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Articles 421 - 450 of 535
Full-Text Articles in Public Health
Provider Survey Of Use Of Ebp Billing Codes Vs. Utilization, Evidence To Practice, Cep Briefs, Kaylin Beiter, Stephen Phillippi, Bumbarger
Provider Survey Of Use Of Ebp Billing Codes Vs. Utilization, Evidence To Practice, Cep Briefs, Kaylin Beiter, Stephen Phillippi, Bumbarger
Policy & Position Papers
No abstract provided.
Psychometric Properties Of The Poagts: A Tool For Understanding Parents' Perceptions Regarding Autism Spectrum Disorder Genetic Testing, Shixi Zhao, Wei-Ju Chen, Oi-Man Kwok, Shweta U. Dhar, Tanya N. Eble, Tung-Sung Tseng, Lei-Shih Chen
Psychometric Properties Of The Poagts: A Tool For Understanding Parents' Perceptions Regarding Autism Spectrum Disorder Genetic Testing, Shixi Zhao, Wei-Ju Chen, Oi-Man Kwok, Shweta U. Dhar, Tanya N. Eble, Tung-Sung Tseng, Lei-Shih Chen
School of Public Health Faculty Publications
Due to the increased prevalence of Autism Spectrum Disorder (ASD), more children with ASD may be referred for genetic testing. It is important to develop a tool to help parents consider the benefits and drawbacks of genetic testing for ASD before pursuing genetic testing for children with ASD. We developed the first theory-based survey—Perceptions of ASD Genetic Testing Survey (POAGTS), as a tool to assist healthcare providers to better understand parents’ perceptions and concerns regarding ASD genetic testing. The psychometric properties of POAGTS were first pre-tested and then formally tested with 308 parents of children with ASD who had not …
Alcohol Intake And Alcohol–Snp Interactions Associated With Prostate Cancer Aggressiveness, Hui Yi Lin, Xinnan Wang, Tung-Sung Tseng, Yu Hsiang Kao, Zhide Fang, Patricia E. Molina, Chia Ho Cheng, Anders E. Berglund, Rosalind A. Eeles, Kenneth R. Muir, Nora Pashayan, Christopher A. Haiman, Hermann Brenner, Jong Y. Park
Alcohol Intake And Alcohol–Snp Interactions Associated With Prostate Cancer Aggressiveness, Hui Yi Lin, Xinnan Wang, Tung-Sung Tseng, Yu Hsiang Kao, Zhide Fang, Patricia E. Molina, Chia Ho Cheng, Anders E. Berglund, Rosalind A. Eeles, Kenneth R. Muir, Nora Pashayan, Christopher A. Haiman, Hermann Brenner, Jong Y. Park
School of Public Health Faculty Publications
Excessive alcohol intake is a well-known modifiable risk factor for many cancers. It is still unclear whether genetic variants or single nucleotide polymorphisms (SNPs) can modify alcohol intake’s impact on prostate cancer (PCa) aggressiveness. The objective is to test the alcohol–SNP interactions of the 7501 SNPs in the four pathways (angiogenesis, mitochondria, miRNA, and androgen metabolism-related pathways) associated with PCa aggressiveness. We evaluated the impacts of three excessive alcohol intake behaviors in 3306 PCa patients with European ancestry from the PCa Consortium. We tested the alcohol–SNP interactions using logistic models with the discovery-validation study design. All three excessive alcohol intake …
The Relationship Between Social Vulnerability And Covid-19 Incidence Among Louisiana Census Tracts, Erin N. Biggs, Patrick M. Maloney, Ariane L. Rung, Edward S. Peters, William T. Robinson
The Relationship Between Social Vulnerability And Covid-19 Incidence Among Louisiana Census Tracts, Erin N. Biggs, Patrick M. Maloney, Ariane L. Rung, Edward S. Peters, William T. Robinson
School of Public Health Faculty Publications
No abstract provided.
Racial Disparity In The Timely Treatment Of Non-Small Cell Lung Cancer, P Neroda, Mei-Chin Hsieh, Xiao-Cheng Wu, K Cartmell, R Mayo, Jiande Wu, Chindo Hicks, L Zhang
Racial Disparity In The Timely Treatment Of Non-Small Cell Lung Cancer, P Neroda, Mei-Chin Hsieh, Xiao-Cheng Wu, K Cartmell, R Mayo, Jiande Wu, Chindo Hicks, L Zhang
School of Public Health Faculty Publications
No abstract provided.
2021 Annual Report, Evidence To Practice, Cep Annual Reports, Stephen Phillippi, Sonita Singh, S. Hoffpauir, Denise Danos, Lisa Staples, Brooke Dupre, Willandra Whiting, L. Simpson, K. Beiter, C.L. Thomas, Ronnie Rubin, Brian Bumbarger
2021 Annual Report, Evidence To Practice, Cep Annual Reports, Stephen Phillippi, Sonita Singh, S. Hoffpauir, Denise Danos, Lisa Staples, Brooke Dupre, Willandra Whiting, L. Simpson, K. Beiter, C.L. Thomas, Ronnie Rubin, Brian Bumbarger
Policy & Position Papers
No abstract provided.
Work-Family Spillover And Depression: Are There Racial Differences Among Employed Women?, Ariane L. Rung, Evrim Oral, Edward S. Peters
Work-Family Spillover And Depression: Are There Racial Differences Among Employed Women?, Ariane L. Rung, Evrim Oral, Edward S. Peters
School of Public Health Faculty Publications
The intersection of work and family life can be a source of burden (negative) and a source of growth (positive). Negative work-to-family and family-to-work spillover have been linked to poor mental health, while positive work-to-family and family-to-work spillover have been linked to improved health outcomes. Less is known about these relationships in racial subgroups. Louisiana, USA, has a large proportion of African Americans, providing a unique population in which to study these relationships. The objectives of this study were to examine, among a sample of women in southern Louisiana in 2017, levels of work-family spillover by race and how the …
The Effect Of Area Deprivation On Covid-19 Risk In Louisiana, Madhav Kc, Evrim Oral, Susanne Straif-Bourgeois, Ariane L. Rung, Edward S. Peters
The Effect Of Area Deprivation On Covid-19 Risk In Louisiana, Madhav Kc, Evrim Oral, Susanne Straif-Bourgeois, Ariane L. Rung, Edward S. Peters
School of Public Health Faculty Publications
Background Louisiana in the summer of 2020 had the highest per capita case count for COVID-19 in the United States and COVID-19 deaths disproportionately affects the African American population. Neighborhood deprivation has been observed to be associated with poorer health outcomes. The purpose of this study was to examine the relationship between neighborhood deprivation and COVID-19 in Louisiana. Methods The Area Deprivation Index (ADI) was calculated and used to classify neighborhood deprivation at the census tract level. A total of 17 US census variables were used to calculate the ADI for each of the 1148 census tracts in Louisiana. The …
Dysphagia And Masticatory Performance As A Mediator Of The Xerostomia To Quality Of Life Relation In The Older Population., Ting-Yu Lu, Jen-Hao Chen, Je-Kang Du, Ying-Chun Lin, Pei-Shan Ho, Chien-Hung Lee, Chih-Yang Hu, Hsiao-Ling Huang
Dysphagia And Masticatory Performance As A Mediator Of The Xerostomia To Quality Of Life Relation In The Older Population., Ting-Yu Lu, Jen-Hao Chen, Je-Kang Du, Ying-Chun Lin, Pei-Shan Ho, Chien-Hung Lee, Chih-Yang Hu, Hsiao-Ling Huang
School of Public Health Faculty Publications
Background: The impact of poor oral health on older adults' quality of life is a public health problem. In this study, the mediating effects of dental status, occlusal condition, dysphagia, and masticatory performance on the association between xerostomia and oral health-related quality of life (OHRQoL) were assessed in the older adult population.Methods: Stratified cluster sampling was used to recruit 1076 community-dwelling adults aged 65 years and older from Kaohsiung, Taiwan. Community care centers were randomly selected according to their geographic classifications (urban, rural, or mountainous areas). Assessments of dental status and occlusal condition were performed by dentists. Information on demographics, …
Blood Pressure Monitoring Following Individual Carpules Of Anesthetic Utilizing Computer-Controlled Anesthetic Delivery, Kristi M. Soileau, Adam E. Degenova, Qingzhao Yu
Blood Pressure Monitoring Following Individual Carpules Of Anesthetic Utilizing Computer-Controlled Anesthetic Delivery, Kristi M. Soileau, Adam E. Degenova, Qingzhao Yu
School of Dentistry Faculty Publications
To date, no study has evaluated blood pressure following administration of each carpule given for dental procedures using a computerized dental anesthesia system. Blood pressures taken prior to performing invasive periodontal procedures were compared with those readings measured following delivery of each of up to three consecutive carpules of Marcaine or Xylocaine in varying order. Pressure differences were also adjusted for age, sex, race, and whether a prescribed anxiolytic was taken beforehand. Neither systolic nor diastolic blood pressures changed significantly as compared to initial blood pressure readings. However, compared with Whites, Hispanics, and Middle Easterners, Blacks had significantly higher systolic …
Vol 1 November '20 Full Issue, Donna L. Williams
Vol 1 November '20 Full Issue, Donna L. Williams
Journal of the Louisiana Public Health Association
No abstract provided.
What A Difference A Year Makes, Donna L. Williams
What A Difference A Year Makes, Donna L. Williams
Journal of the Louisiana Public Health Association
No abstract provided.
Vol 1 November '20 Cover, Publishing Information And Table Of Contents, Donna L. Williams
Vol 1 November '20 Cover, Publishing Information And Table Of Contents, Donna L. Williams
Journal of the Louisiana Public Health Association
No abstract provided.
Public Health In Louisiana: Looking Back And Looking Forward, Rebekah Gee, William R. Boles
Public Health In Louisiana: Looking Back And Looking Forward, Rebekah Gee, William R. Boles
Journal of the Louisiana Public Health Association
No abstract provided.
Apha Affiliates: Go Far Together, Lisa M. Carlson
Apha Affiliates: Go Far Together, Lisa M. Carlson
Journal of the Louisiana Public Health Association
No abstract provided.
Rapid Response Sheltering In A Time Of Covid: Non-Congregate Shelters, David Holcombe
Rapid Response Sheltering In A Time Of Covid: Non-Congregate Shelters, David Holcombe
Journal of the Louisiana Public Health Association
No abstract provided.
Enhanced Outcomes Through Practice-Based Evidence, Pamela M. Aaltonen
Enhanced Outcomes Through Practice-Based Evidence, Pamela M. Aaltonen
Journal of the Louisiana Public Health Association
NOTE FROM THE EDITOR: This editorial was developed from remarks made by Dr. Aaltonen at the Louisiana Public Health Association’s 71st Annual Conference in Alexandria, LA, May 2019. It is notable how applicable these thoughts are, given the COVID-19 pandemic and subsequent rejection of science and evidence by large segments of the population in the United States.
Rapid Response Telehealth Among Behavioral Health Providers In Louisiana During Covid-19: A Story Of Adoption And Adaptation, Stephen Phillippi, Sonita Singh, Brian Bumbarger, Kaylin Beiter, Lindsay Simpson, Ashley Fenton
Rapid Response Telehealth Among Behavioral Health Providers In Louisiana During Covid-19: A Story Of Adoption And Adaptation, Stephen Phillippi, Sonita Singh, Brian Bumbarger, Kaylin Beiter, Lindsay Simpson, Ashley Fenton
Journal of the Louisiana Public Health Association
Background: The COVID-19 pandemic, the Louisiana Governor’s “Stay at Home” order, and subsequent social distancing precautions, necessitated an unprecedented shift to telehealth to access behavioral health services in Louisiana. Methods: Data were collected through a survey sent to 1,554 providers, with 307 (20%) responding, to learn how providers had managed the shift to telehealth. Results: The majority (85%) of providers surveyed reported continuing to see clients via telehealth. Barriers to providing care via telehealth were reported as, “clients’ access to devices, data and internet”, “the client’s knowledge of technology”, and the ability to access clients, specifically “hard to reach populations”. …
Louisiana Tumor Registry Leads By Numbers, Laura Ricks
Louisiana Tumor Registry Leads By Numbers, Laura Ricks
Journal of the Louisiana Public Health Association
No abstract provided.
Stop The Bleed: A Call To Action In Louisiana, Emily Nichols, Shayna Goldfine, Jonathan Fourcade, William Salmeron
Stop The Bleed: A Call To Action In Louisiana, Emily Nichols, Shayna Goldfine, Jonathan Fourcade, William Salmeron
Journal of the Louisiana Public Health Association
Background: In 2018, Louisiana ranked 2nd for the highest death rates due to homicide in the US (13.3 deaths per 100,000 total population). Falling just behind Mississippi, which had 13.4 deaths per 100,000 total population, this LA statistic was an improvement from the prime position held for over five years. While the approach to improving survivability requires the collaboration of many sectors, the Stop the Bleed (STB) education campaign is one example of initiatives taken to address this public health crisis. Methods: Developed by the Joint Committee to Create a National Policy to Enhance Survivability from Mass Casualty Shooting Events, …
The Louisiana Violent Death Reporting System: First Year Report, Norah W. Friar, Andrei Stefanescu, Jane Herwehe
The Louisiana Violent Death Reporting System: First Year Report, Norah W. Friar, Andrei Stefanescu, Jane Herwehe
Journal of the Louisiana Public Health Association
Background: The National Violent Death Reporting System (NVDRS) is a state-based surveillance system that collects information and tracks violent deaths in all fifty states, the District of Columbia, and Puerto Rico. Methods: Louisiana collected data in 2017 in four parishes: Orleans, Jefferson, East Baton Rouge, and Calcasieu. Data presented here are from the 2017 pilot year. Data on violent deaths were collected from law enforcement reports, coroner reports, and death certificates. Violent deaths included homicides, suicides, deaths of undetermined intent, accidental firearm deaths, and legal intervention deaths. Results: In 2017 in Orleans, Jefferson, East Baton Rouge, and Calcasieu Parishes there …
New Orleans Syringe Access Program And Implementation Of Harm Reduction Practices, Nadia Eskildsen, Allison Dejan, Marina Hernandez
New Orleans Syringe Access Program And Implementation Of Harm Reduction Practices, Nadia Eskildsen, Allison Dejan, Marina Hernandez
Journal of the Louisiana Public Health Association
Background: The New Orleans Syringe Access Program (NOSAP) at CrescentCare strives to reduce transmission of HIV and Hepatitis C among people who inject drugs by following harm reduction principles and advocating for clients’ healthcare goals. Methods: NOSAP staff and volunteers educate clients in safer injection methods and wound care. Clients complete annual intake forms that gather data about their drug use and practices (i.e. syringe disposal, sharing needles), track clientele volume, and guide development of program activities. Results: Since 2014, there has been a 269% increase in number of people served. Furthermore, 79 NOSAP clients were integrated into CrescentCare’s health …
Demographics Of Rural Scholars Track Graduates At Louisiana State University Health Sciences Center-New Orleans School Of Medicine, Bailey Gentile, Paula Rhode Brantley, Mary Thoesen Coleman
Demographics Of Rural Scholars Track Graduates At Louisiana State University Health Sciences Center-New Orleans School Of Medicine, Bailey Gentile, Paula Rhode Brantley, Mary Thoesen Coleman
Journal of the Louisiana Public Health Association
Introduction: The Rural Scholars Track (RST) program at Louisiana State University Health Sciences Center School of Medicine integrates rural experiences into medical training. The objective of the RST program is to encourage students to practice medicine in rural Louisiana in exchange for up to four years of tuition exemptions. An exploratory study was conducted to describe common characteristics of successful RST graduates from the program’s initiation in 2005 to present. The exploratory study and subsequent studies aim to identify characteristics among RST students that are predictors of successful matriculation through the program. Prioritizing applicants with these characteristics during the admissions …
Factors Associated With Acquiring Food From A Farmers Market And Community Or Home Garden Among Primarily African American Residents From Under-Resourced Neighborhoods, Jeanette Gustat, Yu-Zhang Lee, Taylor Johnson, Keelia O'Malley, Brian Luckett, Leann Myers
Factors Associated With Acquiring Food From A Farmers Market And Community Or Home Garden Among Primarily African American Residents From Under-Resourced Neighborhoods, Jeanette Gustat, Yu-Zhang Lee, Taylor Johnson, Keelia O'Malley, Brian Luckett, Leann Myers
Journal of the Louisiana Public Health Association
Farmers markets (FMs) and community/home community gardens (C/HGs) can increase access to fresh fruit and vegetables (F/V). There are limited data on FM and C/HG utilization in African American, under-resourced communities. We explored factors associated with acquiring food from these venues. Methods: An interviewer administered, cross-sectional survey was conducted door to door in two, low-income, predominantly African American neighborhoods in New Orleans, Louisiana. Conclusions: Establishing FMs and C/HGs in low-income communities may be a viable strategy for increasing F/V consumption. Future research within low-income minority communities is needed to inform initiatives to reduce nutrition-related health disparities using FMs and C/HGs. …
Examining Associations Of Louisiana’S Gift Program And Race/Ethnicity With Breastfeeding Initiation And Duration Using Prams, Jennifer Le, Andrei Stefanescu, Marci Brewer, Betsy Dancisak, Rosaria Trichilo
Examining Associations Of Louisiana’S Gift Program And Race/Ethnicity With Breastfeeding Initiation And Duration Using Prams, Jennifer Le, Andrei Stefanescu, Marci Brewer, Betsy Dancisak, Rosaria Trichilo
Journal of the Louisiana Public Health Association
Background: The Gift is a program that helps Louisiana birthing facilities improve breastfeeding outcomes. Prior research shows that breastfeeding initiation and duration vary by race/ethnicity. We examined the associations of Gift designation and race/ethnicity with breastfeeding in Louisiana. Methods: We used 2016-2018 weighted Louisiana Pregnancy Risk Assessment Monitoring System (PRAMS) and birth data. Weighted chi-square tests and logistic regression models were used to examine the associations of Gift designation and race/ethnicity with breastfeeding initiation and duration. Results: Women delivering at Gift facilities were more likely to initiate breastfeeding compared to non-designated facilities (p < 0.0001). This association was stronger in Non-Hispanic White women (adjusted odds ratio (aOR) 1.76; 95% confidence interval (CI) 1.22-2.53) than in Non-Hispanic Black women (aOR 1.47; 95% CI 1.08-2.00). We did not find statistically significant associations with breastfeeding duration. Conclusions: Delivering at a Gift facility is beneficial for breastfeeding initiation regardless of race/ethnicity. However, racial disparities persist at Gift facilities.
Geographic And Intra-Racial Disparities In Early-Onset Colorectal Cancer In The Seer 18 Registries Of The United States, Wesal H. Abualkhair, Meijiao Zhou, Carolina O. Ochoa, Leonel Lacayo, Caitlin Murphy, Xiao Cheng Wu, Jordan J. Karlitz
Geographic And Intra-Racial Disparities In Early-Onset Colorectal Cancer In The Seer 18 Registries Of The United States, Wesal H. Abualkhair, Meijiao Zhou, Carolina O. Ochoa, Leonel Lacayo, Caitlin Murphy, Xiao Cheng Wu, Jordan J. Karlitz
School of Medicine Faculty Publications
Background: Although early-onset colorectal cancer (EOCRC) incidence rates (IRs) are increasing, geographic and intra-racial IR disparities are not well defined. Methods: 2000-2015 Surveillance, Epidemiology, and End Results (SEER) program CRC IR Analysis (170,434 cases) was performed from ages 30 to 60 in four US regions, 18 individual registries, metropolitan and nonmetropolitan locations and stratified by race. Analyses were conducted in 1-year and 5-year age increments. Results: Wide US regional EOCRC IR variations exist: For example, age 45 IRs in the south are 26.8/100,000, 36.0% higher than the West, 19.7/100,000 (p < 0.0001). Disparities magnify between individual registries: EOCRC IRs in highest risk registries were 177-348% (Alaska Natives), 75-200% (Hawaii), 76-128% (Louisiana), and 61-125% (Kentucky) higher than lowest risk registries depending on age. EOCRC IRs are 18.2%-25.6% higher in nonmetropolitan versus metropolitan settings. Wide geographic intra-racial disparities exist. Within the White population, the greatest IR difference (78.8%) was between Kentucky (5.9/100,000) and Los Angeles (3.3/100,000) in 30- to 34-year-olds (p <.0001). Within the Black population, the greatest difference (136.2%) was between rural Georgia (30.7/100,000) and California excluding San Francisco-Oakland/San Jose-Monterey/Los Angeles (13/100,000) in 40- to 44-year-olds (p = 0003). Conclusion: Marked geographic EOCRC disparities exist with disproportionately high IRs in Alaska Natives, Hawaii, and southern registries. Geographic intra-racial disparities are present within White and Black populations. In Blacks, there are disproportionately high EOCRC IRs in rural Georgia. Although vigilance is required in all populations, attention must be paid to these higher risk populations. Potential interventions include assuring early investigation of symptoms, targeting modifiable risk factors and utilizing earlier age 45 screening options supported by some guidelines.
A Hyperpigmented Plaque In A Female Patient, Harel G. Schwartzberg, Alexandra Bourgeois, Amber Souers, Jeremy Atkinson, Pamela Martin
A Hyperpigmented Plaque In A Female Patient, Harel G. Schwartzberg, Alexandra Bourgeois, Amber Souers, Jeremy Atkinson, Pamela Martin
School of Medicine Faculty Publications
No abstract provided.
Identification Of Plasma Glycosphingolipids As Potential Biomarkers For Prostate Cancer (Pca) Status, Ashley J. Snider, Michael C. Seeds, Laurel Johnstone, Justin M. Snider, Brian Hallmark, Rahul Dutta, Cristina Moraga Franco, John S. Parks, Jeannette T. Bensen, Corey D. Broeckling, James L. Mohler, Gary J. Smith, Elizabeth T.H. Fontham, Hui Kuan Lin, William Bresette, Susan Sergeant, Floyd H. Chilton
Identification Of Plasma Glycosphingolipids As Potential Biomarkers For Prostate Cancer (Pca) Status, Ashley J. Snider, Michael C. Seeds, Laurel Johnstone, Justin M. Snider, Brian Hallmark, Rahul Dutta, Cristina Moraga Franco, John S. Parks, Jeannette T. Bensen, Corey D. Broeckling, James L. Mohler, Gary J. Smith, Elizabeth T.H. Fontham, Hui Kuan Lin, William Bresette, Susan Sergeant, Floyd H. Chilton
School of Public Health Faculty Publications
Prostate cancer (PCa) is the most common male cancer and the second leading cause of cancer death in United States men. Controversy continues over the effectiveness of prostate-specific antigen (PSA) for distinguishing aggressive from indolent PCa. There is a critical need for more specific and sensitive biomarkers to detect and distinguish low-versus high-risk PCa cases. Discovery metabolomics were performed utilizing ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS) on plasma samples from 159 men with treatment naïve prostate cancer participating in the North Carolina-Louisiana PCa Project to determine if there were metabolites associated with aggressive PCa. Thirty-five identifiable plasma small molecules were …
Cross-Sectional Associations Between The Neighborhood Built Environment And Physical Activity In A Rural Setting: The Bogalusa Heart Study., Jeanette Gustat, Christopher E Anderson, Queendaleen C Chukwurah, Maeve E Wallace, Stephanie T Broyles, Lydia A Bazzano
Cross-Sectional Associations Between The Neighborhood Built Environment And Physical Activity In A Rural Setting: The Bogalusa Heart Study., Jeanette Gustat, Christopher E Anderson, Queendaleen C Chukwurah, Maeve E Wallace, Stephanie T Broyles, Lydia A Bazzano
School of Public Health Faculty Publications
Background: Insufficient physical activity (PA) is a common health risk and more prevalent in rural populations. Few studies have assessed relationships between the built environment and PA in rural settings, and community policy guidance to promote PA through built environment interventions is primarily based on evidence from urban studies.Methods: Participants in the Bogalusa Heart Study, a longitudinal study in rural Louisiana, with International Physical Activity Questionnaire data from 2012 to 2013 and a valid residential address (N = 1245) were included. PA was summarized as the number of weekly metabolic equivalent (MET)-minutes of total, transportation, and leisure time PA. The …
Intratumoral Translocation Positive Heterogeneity In Pediatric Alveolar Rhabdomyosarcoma Tumors Correlates To Patient Survival Prognosis, Katrina Gleditsch, Jorge Peñas, Danielle Mercer, Ayesha Umrigar, James Briscoe, Matthew Stark, Fern Tsien, Andrew D. Hollenbach
Intratumoral Translocation Positive Heterogeneity In Pediatric Alveolar Rhabdomyosarcoma Tumors Correlates To Patient Survival Prognosis, Katrina Gleditsch, Jorge Peñas, Danielle Mercer, Ayesha Umrigar, James Briscoe, Matthew Stark, Fern Tsien, Andrew D. Hollenbach
School of Medicine Faculty Publications
Alveolar rhabdomyosarcoma (ARMS) is characterized by one of three translocation states: t(2;13) (q35;q14) producing PAX3-FOXO1, t(1;13) (p36;q14) producing PAX7-FOXO1, or translocation-negative. Tumors with t(2;13) are associated with greater disease severity and mortality than t(1;13) positive or translocation negative patients. Consistent with this fact, previous work concluded that a molecular analysis of RMS translocation status is essential for the accurate determination of prognosis and diagnosis. However, despite this knowledge, most diagnoses rely on histology and in some cases utilize fluorescence in situ hybridization (FISH) probes unable to differentiate between translocation products. Along these same lines, diagnostic RT-PCR analysis, which can differentiate …