Open Access. Powered by Scholars. Published by Universities.®
Medicinal and Pharmaceutical Chemistry Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Amino Acids, Peptides, and Proteins (1)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Applied Statistics (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
-
- Bioethics and Medical Ethics (1)
- Bioinformatics (1)
- Biophysics (1)
- Chemicals and Drugs (1)
- Chemistry (1)
- Data Science (1)
- Heterocyclic Compounds (1)
- Inorganic Chemicals (1)
- Inorganic Chemistry (1)
- Life Sciences (1)
- Medicinal Chemistry and Pharmaceutics (1)
- Medicinal-Pharmaceutical Chemistry (1)
- Mental and Social Health (1)
- Organic Chemicals (1)
- Organic Chemistry (1)
- Pharmaceutics and Drug Design (1)
- Pharmacology, Toxicology and Environmental Health (1)
- Psychiatric and Mental Health (1)
- Public Health (1)
- Public Health Education and Promotion (1)
- Statistics and Probability (1)
Articles 1 - 2 of 2
Full-Text Articles in Medicinal and Pharmaceutical Chemistry
Designing And Synthesizing A Warhead-Fragment Inhibitory Ligand For Ivyp1 Through Fragment-Based Drug Discovery, Samuel Moore
Designing And Synthesizing A Warhead-Fragment Inhibitory Ligand For Ivyp1 Through Fragment-Based Drug Discovery, Samuel Moore
Symposium of Student Scholars
Fragment-based drug discovery (FBDD) is a powerful tool for developing anticancer and antimicrobial agents. Within this, magnetic resonance spectroscopy (NMR) provides a comprehensive qualitative and quantitative approach to screening and validating weak and robust binders with targeted proteins, making NMR among the most attractive strategies in FBDD. Inhibitor of vertebrate lysozyme (Ivyp1) of P. aeruginosa serves as an excellent target because of its active cellular location and implications in clinical prognosis for cystic fibrosis and immunocompromised patients. This study uses current NMR and biophysical techniques to develop a covalent, fragment-linked warhead inhibitor for Ivyp1 through synthetic methods, warhead linking, and …
Opioid Abuse: Are Doctors Creating The Problem?, Nguyen Tran
Opioid Abuse: Are Doctors Creating The Problem?, Nguyen Tran
Symposium of Student Scholars
Opioid abuse and overdose are serious health problems in the United States. Current research has concentrated on the treatment and prevention of opioid abuse. Using data from the Controlled Substance Utilization Review and Evaluation System (CURES) for California zip codes, my research focuses on the causes of opioid overdose by considering the relationships between the following variables within each zip code: population size, average number of prescriptions per doctor, percentage of people who receive opioid prescriptions, percentage of people receiving the same prescription drug from 3 or more doctors, average number of opioid pills per prescription and number of people …