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Full-Text Articles in Medicinal and Pharmaceutical Chemistry
Synthesis And Evaluation Of Cocaine Analogs For Activity As Cocaine Antagonists And Synthesis Of Novel Prodrugs With Antiarthritic Potential, Bonnie Lisa Barr
Synthesis And Evaluation Of Cocaine Analogs For Activity As Cocaine Antagonists And Synthesis Of Novel Prodrugs With Antiarthritic Potential, Bonnie Lisa Barr
MUSC Theses and Dissertations
As a follow up to interest in a new class of agents that have potential for the treatment of arthritic conditions, two series of cocaine derivatives were synthesized. Specifically, an N-alkyl series consisting of the ethyl, n-propyl, isopropyl, n-butyl and benzyl norcocaine derivatives and an N-acyl series consisting of the acetyl, propionyl, butyryl, and benzoyl norcocaine derivatives were synthesized. The structures of these compounds were verified using GC/MS, 1H NMR, and FT-IR with support from elemental analysis. Evaluation of the effect of these cocaine analogs on the inhibition of dopamine uptake represented the biological focus of this project. Each of …
What Is The Risk Of Teratogenicity With The Use Of Selective Serotonin Reuptake Inhibitors During Pregnancy?, Michael Z. Wincor, Mary Gutierrez, Ann Nguyen
What Is The Risk Of Teratogenicity With The Use Of Selective Serotonin Reuptake Inhibitors During Pregnancy?, Michael Z. Wincor, Mary Gutierrez, Ann Nguyen
Pharmacy Faculty Articles and Research
"The lifetime prevalence of major depressive disorder in women is 10 to 25%, with an average age of onset in the mid-20s.1 Over the nine years that the selective serotonin reuptake inhibitors (SSRis) have been available, for many prescribers, they have become first-line agents in the treatment of depression. In addition, sorne of them are also being used in the treatment of obsessive- compulsive disorder and panic disorder. In light of these facts, itis not unlikely that women of childbearing age would be treated with one of the SSRis. In considering the risks of exposing a fetus to an SSRI, …