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Medicinal and Pharmaceutical Chemistry Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
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- Acanthus ilicifolius (1)
- Anemia (1)
- Antiepileptics (1)
- Antiosteoporosis (1)
- Apomorphine; haloperidol; stereotypy; catalepsy; Myrica esculenta (1)
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- Atomic absorption spectrophotometry; iron absorption (1)
- COVID-19; SARS-CoV-2 spike protein; dermaseptin; antiviral peptide; in silico study (1)
- CUL4B-DDB1-AhR (1)
- Citrus peel; flavonoid; elastase; collagenase; in silico (1)
- Dried blood spot (1)
- Drug delivery system; gastroretentive; bioadhesive; mucoadhesive dosage forms (1)
- ERa (1)
- Estrogen receptor (1)
- Ferrous fumarate (1)
- Iron sand (1)
- Microsampling (1)
- Volumetric absorptive microsampling (1)
Articles 1 - 7 of 7
Full-Text Articles in Medicinal and Pharmaceutical Chemistry
Challenges And Future Perspective Of Gastroretentive Mucoadhesive Dosage Forms, Rayhan Akbar, Heri Setiawan, Baitha Palanggatan Maggadani, Raditya Iswandana, Kurnia Sari Setio Putri
Challenges And Future Perspective Of Gastroretentive Mucoadhesive Dosage Forms, Rayhan Akbar, Heri Setiawan, Baitha Palanggatan Maggadani, Raditya Iswandana, Kurnia Sari Setio Putri
Pharmaceutical Sciences and Research
Gastroretentive Mucoadhesive Dosage Form (GMDF) is one type of Gastroretentive Drug Delivery System (GRDDS) technology designed to exploit the adhesiveness of dosage forms in the gastric mucosa. This aims to increase drug residence time, enhance drug solubility and absorption, and ultimately improve drug bioavailability and therapeutic effect. Various studies have explored the use of different polymers to develop GMDF systems and dosage forms. However, despite extensive research in this field, there are still limited GMDF products approved by the US FDA and INA FDA. Therefore, this review addresses the challenges in developing GMDF, its current state, and potential future opportunities. …
Recent Updates On Dried Blood Spot And Volumetric Absorptive Microsampling As Microsampling Technique For Antiepileptic Drug Determination: A Systematic Review, Asmiladita Pridilla, Yahdiana Harahap, Denni Joko Purwanto, Baitha Palanggatan Maggadani
Recent Updates On Dried Blood Spot And Volumetric Absorptive Microsampling As Microsampling Technique For Antiepileptic Drug Determination: A Systematic Review, Asmiladita Pridilla, Yahdiana Harahap, Denni Joko Purwanto, Baitha Palanggatan Maggadani
Pharmaceutical Sciences and Research
Implementation of Therapeutic Drug Monitoring (TDM) can be useful for patients with uncontrolled seizures. This review article aims to collect and compare the recent development of bioanalytical methods for antiepileptic drugs using microsampling techniques, namely DBS (Dried Blood Spot) and VAMS (Volumetric Absorptive Microsampling). Studies were searched through databases, namely Science Direct, Pubmed, and the Google Scholar search engine using pre-determined keywords. Studies published between 2019 and 2024 and used micro-sampling techniques for antiepileptic drug analysis were included. Non-English studies, non-related studies, duplication, and full text unavailable were excluded. Primary sources were used to build a conclusion regarding the purpose …
Molecular Docking Analysis Of Acanthus Ilicifolius Compounds Toward Cul4b-Ddb1-Ahr-Erα Complex Protein For Antiosteoporosis Discovery, Binar Asrining Dhiani, Sarmoko Sarmoko, Retno Wahyuningrum, Akbar Yulianto
Molecular Docking Analysis Of Acanthus Ilicifolius Compounds Toward Cul4b-Ddb1-Ahr-Erα Complex Protein For Antiosteoporosis Discovery, Binar Asrining Dhiani, Sarmoko Sarmoko, Retno Wahyuningrum, Akbar Yulianto
Pharmaceutical Sciences and Research
Osteoporosis represents a significant global public health issue, particularly among the aging population. Its incidence reaches 18.3% of the total population, with the highest prevalence observed in elderly postmenopausal women. A key factor in osteoporosis is the decreased expression level of estrogen receptor alpha (ERα), attributed to its degradation by the ubiquitin ligase protein complex Cullin4B (CUL4B), DNA damage binding 1 (DDB1), and aryl hydrocarbon receptor (AhR), collectively known as CUL4BAhR. Acanthus ilicifolius L contains compounds exhibiting antiosteoporosis activity, primarily by inhibiting osteoclastogenesis via RANKL. However, no reports exist of antiosteoporosis agents that act by inhibiting ERα degradation via CUL4BAhR. …
Synthesis Of Ferrous Fumarate From Indonesian Iron Sand And In Vivo Body Weight Gain Test In Rats, Taufiq Indra Rukmana, Felicia Natalia Kurniadi, Harmita Harmita
Synthesis Of Ferrous Fumarate From Indonesian Iron Sand And In Vivo Body Weight Gain Test In Rats, Taufiq Indra Rukmana, Felicia Natalia Kurniadi, Harmita Harmita
Pharmaceutical Sciences and Research
Iron deficiency anemia (IDA) is a health problem in Indonesia. Prevention and treatment of IDA is carried out by giving fortified foods and oral iron therapy. Both can use ferrous fumarate which is made with reacting bivalent iron and disodium fumarate. Bivalent iron can be obtained from iron sand in Indonesia. This study aims to synthesize ferrous fumarate from Indonesian iron sand, which is from Malang, Sukabumi, and Cianjur area, and to determine its absorption through in vivo body weight gain test in male Wistar white rats (Rattus norvegicus). First, ferrous fumarate was synthesized through reaction of ferrous …
Insights Into Molecular Interaction Of Flavonoid Compounds In Citrus Peel Bound To Collagenase And Elastase Enzymes: A Computational Study, Sani Ega Priani, Taufik Muhammad Fakih
Insights Into Molecular Interaction Of Flavonoid Compounds In Citrus Peel Bound To Collagenase And Elastase Enzymes: A Computational Study, Sani Ega Priani, Taufik Muhammad Fakih
Pharmaceutical Sciences and Research
Citrus peels contain various phytochemical active compounds such as flavonoids that are useful for antiaging cosmetic products. This study was conducted to identify the anti-collagenase and anti-elastase activities of flavonoid compounds in citrus peel and to determine the molecular interaction mechanism using the molecular docking method. The study was carried out through several stages, including preparation of enzyme macromolecules, preparation of flavonoid compound molecules, validation of molecular docking, identification of binding-free energy, visualization of interaction conformations, and predictions of molecular skin toxicity. The result showed that the flavonoid compounds in citrus peel (hesperidin, naringin, nobiletin, and tangeretin) could bind to …
Evaluation Of Antipsychotic Activity Of Ethanolic Bark Extract Of Myrica Esculenta In Rats, Biswash Sapkota, Ankit Acharya, Bishal Dangi, Annegowda Hv
Evaluation Of Antipsychotic Activity Of Ethanolic Bark Extract Of Myrica Esculenta In Rats, Biswash Sapkota, Ankit Acharya, Bishal Dangi, Annegowda Hv
Pharmaceutical Sciences and Research
The antipsychotic properties of Myrica esculenta stem bark were evaluated. The stem bark was collected, shade dried, and pulverized. Extraction was carried out with 70% ethanol by occasional shaking. Preliminary phytochemical screening of the extract was investigated in this study. Antipsychotic activity was evaluated against apomorphine-induced stereotypy using cook’s pole climbing apparatus and haloperidol-induced catalepsy models. Bioamine determination of noradrenaline and dopamine was also performed. The extract contains phytochemicals, including glycosides, flavonoids, volatile oils, proteins, saponins, phenolics, and tannins. The result showed decreased apomorphine-induced stereotyped behavior. This study reported significant dose-dependent potentiation of haloperidol-induced catalepsy in rats and a longer …
Dermaseptin-Based Antiviral Peptides To Prevent Covid-19 Through In Silico Molecular Docking Studies Against Sars-Cov-2 Spike Protein, Taufik Muhammad Fakih
Dermaseptin-Based Antiviral Peptides To Prevent Covid-19 Through In Silico Molecular Docking Studies Against Sars-Cov-2 Spike Protein, Taufik Muhammad Fakih
Pharmaceutical Sciences and Research
A pandemic coronavirus disease of 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now been declared a global pandemic by the World Health Organization. The search for new drugs, especially by utilizing antiviral peptides is a very potential area. Through this study, protein-peptide docking and protein-protein docking simulations were conducted using in silico methods to identify, evaluate, and explore the molecular affinity and interaction of dermaseptin peptide molecules produced by frogs of the genus Phyllomedusa against the SARS-CoV-2 spike protein macromolecule, and its effect on attachment to the surface of the ACE-2 (Angiotensin Converting Enzyme-2) receptor. …