Pharmacy and Pharmaceutical Sciences Commons^™

Regulation Amendment To Improve Thai Drug Importation Control System, Neeranart Potiyanon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Drug importation is critical for ensuring access to essential medicines in Thailand. However, the current system faces significant challenges, including outdated regulations, inefficient processes, and limited use of modern technology. This study aimed to identify regulatory and operational gaps and propose improvements to enhance the effectiveness of Thailand’s drug importation control. Methods: A two-phase mixed-methods study was conducted in Bangkok from 2019 to 2021. Phase 1 employed the Context, Input, Process, and Product (CIPP) model to analyze content from semi-structured interviews with 19 key informants representing both government and private sectors. In Phase 2, the Multi-Criteria Decision Analysis (MCDA) …

Thermally Conductive Adhesive Based On Carbon Quantum Dots/Graphene Nanoplatelets-Epoxy Composites For Electronic Packaging, Thanayuth Jongrungrotbaworn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Conventional bottom-up synthesis of carbon quantum dots (CQDs) often requires extended reaction times, high energy input, and specialized equipment, limiting scalability and sustainability. In this study, we present an eco-friendly and energy-efficient method for synthesizing CQDs using H₂CO₃ as a carbon precursor at just 72 °C for 1 hour—representing one of the lowest reported synthesis temperatures and shortest reaction times using simple apparatus. Graphene oxide vacancies act as catalytic and nucleation sites, promoting the formation of CQDs under these mild conditions. The resulting CQD solution exhibits strong yellow photoluminescence, with a maximum emission at 533 nm and excitation-independence across the …

Antibacterial And Anti-Inflammatory Activities Of Herbal Formulas And Its Components: Ya-Kao Formula And The Formula Of Propolis Extract And Hemp Extract, Naruemon Perstwong

Chulalongkorn University Theses and Dissertations (Chula ETD)

The COVID-19 pandemic has prompted the Thai government to explore herbal medicines grounded in Traditional Thai Medicine (TTM) knowledge and review literature. Highlighted herbs formula, including Ya-Kao formula and propolis extract, have been recommended as supportive treatments for non-symptomatic COVID-19 patients. Additionally, Cannabis sativa (C. sativa) has gained recognition for its pharmacological properties, such as analgesic effects, pain relief, and anti-SARS-CoV-2 activity. One formula, Ya-Kao, traditionally used for fever relief, is documented in TTM textbook. The second formula is propolis extract (PE) was combined with C. sativa extract (CS). However, the efficacy and effectiveness require further scientific investigation. This study …

Safety And Efficacy Of Bispecific Antibodies In Hematologic Neoplasms: A Systematic Review, Khanittha Lommuang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: The global burden of hematologic neoplasms is rising. Despite advances in therapy, relapse, resistance, and limited options persist. Bispecific antibodies (BsAbs) offer a novel approach by targeting multiple antigens. This systematic review assesses their efficacy and safety. Methods: We conducted this systematic review following the PRISMA 2020 guidelines. Articles published up to 1 February 2025 were searched across PubMed, Scopus, Web of Science, and Embase. The clinical trials, focusing on SAEs, grade ≥ 3 AEs, hematologic and non-hematologic toxicities, and efficacy outcomes (ORR, CR, OS, and PFS), were included. Results were summarized qualitatively. Results: Twenty-three studies evaluating fifteen different …

Developemnt Of Hyaluronic Acid Grafted With Poly N-Isopropyl Acrylamide Nanogel Incorporating Hemp Extract Containing Cbd, May Thu Thu Kyaw

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cannabidiol (CBD), a major phytocannabinoid present in Cannabis sativa, possesses multiple effective pharmacological activities, such as neuroprotective, cardioprotective and anti-inflammatory properties. However, its hydrophobic nature and rapid degradation mechanisms limit its clinical usefulness. Encapsulation of lipophilic compounds inside modified polymers with hydrophilic properties can improve the aqueous solubility and stability of drugs in specific environments. Therefore, this study focused on self-assembled poly N-isopropyl acrylamide (pNIPAM) grafted hyaluronic acid (HA) nanogels for encapsulating CBD. At the highest concentration 0.25 % w/w of HA-g-pNIPAM, encapsulation efficiency (% EE) of CBD 87.57 % was achieved compared to other two formulations 0.15 % w/w …

การประเมินคุณภาพชีวิตด้านสุขภาพ คุณภาพชีวิตด้านการใช้ยา และความเต็มใจที่จะจ่ายในผู้ป่วยโรคเพมฟิกัสและผู้ป่วยโรคบูลลัสเพมฟิกอยด์, อริสรา เหลืองสุขฤกษ์

Chulalongkorn University Theses and Dissertations (Chula ETD)

วัตถุประสงค์: เพื่อประเมินคุณภาพชีวิตด้านสุขภาพ คุณภาพชีวิตด้านการใช้ยา และความเต็มใจที่จะจ่าย รวมถึงศึกษาปัจจัยที่มีความสัมพันธ์กับคุณภาพชีวิตด้านสุขภาพ คุณภาพชีวิตด้านการใช้ยา และความเต็มใจที่จะจ่ายในผู้ป่วยโรคเพมฟิกัสและผู้ป่วยโรคบูลลัสเพมฟิกอยด์ วิธีการศึกษา: การศึกษาวิจัยเชิงวิเคราะห์แบบภาคตัดขวางในผู้ป่วยโรคเพมฟิกัสและผู้ป่วยโรคบูลลัสเพมฟิกอยด์ที่มีอายุ 18-90 ปีที่เข้ารับการรักษาในสถาบันโรคผิวหนัง ระหว่างเดือนมกราคมถึงพฤษภาคม 2568 จำนวน 178 ราย โดยใช้แบบสอบถามคุณภาพชีวิตด้านสุขภาพ EQ-5D-5L และ Dermatology Life Quality Index (DLQI) แบบสอบถามคุณภาพชีวิตด้านการใช้ยา Patient-Reported Outcomes Measure of Pharmaceutical Therapy (PROMPT) และแบบสอบถามความเต็มใจที่จะจ่าย ผลการศึกษา: ผู้ป่วยส่วนใหญ่มีคุณภาพชีวิตด้านสุขภาพและด้านการใช้ยาในระดับดี โดยมิติที่มีผู้ป่วยรายงานปัญหามากที่สุดในแบบสอบถาม EQ-5D-5L คือ มิติอาการเจ็บปวดหรือไม่สบายตัว ขณะที่มิติอาการและความรู้สึกในแบบสอบถาม DLQI เป็นมิติที่ได้รับผลกระทบมากที่สุด สำหรับแบบสอบถาม PROMPT พบว่ามิติผลกระทบทางด้านจิตใจของการใช้ยามีคะแนนต่ำที่สุด ปัจจัยที่มีความสัมพันธ์กับคุณภาพชีวิตด้านสุขภาพ ได้แก่ อายุ ระดับการศึกษา ระดับความรุนแรงของโรค และจำนวนโรคร่วม ส่วนเพศ อายุ ระดับการศึกษา และสภาวะโรคปัจจุบันสัมพันธ์กับคุณภาพชีวิตด้านการใช้ยา ขณะที่รายได้ต่อเดือนและระดับการศึกษามีความสัมพันธ์กับมูลค่าความเต็มใจที่จะจ่ายอย่างมีนัยสำคัญทางสถิติ สรุปผล: ผู้ป่วยโรคเพมฟิกัสและผู้ป่วยโรคบูลลัสเพมฟิกอยด์ได้รับผลกระทบต่อคุณภาพชีวิตในหลายมิติ ทั้งจากตัวโรค การรักษา และการใช้ยา ข้อมูลที่ได้สามารถใช้ประโยชน์ในการวางแผนการรักษา การให้คำปรึกษาด้านยา และสนับสนุนการกำหนดนโยบายเพื่อเพิ่มการเข้าถึงยาที่จำเป็นให้แก่ผู้ป่วยมากยิ่งขึ้น

In Silico And In Vitro Studies On Ha-G-Pnipam Modified Liposomal Curcumin For Cancer Treatment, Abd. Umar

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cancer remains the leading cause of global mortality, with conventional chemotherapy drugs often limited by poor selectivity, side effects, and drug resistance. As a promising alternative and adjuvant, curcumin offers potent anticancer properties, but its low bioavailability highlights the need for targeted delivery systems to enhance its therapeutic potential. This study designs a targeted delivery system for curcumin using hyaluronic acid-grafted pNIPAM (HA-g-pNIPAM) modified liposomes, characterized both experimentally and computationally. The results show that the nanoparticle system has a size range of 80-120 nm, a PDI of 0.12-0.3, a zeta potential of -13.2 to -50.8 mV, and an absorption efficiency …

Bioactive Extracts Of The Roots Of Cannabis Sativa L. Against Dental Pathogens, Pattarapol Udomlarp

Chulalongkorn University Theses and Dissertations (Chula ETD)

The roots of Cannabis sativa L. are often underutilized and regarded as agricultural waste, despite reports of bioactive compounds with potential pharmaceutical applications. This study focused on developing an ecofriendly method for extracting triterpenoids and investigating the oral antimicrobial activity of cannabis root extracts. The primary objectives were to optimize an extraction process yielding high triterpenoid content and evaluate the potential of extracts to inhibit dental pathogens, thereby promoting the value of cannabis roots for future applications.The efficiency of Soxhlet solvent extraction, ultrasonic-assisted extraction (UAE), subcritical water extraction, and subcritical dimethyl ether extraction (SDMEE) was compared for yielding triterpenoids, particularly …

การพัฒนารายการยาที่มีแนวโน้มไม่เหมาะสมสำหรับพระภิกษุอาพาธสูงอายุ (Pim-Bhikkhu), พัชรินทร์ ประภัสสรกุล

Chulalongkorn University Theses and Dissertations (Chula ETD)

วัตถุประสงค์: เพื่อพัฒนารายการยาที่มีแนวโน้มไม่เหมาะสมสำหรับพระภิกษุอาพาธสูงอายุ (PIM-BHIKKHU) โดยใช้เทคนิคเดลฟาย และเปรียบเทียบความชุกของการใช้ยาที่มีแนวโน้มไม่เหมาะสมซึ่งประเมินโดยเกณฑ์ที่พัฒนาขึ้นกับ Beers ปี 2023 และ STOPP version 3 ปี 2023 วิธีการศึกษา: ระยะที่ 1 การศึกษาเชิงคุณภาพเพื่อพัฒนารายการ PIM-BHIKKHU โดยใช้เทคนิคเดลฟายกับผู้เชี่ยวชาญรวม 18 คน ประกอบด้วยแพทย์และเภสัชกร ระยะที่ 2 การศึกษาเชิงพรรณนาแบบภาคตัดขวางย้อนหลัง โดยทบทวนรายการยาของพระภิกษุอาพาธที่มีอายุ 65 ปีขึ้นไป และรับการรักษาแบบผู้ป่วยนอก โดยมีรายการยาที่ได้รับร่วมกันอย่างน้อย 5 รายการ จากโรงพยาบาลสงฆ์ ผลการศึกษา: จากกระบวนการเดลฟาย 2 รอบในระยะที่ 1 ได้ข้อยุติเกณฑ์ PIM-BHIKKHU จำนวน 89 รายการยา/กลุ่มยา ในระยะที่ 2 จากพระภิกษุอาพาธสูงอายุ 225 รูป พบความชุกของการใช้ยาที่มีแนวโน้มไม่เหมาะสมตามเกณฑ์ Beers ปี 2023, STOPP version 3 ปี 2023 และ PIM-BHIKKHU ปี 2024 เท่ากับร้อยละ 60.0, 45.33 และ 86.7 ตามลำดับ โดยมีความแตกต่างอย่างมีนัยสำคัญทางสถิติ (p < 0.05) ทั้งนี้ ความชุกของการใช้ PIMs สูงกว่าในกลุ่มอายุ ≥75 ปีเมื่อเทียบกับกลุ่มอายุ 65–74 ปีในทุกเกณฑ์ สรุป: รายการยาที่มีแนวโน้มไม่เหมาะสมที่พัฒนาขึ้น มีความจำเพาะกับบริบทของพระภิกษุอาพาธสูงอายุนิกายเถรวาทในประเทศไทย ทั้งนี้ ควรมีการศึกษาเพิ่มเติมเพื่อประเมินประสิทธิผลทางคลินิกเมื่อมีการใช้ในในเวชปฏิบัติจริง

คุณภาพชีวิตด้านสุขภาพ ภาวะซึมเศร้า และคุณภาพการนอนหลับในผู้ป่วยไทยโรคสมองขาดเลือด, รัตยาภรณ์ ใจกุศล

Chulalongkorn University Theses and Dissertations (Chula ETD)

วัตถุประสงค์: เพื่อประเมินคุณภาพชีวิตด้านสุขภาพ (HRQOL)ในผู้ป่วยโรคสมองขาดเลือดด้วยเครื่องมือ EQ-5D-5L, เพื่อประเมินภาวะซึมเศร้า (PSD) ด้วยเครื่องมือ PSDS-T, เพื่อประเมินคุณภาพการนอนหลับด้วยเครื่องมือ T- PSQI เพื่อหาความสัมพันธ์ระหว่าง HRQOL, PSD, คุณภาพการนอนหลับกับปัจจัยด้านประชากรศาสตร์และทางคลินิก วิธีดำเนินการวิจัย: การศึกษาเชิงวิเคราะห์แบบภาคตัดขวางเก็บข้อมูลจากผู้ป่วยนอกโรคสมองขาดเลือดที่คลินิกโรคหลอดเลือดสมองและอายุรกรรมประสาท 2 โรงพยาบาลจุฬาลงกรณ์ เครื่องมือที่ใช้: 1) EQ-5D-5L ฉบับภาษาไทย 2) PSDS-T 3) T- PSQI ผลการวิจัย: ผู้ป่วยทั้งหมด 360 คน ส่วนใหญ่เป็นเพศชาย(ร้อยละ 54.2) ค่าเฉลี่ยอายุ 64 ± 13.8 ปี และโรคสมองขาดเลือดมีค่าเฉลี่ยระยะเวลา 4.8 ± 3.8 เดือน. การประเมิน HRQOL ด้วยเครื่องมือ EQ-5D-5L พบปัญหาส่วนใหญ่ด้านอาการเจ็บปวด (ร้อยละ 32.0) ค่าเฉลี่ยอรรถประโยชน์ EQ-5D-5L (0.67 ± 0.31) และ EQ-VAS (0.72 ± 0.18) และพบ 5 ปัจจัยที่ส่งผลต่อ HRQOL .การประเมิน PSD ด้วยเครื่องมือ PSDS-T พบความชุก PSD (ร้อยละ 8.1) คุณภาพชีวิตด้านสุขภาพผู้ป่วยที่มีภาวะ PSD แย่กว่าอย่างมีนัยสำคัญ (p<0.001) และพบ 2 ปัจจัยที่สัมพันธ์กับ PSD คือจำนวนยาโรคประจำตัวที่ได้รับ (p=0.035). และการเกิดโรค สมองขาดเลือดซ้ำภายใน 1 ปี (p<0.001). การประเมินคุณภาพการนอนหลับด้วยเครื่องมือ TPSQI พบผู้ป่วยร้อยละ 57.2 คะแนนเฉลี่ย (PSQI>5) 8.21 ± 2.33 คะแนน และพบ 3 ปัจจัยที่ ส่งผลได้แก่ ประวัติการได้รับยานอนหลับ (p<0.001) ระดับความ mRS ≥3 คะแนน (p<0.008) และ PSD (คะแนน PSDS-T>6) (p<0.001). สรุปผลการวิจัย:การเกิดโรคสมองขาดเลือดส่งผลต่อ คุณภาพชีวิตด้านสุขภาพ ภาวะซึมเศร้าหลังเกิดโรคสมองขาดเลือด และคุณภาพการนอนหลับของผู้ป่วย

Advancements In The Synthesis Of Polyoxygenated Oxepanes And Thiepanes For Applications To Natural Products, Aditya R. Pote, Shayne M. Weierbach, Mark W. Peczuh, Kyle M. Lambert

Chemistry & Biochemistry Faculty Publications

Oxepanes are central motifs and tenants of many biologically important molecules, and their synthetic construction often presents a challenge to chemists due to consequential entropic and enthalpic barriers that have limited the synthetic toolbox to access these seven-membered oxacycles. This review covers the breadth of synthetic methods to afford the oxepane/thiepane moiety, with a focus on polyoxygenated oxepanes and includes radical cyclizations, Lewis acid-mediated cyclizations, ring closing-metathesis, Nicholas-Ferrier rearrangement, homologations, and ring-expansion strategies. Implementation of these tactics towards sugar-based and non-sugar based (de novo) approaches is presented alongside their extensive application to the total synthesis of several complex polyoxygenated oxepane-containing …

Evidence Synthesis Methodology: Promoting Reproducible Methodology Through Modified Assignments, Laura Lipke, Neyda Gilman

Library Created Resources

Initially, systematic reviews in healthcare served to synthesize findings from clinical studies, aiding comprehensive access to the most effective treatments within evidence-based practice. Over time, their scope has broadened beyond treatment effectiveness, leading to a surge in publication. Consequently, many health science faculty now assign systematic reviews in classrooms without a full grasp of the standardized process, leaving students ill-equipped due to insufficient guidance and resources.

While mastering systematic review techniques is crucial for evidence-based practice, faculty can opt for modified assignments to foster a deeper understanding of the review process. These modified tasks, can be completed within a semester, …

Recent Trends In Stimulant Prescribing In Kentucky, 2021-2023, Jordan Shannon

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Abstract

Introduction

Prescription stimulants have a long history of clinical use dating as far back as the 1930s. In the United States stimulant prescribing rates have steadily climbed over the last 3 decades. The primary objective is to describe recent (2021-2023) prescribing trends of stimulant medications in the Commonwealth of Kentucky

Methods

Prescription data collected from Kentucky’s prescription drug monitoring (PDMP) database known as the Kentucky All Schedule Prescription Electronic Reporting System (KASPER). Annual and quarterly trends in stimulant prescribing between 2021-2023 were calculated, examined by age, sex, and geographic location.

Results

Stimulant prescribing increased by ~15% where the majority …

Enhancing Safety Surveillance During Clinical Trials: The Development Of A Safety Data Review Handbook To Support Pharmacovigilance Clinicians, Lauren Wilson

DNP Scholarly Projects

Abstract

BACKGROUND: Pharmacovigilance (PV) Sciences include activities related to safety surveillance of pharmaceutical products, and is critical for developing safe and effective medications, vaccines and medical devices. Safety monitoring starts with preclinical research and continues through clinical trial and post marketing phases. PV scientists ensure patient safety during clinical trials through regular review and analysis of safety data. Regulations have become increasingly complex, leading to inadequately defined methods for reviewing large clinical trial safety datasets. Inconsistent safety data review (SDR) practices can result in delayed detection of adverse drug reactions (ADRs) or safety signals.

METHODS: This quality improvement project used …

Home Blood Pressure Monitoring Bundle For Hypertension Outcomes In Adult Patients Receiving Care In Public Health Clinics, Christine Jennifer Victorian

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Background: Hypertension (HTN) that is not adequately controlled leads to cardiovascular disease, stroke, and heart disease. It affects 116 million adults (47%) in the United States (U.S.). The HTN compliance rate in a South Texas public health clinic was 64%, below the national benchmark of 76%. Home blood pressure monitoring (HBPM) was recommended in a joint statement by the American Heart Association (AHA) and the American Medical Association (AMA). Literature evidence revealed that the HBPM bundle increased BP control (< 140/90 mmHg) compliance.

Methods: A quality improvement (QI) bundle was initiated to address the low HTN compliance rate from a quality management perspective. …

Clinical Practice Guideline For The Management Of Depression In Primary Care, Estrella Catherine Villarreal

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Background: The prevalence of depression poses a significant challenge in primary care, emphasizing the urgent need to address this issue during patient visits. Primary care providers are at the forefront of managing depression, yet they encounter difficulties in screening, diagnosing, assessing, and treating this complex condition. Clinical guidelines serve as valuable tools for primary care providers and practices, offering support in identifying and addressing depression effectively. An evidence-based approach to treating depression in primary care, with a focus on collaborative interventions with behavioral health to enhance depression management for American Indian/Alaskan Native (AI/AN) communities.

Methods: The descriptive analysis was conducted …

Implementation Of Prognosticator Algorithm For Initiation Of Serious Illness Discussions And Improving The Rate Of Palliative And Hospice Referrals, Joy Isebor

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Context: Early serious illness conversations related to end-of-life and goals of care with seriously ill patients have been associated with improving patients' outcomes and quality of care (Bernacki et al., 2015). However, initiating these serious illness discussions has been challenging in the home-based primary care setting.

Objectives: To train and support home-based primary care clinicians in integrating best practices in serious illness discussions and decision-making engagement among patients sixty-five and older with serious illnesses, optimize the alignment between patient goals and the medical care they receive, improving their quality of life and the rate of palliative care and hospice referrals. …

Investigating A New Drug Target In Alzheimer’S Disease: Nox2, Tiffany Adams

Theses and Dissertations--Pharmacy

Introduction: Alzheimer’s disease (AD) is a neurodegenerative disease with neuropathological changes in the blood-brain barrier that offers possible therapeutic targets. Oxidative stress is one driving factor for AD. NADPH oxidase 2 (NOX2) in the capillary endothelium produces reactive oxygen species, leading to oxidative stress-mediated blood-brain barrier dysfunction. We hypothesized that using a specific NOX2 inhibitor, PhoxI2, has the potential to reduce reactive oxygen species and repair amyloid-β (Aβ)-driven blood-brain barrier leakage in an AD mouse model.

Methods: For this study, 5xFAD (Familiar Alzheimer Disease) mice were treated with vehicle or PhoxI2, a NOX2 inhibitor. Techniques utilized were Enzyme-Linked Immunosorbent Assay …

Design Of Kappa Opioid Receptor Agonists For Potential Treatment Of Multiple Sclerosis, Lindsay Kornberger

Theses and Dissertations--Pharmacy

Multiple Sclerosis (MS) is a neurodegenerative disease of the central nervous system characterized by demyelination and neuroinflammation. There is currently no cure for MS. There is a critically unmet need for the development of pharmacotherapies that can induce remyelination promoting both repair and recovery. The kappa opioid receptor (KOR) has been identified as a potential target for the development of remyelinating pharmacotherapies. KOR activation has been shown to promote functional recovery and remyelination preclinically. However, typical KOR agonists like U50,488 have limitations such as sedation and dysphoria limiting their use. This necessitates further development of new KOR agonists that maintain …

Sensitizing Keap1 Loss Non-Small Cell Lung Cancer To Artesunate Anti-Cancer Activity, Keng Hee Peh

Theses and Dissertations--Pharmacy

Lung cancer is the global leading cause of cancer related death. Non-small cell lung cancer (NSCLC) accounts for 80% of lung cancer diagnoses conferring a significant disease burden. However, certain mutations in tumor suppressors such as Kelch-like ECH-associated protein 1 (KEAP1) confers resistance to standard of care therapy in NSCLC. KEAP1 is known to regulate multiple cellular processes such as oxidative stress response and anti-apoptotic pathways. Furthermore, KEAP1 loss of function in NSCLC is associated with poorer clinical outcomes and there are no currently approved therapies for KEAP1 loss NSCLC and represents an unmet clinical need. Artesunate (Art) demonstrated anti-cancer …

Inhibiting Pi3k/Akt To Enhance Brain Uptake Of Anticancer Agents In Glioblastoma, Louis Rodgers

Theses and Dissertations--Pharmacy

Glioblastoma (GBM) is the deadliest and most common malignant CNS tumor. Despite advances in understanding its biology and the development of targeted therapies, effective treatment options remain limited. As a result, patient survival rates are dismal, with a 5-year survival rate of only 6.8% and an overall survival of less than two years. This poor outcome is partly due to our inability to treat GBM cells that infiltrate the whole brain. Focal treatments like surgery and radiotherapy alone are insufficient due to these invasive tumor cells. Therefore, chemotherapy following resection and irradiation of the primary tumor is essential to eliminate …

Pharmacy Involvement In Increased Access To Opioid Treatment Programs, Catherine O'Rourke

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The opioid epidemic still affects many Americans today. Despite approved medication treatments for opioid use disorder (OUD), a majority of the population with OUD have not received treatment. Since pharmacists are the most accessible health care professional and had an important role providing care during the COVID-19 pandemic, there has been a push to expand pharmacists’ scope of practice. The primary purpose of this investigation was to identify the benefits and barriers to community pharmacist-led treatment of OUD. The secondary purpose was to determine whether pharmacist participation in opioid treatment programs (OTPs) or office based opioid treatment (OBOT) would be …

Development And Validation Of Green Stability-Indicating Rp-Hplc Method For Estimation Of Ertapenem: Degradation Kinetics And Structural Mass Elucidation Using Ms, Sohair M. Aboelghar, Hebatallah A. Wagdy, Maha A. Hegazy

Pharmacy

Ertapenem is an antibiotic that is used in the treatment of several bacterial infections, and it was recently approved for the treatment of the COVID-19 virus. A simple validated stability-indicating reversed phase High Performance Liquid Chromatographic (RP-HPLC) method was developed for ertapenem estimation. The separation was done using Pronto SIL® C18 (300 × 4.6 mm, 5 μm) as the stationary phase, methanol, and acidified water as the mobile phase in gradient mode with a flow rate of 1 mL/min and a pH 4.0 adjusted by orthophosphoric acid. The method was validated according to ICH guidelines. The linearity ranges from 5.00-120.00 …

Zeitlin’S Top 200 Dental Deckades (January 2024), Benjamin D. Zeitlin

Pacific Open Texts

Pharmacology courses in any institution are information intensive with a constant, high volume of new material. With that in mind, the standards that the American Dental Education Association set for Pharmacology include that: “the student must identify the influences drugs taken for non-dental purposes may have on a proposed treatment (…) and the student must recognize therapeutic agents used in the routine practice of clinical dentistry.” This requires that students at a minimum, recognize common drugs and know their major implications for dental therapy.

This learning tool has been created to address the drug recognition aspect of that standard.

See …

Dental Students’ Psychological Stress: A Comprehensive Investigation Of Stress Inducing Factors At Mohammed Vi University Of Sciences And Health, Latifa El Mouden, Elmehdi Fettach

Health Sciences

Dental students are significantly confronted with mental health problems. We conducted a prospective recruitment of students at the Faculty of Dentistry of the Mohammed VI University of Sciences and Health to investigate the determinants of stress specific to this population in order to find solutions to improve their quality of life. In our study, 410 students responded to the survey, the average age of the students was 21.51 ± 2.102 years, 70% were female, 30% were in their 6th year, and 60% of the students were from Casablanca. The average MSP-25B score was 101.94 ± 33.035. In our study, there …

Application Of Interpretable Machine Learning Methods To Study The Disease Characteristics And Healthcare Expenditures In Hodgkin’S Lymphoma, Zasim Azhar Dil Hasan Siddiqui

Graduate Theses, Dissertations, and Problem Reports (ETD)

Hodgkin’s lymphoma (HL) is a rare malignancy of lymphocytes that predominantly occurs in young adults aged 20-30 years or elderly individuals aged 65-75 years. Despite its low incidence, there were an estimated 223,512 HL survivors in the US in 2020. Hodgkin’s lymphoma shows a favorable prognosis among young adults, with a high cure rate of 85-90%; however, older adults experience poor prognosis, with a 5-year overall survival rate of 40-55% in patients over 60 years. HL survivors incur high total and out-of-pocket (OOP) healthcare expenditures, averaging $78,183 and $4,180 per patient in the first year after diagnosis, highlighting a considerable …

Acute Toxicity Study Of Canine Mesenchymal Stem Cell (Msc)-Derived Exosome Preparation For Drug Registration, Anatcha Thongsit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Exosomes, spherical vesicles secreted by cells containing diverse biomolecules, are gaining attention in veterinary medicine. Mesenchymal stem cell (MSC)-derived exosomes show promise for treating animal diseases. However, their safety profile, particularly the acute toxicity of canine MSC-derived exosomes, has yet to be adequately explored. This study evaluates the acute toxicity of canine MSC-derived exosomes on rat systemic health, adhering to ISO 10993-11 guidelines for systemic toxicity testing to support veterinary drug registration and development. The study tested acute toxicity in five female Sprague Dawley rats by administering exosomes at a concentration of 1×109 particles/mL via intravenous injection into the tail …

Expression Optimization And Characterization Of Plant-Produced Human Interleukin-15, Chalatorn Charnsatabut

Chulalongkorn University Theses and Dissertations (Chula ETD)

Human interleukin-15 (hIL-15) is a cytokine that plays a crucial role in immune responses like T cell proliferation, activation, and prolongation of natural killer (NK) cells. This cytokine also impacts the cell proliferation of human adult low calcium temperature (HaCaT) keratinocytes which can lead to the wound-healing effect. This study aimed to optimize the expression and characterize the recombinant hIL-15 in Nicotiana benthamiana with the Agrobacterium-mediated transient expression system. The hIL-15 gene was fused with the Fc domain from the IgG1 antibody for purification. The expression cassette was optimized for sub-cellular targeting and agroinfiltration. The transiently expressed hIL-15-Fc was purified …

Molecular Mechanism Of Lusianthridin On Platelet Aggregation Inhibition And Endothelial Cell Protection, Fozia -

Chulalongkorn University Theses and Dissertations (Chula ETD)

Lusianthridin (LST), a bioactive compound isolated from Dendrobium venustum, exhibits notable vasoprotective properties. This study aimed to elucidate the underlying molecular mechanisms of LST by evaluating its effects on platelet function and endothelial cell activation in vitro. In human platelets, LST significantly inhibited collagen-induced aggregation, an effect associated with elevated phosphorylation of vasodilator-stimulated phosphoprotein (VASP) and suppression of Akt phosphorylation. In EA.hy926 endothelial cells, LST attenuated tumor necrosis factor-alpha (TNF-α)-induced endothelial dysfunction by reducing nitric oxide (NO) production and suppressing the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6) and interleukin-1β (IL-1β). Mechanistic investigations revealed that LST inhibited key inflammatory signaling …

Predicting The Eq-5d-5l Utility Scores From The Impact Of Vision Impairment (Ivi) Questionnaire In Thai Patients, Emilia Audrey Tunmas Pasenggong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives : (1) This study aims to predict the EQ-5D-5L utility scores from the impact of vision impairment (IVI) questionnaire in Thai patients using mapping techniques. (2) To investigate the association between sociodemographic and clinical variables with the EQ-5D-5L index scores. Methods : This is a secondary data analysis. A total of 499 patients with multiple levels of visual impairment were recruited from King Chulalongkorn Memorial Hospital Thailand between February and July 2022. Ordinary least square (OLS), Tobit, Censored least absolute deviation (CLAD), and Adjusted limited dependent variable mixture model (ALDVMM) regression models were used to map the IVI questionnaire …