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2022

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Articles 691 - 693 of 693

Full-Text Articles in Pharmacy and Pharmaceutical Sciences

Screening Of Hydrocarbon-Stapled Peptides For Inhibition Of Calcium-Triggered Exocytosis, Ying Lai, Michael J Tuvim, Jeremy Leitz, John Peters, Richard A Pfuetzner, Luis Esquivies, Qiangjun Zhou, Barbara Czako, Jason B Cross, Philip Jones, Burton F Dickey, Axel T Brunger Jan 2022

Screening Of Hydrocarbon-Stapled Peptides For Inhibition Of Calcium-Triggered Exocytosis, Ying Lai, Michael J Tuvim, Jeremy Leitz, John Peters, Richard A Pfuetzner, Luis Esquivies, Qiangjun Zhou, Barbara Czako, Jason B Cross, Philip Jones, Burton F Dickey, Axel T Brunger

Faculty, Staff and Student Publications

The so-called primary interface between the SNARE complex and synaptotagmin-1 (Syt1) is essential for Ca2+-triggered neurotransmitter release in neuronal synapses. The interacting residues of the primary interface are conserved across different species for synaptotagmins (Syt1, Syt2, Syt9), SNAP-25, and syntaxin-1A homologs involved in fast synchronous release. This Ca2+-independent interface forms prior to Ca2+-triggering and plays a role in synaptic vesicle priming. This primary interface is also conserved in the fusion machinery that is responsible for mucin granule membrane fusion. Ca2+-stimulated mucin secretion is mediated by the SNAREs syntaxin-3, SNAP-23, VAMP8, Syt2, and other proteins. Here, we designed and screened a …

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Evaluation Of Vancomycin Based On Risk Factors In Emergent And Critically Ill Patients, Morgan Ragsdale, Lisa Hal Zimmerman, Elizabeth Messana, Derek Volgyi Jan 2022

Evaluation Of Vancomycin Based On Risk Factors In Emergent And Critically Ill Patients, Morgan Ragsdale, Lisa Hal Zimmerman, Elizabeth Messana, Derek Volgyi

Conference Presentation Abstracts

INTRODUCTION: Methicillin-resistant Staphylococcus aureus (MRSA) infections are associated with prolonged hospital length of stay and mortality rates up to 20%. Risk factors for MRSA and presumed type of infection often guide vancomycin prescribing. This study evaluated the presence of MRSA risk factors in emergent and critically ill patients who received vancomycin therapy. METHODS: This retrospective study evaluated emergent and critically ill patients who received vancomycin for at least 24 hours for a presumed infection from 1/2020—3/2020. Patients were excluded if vancomycin was administered for surgical prophylaxis. Patients were divided into groups: MRSA Risk (MRSA-R) vs MRSA No Risk (MRSA-NR). MRSA …

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Guide To Common Shallow Sponges Of St. Thomas, Usvi, Deborah Gochfeld, M. Cristina Diaz Jan 2022

Guide To Common Shallow Sponges Of St. Thomas, Usvi, Deborah Gochfeld, M. Cristina Diaz

Faculty and Student Publications

No abstract provided.

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