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Psychiatry and Psychology Commons

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2023

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Articles 211 - 240 of 720

Full-Text Articles in Psychiatry and Psychology

The Impact Of Covid-19 On Psychosocial Services And Perceived Supports For Pediatric Patients, Samantha Martinez Jul 2023

The Impact Of Covid-19 On Psychosocial Services And Perceived Supports For Pediatric Patients, Samantha Martinez

Theses and Dissertations

In March 2020, the World Health Organization named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a global pandemic. While the physiological damage of COVID-19 on individuals and communities is itself immeasurable, both because variants continue to spread and because of the unpredictable nature of “long COVID,” we know even less about the long-term psychological impacts on individuals. Lockdown procedures, including school closures, were necessary to prevent transmission of the virus and to protect the most vulnerable bodies (namely, the elderly and immuno-compromised). However, the effect of the closures disproportionately resulted in psychological damage to children and adolescents. Previous studies have …


The Emergence And Predictive Utility Of Early Markers Of Social Anxiety In Young Children With Fragile X Syndrome, Conner James Black Jul 2023

The Emergence And Predictive Utility Of Early Markers Of Social Anxiety In Young Children With Fragile X Syndrome, Conner James Black

Theses and Dissertations

Fragile X syndrome (FXS) is a monogenic neurodevelopmental disorder characterized by elevated rates of intellectual disability, autism, and anxiety. Social anxiety affects approximately 60 percent of individuals with FXS and is cited as one of the most impairing comorbid disorders in FXS; however, little is understood about the developmental patterns of social anxiety markers in young children with FXS. The current study investigates cardiac and behavioral markers of social anxiety across the first five years of life and tests the predictive utility of these variables on social anxiety symptomatology. Participants included 80 children with FXS and 50 neurotypical controls. Participants …


Reward Processing In Psychiatric Inpatients With Depression, Hyuntaek Oh, Jaehoon Lee, Michelle A Patriquin, John Oldham, Ramiro Salas Jul 2023

Reward Processing In Psychiatric Inpatients With Depression, Hyuntaek Oh, Jaehoon Lee, Michelle A Patriquin, John Oldham, Ramiro Salas

Staff and Researcher Publications

Background: Previous neuroimaging studies have investigated reward-processing dysfunction in major depressive disorder and have led to the common finding that major depressive disorder is associated with reduced reward responses within the reward circuit. Yet it is unclear whether such reward-processing dysfunction is specifically associated with the severity of depressive symptoms in major depressive disorder or is associated with common comorbidities.

Methods: We investigated reward-processing differences using a classic juice-delivery functional magnetic resonance imaging experiment to compare psychiatric patients with severe depressive symptoms (DEPs) to both psychiatric control subjects (PCs) and healthy control subjects. In this study, the DEPs (n = …


Characterizing The Influence Of Exposure To Military Sexual Trauma And Intimate Partner Violence On Mental Health Outcomes Among Female Veterans, Carrie Esopenko, Nicola De Souza, Elisabeth A Wilde, Kristen Dams-O'Connor, Ellen Teng, Deleene S Menefee Jul 2023

Characterizing The Influence Of Exposure To Military Sexual Trauma And Intimate Partner Violence On Mental Health Outcomes Among Female Veterans, Carrie Esopenko, Nicola De Souza, Elisabeth A Wilde, Kristen Dams-O'Connor, Ellen Teng, Deleene S Menefee

Faculty, Staff and Students Publications

Military sexual trauma (MST) has deleterious long-term psychological consequences. Among female U.S. military members, MST is associated with increased risk for future interpersonal victimization, such as experiencing intimate partner violence (IPV). Few studies have investigated the implications of the cumulative effects of IPV and MST on psychological functioning. This study examined rates of co-exposure to MST, IPV, and their cumulative impact on psychological symptoms. Data were collected from 308 female Veterans (FVets; age:


Five New Ways To Advance Diagnostic Safety In Your Clinical Practice, Andrea Bradford, Christine Goeschel, Marjorie Shofer, Hardeep Singh Jul 2023

Five New Ways To Advance Diagnostic Safety In Your Clinical Practice, Andrea Bradford, Christine Goeschel, Marjorie Shofer, Hardeep Singh

Faculty, Staff and Students Publications

No abstract provided.


Long-Term Continuous Glucose Monitor Use In Very Young Children With Type 1 Diabetes: One-Year Results From The Sence Study, Michelle A Van Name, Lauren G Kanapka, Linda A Dimeglio, Kellee M Miller, Anastasia Albanese-O'Neill, Persis Commissariat, Sarah D Corathers, Kara R Harrington, Marisa E Hilliard, Barbara J Anderson, Jennifer C Kelley, Lori M Laffel, Sarah A Macleish, Brandon M Nathan, William V Tamborlane, R Paul Wadwa, Steven M Willi, Kristen M Williams, Kupper A Wintergerst, Stephanie Woerner, Jenise C Wong, Daniel J Desalvo Jul 2023

Long-Term Continuous Glucose Monitor Use In Very Young Children With Type 1 Diabetes: One-Year Results From The Sence Study, Michelle A Van Name, Lauren G Kanapka, Linda A Dimeglio, Kellee M Miller, Anastasia Albanese-O'Neill, Persis Commissariat, Sarah D Corathers, Kara R Harrington, Marisa E Hilliard, Barbara J Anderson, Jennifer C Kelley, Lori M Laffel, Sarah A Macleish, Brandon M Nathan, William V Tamborlane, R Paul Wadwa, Steven M Willi, Kristen M Williams, Kupper A Wintergerst, Stephanie Woerner, Jenise C Wong, Daniel J Desalvo

Faculty, Staff and Students Publications

OBJECTIVES: Achieving optimal glycemic outcomes in young children with type 1 diabetes (T1D) is challenging. This study examined the durability of continuous glucose monitoring (CGM) coupled with a family behavioral intervention (FBI) to improve glycemia.

STUDY DESIGN: This one-year study included an initial 26-week randomized controlled trial of CGM with FBI (CGM+FBI) and CGM alone (Standard-CGM) compared with blood glucose monitoring (BGM), followed by a 26-week extension phase wherein the BGM Group received the CGM+FBI (BGM-Crossover) and both original CGM groups continued this technology.

RESULTS: Time in range (70-180 mg/dL) did not improve with …


Defining The Full Spectrum Of Pediatric Firearm Injury And Death In The United States: It Is Even Worse Than We Think, Bindi J Naik-Mathuria, Cary M Cain, Elizabeth A Alore, Liang Chen, Lisa A Pompeii Jul 2023

Defining The Full Spectrum Of Pediatric Firearm Injury And Death In The United States: It Is Even Worse Than We Think, Bindi J Naik-Mathuria, Cary M Cain, Elizabeth A Alore, Liang Chen, Lisa A Pompeii

Faculty, Staff and Students Publications

OBJECTIVE: To characterize the full spectrum of pediatric firearm injury in the United States by describing fatal and nonfatal injury data epidemiology, vulnerable populations, and temporal trends.

BACKGROUND: Firearm injury is the leading cause of death in children and adolescents in the United States. Nonfatal injury is critical to fully define the problem, yet accurate data at the national level are lacking.

METHODS: A cross-sectional study combining national firearm injury data from the Centers for Disease Control (fatal) and the National Trauma Data Bank (nonfatal) between 2008 and 2019 for ages 0 to 17 years. Data were analyzed using descriptive …


Geospatial Distribution Of Obsessive-Compulsive Disorder Specialists: Understanding Access As A Function Of Distance, Insurance Status, And Neighborhood Socioeconomic Status, Abiodun O Oluyomi, Sophie C Schneider, Catherine Christian, Juan M Alvarez, Orri Smárason, Wayne K Goodman, Eric A Storch Jul 2023

Geospatial Distribution Of Obsessive-Compulsive Disorder Specialists: Understanding Access As A Function Of Distance, Insurance Status, And Neighborhood Socioeconomic Status, Abiodun O Oluyomi, Sophie C Schneider, Catherine Christian, Juan M Alvarez, Orri Smárason, Wayne K Goodman, Eric A Storch

Faculty, Staff and Students Publications

Obsessive-compulsive disorder is an impairing psychiatric condition affecting 1-2% of adults and youth. Cognitive-behavioral therapy with exposure and response prevention (CBT) is an efficacious intervention but requires specialty training and access is often limited. While certain factors are associated with treatment access, one key barrier that has not been explored is the geographic availability of OCD treatment providers. Using integrated geographically-referenced data, we examined the geographic distribution of OCD CBT specialty providers across the state of Texas, with particular attention to the relationship to neighborhood socioeconomic disadvantage, insurance status, and rural versus urban status. We found that specialist providers are …


Characterization Of Extended-Release Lorazepam: Pharmacokinetic Results Across Phase 1 Clinical Studies, Sanjay J Mathew, Shedly Jean-Lys, Rupinder Phull, Rama Yarasani Jul 2023

Characterization Of Extended-Release Lorazepam: Pharmacokinetic Results Across Phase 1 Clinical Studies, Sanjay J Mathew, Shedly Jean-Lys, Rupinder Phull, Rama Yarasani

Staff and Researcher Publications

Purpose/background: Once-daily extended-release (ER) lorazepam was developed to reduce fluctuations in plasma levels compared with lorazepam immediate-release (IR) for short-term anxiety relief. Here we report a series of phase 1 randomized, open-label, multiperiod crossover studies characterizing ER lorazepam pharmacokinetics and safety in healthy adults.

Methods/procedures: These phase 1 studies assessed the pharmacokinetics of ER lorazepam administered: (study 1) 3 mg once daily versus IR lorazepam 1 mg 3 times a day (TID; every 8 hours), (study 2) with or without food, and (study 3) intact versus sprinkled onto food. Study 3 further evaluated the proportionality of 1 × 4- versus …


Fkbp5 Inhibitors Modulate Alcohol Drinking And Trauma-Related Behaviors In A Model Of Comorbid Post-Traumatic Stress And Alcohol Use Disorder, Bryan Cruz, Valentina Vozella, Benjamin A Carper, Joy C Xu, Dean Kirson, Shawn Hirsch, Tracy Nolen, Lauren Bradley, Katie Fain, Meg Crawford, Thomas R Kosten, Eric P Zorrilla, Marisa Roberto Jul 2023

Fkbp5 Inhibitors Modulate Alcohol Drinking And Trauma-Related Behaviors In A Model Of Comorbid Post-Traumatic Stress And Alcohol Use Disorder, Bryan Cruz, Valentina Vozella, Benjamin A Carper, Joy C Xu, Dean Kirson, Shawn Hirsch, Tracy Nolen, Lauren Bradley, Katie Fain, Meg Crawford, Thomas R Kosten, Eric P Zorrilla, Marisa Roberto

Faculty, Staff and Students Publications

Post-traumatic stress disorder (PTSD) leads to enhanced alcohol drinking and development of alcohol use disorder (AUD). Identifying shared neural mechanisms might help discover new therapies for PTSD/AUD. Here, we employed a rat model of comorbid PTSD/AUD to evaluate compounds that inhibit FK506-binding protein 51 (FKBP5), a co-chaperone modulator of glucocorticoid receptors implicated in stress-related disorders. Male and female rats received a familiar avoidance-based shock stress followed by voluntary alcohol drinking. We then assessed trauma-related behaviors through sleep bout cycles, hyperarousal, fear overgeneralization, and irritability. To evaluate the role of stress and alcohol history on the sensitivity to FKBP5 inhibitors, in …


Predictors Of Self-Reported General Health Status In People Experiencing Homelessness With Serious Mental Illness, Landon Presnall, Robert Suchting, Gaybrielle Hicks, Jane Hamilton Jul 2023

Predictors Of Self-Reported General Health Status In People Experiencing Homelessness With Serious Mental Illness, Landon Presnall, Robert Suchting, Gaybrielle Hicks, Jane Hamilton

Faculty, Staff and Student Publications

PURPOSE: The growing homeless population in the U.S.A. is disproportionately impacted by poor mental and physical health status, including a higher incidence of acute and chronic health problems, increased hospitalizations, and premature mortality compared to the general population. This study examined the association between demographic, social, and clinical factors and perceptions of general health status among the homeless population during admission to an integrated behavioral health treatment program.

METHODS: The study sample included 331 adults experiencing homelessness with a serious mental illness or co-occurring disorder. Participants were enrolled in services at a day program for unsheltered homeless adults, a residential …


Obsessive-Compulsive Disorder In Youth And Young Adults With Depression: Clinical Characteristics Of Comorbid Presentations, David B Riddle, Andrew Guzick, Abu Minhajuddin, Orri Smárason, Gabrielle M Armstrong, Holli Slater, Taryn L Mayes, Lynnel C Goodman, Denise L Baughn, Sarah L Martin, Sarah M Wakefield, Joseph Blader, Ryan Brown, Wayne K Goodman, Madhukar H Trivedi, Eric A Storch Jul 2023

Obsessive-Compulsive Disorder In Youth And Young Adults With Depression: Clinical Characteristics Of Comorbid Presentations, David B Riddle, Andrew Guzick, Abu Minhajuddin, Orri Smárason, Gabrielle M Armstrong, Holli Slater, Taryn L Mayes, Lynnel C Goodman, Denise L Baughn, Sarah L Martin, Sarah M Wakefield, Joseph Blader, Ryan Brown, Wayne K Goodman, Madhukar H Trivedi, Eric A Storch

Faculty, Staff and Students Publications

Obsessive-compulsive disorder (OCD), anxiety disorders, and depressive disorders are highly comorbid, and each contribute to significant functional impairment for affected youth. Comorbid anxiety disorders in depressed youth have been associated with greater depressive symptom severity and impairment, but the impact of comorbid OCD in this population remains unclear. Accordingly, the present study examined the differential clinical characteristics of youth with depression and comorbid OCD relative to age/gender matched depressed youth with no such comorbidity and to those with depression and a comorbid (non-OCD) anxiety disorder. A sample of 797 youth and young adults ages 8-20 years who met diagnostic criteria …


On-Campus Mental Health Service Use Among College Students With Autism: A Case Study Applying The Andersen Behavioral Model Of Health Services Use, Estella C. Lilyquist Jul 2023

On-Campus Mental Health Service Use Among College Students With Autism: A Case Study Applying The Andersen Behavioral Model Of Health Services Use, Estella C. Lilyquist

Electronic Theses and Dissertations

The unique set of impairments and limitations presented by students with autism spectrum disorder (ASD) make the accessing of campus-based nonacademic resources more difficult and complicated than their typically developed peers. Each year, the rate of students entering college with disabilities continues to grow, but their mental well-being is relatively poor. The purpose of this qualitative case study was to apply the conceptual framework of the Andersen behavioral model of health services use (ABMHSU) to the experiences of college students with ASD to understand and predict their utilization of campus-provided mental health resources. The participants were seven college students with …


Hippocampal Volume And The Detection Of Mild Cognitive Impairment In An Older Adult Population: Assessing Performance On Cognitive Screeners Administered In-Person And Electronically, Kristen Fabrizi Jul 2023

Hippocampal Volume And The Detection Of Mild Cognitive Impairment In An Older Adult Population: Assessing Performance On Cognitive Screeners Administered In-Person And Electronically, Kristen Fabrizi

Dissertations

The present study investigated how performance on in-person and electronic neuropsychological assessment measures predicted subcortical hippocampal volume and cognitive decline consistent with mild cognitive impairment. It was hypothesized that the Montreal Cognitive Assessment would display better predictive strength than the Cogstate Brief Battery when evaluating subcortical hippocampal volume measured via structural magnetic resonance imaging. It was further hypothesized that the Montreal Cognitive Assessment would be more sensitive to predicting group membership to the diagnostic classification of mild cognitive impairment compared to the Cogstate Brief Battery. The sample included 445 older adult participants selected from the Alzheimer’s Disease Neuroimaging Initiative 3. …


A Mendelian Randomization Study Of Genetic Liability To Post-Traumatic Stress Disorder And Risk Of Ischemic Stroke, Opeyemi Soremekun, Clarisse Musanabaganwa, Annette Uwineza, Maddalena Ardissino, Skanda Rajasundaram, Agaz H Wani, Stefan Jansen, Jean Mutabaruka, Eugene Rutembesa, Chisom Soremekun, Cisse Cheickna, Mamadou Wele, Joseph Mugisha, Oyekanmi Nash, Eugene Kinyanda, Dorothea Nitsch, Myriam Fornage, Tinashe Chikowore, Dipender Gill, Derek E Wildman, Leon Mutesa, Monica Uddin, Segun Fatumo Jul 2023

A Mendelian Randomization Study Of Genetic Liability To Post-Traumatic Stress Disorder And Risk Of Ischemic Stroke, Opeyemi Soremekun, Clarisse Musanabaganwa, Annette Uwineza, Maddalena Ardissino, Skanda Rajasundaram, Agaz H Wani, Stefan Jansen, Jean Mutabaruka, Eugene Rutembesa, Chisom Soremekun, Cisse Cheickna, Mamadou Wele, Joseph Mugisha, Oyekanmi Nash, Eugene Kinyanda, Dorothea Nitsch, Myriam Fornage, Tinashe Chikowore, Dipender Gill, Derek E Wildman, Leon Mutesa, Monica Uddin, Segun Fatumo

Faculty, Staff and Student Publications

Observational studies have shown an association between post-traumatic stress disorder (PTSD) and ischemic stroke (IS) but given the susceptibility to confounding it is unclear if these associations represent causal effects. Mendelian randomization (MR) facilitates causal inference that is robust to the influence of confounding. Using two sample MR, we investigated the causal effect of genetic liability to PTSD on IS risk. Ancestry-specific genetic instruments of PTSD and four quantitative sub-phenotypes of PTSD, including hyperarousal, avoidance, re-experiencing, and total symptom severity score (PCL-Total) were obtained from the Million Veteran Programme (MVP) using a threshold P value (P) of <5 >× 10


The Role Of Expressed Emotion On Post-Traumatic Stress Disorder, Steven Drosky, Natasha Reddy, Eduardo Espiridion Jun 2023

The Role Of Expressed Emotion On Post-Traumatic Stress Disorder, Steven Drosky, Natasha Reddy, Eduardo Espiridion

Transformative Medicine

Introduction: This case report explores the impact of expressed emotion (EE) on the management of a patient with post-traumatic stress disorder. EE is a term used to denote the attitude of familial caregivers toward a person with a mental disorder.

Clinical Findings: We describe the case of a paraplegic patient living in an environment of high expressed emotion. The patient had no history of psychiatric illness prior to suffering a spinal cord injury. Since the injury the patient reports recurring symptoms consistent with post-traumatic stress disorder and worsening of symptoms due to family members expressing negative attitudes.

Conclusion: The construct …


Arnold-Chiari Malformation-I Borderline Personality Disorder, Aric Huber, Matthew Driben, Eduardo Espiridion Jun 2023

Arnold-Chiari Malformation-I Borderline Personality Disorder, Aric Huber, Matthew Driben, Eduardo Espiridion

Transformative Medicine

Introduction:
Arnold-Chiari Malformation I (AM-I) is a congenital anomaly that manifests with cerebellar dysfunction. There is a displacement of cerebellar tonsils into the foramen magnum. Several mood disorders, personality disorders, and intellectual disabilities are associated with AM-I. Borderline personality disorder (BPD) is characterized by symptoms of mood lability, impulsivity, extreme efforts of abandonment, splitting and dysfunctional relationships.

Case Description:
The patient is an early aged adult with a past medical history of AM-I, hypothyroidism, Wolff-Parkinson-White syndrome, and diabetes mellitus type II. The patient was admitted to the hospital after ingesting foreign bodies. He/she presented with mood lability, sad mood, anhedonia, …


Understanding The Effects Of Empathy And Masculine Gender Role Stress On The Relationship Between Gender And The Understanding Of Consent In Adolescents: A Moderated Mediation Framework, Kate Degenhardt Jun 2023

Understanding The Effects Of Empathy And Masculine Gender Role Stress On The Relationship Between Gender And The Understanding Of Consent In Adolescents: A Moderated Mediation Framework, Kate Degenhardt

Clinical Psychology Dissertations

This research examined the relationship between masculine gender role stress and empathy in youths ages 11-19 and their ability to understand the concept of consent. I examined a moderated mediation model where the effect of gender on the understanding of consent via masculine gender role stress was permitted to differ as a function of levels of empathy. The moderated mediation was evaluated in a stepwise fashion. A simple mediation examining the degree to which MGRS mediated the relation of gender on consent revealed all effects were significant, including the indirect effect (B = 0.561, SE = .292 95, CI 0.100, …


Dog Guardians’ Subjective Well-Being During Times Of Stress And Crisis: A Diary Study Of Affect During Covid-19, Lori S. Hoy, Brigitte Stangl, Nigel Morgan Jun 2023

Dog Guardians’ Subjective Well-Being During Times Of Stress And Crisis: A Diary Study Of Affect During Covid-19, Lori S. Hoy, Brigitte Stangl, Nigel Morgan

People and Animals: The International Journal of Research and Practice

The impacts of companion animals on human well-being have been receiving increased media and research attention, especially in relation to the COVID-19 pandemic. Previously, there have been calls for research to consider the major components of subjective well-being separately and for research designs to include assessments over time. In line with this suggestion, the purpose of this study was to gain a more comprehensive understanding of how being a dog guardian can impact affect and contribute to the overall assessment of subjective well-being. This study used a seven-day diary design to capture 31 dog guardians’ day-to- day feelings and thoughts …


How Did The Landscape Of Student Belonging Shift During Covid-19?, Shruti Misra, Neha Kardam, Jennifer Vanantwerp, Denise Wilson Jun 2023

How Did The Landscape Of Student Belonging Shift During Covid-19?, Shruti Misra, Neha Kardam, Jennifer Vanantwerp, Denise Wilson

University Faculty Publications and Creative Works

The goal of this study is to understand if and how emergency remote teaching (ERT) used during the COVID-19 pandemic changed the ways in which instructional support and interactions were linked to belonging among engineering students. Belonging is a fundamental human motivation associated with a wide range of positive psychological, educational, social, and job outcomes. Frequent and predominantly conflict-free interactions within a stable, relational framework of caring are required to facilitate belonging. To better understand potential shifts in belonging that occurred from prepandemic to mid-pandemic, this study used survey data from a cross-sectional dataset at a single, large institution comprised …


Parents’ Perspectives On The Utility Of Genomic Sequencing In The Neonatal Intensive Care Unit, Amy A. Lemke, Michelle L. Thompson, Emily C. Gimpel, Katelyn C. Mcnamara, Carla A. Rich, Candice R. Finnila, Meagan E. Cochran, James M.J. Lawlor, Kelly M. East, Kevin M. Bowling, Donald R. Latner, Susan M. Hiatt, Michelle D. Amaral, Whitley V. Kelley, Veronica Greve, David E. Gray, Stephanie A. Felker, Hannah Meddaugh, Ashley Cannon, Amanda Luedecke, Kelly E. Jackson, Laura G. Hendon, Hillary M. Janani, Marla Johnston, Lee Ann Merin, Sarah L. Deans, Carly Tuura, Trent Hughes Jun 2023

Parents’ Perspectives On The Utility Of Genomic Sequencing In The Neonatal Intensive Care Unit, Amy A. Lemke, Michelle L. Thompson, Emily C. Gimpel, Katelyn C. Mcnamara, Carla A. Rich, Candice R. Finnila, Meagan E. Cochran, James M.J. Lawlor, Kelly M. East, Kevin M. Bowling, Donald R. Latner, Susan M. Hiatt, Michelle D. Amaral, Whitley V. Kelley, Veronica Greve, David E. Gray, Stephanie A. Felker, Hannah Meddaugh, Ashley Cannon, Amanda Luedecke, Kelly E. Jackson, Laura G. Hendon, Hillary M. Janani, Marla Johnston, Lee Ann Merin, Sarah L. Deans, Carly Tuura, Trent Hughes

School of Medicine Faculty Publications

Background: It is critical to understand the wide-ranging clinical and non-clinical effects of genome sequencing (GS) for parents in the NICU context. We assessed parents’ experiences with GS as a first-line diagnostic tool for infants with suspected genetic conditions in the NICU. Methods: Parents of newborns (N = 62) suspected of having a genetic condition were recruited across five hospitals in the southeast United States as part of the SouthSeq study. Semi-structured interviews (N = 78) were conducted after parents received their child’s sequencing result (positive, negative, or variants of unknown significance). Thematic analysis was performed on all interviews. Results: …


Reconceptualizing The Interaction Between Adhd Symptoms And Environmental Context, Oliver G. Mcfadden Jun 2023

Reconceptualizing The Interaction Between Adhd Symptoms And Environmental Context, Oliver G. Mcfadden

University Honors Theses

Difficult questions regarding etiology, prevalence, and individual treatment allude to the heterogenous and complex neurocognitive profile ADHD. Current understandings do not point to there being any yet-undiscovered, succinct set of features for the condition that will answer these questions. ADHD in fact has a heterogeneous etiology and neurocognitive profile, suffers from both overdiagnosis and underdiagnosis, and a variety of styles of treatment are conceivable to address this. Sociocultural factors have crucially guided the direction of ADHD pathology and medicalization and are woven into institutional environments. These extant problems have eluded ADHD research, and the debate over the construction and validity …


Tattoos And Trauma: Are Tattoos Healing For Trauma?, Krystal Bell Jun 2023

Tattoos And Trauma: Are Tattoos Healing For Trauma?, Krystal Bell

University Honors Theses

Prior research and literature reviews suggest that there is medicinal value in tattooing for the healing of trauma. However, tattooing is still a burgeoning topic in academic studies and still mostly taboo as a western societal practice, so there are gaps in qualitative and quantitative data that could further validate the healing benefits of tattoos for trauma. This literature review analyzed 30 peer reviewed articles that focus on "contemporary tattoo data," "indigenous traditions and practices," "tattoos and trauma," and other alternative healing such as "MDMA, psilocybin, EMDR" to establish a well-rounded investigation into tattoos as an alternative healing option. The …


Intranasal Carbetocin Reduces Hyperphagia, Anxiousness, And Distress In Prader-Willi Syndrome: Care-Pws Phase 3 Trial, Elizabeth Roof, Cheri L Deal, Shawn E Mccandless, Ronald L Cowan, Jennifer L Miller, Jill K Hamilton, Elizabeth R Roeder, Shana E Mccormack, Tamanna R Roshan Lal, Hussein D Abdul-Latif, Andrea M Haqq, Kathryn S Obrynba, Laura C Torchen, Alaina P Vidmar, David H Viskochil, Jean-Pierre Chanoine, Carol K L Lam, Melinda J Pierce, Laurel L Williams, Lynne M Bird, Merlin G Butler, Diane E Jensen, Susan E Myers, Oliver J Oatman, Charumathi Baskaran, Laura J Chalmers, Cary Fu, Nathalie Alos, Scott D Mclean, Ajay Shah, Barbara Y Whitman, Brent A Blumenstein, Sarah F Leonard, Jessica P Ernest, Joseph W Cormier, Sara P Cotter, Davis C Ryman Jun 2023

Intranasal Carbetocin Reduces Hyperphagia, Anxiousness, And Distress In Prader-Willi Syndrome: Care-Pws Phase 3 Trial, Elizabeth Roof, Cheri L Deal, Shawn E Mccandless, Ronald L Cowan, Jennifer L Miller, Jill K Hamilton, Elizabeth R Roeder, Shana E Mccormack, Tamanna R Roshan Lal, Hussein D Abdul-Latif, Andrea M Haqq, Kathryn S Obrynba, Laura C Torchen, Alaina P Vidmar, David H Viskochil, Jean-Pierre Chanoine, Carol K L Lam, Melinda J Pierce, Laurel L Williams, Lynne M Bird, Merlin G Butler, Diane E Jensen, Susan E Myers, Oliver J Oatman, Charumathi Baskaran, Laura J Chalmers, Cary Fu, Nathalie Alos, Scott D Mclean, Ajay Shah, Barbara Y Whitman, Brent A Blumenstein, Sarah F Leonard, Jessica P Ernest, Joseph W Cormier, Sara P Cotter, Davis C Ryman

Faculty, Staff and Students Publications

Context: Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by endocrine and neuropsychiatric problems including hyperphagia, anxiousness, and distress. Intranasal carbetocin, an oxytocin analog, was investigated as a selective oxytocin replacement therapy.

Objective: To evaluate safety and efficacy of intranasal carbetocin in PWS.

Design: Randomized, double-blind, placebo-controlled phase 3 trial with long-term follow-up.

Setting: Twenty-four ambulatory clinics at academic medical centers.

Participants: A total of 130 participants with PWS aged 7 to 18 years.

Interventions: Participants were randomized to 9.6 mg/dose carbetocin, 3.2 mg/dose carbetocin, or placebo 3 times daily during an 8-week placebo-controlled period (PCP). During a subsequent …


Missed And Prior Diagnoses In Children Later Diagnosed With Autism, Maire Diemer Jun 2023

Missed And Prior Diagnoses In Children Later Diagnosed With Autism, Maire Diemer

Dissertations

Awareness of autism is rising, yet social determinants of health continue to impact rates, ages of diagnosis, and diagnostic load. Different psychiatric labels carry stigmas; unequal rates of diagnoses may indicate biases in the healthcare system. This study investigates six prior diagnoses (ADHD, disorders of conduct, adjustment, anxiety, mood, and intellectual disability) assigned to children who are later diagnosed with autism. The study investigates how race, sex, and geographic factors were associated with age of diagnosis and diagnostic load. This study utilized a sample of 13,850 children aged 2-10 who were diagnosed with autism on Missouri Medicaid between 2015 and …


Snx3 Is Important For Mammalian Neural Tube Closure Via Its Role In Canonical And Non-Canonical Wnt Signaling, Lei Dong, Mengchuan Xu, Yang Li, Wanting Xu, Chengwei Wu, Hanfei Zheng, Zhenyu Xiao, Guochen Sun, Lei Ding, Xiaobo Li, Wenming Li, Liying Zhou, Qin Xia Jun 2023

Snx3 Is Important For Mammalian Neural Tube Closure Via Its Role In Canonical And Non-Canonical Wnt Signaling, Lei Dong, Mengchuan Xu, Yang Li, Wanting Xu, Chengwei Wu, Hanfei Zheng, Zhenyu Xiao, Guochen Sun, Lei Ding, Xiaobo Li, Wenming Li, Liying Zhou, Qin Xia

Faculty, Staff and Student Publications

Cancer cells consistently utilize the unfolded protein response (UPR) to encounter the abnormal endoplasmic reticulum (ER) stress induced by the accumulation of misfolded proteins. Extreme activation of the UPR could also provoke maladaptive cell death. Previous reports have shown that NRF2 antioxidant signaling is activated by UPR and serves as noncanonical pathway to defense and reduce excessive ROS levels during ER stress. However, the mechanisms of regulating NRF2 signaling upon ER stress in glioblastoma have not been fully elucidated. Here we identify that SMURF1 protects against ER stress and facilitates glioblastoma cell survival by rewiring KEAP1-NRF2 pathway. We show that …


Exenatide As An Adjunct To Nicotine Patch For Smoking Cessation And Prevention Of Postcessation Weight Gain Among Treatment-Seeking Smokers With Pre-Diabetes And/Or Overweight: Study Protocol For A Randomised, Placebo-Controlled Clinical Trial, Luba Yammine, Christopher D Verrico, Francesco Versace, Heather E Webber, Robert Suchting, Michael F Weaver, Thomas R Kosten, Husein Alibhai, Paul M Cinciripini, Scott D Lane, Joy M Schmitz Jun 2023

Exenatide As An Adjunct To Nicotine Patch For Smoking Cessation And Prevention Of Postcessation Weight Gain Among Treatment-Seeking Smokers With Pre-Diabetes And/Or Overweight: Study Protocol For A Randomised, Placebo-Controlled Clinical Trial, Luba Yammine, Christopher D Verrico, Francesco Versace, Heather E Webber, Robert Suchting, Michael F Weaver, Thomas R Kosten, Husein Alibhai, Paul M Cinciripini, Scott D Lane, Joy M Schmitz

Faculty, Staff and Student Publications

INTRODUCTION: Obesity and smoking are the two leading causes of preventable death in the USA. Unfortunately, most smokers gain weight after quitting. Postcessation weight gain (PCWG) is frequently cited as one of the primary barriers to a quit attempt and a common cause of relapse. Further, excessive PCWG may contribute to the onset or progression of metabolic conditions, such as hyperglycaemia and obesity. The efficacy of the current treatments for smoking cessation is modest, and these treatments have no clinically meaningful impact on mitigating PCWG. Here, we outline a novel approach using glucagon-like peptide 1 receptor agonists (GLP-1RA), which have …


Aggression And Mao-A Gene, Sacheta Sudhendra Kulkarni, Shilpa Sam S, Kishor Manohar Rao, Abhijith Devaraju Jun 2023

Aggression And Mao-A Gene, Sacheta Sudhendra Kulkarni, Shilpa Sam S, Kishor Manohar Rao, Abhijith Devaraju

International Journal of Health and Allied Sciences

No abstract provided.


Treatment Burden, Not Health Risk Attitude Associated With Adherence In Patients With Mental Illness In South India, Dushad Ram, Neethu Benny, Shruthy Kv Jun 2023

Treatment Burden, Not Health Risk Attitude Associated With Adherence In Patients With Mental Illness In South India, Dushad Ram, Neethu Benny, Shruthy Kv

International Journal of Health and Allied Sciences

Background: Attitude towards health risks and treatment burden may mediate treatment adherence in therapeutic care. There is a paucity of study examining the levels and relationships of these variables in patients with mental illness. Objective: This study was conducted to know the relationships of health risk attitude & treatment burden and medication adherence in patients with mental illness. Settings and design: Cross-sectional, Hospital-based study. Methods and material: One hundred seventy consecutive participants in remission of mental illness were recruited. The patient's details were assessed with Sociodemographic proforma while attitude towards health risk was assessed with Health-Risk Attitude Scale (HRAS). To …


Perceived Adequacy Of Training And Identification Of Barriers To Choosing Academic Faculty Positions Among Psychiatry Postgraduate Students In India, Raviteja Innamuri, Ambuja Dacha, Rajendhar Soorinedu, Siva Kumar Chennam Setty, Kishor Manohar Rao Jun 2023

Perceived Adequacy Of Training And Identification Of Barriers To Choosing Academic Faculty Positions Among Psychiatry Postgraduate Students In India, Raviteja Innamuri, Ambuja Dacha, Rajendhar Soorinedu, Siva Kumar Chennam Setty, Kishor Manohar Rao

International Journal of Health and Allied Sciences

The increasing burden of psychiatric morbidity will proportionately increase the need for teachers of psychiatry in medical colleges. There are no studies on the current postgraduates’ perception about taking up faculty positions. We conducted an online cross-sectional study among 101 postgraduates using self-reporting questionnaires from October 2021 to November 2021. Majority were female, in 25-30 years age group, studying final year in private medical college. They willing to consider teaching positions and expressed interest in training programs. Significant facilitators and barriers to taking up faculty posts included interest in private practice, politics and vacancies available in place of interest.