Psychiatry and Psychology Commons^™

Neurocognitive Dysfunction With Neuronal Injury In People With Hiv On Long-Duration Antiretroviral Therapy, Cynthia Mcmahan, Devon K Dietrich, Elizabeth F Horne, Erin Kelly, Katrina Geannopoulos, Peter Selim Siyahhan Julnes, Lillian Ham, Ulisses Santamaria, Chuen-Yen Lau, Tianxia Wu, Hsing-Chuan Hsieh, Anuradha Ganesan, Catherine Berjohn, Suad Kapetanovic, Daniel S Reich, Govind Nair, Joseph Snow, Brian K Agan, Avindra Nath, Bryan R Smith

Staff and Researcher Publications

Background and objectives: Neurologic outcomes in people with HIV (PWH) on long-duration antiretroviral therapy (ART) are not fully understood, and the underlying pathophysiology is unclear. To address this, we established a cohort of such individuals and compared them with HIV-negative controls using a novel matching technique. Both groups underwent extensive cognitive testing, evaluation for psychiatric measures, and MRI and CSF analyses.

Methods: Participants underwent comprehensive neuropsychological testing and completed standardized questionnaires measuring depressive symptoms, perceptions of own functioning, and activities of daily living as part of an observational study. Brain MRI and lumbar puncture were optional. Coarsened Exact Matching was …

Infant Effortful Control Predicts Bmi Trajectories From Infancy To Adolescence, Lillybelle K. Deer, Jenalee R. Doom, Kylie K. Harrall, Deborah H. Glueck, Laura M. Glynn, Curt A. Sandman, Elysia Poggi Davis

Psychology Faculty Articles and Research

Background

Effortful control, or the regulation of thoughts and behaviour, is a potential target for preventing childhood obesity.

Objectives

To assess effortful control in infancy through late childhood as a predictor of repeated measures of body mass index (BMI) from infancy through adolescence, and to examine whether sex moderates the associations.

Methods

Maternal report of offspring effortful control and measurements of child BMI were obtained at 7 and 8 time points respectively from 191 gestational parent/child dyads from infancy through adolescence. General linear mixed models were used.

Results

Effortful control at 6 months predicted BMI trajectories from infancy through adolescence, …

An Erp Measure Of Non-Conscious Memory Reveals Dissociable Implicit Processes In Human Recognition Using An Open-Source Automated Analytic Pipeline, Richard J. Addante, Javier Lopez-Calderon, Nathan Allen, Carter Luck, Alana Muller, Lindsey Sirianni, Cory S. Inman, Daniel L. Drake

Psychology Student Publications

Non-conscious processing of human memory has traditionally been difficult to objectively measure and thus understand. A prior study on a group of hippocampal amnesia (N = 3) patients and healthy controls (N = 6) used a novel procedure for capturing neural correlates of implicit memory using event-related potentials (ERPs): old and new items were equated for varying levels of memory awareness, with ERP differences observed from 400 to 800 ms in bilateral parietal regions that were hippocampal-dependent. The current investigation sought to address the limitations of that study by increasing the sample of healthy subjects (N = …

The Novel Uncompetitive Nmda Receptor Antagonist Esmethadone (Rel-1017) Has No Meaningful Abuse Potential In Recreational Drug Users, Megan J Shram, Jack E Henningfield, Glen Apseloff, Charles W Gorodetzky, Sara De Martin, Frank L Vocci, Frank L Sapienza, Thomas R Kosten, Jeff Huston, August Buchhalter, Judy Ashworth, Ryan Lanier, Franco Folli, Andrea Mattarei, Clotilde Guidetti, Stefano Comai, Cedric O'Gorman, Sergio Traversa, Charles E Inturrisi, Paolo L Manfredi, Marco Pappagallo

Faculty, Staff and Students Publications

Esmethadone (REL-1017) is the opioid-inactive dextro-isomer of methadone and a low-affinity, low-potency uncompetitive NMDA receptor antagonist. In a Phase 2, randomized, double-blind, placebo-controlled trial, esmethadone showed rapid, robust, and sustained antidepressant effects. Two studies were conducted to evaluate the abuse potential of esmethadone. Each study utilized a randomized, double-blind, active-, and placebo-controlled crossover design to assess esmethadone compared with oxycodone (Oxycodone Study) or ketamine (Ketamine Study) in healthy recreational drug users. Esmethadone 25 mg (proposed therapeutic daily dose), 75 mg (loading dose), and 150 mg (Maximum Tolerated Dose) were evaluated in each study. Positive controls were oral oxycodone 40 mg …

Humanity In Trauma, Alyssa K. Thompson

University Honors Theses

The main objective of the literature review is to use the trauma-informed care paradigm to argue that the current implementation of trauma-informed care reinforces hierarchies of harm, leading to feelings of moral obligation and moral injury while perpetuating othering. This literature review criticizes trauma-informed care, emphasizing lived experiences against the characteristics trauma-informed care aspires to reflect. The review centers on the broad themes of understanding, universality, and acceptance of the present trauma-informed care paradigm. The critique comes from the silently excluded group of healthcare workers, with a personal perspective from a professional who worked in an urban hospital emergency department …

Effects Of Daylight On College Students’ Physical And Mental Well-Being, Sathya Thenappan

Quantitative Social Science Undergraduate Senior Theses

While existing literature predominantly deals with the impact of daylight on adults in general and more specifically at the workplace, less is known about its impact on the college student demographic and daylight exposure levels at college residences. Given its considerable impact on both the physical and mental well-being of individuals, daylight has been used in the treatment of an assortment of diseases from seasonal affective disorder to depression. With college students constituting the majority of today’s people who suffer from mental health issues in society, uncovering the link between daylight exposure and its impact on the physical and mental …

Role Of Chronic Stress-Induced Neuroinflammation In Rodent Locus Coeruleus Physiology And Anxiety-Like Behaviors, Arthur Anthony Alfonso Reyes

Graduate School of Biomedical Sciences Theses and Dissertations

The locus coeruleus (LC), the primary site of brain norepinephrine (NE), is a key anatomical brain region implicated in the stress response. Stress is a neuroendocrine physiologic response to a stressor that promotes organism survival through adaptive change and restoration of homeostasis. The central stress response, which drives behavioral and physiological change, is primarily mediated by activating the hypothalamic-pituitary-adrenal (HPA) axis. While advantageous in the short term, chronic stress exposure can lead to HPA axis and LC dysregulation, which are thought to contribute to the etiology of anxiety disorders. Previous studies demonstrate the effects of acute stress in increasing LC …

Interleukin-1 Signaling And Alcohol-Induced Cortical Dysfunction, Florence Varodayan, Amanda Pahng, Tony Davis, T. Nadav, I. Polis, C.C. Cates-Gatto, Michal Bajo, Michael D. Burkart, Scott Edwards, Amanda J. Roberts, Marisa Roberto

School of Medicine Faculty Publications

Alcoholism and Stress: A Framework for Future Treatment Strategies; Volterra, Italy; May 16-19, 2023

Stress Reactivity After Pediatric Traumatic Brain Injury: Relation With Behavioral Adjustment, Taiane De Azevedo Cardoso, Ritele H Silva, Jessica L Fernandes, Camila O Arent, Graziela Amboni, Laura A Borba, Alex Paulo Z Padilha, Maria Eduarda M Botelho, Amanda L Maciel, Tatiana Barichello, Rodrigo Morales, Silvio José B Soares, Margarete D Bagatini, Claudia Dallagnol, Marta Elisa Brighenti, Zuleide Maria Ignácio, João Quevedo, Luciane B Ceretta, Gislaine Z Réus

Faculty, Staff and Student Publications

BACKGROUND: Although many studies have pointed out a possible relationship between COVID-19 and the presence of psychiatric disorders, the majority of the studies have significant limitations. This study investigates the influence of COVID-19 infection on mental health.

METHODS: This cross-sectional study included an age- and sex-matched sample of adult individuals positive (cases) or negative (controls) for COVID-19. We evaluated the presence of psychiatric conditions and C-reactive protein (CRP).

RESULTS: Findings showed greater severity of depressive symptoms, higher levels of stress, and greater CRP in cases. The severity of depressive and insomnia symptoms, as well as the CRP were more remarkable …

Effects Of Different Spectrum Of Leds On Retinal Degeneration Through Regulating Endoplasmic Reticulum Stress, Wenyi Chen, Rong Lin, Kunhong Xiao, Kun Yuan, Zhongjiang Chen, Yan Huang

Faculty, Staff and Student Publications

PURPOSE: To evaluate the impact of full-spectrum light-emitting diodes (LEDs) on albino guinea pigs' retina and investigate the roles of short-wavelength opsin (S-opsin) and endoplasmic reticulum (ER) stress in light-induced retinal degeneration (LIRD).

METHODS: Three-week-old albino guinea pigs (n = 30) were distributed into five groups under 12/12 light/dark cycles with indoor natural light (NC; 300-500 lux, n = 6), full-spectrum LEDs (FL; 300 lux, n = 6; 3000 lux, n = 6), and commercial cold-white LEDs (CL; 300 lux, n = 6; 3000 lux, n = 6) and raised for 28 days. Hematoxylin and eosin staining and transmission electron …

A Gift To My Self: A Psychoanalytic Approach To Understanding The Experiences Of Women Who Choose Not To Have Children, Irina D. Tchania

Dissertations, Theses, and Capstone Projects

Although motherhood has long been a normative female experience, individual decisions regarding bearing and mothering children vary among women. Partly due to shifts in gender roles and contemporary societal expectations, the conflation of womanhood with motherhood – and the centrality of motherhood within female identity – is being increasingly challenged. Women who choose to remain childless make up a growing, unique, and understudied population group. Decisions regarding intentional childlessness have been considered through the lenses of sociology and feminist critique, while psychologically and psychoanalytically oriented scholarship is more limited. This study aimed to further our understanding of the voluntarily childless …

Effects Of Short-Term Nicotine Deprivation On Delay Discounting Among Young, Experienced, Exclusive Ends Users: An Initial Study, Irene Pericot-Valverde, Jin H Yoon, Kaileigh A Byrne, Moonseong Heo, Jiajing Niu, Alain H Litwin, Diann E Gaalema

Faculty, Staff and Student Publications

Delay discounting describes how rapidly delayed rewards lose value as a function of delay and serves as one measure of impulsive decision-making. Nicotine deprivation among combustible cigarette smokers can increase delay discounting. We aimed to explore changes in discounting following nicotine deprivation among electronic nicotine delivery systems (ENDS) users. Thirty young adults (aged 18-24 years) that exclusively used ENDS participated in two laboratory sessions: one with vaping as usual and another after 16 hr of nicotine deprivation (biochemically assessed). At each session, participants completed a craving measure and three hypothetical delay discounting tasks presenting choices between small, immediate rewards and …

Promoting Ocd Wellness And Resilience (Power) Study: Rationale, Design, And Methods, Jessica D Leuchter, Minjee Kook, Daniel A Geller, Alyssa G Hertz, Jessica Garcia, Erika S Trent, Tracey Dibbs, Ogechi Onyeka, Wayne K Goodman, Andrew G Guzick, Andrew D Wiese, Amanda D Palo, Brent J Small, H Blair Simpson, Lauren K Havel, Sohail A Nibras, Kirti Saxena, Eric A Storch

Faculty, Staff and Students Publications

Obsessive-compulsive disorder (OCD) affects 1-2% of children and is associated with functional impairment and diminished quality of life. Several treatments are efficacious: cognitive behavioral therapy (CBT) with exposure and response prevention, serotonin reuptake inhibitor (SRI) monotherapy, and combined treatment (SRI + CBT). Expert clinician-informed practice parameters suggest that youth with mild to moderate OCD should be treated initially with CBT yet SRIs are frequently employed as the first-line intervention or in combination with psychotherapy in applied practice. Empirical data to guide SRI discontinuation in pediatric OCD are very limited. This study, Promoting OCD Wellness and Resiliency (POWER), aims to address …

Promoting Ocd Wellness And Resilience (Power) Study: Rationale, Design, And Methods, Jessica D Leuchter, Minjee Kook, Daniel A Geller, Alyssa G Hertz, Jessica Garcia, Erika S Trent, Tracey Dibbs, Ogechi Onyeka, Wayne K Goodman, Andrew G Guzick, Andrew D Wiese, Amanda D Palo, Brent J Small, H Blair Simpson, Lauren K Havel, Sohail A Nibras, Kirti Saxena, Eric A Storch

Faculty, Staff and Students Publications

Obsessive-compulsive disorder (OCD) affects 1-2% of children and is associated with functional impairment and diminished quality of life. Several treatments are efficacious: cognitive behavioral therapy (CBT) with exposure and response prevention, serotonin reuptake inhibitor (SRI) monotherapy, and combined treatment (SRI + CBT). Expert clinician-informed practice parameters suggest that youth with mild to moderate OCD should be treated initially with CBT yet SRIs are frequently employed as the first-line intervention or in combination with psychotherapy in applied practice. Empirical data to guide SRI discontinuation in pediatric OCD are very limited. This study, Promoting OCD Wellness and Resiliency (POWER), aims to address …

Evidence-Based Practices And Self-Efficacy: A Quantitative Study Of Mental Health Counselors Treating Clients With Substance Use Disorder, Carl Bastien

Dissertations

Substance use disorder affects a substantial number of individuals in the United States. The specific problem of this research is that it was not known to what extent their use of evidence-based practices is driven by their sense of self-efficacy. The purpose of this quantitative correlational research was to examine to what extent the use of evidence-based practices covary with a sense of self-efficacy for mental health counselors treating individuals diagnosed with a substance use disorder. The study population was 121 mental health counselors who specialized in substance use disorder treatment who completed a digital survey. The study findings did …

Neural Correlates Of Comorbidity Of Anxiety Disorders And Eating Disorders, Karsen Coelho

University Honors Theses

The presence of eating disorder and anxiety disorder comorbidity has raised the question of whether or not there is a causal relationship between them. Previous studies have found that this comorbidity has been present in various patients with anxiety disorders and eating disorders, going further to try and determine which diagnosis came first. By conducting a literature review, studies were examined to determine neurobiological regions impacted by both disorders. Prefrontal cortex abnormalities are consistent among both disorders, contributing to differences in behavior and reward systems. With the irregular structure and activation of the amygdala, emotion and fear regulation are disrupted …

Examining Benefits Of Early Intervention In Cases Of Pediatric Chronic Hypoxia, Kendra Stefan

University Honors Theses

There is a strong foundation of evidence and consensus in the literature that hypoxia has adverse impacts on brain function. Recent research has broadened the field in two directions. One is the treatment for acute hypoxic injuries, and the second is regarding the accumulative impact of intermittent or chronic hypoxia. Historically, in cases of acute hypoxia, action is taken to remedy the source of hypoxia. Physical and cognitive rehabilitation has typically been provided as needed depending on the severity of the injury. While cases of intermittent or chronic hypoxia may not demonstrate an acute urgency for treatment and rehabilitation, current …

Adverse Childhood Experiences In Mothers And Their Children With Hearing Loss, Elizabeth A. Rosenzweig

Journal of Early Hearing Detection and Intervention

This study examined the relationship between maternal and child ACEs in children with hearing loss ages 3-12. One hundred twenty-four mother-child dyads completed assessments of mother and child ACEs. Adverse cChildhood eExperiences (ACEs) were measured using the Center for Youth Wellness Adverse Childhood Experiences Questionnaire (CYW ACE-Q; Burke Harris & Renschler, 2015).

Both maternal and child participants in this study reported higher levels of ACE exposure than previously reported in studies of the general population. Maternal and child ACEs were significantly correlated. White/Caucasian mothers experienced significantly fewer ACEs than mothers of other races/ethnicities. Children living in adoptive, foster, or guardianship …

Interview Of Pilots’ Inflight Loss Of Control Experiences, Neelakshi Majumdar, Karen Marais

International Symposium on Aviation Psychology - 2023

Inflight loss of control (LOC-I) continues to be a significant cause of General Aviation fixed-wing aircraft accidents. Nearly 20% of fixed-wing aircraft accidents in the last two decades involved LOC-I, and approximately 45% of LOC-I accidents are fatal. Previous studies suggest that the leading factors in aviation accidents are human factors-related. One approach to better understand the causes of LOC-I accidents is to analyze accidents using sources such as the National Transportation Safety Board (NTSB) database. However, the NTSB General Aviation accident reports include limited detail on human factors, specifically pilot actions and conditions. We interviewed pilots about their LOC-I …

A Multi-Method Approach To Work Design For Crew In Future Remotely Piloted Aircraft Operations, Kayler Marshall, Penelope Sanderson, Andrew Neal

International Symposium on Aviation Psychology - 2023

Globally, most safety regulators only allow crew to operate one remotely piloted aircraft (RPA) at a time due to workload concerns. More sophisticated automation is anticipated to alleviate operator workload, allowing crew to simultaneously operate more than one RPA. However, how work should be distributed amongst crew is still unknown. We employ a complementary set of methods for work design in a future system of RPA operation: Cognitive Work Analysis, computational modelling, and human-in-the-loop experiments. In this paper we describe each method, outlining the unique insights gained and how these are applied in the evaluation of work in a future …

Exploring Informal Learning Structures In Airline Operations, Barth Baron Jr., Dorrit Billman, Randall J. Mumaw

International Symposium on Aviation Psychology - 2023

Airline pilot training is extensive, highly structured, and driven by aircraft and airspace system operating requirements, yet pilots describe a tradition of between-pilot knowledge transfer and self-directed learning. While industry and regulators focus on “formal learning” systems, pilots report relying on this “informal learning” to build operational expertise, suggesting gaps in how successfully formal learning prepares pilots to handle operational complexities. The community that researches learning has extensively studied informal learning, including in a workplace setting, and its characteristics align with how pilots report increasing their skills and knowledge informally. However, no research into informal learning practices among airline pilots …

Resilient Strategies In Commercial Aviation, Michael Stewart, Bryan Matthews

International Symposium on Aviation Psychology - 2023

When we fly and nothing scary happens, is the system’s design affording this success? Not always — sometimes humans are the cause of success. This resilient performance is often overlooked. We explore two types of resilient performance strategies: countermeasures and modifications. countermeasures are behaviors triggered by variables anticipated to be challenging or problematic (i.e., pressures). To capture this, we look at examples of how a problem was avoided. For example, a country road may have a hairpin turn where accidents more frequently occur. With this pressure identified, we look at successful drivers for insights. Modifications are changes that are created …

Extracting Lessons Of Resilience Using Machine Mining Of The Asrs Database, Immanuel Barshi, Bryan Matthews, Jolene Feldman

International Symposium on Aviation Psychology - 2023

NASA’s Aviation Safety Reporting System (ASRS) database is the world's largest repository of voluntary, confidential safety information provided by aviation's frontline personnel. The database contains close to 2 million narratives, many of which describe everyday situations in which people saved the day. In these situations, people’s resilient behavior solved a problem, dealt with a malfunction, and maintained a safe operation despite a serious perturbation. To be able to extract lessons of such resilience from this large database, the use of machine learning algorithms is being explored. In this report, we describe a comparison between two such algorithms: BERT and Word2Vec. …

The Viability Of See-And-Avoid For Urban Air Mobility Operations, Richard Mogford, Walter Johnson

International Symposium on Aviation Psychology - 2023

Urban Air Mobility (UAM) is an emerging aviation concept that could supplement today’s ground and air transportation systems. For UAM, it is generally assumed that the private sector will manage separation and not rely on the U.S. Federal Aviation Administration air traffic control system. To date, discussions of initial operations focus on using the visual abilities of the pilot to see-and-avoid (SAA) other aircraft. Decades of research on SAA has demonstrated that it is inadequate for reliable detection of aircraft that might pose a collision risk. The literature on multi-object tracking is also reviewed for findings on how well humans …

Nasa Human Factors Red Light/Green Light Analysis: Overview And Spacshiptwo Rl/Gl Case Study, Tracy Dillinger, Isabel Hernandez

International Symposium on Aviation Psychology - 2023

Historically, learning from accidents and incidents involves identifying errors of commission or omission and “things that go wrong” and how to reduce their recurrence. While well-intentioned, infrequent failures receive more attention than everyday successes. Human Factors analysis need not limit itself to learning from failures. Learning from “what goes right” involves identifying resilience factors associated with behaviors and processes that strengthen the system and reduce risk. This article provides an overview of how the National Aeronautics and Space Administration (NASA) Human Factors Task Force (HFTF) constructed the NASAHFACS model and the Red Light/Green Light approach. Using SpaceShipTwo as a case …

Concept Of A Cognitive Agent Supporting Collaboration In Human Teams, Wolfgang Sachsenhauser, Axel Schulte

International Symposium on Aviation Psychology - 2023

This contribution aims at the support of human teamwork between crew members of next generation combat aircraft by means of a distributed and adaptive assistant system. In future combined air operations several aircraft, manned and unmanned, operate together to achieve a common mission objective. That requires a high degree of coordination amongst the pilots, each of them being highly charged with e.g., managing unmanned vehicles from their cockpits. Our approach is to develop a distributed assistant system that observes each pilot in their cockpits. By use of a task model, it shall create and update a shared representation of the …

Concept Of An Automated Activity Determination In The Temporal Domain For Adaptive Pilot Assistance, Karl Tschurtschenthaler, Axel Schulte

International Symposium on Aviation Psychology - 2023

In this contribution, we describe our initial conceptual thoughts on how to determine pilot activity in real-time within a multitasking environment. The presented concept extends our previous research on determining the pilot activity which analyses manual and gaze interactions by evidential reasoning. This approach resulted in a fragmented pattern of activities over time due to the high frequency of gaze shifts. Our concept suggests concatenating the activities and using the resulting sequence as a feature set for classification. We hypothesize that this representations of activities reflects the complex nature of concurrent and serial multitasking more appropriately. For probabilistic inference, we …

Analyses Of The Boeing 737max Accidents: Formal Models And Psychological Perspectives, Immanuel Barshi, Asaf Degani, Robert Mauro, Randal J. Mumaw

International Symposium on Aviation Psychology - 2023

Two fatal accidents involving the B737MAX resulted from the flight crews’ inability to overcome the effects of the Maneuvering Characteristics Augmentation System (MCAS). MCAS was designed to mimic the control column feel pressure and pitching behavior of the B737NG, which was the certification basis for the B737MAX. We briefly describe the potential role of formally modeling different perspectives during system design, and how such modeling can reveal gaps and conflicts between perspectives. We also discuss some of the relevant human factors issues involved in these accidents and how the aircraft’s behavior may have affected the pilots’ psychological states. Implications for …

Development And Psychometric Evaluation Of Us Air Force Aptitude Composites For Aircrew Training, Montana R. Woolley, Thomas R. Carretta

International Symposium on Aviation Psychology - 2023

The Air Force Officer Qualifying Test (AFOQT) is used to qualify applicants for officer commissioning and for aircrew training. Although the current aircrew aptitude composites have shown predictive validity against initial aircrew training outcomes for many years, they also have demonstrated moderate to large mean score subgroup differences (SGDs) for females and racial/ethnic minorities. Historically, AFOQT aptitude composites have been computed from a combination of the cognitive subtests. The current study examined the utility of Predictive Success Models (PSMs) which added personality facets from the Self-Description Inventory for Officers to the existing cognitive composites. Three statistical methods were utilized to …

Initial Testing Of The Uncrewed Aerial System Pilot Kit (Uasp-Kit) In Operational Settings, Lynne Martin, Lauren Roberts, Joey Mercer, Yasmin Arbab, Charles Walter, William Mccarty, Charles Sheehe Iii, David Fuller

International Symposium on Aviation Psychology - 2023

Pilots for small uncrewed aerial systems (sUAS) are at a disadvantage for building situation awareness of the remote airspace in which they are flying, simply because they are distant from their vehicles. A tool to provide increased air traffic situation awareness for an sUAS pilot is being developed. The UAS pilot kit, “UASP-kit,” is small and self-contained, with its chief capability being to collect and display Automatic Dependent Surveillance-Broadcast reports from local aircraft. UASP-kits were taken into the field, introduced to users during a training course, and then left with them for use throughout the summer fire season. sUAS pilots …