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Full-Text Articles in Medicinal and Pharmaceutical Chemistry
Synthesis And Biological Evaluation Of Sparsomycin Analogues, Scherer Preston Sanders
Synthesis And Biological Evaluation Of Sparsomycin Analogues, Scherer Preston Sanders
Theses and Dissertations
In 1962, Owen, Dietz, and Camiener reported the isolation of a new antitumor antibiotic from the culture filtrate of Streptomyces sparsogenes. The structure of the crystalline antibiotic, named sparsomycin, remained elusive until 1970, when Wiley and MacKellar reported results of spectroscopic and degradation studies which elucidated the structure. In addition to the molecular structure, investigators have examined the mechanism of action, toxicity, and related analogues, striving to establish sparsomycin or a synthetic analogue's usefulness as an effective chemotherapeutic agent.
The initial pharmacological evaluation of sparsomycin revealed it possessed activity against KB human epidermoid carcinoma cells, a variety of gram-negative and …
Toxicology And Pharmacology Of N¹-Acetylspermidine And N⁸-Acetylspermidine, Othman A. Alshabanah
Toxicology And Pharmacology Of N¹-Acetylspermidine And N⁸-Acetylspermidine, Othman A. Alshabanah
University of the Pacific Theses and Dissertations
The polyamines are a group of natural compounds which have been found in almost all living tissues. N1- and N8- acetylspermidine have been known for a considerable time as normal constituents in human urine, but their physiological role is unknown. Recent studies have indicated the presence of enzymes in the tissues capable of converting spermidine into N1-acetylspermidine and N8-acetylspermidine and other enzyme activities which catalyze deacetylation and interconversion reactions.
One approach for determining physiologic activity of an endogenous compound is to observe their pharmacologic and toxicologic effects. In the present study, the …