Pharmacy and Pharmaceutical Sciences Commons^™

Science-Based Regulation Of Pharmacological Substances In Competition Horses, Jacob Machin

Theses and Dissertations--Toxicology and Cancer Biology

Current testing methodologies within equine forensic toxicology focus on arbitrary thresholds and zero-tolerance policy. Modern analytical chemistry’s limits of detection are low enough that oftentimes femtogram-per-milliliter amounts of a substance can readily be identified in both blood and urine of a horse. For most pharmacologically relevant compounds, these concentrations have no relevance to pharmacological effect. It is therefore crucial that testing methodologies to determine appropriate thresholds and cut-offs be developed that are driven by biological activity rather than arbitrary limits of detection. This dissertation looks to address this by suggesting a system of calculated Effective Plasma Concentrations by which a …

Development Of An Online Warfarin Dosing Platform Using R Programming Language To Facilitate Healthcare Professional Duties And Limit Medication Related Errors., Monther Alsultan

Graduate Research Posters

Development of an online warfarin dosing platform using R programming language to facilitate healthcare professional duties and limit medication related errors.

Monther Alsultan, Joshua M. Morriss, Daniel Contaifer Jr, Suad Alshammari; Silas Contaifer, Rachel W Flurie, Dayanjan S. Wijesinghe

Department of Pharmacotherapy and Outcome Sciences

Objective: 1) Gain experience in developing platform agnostic, fully operational and clinically relevant web applications for effective pharmacist led patient care. 2) Create a decision- support tool using open source software to facilitate evidence-based management therapy of warfarin in clinical settings where it is available for everyone to use at anytime and anywhere.

Introduction: Healthcare …

Digging Deeper: Improving Health Communication With Patients, Jennifer Ko, Miranda Steinkopf, Abby A. Kahaleh, Sharon Connor

Pharmacy Faculty Books and Book Chapters

At the end of this activity, students will be able to:

• Identify five theories and models that can be used to facilitate the patient-provider health communication process
• Describe opportunities to optimize communication with patients in healthcare settings
• Apply health communication theories within patient care, providing specific approaches and language to utilize

A Case Of Primary Infertility Treated With Icsi And Tesa, Saumya Raj

Digital Journal of Clinical Medicine

No abstract provided.

2021 Apothecary, Southwestern Oklahoma State University

Apothecary

It is with great honor we present the 2021 Apothecary issue. This year’s Apothecary was made possible by the provision of generous financial contributions from many stores, businesses, and Southwestern College of Pharmacy alumni. We greatly appreciate and thank you for your continued support.

The Apothecary staff would like to thank Dr. David Ralph and Adina Foust for their patience, countless hours, and unfailing efforts throughout this year. We also want to give huge thanks to the SWOSU Design Studio for their hard work in creating this year’s amazing cover and dividers. You always help bring our ideas to life …

2021 Edition, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - 2021 Edition

Nsu College Of Pharmacy_Brochure_2021, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Development Of Mucoadhesive Polymeric Nanoparticles For Intranasal Delivery Of Favipiravir In Treating Sars-Cov-2 Infection, Khent Alcantara

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nanoparticles (NPs) have been used as an effective carrier for transmucosal delivery of drugs through their prolonged residence time and deposition, or the enhanced permeation through the mucosa. In this study, we aimed to design a nanocarrier using the combined mucoadhesive (M) properties of chitosan (CS) and alginate (ALG) polymers for the intranasal delivery of favipiravir (FVR) in treating SARS-CoV-2 infection. The optimized FVR-loaded mucoadhesive CS-coated ALG-NPs (FVR-MCS-ALG-NPs) rendered suitable size (233.5 nm), zeta potential (-21.6 mV), loading capacity (26.0%), and encapsulation efficiency (84.6%) for transmucosal delivery. Superior mucoadhesiveness and higher permeation and deposition in the porcine nasal mucosa of …

Development Of Thiol Specific Fluorogenic Benzofurazan Derivatives For Live Cell Subcellular Organelle Thiol Imaging, Shenggang Wang

Electronic Theses and Dissertations

No abstract provided.

Design, Synthesis, And Evaluation Of Glutathione Derivatives As Brain Targeting Agents, Yue Huang

Electronic Theses and Dissertations

Treatment of central nervous system (CNS) diseases, such as Alzheimer’s disease, Parkinson’s diseases, and brain tumors, is still a challenge due to the existence of the blood-brain barrier (BBB). The BBB as a membrane barrier that separates systemic blood circulation from the CNS is structurally formed by endothelial cells, astrocyte, pericyte and neurons and is one of the crucial protection mechanisms for the CNS. The BBB protects the brain by preventing foreign compounds (non-endogenous compounds) from entering the brain and helps maintain brain homeostasis. In addition, the presence of drug efflux pumps (i.e., P-glycoproteins, multidrug-resistance proteins) in the BBB helps …

Development And Evaluation Of Wound Healing Property Of In-Situ Hydrogel Formulation For Topical Delivery Of Short-Chain Hyaluronic Acid In Dental Use, Porniweat Rosaming

Chulalongkorn University Theses and Dissertations (Chula ETD)

Regeneration of damaged periodontal tissues becomes one of the biggest challenges that is hard to overcome, even without the presence of any pathogens. Tissue engineering was proposed as a possible technique for the lost tissues’ restoration. In this study, methacrylated hyaluronic acid (MeHA) hydrogel was developed with different concentrations of low molecular weight (short-chain) hyaluronic acid to achieve the hydrogels with suitable physical properties and biological properties for dental tissue regeneration. The results revealed that short-chain hyaluronic acid (sHA) could interfere with some behaviors of networking systems; however, overall properties (including gelation time, mechanical properties, swelling and degradation profiles, and …

Effect Of 5-O-(N-Boc-L-Alanine)-Renieramycin T In The Suppression Of Lung Cancer Stem Cells, Darinthip Suksamai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cancer stem cells (CSCs) drive aggressiveness and metastasis by utilizing stem cell-related signals. In this study, 5-O-(N-Boc-L-alanine)-renieramycin T (OBA-RT) was demonstrated to suppress CSC signals and induce apoptosis. OBA-RT exerted cytotoxic effects with a half-maximal inhibitory concentration of approximately 7 µM and mediated apoptosis as detected by annexin V/PI and nuclear staining assays. Mechanistically, OBA-RT exerted dual roles, activating p53-dependent apoptosis and concomitantly suppressing CSC signals. A p53-dependent pathway was indicated by the induction of p53 and the depletion of anti-apoptotic Mcl-1 and Bcl-2 proteins. Cleaved PARP was detected in OBA-RT-treated cells. Interestingly, OBA-RT exerted strong CSC-suppressing activity, reducing the …

Anti-Addictive Activity Of Quinuclidine Derivatives In Nicotine-Induced Conditioned Place Preference Test In Mice, Saranda Nianpanich

Chulalongkorn University Theses and Dissertations (Chula ETD)

Quinuclidine derivatives (s)-T1, (s)-T2, and (s)-T6 are the ligands of α3β4 nicotinic acetylcholine receptor (nAChR). α3β4 nAChRs are highly expressed in medial habenula (MHb). The MHb connects to the brain rewarding pathway and mediates nicotine induce rewarding effect. Various α3β4 nicotinic acetylcholine antagonists have been investigated for their anti-addictive effect in animal models of nicotine addiction. The present study was aimed to evaluate the anti-addictive effects and mechanisms of quinuclidine derivatives, (s)-T1, (s)-T2, and (s)-T6 in nicotine-induced conditioned place preference (CPP) in mice. In the first experiment, mice received either nicotine (0.5 mg/kg, s.c.), (s)-T1 (1, 3, or 10 mg/kg, …

Reward-Related Effects Of Amphetamines Administered By Electronic Cigarette, Lucas Wohler

Theses and Dissertations

While e-cigarette vaporizers are primarily used for the delivery of nicotine, they can also be used to administer a wide range of other substances of abuse including stimulants such as d-amphetamine and methamphetamine. Methamphetamine and prescription amphetamines are widely abused throughout the United States and across the world leading us to believe there may be abuse potential with vaping methamphetamine as vaping becomes increasingly popular. In the present study, methamphetamine and amphetamine vapor were assessed using vapor capture methods. The vapor samples were then analyzed using liquid chromatography mass spectroscopy (LC-MS). Three experiments were carried out to examine the abuse …

Overcoming Mechanisms Of Acquired And Innate Doxorubicin Resistance Using Nanomedicine And Tumor-Associated Macrophage Immunotherapy, Rashed M. Almuqbil

Theses and Dissertations

ABSTRACT

Overcoming Mechanisms of Acquired and Innate Doxorubicin Resistance Using Nanomedicine and Tumor-Associated Macrophage Immunotherapy

By Rashed M. Almuqbil, Pharm.D.

Director: Sandro R.P. da Rocha, PhD

Cancer is a leading cause of death worldwide. The available treatment for solid tumors may include surgery, radiotherapy, immunotherapy, and chemotherapy or a combination of all those regimens. Chemotherapy is widely used in the treatment of both lung cancers and breast cancer, including metastases, irrespective of type and stage. The poor rates of survival can be attributed to late diagnosis, and due to the development of acquired and innate chemoresistance. Lung tumors are intrinsically …

Standardization Of E-Cigarette Research: Addressing The Analysis Of Total Nicotine And Free Base Nicotine In E-Cigarettes, Vinit Gholap

Theses and Dissertations

Electronic cigarettes (e-cigarettes) are one of the major sources of exposure to nicotine, an addictive chemical. Since 2016, the Food and Drug Administration (FDA) has started regulating these products under the Tobacco Control Act yet, specifications about the nicotine content in these products have not been established. In e-cigarettes, nicotine concentration ranges from 0 to >50mg/mL. Additionally, several e-cigarette related parameters have been identified which can affect nicotine delivery to users. Of these factors, nicotine forms (protonated and free base) have been found to play a significant role in nicotine absorption profiles yet, a limited and contradictory research is available …

The Time Trial® Network Facilitates Rapid Clinical Trial Activation, Patient Screening, And Enrollment In Molecularly Targeted Trials, Stephanie O'Leary, Megan Shulman, Kevin Ritt, Meghan Degele, Ewelina Protomastro, Jennifer Clauson, Amy Franzen, Ian Churchill Anderson, Minal A. Barve, David N. Oubre, Victor Priego, Angela Saverimuthu, Francis Mark Senecal, Raju Kumar Vaddepally, Kimberly L. Blackwell, Matthew M. Cooney

Articles, Abstracts, and Reports

No abstract provided.

Isolation Of Marker Compounds From Copaiba Essential Oil And Mimosa Pigra For Quality Evaluation Of Dietary Supplements, Mohammed Hawwal

Electronic Theses and Dissertations

Natural products have been used as a primary means of treating illness since ancient times, and they remain an important pool of U.S. FDA approved drugs. Approximately 33% of all current pharmaceutical medications discovered between 1981 and 2014 are either natural products or derived from natural products (Newman and Cragg 2016). The process of isolating specialized metabolites from medicinal plants has led to the development of particularly important medicines worldwide (Rakotomalala, Agard et al. 2013) such as Taxol® from Taxus brevifolia Nutt. (Taxaceae) and salicylic acid from the bark of Salix spp. This research is composed of five chapters; the …

Evaluation Of Albumin Use In A Community Hospital Setting: A Retrospective Study Looking At Appropriate Use And Prescribing Patterns., Timothy Coyle, Samuel John

PCOM Scholarly Works

PURPOSE: Albumin has been shown to be safe and effective in clinical practice for a wide variety of indications. The purpose of this medication use evaluation is to quantify the use of albumin in the community hospital setting based on indication and prescribing department.

METHODS: This study is a retrospective, single-center, chart review over a 6-month period of 186 patients aged 18 and older who were treated with IV human albumin 5% or 25% at a single 202-bed community hospital setting from February 1, 2020, to August 1, 2020. A chart review was completed for each patient and the data …

Late-Stage Product Development And Approvals By Biotechnology Companies After Initial Public Offering, 1997-2016, Laura M. M. Mcnamee, Ekaterina Galkina Cleary, Sunyi Zhang, Usama Salim, Fred D. Ledley

Natural & Applied Sciences Faculty Publications

Purpose: This work describes the late-stage product portfolios of the biotechnology companies that completed initial public offerings (IPOs) from 1997 to 2016. We asked whether these emerging companies continue to develop innovative, biologic products and produce the innovation promised by the early biotechnology industry.

Methods: We identified therapeutic products that reached Phase III development from 1997 to 2016, the characteristics of the products, the dates of the initiation of Phase III and product approval, proxy indicators of the innovativeness of each product, and the contribution of each biotechnology company. Companies were characterized by IPO window and clinical status of the …

ปัจจัยที่สัมพันธ์กับพิษต่อไตในผู้ป่วยมะเร็งที่ได้รับยาเคมีบำบัดกลุ่มแพลตินัม, ปทิตตา ลิ่มสกุล

Chulalongkorn University Theses and Dissertations (Chula ETD)

การศึกษานี้เป็นการศึกษาเชิงสังเกตเพื่อหาปัจจัยที่สัมพันธ์กับการเกิดพิษต่อไตจากยาเคมีบำบัดกลุ่มแพลตินัมในผู้ป่วยมะเร็งชาวไทย เก็บข้อมูลจากเวชระเบียนผู้ป่วยที่อายุตั้งแต่ 18 ปีขึ้นไป ที่ได้รับสูตรยาเคมีบำบัดกลุ่มแพลตินัม ณ โรงพยาบาลจุฬาลงกรณ์ ระหว่างวันที่ 1 มกราคม พ.ศ. 2561 ถึง 31 ธันวาคม พ.ศ. 2561 โดยการประเมินพิษต่อไตประเมินจากระดับซีรัมครีเอทินีนที่เพิ่มขึ้นจากค่าพื้นฐานอย่างน้อยร้อยละ 25 ในการศึกษามีผู้ป่วย 240 คน อายุเฉลี่ย 55.6 ± 12.6 ปี เป็นเพศหญิงร้อยละ 55 ส่วนใหญ่เป็นมะเร็งระบบทางเดินอาหาร ร้อยละ 36.3 เป็นมะเร็งระยะแพร่กระจายร้อยละ 60 โดยส่วนใหญ่จะได้รับยาเคมีบำบัดกลุ่มแพลตินัมร่วมกับยาเคมีบำบัดชนิดอื่นในการรักษาร้อยละ 70.4 และได้รับรังสีรักษาร่วมด้วยร้อยละ 32.9 พบอุบัติการณ์การเกิดพิษต่อไต 63 คน (ร้อยละ 26.3) ผลการวิเคราะห์ถดถอยพหุคูณพบว่ามีปัจจัยที่สัมพันธ์กับการเกิดพิษต่อไตจากยาเคมีบำบัดกลุ่มแพลตินัมทั้งหมด 5 ปัจจัย โดยเป็นปัจจัยเสี่ยง 4 ปัจจัย ได้แก่ มีคะแนนสมรรถภาพร่างกาย ECOG PS 2 (ORadj = 11.447, 95%CI 1.84-71.40, p = 0.009) น้ำหนักตัวตั้งแต่ 60 กิโลกรัมขึ้นไป (ORadj = 2.200, 95%CI 1.05-4.63, p = 0.038) มีโรคประจำตัวตั้งแต่ 2 โรคขึ้นไป (ORadj = 2.884, 95%CI 1.30-6.38, p = 0.009) และโรคมะเร็งในระยะลุกลาม (ORadj = 4.595, 95%CI 1.30-16.28, p = 0.018) และปัจจัยป้องกัน 1 ปัจจัย คือ การได้รับคาร์โบพลาตินหรือออกซาลิพลาติน (ORadj = …

Cholesterol-Lowering And Probiotic Properties Of Selected Lactic Acid Bacteria, Engkarat Kingkaew

Chulalongkorn University Theses and Dissertations (Chula ETD)

Ninety strains of lactic acid bacteria (LAB) isolated from fermented foods and bark of Tamarindus indica were screening cholesterol-lowering effects, selected and identified based on the phenotypic, chemotaxonomic characteristics and 16S rRNA gene sequence analysis. They were identified as Companilactobacillus farciminis (5 strains), C. formosensis (10 strains), C. futsaii (6 strains), C. pabuli (4 strains), Enterococcus thailandicus (2 strains), Lactiplantibacillus argentoratensis (3 strains), Lactiplantibacillus pentosus (10 strains), Lactiplantibacillus plantarum subsp. plantarum (17 strains), Lactococcus lactis subsp. lactis (2 strains), Lentilactobacillus buchneri (8 strains), Limosilactobacillus fermentum (2 strains), P. pentosaceus (12 strains) and each of En. durans, En. hirae, En. lactis, …

A Role For The Hydroxybenzoic Acid Metabolites Of Flavonoids And Aspirin In The Prevention Of Colorectal Cancer, Ranjini Sankaranarayanan

Electronic Theses and Dissertations

Flavonoids are a group of polyphenolic compounds, with established antioxidant properties, that are present ubiquitously in plants, fruits, and vegetables. Their universal presence in nature is evident by the fact that more than 4000 types of flavonoids have been identified till date. Additionally, they have also become part of the daily diet through consumption of fruits such as berries, grapes, pomegranate, and cherries, and vegetables such as onions, kale, and eggplant. High levels of flavonoids are also consumed through beverages such as tea and red wine. Numerous studies have demonstrated that a diet rich in flavonoids decreases the incidences of …

A Brief Review Of Fda’S Novel Tools For Ensuring Pharmaceutical Quality In The Human Drug Supply Chain, Heather R. Campbell, Robert A. Lodder

Pharmaceutical Sciences Faculty Publications

Purpose

Pharmaceutical manufacturers execute quality control operations and Good Manufacturing Practices (GMP) to provide safe drugs. The Federal Drug and Food Administration (FDA) is tasked with ensuring manufacturers are performing such procedures. Faced with limited resources the FDA has developed novel tools to aid pharmaceutical manufacturing oversight. This paper briefly reviews these tools.

Methods

Current inspection approaches employed by the FDA are identified by searching the FDA’s guidances, the Code of Federal Regulations, public reports and other online resources.

Outcomes

Industry

A risk-based site selection model (SSM) is used to prioritize on-site inspections for FDA investigators. Theoretically, the SSM allows …

School Of Pharmacy Intellectual Property Report Fy21, Second Quarter Report - Revised July 6, 2021, Soumyajit Majumdar

U. S. Patents, School of Pharmacy

School of Pharmacy Intellectual Property Report FY21, Fourth Quarter Report (as of 12/31/2020) - Revised July 6, 2021

School Of Pharmacy Intellectual Property Report Fy21, Third Quarter Report - Revised July 6, 2021, Soumyajit Majumdar

U. S. Patents, School of Pharmacy

School of Pharmacy Intellectual Property Report FY21, Third Quarter Report (as of 3/31/2021) – Revised July 6, 2021

Responses Of Predatory Myxobacteria To Prey Signaling Molecules & Features Of A Pseudomonas Prey Avoiding Predation, Shukria Akbar

Electronic Theses and Dissertations

Gram-negative unicellular myxobacteria, along with their multicellular lifestyle andbiologically active specialized metabolites, are known for the predatory interactions with Gram-negative/ Gram-positive bacteria and fungi. Although myxobacterial predation range have been exploited extensively, little is known about the prey associated molecules contributing to myxobacterial predator-prey dynamics. By employing transcriptomics and untargeted metabolomics approaches, we demonstrate two structurally distinct classes of signaling molecules from Gram-negative bacterial prey elicit significant omics responses from myxobacteria, Myxococcus xanthus and Cystobacter ferrugineus. An overlapping and general response to acylhomoserine lactones, whereas a distinctive response to a quinolone signaling molecule is observed from both myxobacteria. Similarly, by …

Responses Of Myxobacteria To Plant-Related Chemosignals Suggests Their Roles In The Rhizobiome, Barbara Iyare Adaikpoh

Electronic Theses and Dissertations

In the rhizosphere, plants curate and maintain distinct rhizobiome, some of which serve as secondary defense mechanisms against pathogenic microorganisms. Additionally, in response to biotic stress, plants generate phytohormones which regulate signaling pathways to activate systemic resistance. These phytohormones contribute to the chemical space within the rhizosphere in addition to other low-molecular-weight metabolites used for cell-to-cell communication within species and across kingdoms. However, little is known about the influences of stress-related phytohormones on beneficial bacteria even though biocontrol strategies abundantly explore plant-beneficial microorganisms to manage pathogens in agricultural systems. Myxobacteria are competent predators of plant pathogens and have demonstrated responses …

Influence Of Rage Signaling On Cellular Communication In Diabetes-Mediated Vascular Calcification, Amber Michelle Kennon

Electronic Theses and Dissertations

Chronic hyperglycemia is one of the main characteristics of type 2 diabetes mellitus (T2DM). With the increased prevalence of T2DM, the risk of cardiovascular complications, including heart attack or stroke, is increased. Complications linked to the vasculature are increased vascular calcification (VC) or mineral deposition within the medial layer of conducting arteries. Under calcification conditions, vascular smooth muscle cells (VSMCs) undergo an osteogenic switch to an osteoblast-like cell and begin producing bone proteins. Chronic hyperglycemia can also result in increased extracellular matrix (ECM) synthesis, accumulation, and crosslinking. One of the cell types responsible for increased ECM synthesis are ‘activated’ fibroblasts …

Correlation Of Cyp2d6 Polymorphisms And Pharmacokinetics Of Primaquine In Thai Army Population On The Thailand-Cambodia Border Area, Waritda Pookmanee

Chulalongkorn University Theses and Dissertations (Chula ETD)

The antimalarial drug primaquine (PQ), which has minimal activity, has to be metabolized through the CYP2D6 enzyme for its most effective antimalarial activity. The stable form 5,6-orthoquinone-primaquine (5,6-PQ) was used as a representative marker for PQ active metabolite quantification. However, the relationship between CYP2D6 polymorphisms and the pharmacokinetic (PK) parameters of 5,6-PQ has not been reported. We assessed the relationship between CYP2D6 polymorphisms and PKs of both PQ and 5,6-PQ in the Thai army population on the Thailand-Cambodia border area. We found that 56% of volunteers were CYP2D6 normal metabolizers (CYP2D6 NMs) and 44% were CYP2D6 intermediate metabolizers (CYP2D6 IMs). …