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Articles 361 - 390 of 2413
Full-Text Articles in Public Health
Evaluation Of Processes And Procedures For Care Of The Opioid Recipient Patient In The Primary Care Setting, Anne Sproat
Evaluation Of Processes And Procedures For Care Of The Opioid Recipient Patient In The Primary Care Setting, Anne Sproat
Doctoral Projects
Introduction: Chronic non-cancer pain is far reaching, affecting over 100 million Americans (Zgierska et al., 2018). Opioids are commonly prescribed for chronic pain, with approximately 20% of patients presenting to primary care offices with symptoms of pain or pain-related diagnoses (Dowell, Haegerich, & Chou, 2016). As a result, opioid prescribing rates are increasing at a faster rate for primary care practice compared with other specialties (Dowell et al., 2016). Within the United States population, it is estimated that three percent to four percent of the adult population are prescribed long-term opioids for the treatment of chronic non-cancer pain (Dowell et …
Interrupted Time Series Design To Evaluate The Effect Of The Icd-9-Cm To Icd-10-Cm Coding Transition On Injury Hospitalization Trends, Svetla Slavova, Julia F. Costich, Huong Luu, Judith Fields, Barbara A. Gabella, Sergey Tarima, Terry L. Bunn
Interrupted Time Series Design To Evaluate The Effect Of The Icd-9-Cm To Icd-10-Cm Coding Transition On Injury Hospitalization Trends, Svetla Slavova, Julia F. Costich, Huong Luu, Judith Fields, Barbara A. Gabella, Sergey Tarima, Terry L. Bunn
Biostatistics Faculty Publications
Background: Implementation of the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) in the U.S. on October 1, 2015 was a significant policy change with the potential to affect established injury morbidity trends. This study used data from a single state to demonstrate 1) the use of a statistical method to estimate the effect of this coding transition on injury hospitalization trends, and 2) interpretation of significant changes in injury trends in the context of the structural and conceptual differences between ICD-9-CM and ICD-10-CM, the new ICD-10-CM-specific coding guidelines, and proposed ICD-10-CM-based framework for reporting of injuries by intent …
Geph 7134 Social Marketing For Health Communication, Dziyana Nazaruk
Geph 7134 Social Marketing For Health Communication, Dziyana Nazaruk
College of Public Health: Faculty Syllabi (2014-2021)
This course is designed to familiarize students with the history and current applications of health communication theory and strategies to public health practice and research. This course examines how to structure, develop and evaluate social marketing, media advocacy, risk communication and advocacy skills for change. In addition, systematic qualitative data collection processes such as interviewing skills, participant observation and focus groups will be developed. Emphasis is placed on critical thinking skills to help students analyze and utilize these skills in research and practice.
Dietary Intake And Physical Activity Assessment: Current Tools, Techniques, And Technologies For Use In Adult Populations., Holly L. Mcclung, Lauren T. Ptomey, Robin P. Shook, Anju Aggarwal, Anna M. Gorczyca, Edward S. Sazonov, Katie Becofsky, Rick Weiss, Sai Krupa Das
Dietary Intake And Physical Activity Assessment: Current Tools, Techniques, And Technologies For Use In Adult Populations., Holly L. Mcclung, Lauren T. Ptomey, Robin P. Shook, Anju Aggarwal, Anna M. Gorczyca, Edward S. Sazonov, Katie Becofsky, Rick Weiss, Sai Krupa Das
Manuscripts, Articles, Book Chapters and Other Papers
Accurate assessment of dietary intake and physical activity is a vital component for quality research in public health, nutrition, and exercise science. However, accurate and consistent methodology for the assessment of these components remains a major challenge. Classic methods use self-report to capture dietary intake and physical activity in healthy adult populations. However, these tools, such as questionnaires or food and activity records and recalls, have been shown to underestimate energy intake and expenditure as compared with direct measures like doubly labeled water. This paper summarizes recent technological advancements, such as remote sensing devices, digital photography, and multisensor devices, which …
Associations Between Environmental Quality And Infant Mortality In The United States, 2000–2005, Achal P. Patel, Jyotsna S. Jagai, Lynne C. Messer, Christine L. Gray, Kristen M. Rappazzo
Associations Between Environmental Quality And Infant Mortality In The United States, 2000–2005, Achal P. Patel, Jyotsna S. Jagai, Lynne C. Messer, Christine L. Gray, Kristen M. Rappazzo
OHSU-PSU School of Public Health Faculty Publications and Presentations
Background: The United States (U.S.) suffers from high infant mortality (IM) rates and there are significant racial/ethnic differences in these rates. Prior studies on the environment and infant mortality are generally limited to singular exposures. We utilize the Environmental Quality Index (EQI), a measure of cumulative environmental exposure (across air, water, land, sociodemographic, and land domains) for U.S. counties from 2000 to 2005, to investigate associations between ambient environment and IM across maternal race/ethnicity.
Methods: We linked 2000–2005 infant data from the U.S. Centers for Disease Control and Prevention to the EQI (n = 22,702,529; 144,741 deaths). We utilized multi-level …
Lifetime Economic Burden Of Intimate Partner Violence Among U.S. Adults, Cora Peterson, Megan C. Kearns, Wendy Likamwa Mcintosh, Lianne Fuino Estefen, Christina Nicolaidis, Kathryn E. Mccollister, Amy Gordon, Curtis Florence
Lifetime Economic Burden Of Intimate Partner Violence Among U.S. Adults, Cora Peterson, Megan C. Kearns, Wendy Likamwa Mcintosh, Lianne Fuino Estefen, Christina Nicolaidis, Kathryn E. Mccollister, Amy Gordon, Curtis Florence
School of Social Work Faculty Publications and Presentations
Introduction: This study estimated the U.S. lifetime per-victim cost and economic burden of intimate partner violence.
Methods: Data from previous studies were combined with 2012 U.S. National Intimate Partner and Sexual Violence Survey data in a mathematical model. Intimate partner violence was defined as contact sexual violence, physical violence, or stalking victimization with related impact (e.g., missed work days). Costs included attributable impaired health, lost productivity, and criminal justice costs from the societal perspective. Mean age at first victimization was assessed as 25 years. Future costs were discounted by 3%. The main outcome measures were the mean per-victim (female and …
Boys’ Sex Education In Rural Maharashtra: Context, Community, And Trust, Sierra Bradshaw-Kreimer
Boys’ Sex Education In Rural Maharashtra: Context, Community, And Trust, Sierra Bradshaw-Kreimer
Independent Study Project (ISP) Collection
The primary research question of this study is: do alumni of CRHP’s Adolescent Boy’s Program (ABP) and parents of alumni of the ABP report that the boys have changed after completing the program, and if yes, in what ways? Beyond that, the study is also concerned with examining potential reasons behind the results of the primary research question. The researcher conducted interviews with 3 ABP alumni and 3 parents of ABP alumni, in addition to attending information sessions and observing the workings of CRHP. The primary findings were that yes, the respondents reported a change. The change was described as …
Trust, Access, And Adaptation To Needs: The Role Of Community-Based Promoters In Health Insurance Delivery In Gujarat, India, Lauryn Stafford
Trust, Access, And Adaptation To Needs: The Role Of Community-Based Promoters In Health Insurance Delivery In Gujarat, India, Lauryn Stafford
Independent Study Project (ISP) Collection
The research question this study addresses is: How do community-based promoters contribute to the delivery and utilization of health insurance among marginalized populations in India? To address this question, the successes and difficulties experienced by VimoSEWA community-based insurance promoters, called aagewans, were investigated through field visits and personal interviews in Ahmedabad and nearby rural districts in Gujarat. VimoSEWA’s insurance delivery model is an appropriate topic of investigation for this study because its beneficiaries are self-employed women with limited prior access to financial protection. Both aagewans and insurance members were interviewed during this study to develop a comprehensive understanding of the …
Poly Cystic Ovarian Syndrome In India: A Socio-Cultural Perspective, Hannah Wickham
Poly Cystic Ovarian Syndrome In India: A Socio-Cultural Perspective, Hannah Wickham
Independent Study Project (ISP) Collection
This study examines the ways in which cultural determinants affect the health-seeking, diagnosis and treatment process of women with Poly Cystic Ovarian Syndrome (PCOS) as well as the underlying socio-cultural causes of the illness. Often coined as a “lifestyle disease”, PCOS is becoming a growing concern of physicians and women alike as its prevalence is on the rise with no signs of slowing down. Lifestyle, stigmas/taboos, PCOS’s effect on identity, and quality of life are all areas that are examined throughout this paper. A mixture of patients’ and doctors’ perspectives on PCOS were gathered throughout a three-week time period in …
“If You Seek, You Know You Will Find And If You Find You Have Cancer, Why Do You Seek?” Knowledge And Practices Regarding Cancer Screening And Prevention In Cato Manor, Lilly Hennessey
Independent Study Project (ISP) Collection
The incidence of cancer continues to increase in South Africa, creating a serious concern for public health. There are currently several cancer awareness programs operating in the Durban area, but little is known as to whether they are having a positive impact on communities. This project aimed to understand the knowledge and practices regarding cancer screening and prevention in Cato Manor, KwaZulu-Natal. In doing so, it assessed the effectiveness and knowledge of current programs which work to increase cancer awareness.
This study used a mixed methodology approach. Surveys were given to 30 residents of Cato Manor to gain a quantitative …
The Association Of Hospital Practices To Breastfeeding Behaviors In South Carolina: Analysis Of 2013-2015 Pregnancy Risk Assessment Monitoring System (Prams) Data, Larisa Donnette Bruner
The Association Of Hospital Practices To Breastfeeding Behaviors In South Carolina: Analysis Of 2013-2015 Pregnancy Risk Assessment Monitoring System (Prams) Data, Larisa Donnette Bruner
Theses and Dissertations
Objective: The purpose of this study was to determine whether hospital practices are associated with breastfeeding initiation and breastfeeding duration for ≥10 weeks.
Methods: We analyzed the 2013-2015 South Carolina Pregnancy Risk Assessment Monitoring System (PRAMS) data. The population of interest was mothers who delivered a single live birth in the hospital. The infant was alive and living with the mother at the time of the survey. Chi-square and logistic regression were used to examine breastfeeding initiation and duration among all women who delivered in a hospital and those who stated that they initiated breastfeeding while in the …
Physical Activity During Pregnancy And Birth Outcomes In South Carolina 2009-2015, Andrew Tyler Broadway
Physical Activity During Pregnancy And Birth Outcomes In South Carolina 2009-2015, Andrew Tyler Broadway
Theses and Dissertations
Physical activity is known to be beneficial to adults in general, including pregnant women, but the literature on physical activity and neonatal outcomes has been inconsistent. Few studies have differentiated between physical activity prior to pregnancy and during pregnancy to see whether the typical beneficial effect is not due to having a more active lifestyle in general. The Pregnancy Risk Assessment Monitoring System (PRAMS) is a national cross-sectional surveillance system. Our data from SC PRAMS included 6391 respondents and was weighted to be representative of population of pregnant women that delivered in the state. We excluded births that were not …
Perceived Causes Of Adverse Pregnancy Outcomes And Remedies Adopted By Kalenjin Women In Rural Kenya, Roselyter Riang’A, Anne Nangulu, Jacqueline Broerse
Perceived Causes Of Adverse Pregnancy Outcomes And Remedies Adopted By Kalenjin Women In Rural Kenya, Roselyter Riang’A, Anne Nangulu, Jacqueline Broerse
Population Health, East Africa
Background: There have been few studies about the basis on which women in developing regions evaluate and choose traditional rather than western maternal care. This qualitative study explores the socio-cultural perceptions of complications associated with pregnancy and childbirth and how these perceptions influence maternal health and care-seeking behaviours in Kenya.
Methods: Kalenjin women (n = 42) aged 18–45 years, who were pregnant or had given birth within the last 12 months, were interviewed. A semi-structured interview guide was used for data collection. A further nine key informant interviews with Traditional Birth Attendants (TBAs) who were also herbalists (n …
Integrated Mental Health Care In Education For Syrian Refugees: An Exploratory Study, Emily Goldstein
Integrated Mental Health Care In Education For Syrian Refugees: An Exploratory Study, Emily Goldstein
Independent Study Project (ISP) Collection
Trauma-inducing experiences during conflict can significantly impede the ability to function and effectively learn in the classroom; thus, it is essential to integrate mental health services into the school setting for refugee populations. This study investigated the state of integrated mental healthcare for Syrian refugees in Jordan by surveying Syrian students on their attitudes towards seeking mental health and interviewing educators on their classroom practices. The scope of the study was extremely limited, as data was collected on only 21 students and 5 educators in one school and a number of biases could have skewed the results. It was found …
Short-Term Association Between Black Carbon Exposure And Cardiovascular Diseases In Pakistan’S Largest Megacity, Daniel Malashock, Haider Khwaja, Zafar Fatmi, Azhar Siddique, Yi Lu, Shao Lin, David Carpenter
Short-Term Association Between Black Carbon Exposure And Cardiovascular Diseases In Pakistan’S Largest Megacity, Daniel Malashock, Haider Khwaja, Zafar Fatmi, Azhar Siddique, Yi Lu, Shao Lin, David Carpenter
Community Health Sciences
This study investigated the association between black carbon (BC) exposure and hospital admissions (HAs) and outpatient department/emergency room (OPD/ER) visits for cardiovascular diseases (CVD) among residents of Karachi, the largest city in Pakistan. We measured daily concentrations of BC in fine particulate matter (PM2.5) and collected records of HAs and OPD/ER visits for CVD from 2 major tertiary care hospitals serving Karachi for 6 weeks continuously during each quarter over 1 year (August 2008–August 2009). We subsequently analyzed daily counts of hospital and BC data over 0–3 lag days. Daily mean BC concentrations varied from 1 to 32 µg/m3 . …
Barriers To Receipt Of Prenatal Tetanus Toxoid, Reduced Diptheria Toxoid, And Acellular Pertussis Vaccine Among Mothers Of Infants Aged < 4 Months With Pertussis — California, 2016, Sarah New, Kathleen Winter, Kathleen Harriman, Anya Gutman, Amber Christiansen, Sarah Royce
Barriers To Receipt Of Prenatal Tetanus Toxoid, Reduced Diptheria Toxoid, And Acellular Pertussis Vaccine Among Mothers Of Infants Aged < 4 Months With Pertussis — California, 2016, Sarah New, Kathleen Winter, Kathleen Harriman, Anya Gutman, Amber Christiansen, Sarah Royce
Epidemiology and Environmental Health Faculty Publications
No abstract provided.
Étude Des Qualités Psychométriques De L’Outil D’Identification De La Situation De Handicap Au Travail (Oisht) Utilisé Auprès De Travailleurs Ayant Un Trouble Musculosquelettique Ou Un Trouble Mental Courant, Marie-José Durand, Marie-France Coutu, Éric Vaillancourt, Djamal Berbiche
Étude Des Qualités Psychométriques De L’Outil D’Identification De La Situation De Handicap Au Travail (Oisht) Utilisé Auprès De Travailleurs Ayant Un Trouble Musculosquelettique Ou Un Trouble Mental Courant, Marie-José Durand, Marie-France Coutu, Éric Vaillancourt, Djamal Berbiche
Rapports de recherche scientifique
L’outil d’identification de la situation de handicap au travail (OISHT) consiste en une entrevue structurée qui a été développée pour aider les cliniciens à identifier de façon systématique les facteurs liés à l’incapacité au travail. L’OISHT est un des rares outils disponibles en réadaptation pour la clientèle en phase chronique d’incapacité au travail. Il tient compte de l’influence de différents systèmes (personnel, santé, travail, indemnisation) et a été élaboré pour les deux principales problématiques de santé associées à l’incapacité au travail, soit les troubles musculosquelettiques (TMS) et les troubles mentaux courants (TMC).
L’objectif de cette étude visait la validation de …
Utilisation Des Cellules Dendritiques En Tant Que Biosenseurs Pour La Surveillance De La Qualité Biologique De L’Air, Magali Boucher, Pascale Blais Lecours, Marc Veillette, Caroline Duchaine, David Marsolais
Utilisation Des Cellules Dendritiques En Tant Que Biosenseurs Pour La Surveillance De La Qualité Biologique De L’Air, Magali Boucher, Pascale Blais Lecours, Marc Veillette, Caroline Duchaine, David Marsolais
Rapports de recherche scientifique
Le nombre d’environnements de travail touchés par des problématiques de santé reliées aux bioaérosols est si considérable qu’il est difficile d’en faire un dénombrement précis. Les exemples les plus connus sont les porcheries, fermes laitières, tourbières, scieries et usines alimentaires. Aucune limite d’exposition n’existe pour les différentes composantes des bioaérosols, hormis les recommandations pour les endotoxines et certaines poussières. Toutefois, il est bien connu que l’état sanitaire de ces environnements diffère de site en site et selon leur classe. La nature des bioaérosols détectés dans ces environnements n’est que partiellement définie. Cette situation rend difficile la mise en place des …
A Requirement For Slc15a4 In Imiquimod-Induced Systemic Inflammation And Psoriasiform Inflammation In Mice, Alexis D. Griffith, Asifa K. Zaidi, Ashley Pietro, Matthew Hadiono, Jessica S. Yang, Rachel Davis, Daniel L. Popkin
A Requirement For Slc15a4 In Imiquimod-Induced Systemic Inflammation And Psoriasiform Inflammation In Mice, Alexis D. Griffith, Asifa K. Zaidi, Ashley Pietro, Matthew Hadiono, Jessica S. Yang, Rachel Davis, Daniel L. Popkin
Faculty Publications
There is competing evidence that plasmacytoid dendritic cells (pDC), the most potent source of IFN-I, may initiate psoriasis. We targeted pDC function using the slc15a4 loss-of-function mouse whose pDC are unresponsive to TLR agonists. slc15a4 treated with the topical TLR7-agonist imiquimod (IMQ) demonstrated decreased epidermal thickening 24 hours post-treatment which was more pronounced by day 5 as compared to wildtype mice. These findings were specific to the acute IMQ model and not the protracted IL23 model that drives inflammation downstream of TLR activation. Systemically, slc15a4 was required for IMQ-induced weight loss and cutaneous accumulation of CD4+ and Siglec H+, but …
What Do Urban College Students Really Think About Health Insurance? A Qualitative Study, P. Christopher Palmedo, Eleni K. Murphy, Katrina F. Mateo, Jennifer Gallo
What Do Urban College Students Really Think About Health Insurance? A Qualitative Study, P. Christopher Palmedo, Eleni K. Murphy, Katrina F. Mateo, Jennifer Gallo
Publications and Research
Objective: To determine barriers and opportunities to health insurance enrollment among an undergraduate students at a large urban university. Participants: Participants were 31 college students enrolled in 4-year and community colleges in the City University of New York (CUNY), and six health services and insurance enrollment specialists who facilitate and assist in the health insurance enrollment process for CUNY students. Methods: Focus groups were conducted with students and in-depth interviews with key informants in May 2017. Results: The research revealed important insights into how students perceive and value insurance and yielded recommendations for the university to improve enrollment of its …
In Memoriam: Irina V. Tarasevich, Marina Eremeeva
In Memoriam: Irina V. Tarasevich, Marina Eremeeva
Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications
Article published in New Microbes and New Infections.
Stairway Uniformity Measurement: What Lateral Location Should Be Measured, Roger C. Jensen, Lee Calf Looking
Stairway Uniformity Measurement: What Lateral Location Should Be Measured, Roger C. Jensen, Lee Calf Looking
Safety Health & Industrial Hygiene
An experimental study sought to extend understanding of the nosing-to-nosing method for measuring dimensions of steps in a stairway. A human factors expert retained to assist an attorney in a case of injury or death from a stairway fall needs to decide the lateral location for taking the measurements. This experiment was undertaken to provide experts with a justifiable basis for choosing the location. Using a campus stairway and 16 student subjects, a randomized complete block experiment compared their lateral location while performing four tasks—ascending with or without the handrail, and descending with or without the handrail. Results showed task …
Ua12/2/1 Fit: A Health & Wellness Guide, Wku Student Affairs
Ua12/2/1 Fit: A Health & Wellness Guide, Wku Student Affairs
WKU Administration Documents
Special magazine of College Heights Herald regarding health and fitness.
- Childress, Nicole. Welcome to Fit
- Southers, Mariah. CVS Shares 4 Ways to Beat the Flu
- Childress, Nicole. Do It Yourself Face Masks
- Goodlett, Ryan. Juices Add Zest to Life
- Southers, Mariah & Bryson Lacasse. Classic Shortcuts – WKU Campus Map
- Wells, Spencer. Little Fox Bakery Offers Sweet Treats for Every Diet
- Southers, Mariah. Turning Up the Heat – Hot Yoga
- Goodlett, Ryan. Iron Woman – Melinda Grimsley-Smith
- Wells, Spencer. Preston Health & Fitness Center: More Than Just a Gym
Development, Validation, And Testing Of A Self-Determination Theory Instrument Called The Motivation To Prepare Healthy Foods Questionnaire, Ariana Delong Bailey
Development, Validation, And Testing Of A Self-Determination Theory Instrument Called The Motivation To Prepare Healthy Foods Questionnaire, Ariana Delong Bailey
LSU Doctoral Dissertations
The objectives of these studies were to validate and confirm the structure of a previously developed questionnaire that measures the psychosocial constructs defined by the Self-Determination Theory (SDT) and then test this questionnaire in a nutrition education setting. The instrument, titled the Motivation to Prepare Healthy Foods Questionnaire (MPHFQ), included items that measured intrinsic motivation, perceived competence, relatedness, autonomy, and autonomy support. These studies evaluated the questionnaire’s validity and ability to measure changes in the SDT construct scores.
The MPHFQ is a previously developed and reliable instrument intended to measure adults’ intrinsic motivation and perceived competence to prepare healthy foods, …
College Of Public Health News, Georgia Southern University
College Of Public Health News, Georgia Southern University
College of Public Health: News & Publications
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Georgia Southern finds Fish consumption is associated with a decreased risk of death among adults with diabetes.
College Of Public Health News, Georgia Southern University
College Of Public Health News, Georgia Southern University
College of Public Health: News & Publications
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Georgia Southern finds Fish consumption is associated with a decreased risk of death among adults with diabetes.
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Georgia Southern evaluates N95 Filtering Facepiece Respirators on Construction Jobsites for Protection against Airborne Ultrafine Particles
Star Power, Pandemics, And Politics: The Role Of Cultural Elites In Global Health Security, Holly Lynne Swayne
Star Power, Pandemics, And Politics: The Role Of Cultural Elites In Global Health Security, Holly Lynne Swayne
USF Tampa Graduate Theses and Dissertations
Celebrities have historically served a variety of roles in society ranging from the inspirational to the cautionary, utilizing their platforms of visibility to promote themselves, their work, as well as their social and political causes. This study focuses on celebrities as activists engaging with global health issues, with particular attention to the form this engagement takes, the publicity it receives in the mass media, and the types of global health issues that receive the most celebrity attention. An interdisciplinary approach drawing from theories of power, social movement theory, agenda-setting, and cultural studies is used to achieve greater understanding of underlying …
Justice Served Fresh: Associations Between Food Insecurity, Community Gardening, And Property Value, Micajah Daniels, Courtney Coughenour Ph.D
Justice Served Fresh: Associations Between Food Insecurity, Community Gardening, And Property Value, Micajah Daniels, Courtney Coughenour Ph.D
McNair Poster Presentations
Numerous stakeholders in Nevada have used a variety of efforts to combat the growth of food insecurity facing Nevadans. The purpose of this research project is to understand the association between food insecurity, community gardens, and property value. Following the wealth of scholarship on these topics and data collected from community garden agencies in Southern Nevada, the research questions for this project include: (1) Where are community gardens located in SNV? (2) What efforts community gardens agencies are doing to address food insecurity (most interested in their efforts using community gardens)? (3) What are the perceptions of supports and barriers …
Molecular Surveillance Of Respiratory Viruses With Bioaerosol Sampling In An Airport, E. S. Bailey, J. Y. Choi, J. Zemke, M. Yondon, G. C. Gray
Molecular Surveillance Of Respiratory Viruses With Bioaerosol Sampling In An Airport, E. S. Bailey, J. Y. Choi, J. Zemke, M. Yondon, G. C. Gray
Public Health
No abstract provided.
Data For Gaw20: Genome-Wide Dna Sequence Variation And Epigenome-Wide Dna Methylation Before And After Fenofibrate Treatment In A Family Study Of Metabolic Phenotypes, Stella Aslibekyan, Laura Almasy, Michael A. Province, Devin M. Absher, Donna K. Arnett
Data For Gaw20: Genome-Wide Dna Sequence Variation And Epigenome-Wide Dna Methylation Before And After Fenofibrate Treatment In A Family Study Of Metabolic Phenotypes, Stella Aslibekyan, Laura Almasy, Michael A. Province, Devin M. Absher, Donna K. Arnett
Epidemiology and Environmental Health Faculty Publications
GAW20 provided participants with an opportunity to comprehensively examine genetic and epigenetic variation among related individuals in the context of drug treatment response. GAW20 used data from 188 families (N = 1105) participating in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (clinicaltrials.gov identifier NCT00083369), which included CD4+ T-cell DNA methylation at 463,995 cytosine-phosphate-guanine (CpG) sites measured before and after a 3-week treatment with fenofibrate, single-nucleotide variation at 906,600 loci, metabolic syndrome components ascertained before and after the drug intervention, and relevant covariates. All GOLDN participants were of European descent, with an average age of …