Pharmacy and Pharmaceutical Sciences Commons^™

Fixed-Dose Prothrombin Complex Concentrate Versus Weight-Based Dose For Reversal Of Factor Xa Inhibitors, Kevin Chau, Bryce Winn, Peter Martsin

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Cytotoxic Activity Of Non-Specific Lipid Transfer Protein (Nsltp1) And Proteomic Evaluation Of Heparin-Binding Proteins From Ajwain (Trachyspermum Ammi) Seeds, Saud Alshammari

Pharmaceutical Sciences (PhD) Dissertations

Trachyspermum ammi, commonly known as ajwain, is a member of the Apiaceae family. It is a therapeutic herbal spice with diverse pharmacological properties, used in traditional medicine for various ailments. However, all previous studies were conducted using small molecule extracts, leaving the protein’s bioactivity undiscovered. The present study demonstrated the antiproliferative activity of ajwain nsLTP1 in MCF-7, AsPC-1, and MCF10A cell lines and its structural stability in human serum and high-temperature conditions. The antiproliferative activity of ajwain nsLTP1 was evaluated in MCF-7 and AsPC-1 cell lines using an MTT assay. Annexin V-FITC and PI staining were used to detect the …

Discovery Of Ojt010 As A Novel Inhibitor Of Severe Acute Respiratory Syndrome Coronavirus 2, Manvir Kaur

Dissertations (2016-Present)

The current pandemic of coronavirus disease (COVID-19) caused by the highly infectious pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents a global public health challenge. The emergence of deadly SARS-CoV-2 variants with mutations on the viral genes has made it more imperative to discover therapeutics that target the host receptors for COVID-19 treatment. Therefore, our research has targeted the critical host entry receptors: Angiotensin-converting enzyme-2 (ACE2) for SARS-CoV-2 entry into the human cells. SARS-CoV-2 is an enveloped RNA beta coronavirus that infects human cells via interaction with the ACE2 receptor, followed by viral replication and virus dissemination. Spike protein …

Evaluation Of Pharmacist-Led Transitions Of Care (Toc) Discharge Pilot Program For Reducing 30-Day Readmission Rates In Patients With Chronic Obstructive Pulmonary Disease (Copd, Ann Tong, Hyesoo Chae, Addison Pang, Tony Lucchi

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Promoting Adult Pneumococcal Vaccinations Through Pharmacy And Provider Educational Campaigns, Krysia Lesniak

Senior Honors Projects

No abstract provided.

Antimicrobial Stewardship On Hospital Discharge: Pharmacist Intervention On Antibiotic Prescribing Practices, Jenny Zhu, Chinh Nguyen, Brent Footer

Providence Pharmacy PGY1 Program at Providence Milwaukie and Providence Newberg Medical Centers 2022

No abstract provided.

Content And Activity Of Cytochrome P450 3a In Rat Brain Microsomes And Mitochondria, Nouf Alshammari

Pharmaceutical Sciences (MS) Theses

The potential contribution of CYP3A in brain microsomes and mitochondria is crucial to designing appropriate therapeutic strategies and preventing toxicities. Until recently, there has been limited data reported in the literature with respect to CYP3A activity and its expression in the brain tissue. The reason for this limitation is most likely the relatively low level of CYP3A in the brain tissue. To this end, the primary purpose of this study is to develop a CYP3A functional assay in rat brain mitochondria and microsomes to determine the Michaelis-Menten kinetics of the formation of CYP3A-mediated hydroxylated metabolites of midazolam by UPLC-MS/MS. We …

Generation Of A More Immunogenic Fh Vlp Platform To Support Covid-19 Vaccine Development, Jewel E. Voyer, Xinyuan Chen Phd.

Senior Honors Projects

The SARS-CoV-2 based pandemic has seen almost a million deaths in just the United States according to the CDC. This number is due to the increase of variants of COVID-19, therefore calling a demand in vaccine production. Vaccine adjuvants and carriers have been studied to increase the immunogenicity and safety of a variety of immunizations. Flagellin fused Hepatitis B core (FH) virus like particles (VLP) has been studied to have beneficial effects of TLR5, IL6 levels, and lack of body temperature rise in murine study. The FH platform also provides an improvement from its predecessors FljB alone which is a …

Investigating Hybrid Cyclic/Linear And Linear Peptides As Vehicles For Nucleic Acid Delivery, Abdulelah Alhazza

Pharmaceutical Sciences (MS) Theses

Small interfering RNA (siRNA) and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated Protein 9 (Cas9) are advanced biotechnological approaches that have been able to temporarily downregulate gene expression through post-transcription RNA interference or permanently knockdown a protein via creating a mismatch in DNA, respectively. Nucleic acids are anionic and hydrophilic molecule, which cannot enter the cell through passive diffusion and/or interaction with the cell membrane. Cell-penetrating peptides (CPPs) offer a unique carrier for nucleic acid delivery, where positively charged components of CPP bind to the negatively charged nucleic acid and the hydrophobic components enhance the interaction with cell membrane, and …

Standardized Pharmacist Led Medication Review In Patients With Recent Falls, Christopher Houpt, Natsuki Kubotera

Providence Pharmacy PGY2 Program at Providence Medical Group 2022

No abstract provided.

The Impact Of Remote Optimization Of Guideline-Directed Medical Therapy In Patients With Nyha Stage Ii And Iii Heart Failure, Maurice N. Tran, Christine Doran, Trevor Laursen, Kellie Graybosch, Jacob Abraham

Providence Pharmacy PGY2 Program at Providence Medical Group 2022

No abstract provided.

Evaluating The Impact Of Ambulatory Care Clinical Pharmacy Services In The Pediatric Population, Sheila Prabhu, Bonnie Jiron, Vivian Tang

Providence Pharmacy PGY2 Program at Providence Medical Group 2022

No abstract provided.

Protocol Analysis Of An Antimicrobial Renal Dose Protocol At A Large, Tertiary Medical Center, Nicole Hulsebus, Meagan Greckel, Brent Footer

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Prescribing Patterns Of Antipsychotics For Agitation Or Delirium Management In Non-Critically Ill Patients, Emily Chang, Pamela Levine

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Dalbavancin Utilization And Associated Clinical Outcomes Within A Large, Integrated Health System, Meagan Greckel, Brent Footer

Providence Pharmacy PGY2 Program at Providence Medical Group 2022

No abstract provided.

Effects Of Pharmacist Intervention On Blood Pressure In Black Versus White Patients, Angela Kim, Benjamin Rosati, Dawn Fuke

Providence Pharmacy PGY2 Program at Providence Medical Group 2022

No abstract provided.

Retrospective Impact Of Covid-19 Pandemic On Hypertension Management In Primary Care, Carly Barnes, Jayme Johnston, Judy Wong

Providence Pharmacy PGY2 Program at Providence Medical Group 2022

No abstract provided.

Preoperative Phytonadione Supplementation For Mitral Valve Intervention Hemostasis, Katherine M. Nguyen, Joshua Francis, Celine Munoz, Torin P. Fitton

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Evaluation Of A Discharge Medication Access Service Program At Two Large Tertiary Medical Centers, Eva Huang, Theresa Morikawa, Adam Saulles

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Evaluation Of Specialty Pharmacy Productivity Metrics To Create An Updated Standardized Productivity Tool, David Kim, Adam Saulles, Ryan Bradley

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Evaluating The Impact Of A Pharmacist Run Pharmacotherapy Service On Hepatitis C Outcomes In A Large Integrated Health-System, Jessica Hendrix, Charmaine Hunt, Judy Perkins

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Evaluation Of A Beta-Lactam Antibiotic Allergy Assessment Tool For Patients Receiving Surgical Prophylaxis, Katelynn Tran, Alyssa B Christensen, Tobias Pusch, Jennifer Marfori

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

A Review Of The Clinical And Cost Effectiveness Of Intravenous And Intramuscular Pharmacological Treatment On Acute Agitation In Patients Admitted To The Emergency Department, Ryan Ferris, Carol Keller

Providence Pharmacy PGY1 Program at Providence Milwaukie and Providence Newberg Medical Centers 2022

No abstract provided.

Rifaximin (Xifaxan) Therapy Initiation During Hospitalization And Access Facilitation At Discharge, Phuong Phan, Theresa Morikawa, Adam Saulles

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2022

No abstract provided.

Amphiphilic Cyclic Cell-Penetrating Peptides Containing Tryptophan And Arginine As Anticancer Agents And Drug Delivery System, Khalid Zoghebi

Pharmaceutical Sciences (PhD) Dissertations

Amphiphilic cyclic cell-penetrating peptides composed of an increasing number of alternative tryptophan (W) and arginine (R) were synthesized and evaluated as a molecular transporter and for their ability to deliver doxorubicin (Dox) and large molecular weight molecules, such as siRNA and proteins. We prepared a cyclic peptide containing alternative tryptophan (W) and arginine (R) residues and a lysine containing a free side chain amino group. Cyclic peptide [(WR)8WK βA] was conjugated through the free side chain amino group of β-alanine with Dox via a glutarate linker to afford [(WR)8WK]bA-Dox conjugate. The conjugate inhibited the cell viability of ovarian adenocarcinoma (SK-OV-3) …

Targeting Neuronal Nitric Oxide Synthase (Nnos) For Melanoma Treatment, Shirley Tong

Pharmaceutical Sciences (PhD) Dissertations

Human cutaneous melanoma is the most aggressive form of skin cancer and the incidence rates have continued to increase over the years. Neuronal nitric oxide synthase (nNOS) produces nitric oxide (NO) has been found to be overexpressed in human melanoma and the expression of nNOS is induced by interferon-gamma (IFN-γ). In our studies, nNOS has been implicated in IFN-γ-stimulated melanoma progression and the inhibition of nNOS using novel inhibitors effectively inhibited IFN-γ-stimulated tumor growth in a xenograft mouse model. Programmed death-ligand 1 (PD-L1) is overexpressed in melanoma and plays an important role in suppressing the immune system ^12-14. Our …

The Credible Empa-Reg Clinical Trials: Impacts Of Empagliflozin On Patients With Type 2 Diabetes Mellitus And At Risk Of Adverse Cardiovascular Events, Janai D. Minga

Honor’s College Freeman Research Journal

Background and Literature Review: There still exists limited evidence regarding the potential of effects of an inhibitor of sodium–glucose cotransporter 2 known as empagliflozin when it is added as part of the standard care when treating type 2 diabetes patients with a high risk of cardiovascular morbidity and mortality. A significant number of studies have investigated the potential impacts of empagliflozin in lowering the risk of death from heart failure related problems. Available literature reviews and meta-analysis are in consensus that the empagliflozin has positive effects when used to lower the glucose level in the blood of patients with …

Patient Harm Associated With Illegal Online Sellers Of Covid- 19 Drug Products: A Year In Review, Kyla Rae Maloney

Undergraduate Honors Thesis Collection

As the online marketplace continues to expand, more patients are turning to the internet for their needs, including COVID-19 pharmaceuticals. However, the current online marketplace is saturated with illegal sellers offering substandard and falsified (SF) products with the potential of causing harm to patients. The primary objective of this thesis is to identify documented cases of harm resulting from illegal online sale of SF COVID-19 related drug or vaccine products. This review utilizes reports by the Medicines Quality Monitoring Globe (MQM Globe) to assess patient harm associated with illegal online sales of COVID-19 marketed pharmaceuticals. This review found 28 references …

The Effect Of Covid-19 On Substance Use And Mental Health On A College Campus, Georgia Coffman

Undergraduate Honors Thesis Collection

In this research the authors surveyed a university population to determine the impact COVID-19 has had on substance use and mental health. Current research provides significant data indicating worsening mental health and substance use. This paper looks at how applicable those trends are to a small, private university in Indianapolis, Indiana. The data included 261 respondents composed of students, faculty, and staff of the university. The results reveal college students, faculty, and staff experienced statistically significant increases in feelings of unhappiness, depression, loneliness, hopelessness, agitation, and irritability during the pandemic compared to pre-pandemic. Data analysis of survey responses reveals COVID-19 …

Integrating Pharmacists In Hfref Outpatient Care To Improve Use Of Guideline-Directed Medical Therapy, Roy Robertson Md, Mindy Flanagan Phd, Kris Howard Pharmd, Elizabeth Meisberger Pharmd, Emily Keltner Bs, Ma, Lovekirat Singh Ms, Carly Daley Phd, Shauna Wagner Bsn, Rn, Tammy Toscos Phd, Michael Mirro Md, Facc, Fhrs, Faha

Health Services and Informatics Research

Background: Guideline directed medical therapy (GDMT) is the cornerstone of reducing mortality and morbidity in patients with heart failure with reduced ejection fraction (HFrEF); however, uniform prescribing remains low. There is potential for multidisciplinary care teams, including pharmacists, to improve GDMT use in outpatient care for patients with HFrEF. Investigation is needed to understand the impact of pharmacists in outpatient HFrEF care on GDMT prescribing.

Objectives: To examine the impact of integrating a pharmacist into an outpatient cardiology setting on GDMT prescription rates during HFrEF-related clinic visits.

Methods: This retrospective chart review study examined cardiology clinic visits (HF clinic, “general …