Layla A Abushamat, Bing Yu, Ron C Hoogeveen, Caroline Sun, Chao Cheng, Sean M Hartig, Mark A Herman, Ashok Balasubramanyam, Jane Eb Reusch, Elizabeth Selvin, Chiadi E Ndumele, Vijay Nambi, Christie M Ballantyne Feb 2025

Erythritol, Erythronate, And Cardiovascular Outcomes In Older Adults In The Aric Study, Layla A Abushamat, Bing Yu, Ron C Hoogeveen, Caroline Sun, Chao Cheng, Sean M Hartig, Mark A Herman, Ashok Balasubramanyam, Jane Eb Reusch, Elizabeth Selvin, Chiadi E Ndumele, Vijay Nambi, Christie M Ballantyne

Faculty, Staff and Student Publications

BACKGROUND: Circulating erythritol, an endogenously produced metabolite and an artificial sweetener, is associated with cardiovascular outcomes.

OBJECTIVES: The authors assessed associations of erythritol and its downstream metabolite, erythronate, with cardiovascular risk factors and events in older adults in the ARIC (Atherosclerosis Risk In Communities) study (visit 5, 2011-2013).

METHODS: We included 4,006 participants without prevalent cardiovascular disease and with metabolomic profiling. Erythritol and erythronate were measured by mass spectrometry. We analyzed associations of log-transformed erythritol and erythronate with cardiovascular risk factors and events using Cox proportional hazard models.

RESULTS: Participants in the highest tertiles of erythritol or erythronate were older, …


Zika Virus Ns1 Drives Tunneling Nanotube Formation For Mitochondrial Transfer And Stealth Transmission In Trophoblasts, Rafael T Michita, Long B Tran, Steven J Bark, Deepak Kumar, Shay A Toner, Joyce Jose, Indira U Mysorekar, Anoop Narayanan Feb 2025

Zika Virus Ns1 Drives Tunneling Nanotube Formation For Mitochondrial Transfer And Stealth Transmission In Trophoblasts, Rafael T Michita, Long B Tran, Steven J Bark, Deepak Kumar, Shay A Toner, Joyce Jose, Indira U Mysorekar, Anoop Narayanan

Faculty, Staff and Students Publications

Zika virus (ZIKV) is unique among orthoflaviviruses in its vertical transmission capacity in humans, yet the underlying mechanisms remain incompletely understood. Here, we show that ZIKV induces tunneling nanotubes (TNTs) in placental trophoblasts which facilitate transfer of viral particles, proteins, mitochondria, and RNA to neighboring uninfected cells. TNT formation is driven exclusively via ZIKV non-structural protein 1 (NS1). Specifically, the N-terminal 1-50 amino acids of membrane-bound ZIKV NS1 are necessary for triggering TNT formation in host cells. Trophoblasts infected with TNT-deficient ZIKV


1 Studying The Determinants Of Successful Aging: Diet, Lifestyle, And Social Relations In Egypt, Fayrouz Shaltout Feb 2025

1 Studying The Determinants Of Successful Aging: Diet, Lifestyle, And Social Relations In Egypt, Fayrouz Shaltout

Theses and Dissertations

Abstract

Background

The global population is aging rapidly, with projections indicating that by 2050, one in six people will be over the age of 65. In Egypt, the aging population, particularly those aged 60 and above, is expected to grow significantly, posing a growing public health concern. Unhealthful diets (that are associated with overweight and obesity), are one of the main reasons associated with non-communicable diseases (e.g., diabetes and cardiovascular diseases) are major risk factors for poor aging outcomes. Despite this, there is limited research on the specific determinants of successful aging (SA) in Egypt, especially among individuals aged 50 …


Cervical Cancer Screening And Hpv Vaccine Intentions: An Egyptian Population Assessment Through University Channels, Rita Hany Ebeid Feb 2025

Cervical Cancer Screening And Hpv Vaccine Intentions: An Egyptian Population Assessment Through University Channels, Rita Hany Ebeid

Theses and Dissertations

Background: Cervical cancer remains a significant global health burden, disproportionately affecting low- and middle-income countries. While HPV vaccination and cervical cancer screening programs have shown promise in reducing incidence and mortality, access to these interventions remains limited in Egypt. The purpose of this study was to analyze female and male beliefs, knowledge of, and perceptions related to cervical cancer screening and HPV vaccination, and how these factors influence women and men’s intentions to respectively undergo or promote these behaviors in Egypt. This study also aimed to develop recommendations for more effective cervical cancer prevention measures that promote greater uptake among …


Breastfeeding Interventions And Programs Conducted In The Islamic Republic Of Iran: A Scoping Review, Patricia J. Kelly, Amrita Sidhu, Anusha Sajja, Devanshi Majeethia, Elizabeth Dodge, Basil H. Aboul-Enein Feb 2025

Breastfeeding Interventions And Programs Conducted In The Islamic Republic Of Iran: A Scoping Review, Patricia J. Kelly, Amrita Sidhu, Anusha Sajja, Devanshi Majeethia, Elizabeth Dodge, Basil H. Aboul-Enein

College of Nursing Faculty Papers & Presentations

The purpose of this review was to identify interventions promoting breastfeeding (BF), BF practices and their outcomes in Iran. Using the PRISMA-ScR Guidelines, we searched across 14 databases for publications published between 2010 and February 2024 to identify studies published in English or Farsi language in peer-reviewed journals, using search terms 'breastfeeding', 'lactation', 'education', 'promotion', 'intervention' and 'program'. Inclusion criteria included intervention-based studies with quantitative outcomes of pregnant women/mothers receiving education, training or other intervention that promoted BF or exclusive BF. Excluded studies were protocols, those examining Iranian communities outside of Iran publications in other languages, brief communications, gray literature …


A Narrative Review Of Barriers To Utilization Of Surgical Risk Assessment Calculators, Jacob Lahti, Kaiya A. Noe, Abigail Veenstra, Sarah Gallitto, Victoria I. De Leon, Thomas C. Varkey, Nimit Agarwal Feb 2025

A Narrative Review Of Barriers To Utilization Of Surgical Risk Assessment Calculators, Jacob Lahti, Kaiya A. Noe, Abigail Veenstra, Sarah Gallitto, Victoria I. De Leon, Thomas C. Varkey, Nimit Agarwal

Annual Research Symposium

Over the last several decades, it has become the desire of surgical and medical teams to decrease risk levels involved for patients undergoing surgery. However, despite the advent of risk assessment calculators to help physicians obtain more accurate and objective judgements for postoperative complications, these tools are underutilized in standard clinical practices in comparison to other methods of risk assessment. This is likely due at least in part to certain barriers that decrease their functionality and ease of use. This review discusses the major barriers to the utilization of current risk calculators so as to allow for a better understanding …


Building Blocks For New Kinship Partnerships And Coalitions, Kathy L. Dial, Daniel J. Koltz, Janet Salo, Erin Beasley Feb 2025

Building Blocks For New Kinship Partnerships And Coalitions, Kathy L. Dial, Daniel J. Koltz, Janet Salo, Erin Beasley

GrandFamilies: The Contemporary Journal of Research, Practice and Policy

Building successful kinship partnerships and coalitions requires intentional effort to establish trust, align goals, and foster inclusivity. These collaborations are essential for addressing the unique and evolving needs of kinship families, who often face limited access to resources due to the informal nature of many caregiving arrangements. Effective partnerships prioritize clear missions, open communication, and active engagement with stakeholders, particularly those with lived experiences such as kinship caregivers. Research demonstrates that coordinated efforts among organizations enhance resource availability, improve advocacy capabilities, and strengthen service delivery. By integrating diversity, equity, and inclusion principles, coalitions can ensure that diverse perspectives shape solutions …


Assessment Of Chronic Kidney Disease Awareness Among Patients In A Tertiary Care Hospital: A Questionnaire- Based Study, Jyothi Basini, Srija Sadanala, Srinivasa Yadav Poolugari, Susmitha Karakambadi, Teja Apthiri, Ram R Feb 2025

Assessment Of Chronic Kidney Disease Awareness Among Patients In A Tertiary Care Hospital: A Questionnaire- Based Study, Jyothi Basini, Srija Sadanala, Srinivasa Yadav Poolugari, Susmitha Karakambadi, Teja Apthiri, Ram R

International Journal of Health and Allied Sciences

Chronic kidney disease (CKD) is increasingly recognized as a significant global public health concern, influenced by individuals' lifestyle choices. Despite being largely asymptomatic until advanced stages, CKD is associated with heightened risks of cardiovascular disease, premature mortality, and diminished quality of life. Particularly in developing nations like India, where precise prevalence data are scarce, the need for heightened public awareness is paramount. This study, conducted at SVIMS, Tirupati, employed a hospital-based prospective design involving adults (≥18 years) diagnosed with CKD. Through informed consent, participants underwent interviews using structured questionnaires to assess their understanding of CKD. Multivariate logistic regression analysis identified …


Safety And Efficacy Of Different Stent Strategies In Percutaneous Coronary Intervention: A Network Meta-Analysis, Waqas Ullah, Harigopal Sandhyavenu, Syeda Ramsha Zaidi, Mileydis Alonso, Muhammad Atif Khan, Irfan Ullah, Farah Yasmin, Aravind Reddy Polam, Salman Zahid, Arnav Kumar, Ewout Steyerberg, Mohammed Murtaza, Chadi Alraiesm, Jeffrey Rade Feb 2025

Safety And Efficacy Of Different Stent Strategies In Percutaneous Coronary Intervention: A Network Meta-Analysis, Waqas Ullah, Harigopal Sandhyavenu, Syeda Ramsha Zaidi, Mileydis Alonso, Muhammad Atif Khan, Irfan Ullah, Farah Yasmin, Aravind Reddy Polam, Salman Zahid, Arnav Kumar, Ewout Steyerberg, Mohammed Murtaza, Chadi Alraiesm, Jeffrey Rade

Jefferson Health - Northeast Papers (formerly Aria Health Papers)

BACKGROUND: The utility of polymer-permanent, polymer-absorbable, and polymer-free drug-eluting stents (DES) in the context of different eluting drugs in patients undergoing percutaneous coronary intervention (PCI) remains controversial.

OBJECTIVES: The purpose of this study was to compare the efficacy of different DES strategies in post-PCI patients.

METHODS: Digital databases were searched to select all randomized control trials. Different combinations of DES were directly compared with permanent-polymer sirolimus-eluting stents. The primary outcome was major adverse cardiovascular events; a composite of cardiovascular mortality, myocardial infarction (MI), and target vessel revascularization. A network meta-analysis was performed to determine the net relative risk (RR) and …


Crème De La Conference: 8th World Congress Of Pediatric Cardiology And Cardiac Surgery-Wcpccs 2023, Carissa M. Baker-Smith, Liesl Zühlke, Jennifer Co-Vu, Shubhika Srivastava, Renelle George, Shelby Kutty, Ali N. Zaidi, David J. Goldberg, Erica D. Sood, Kathryn M. Dodds, David S. Cooper, Mitchel I. Cohen, Gil Wernovsky, Jeffrey P. Jacobs Feb 2025

Crème De La Conference: 8th World Congress Of Pediatric Cardiology And Cardiac Surgery-Wcpccs 2023, Carissa M. Baker-Smith, Liesl Zühlke, Jennifer Co-Vu, Shubhika Srivastava, Renelle George, Shelby Kutty, Ali N. Zaidi, David J. Goldberg, Erica D. Sood, Kathryn M. Dodds, David S. Cooper, Mitchel I. Cohen, Gil Wernovsky, Jeffrey P. Jacobs

Department of Medicine Faculty Papers

No abstract provided.