Pharmacy and Pharmaceutical Sciences Commons^™

The Impact Of The Covid-19 Pandemic On Self-Reported Management Of Chronic Conditions, Hyllore Imeri, Erin Holmes, Shane Desselle, Meagen Rosenthal

Faculty and Student Publications

Chronic conditions (CCs) management during the COVID-19 pandemic and the impact of the pandemic on patient activation (PA) and health locus of control (HLOC) remain unknown. This cross-sectional online survey study examined the role of COVID-19 pandemic-related worry or fear in PA and HLOC among patients with CCs. Individuals with CCs (n = 300) were recruited through MTurk Amazon. The questionnaire included sociodemographic questions, the Patient Activation Measure, and the Multidimensional Health Locus of Control–Form B. Out of the 300 participants, 9.7% were diagnosed with COVID-19, and 7.3% were hospitalized. Patients with cancer, chronic kidney disease, chronic obstructive pulmonary disease, …

Simultaneous Estimation Of Cinnamaldehyde And Eugenol In Essential Oils And Traditional And Ultrasound-Assisted Extracts Of Different Species Of Cinnamon Using A Sustainable/Green Hptlc Technique, Ahmed I. Foudah, Faiyaz Shakeel, Mohammed H. Alqarni, Samir A. Ross

Faculty and Student Publications

A wide range of analytical techniques are reported for the determination of cinnamaldehyde (CCHO) and eugenol (EOH) in plant extracts and herbal formulations either alone or in combination. Nevertheless, sustainable/green analytical techniques for the estimation of CCHO and EOH either alone or in combination are scarce in the literature. Accordingly, the present research was carried out to establish a rapid, highly sensitive, and sustainable high-performance thin-layer chromatography (HPTLC) technique for the simultaneous estimation of CCHO and EOH in the traditional and ultrasound-assisted methanolic extracts of Cinnamomum zeylanicum, C. burmannii, and C. cassia and their essential oils. The simultaneous estimation of …

Isolation Of Catechins From Cycas Armstrongii Miq. Of An Egyptian Origin, Ahmed Ismail, Mohamed M. Radwan, Hossam M. Hassan, Abeer S. Moawad

Faculty and Student Publications

The phytochemical investigation of Cycas armstrongii Miq. leaves and twigs using different chromatographic techniques led to the isolation of three catechin monomers; catechin (1), epicatechin (2), and epigallocatechin-3-gallate (3), for the first time from this species. The chemotaxonomic significance of the isolated compounds is discussed in the rest of this article.

Hiv-1 Tat And Morphine Differentially Disrupt Pyramidal Cell Structure And Function And Spatial Learning In Hippocampal Area Ca1: Continuous Versus Interrupted Morphine Exposure, William D. Marks, Jason J. Paris, Aaron J. Barbour, Jean Moon

Faculty and Student Publications

About half the people infected with human immunodeficiency virus (HIV) have neurocognitive deficits that often include memory impairment and hippocampal deficits, which can be exacerbated by opioid abuse. To explore the effects of opioids and HIV on hippocampal CA1 pyramidal neuron structure and function, we induced HIV-1 transactivator of transcription (Tat) expression in transgenic mice for 14 d and co-administered time-release morphine or vehicle subcutaneous implants during the final 5 d (days 9–14) to establish steady-state morphine levels. Morphine was withheld from some ex vivo slices during recordings to begin to assess the initial pharmacokinetic consequences of opioid withdrawal. Tat …

An Evaluation Of Antipseudomonal Dosing On The Incidence Of Treatment Failure, Brandon K. Hawkins, Mary Joyce B. Wingler, David A. Cretella, Katie E. Barber

Faculty and Student Publications

Introduction: Significant mortality is associated with delays in appropriate antibiotic therapy in Pseudomonas aeruginosa infections. The impact of empiric dosing on clinical outcomes has been largely unreported. Methods: This retrospective cohort compared treatment failure in patients receiving guideline-concordant or guideline-discordant empiric therapy with cefepime, meropenem, or piperacillin/tazobactam. Patients with culture-positive P. aeruginosa between 1 July 2013 and 31 July 2019 were eligible for inclusion. Patients with cystic fibrosis, polymicrobial infection, and urinary or pulmonary colonization were excluded. The composite primary outcome was treatment failure, defined as (1) therapy modification due to resistance/perceived treatment failure, (2) increased/unchanged qSOFA, or (3) persistent …

Understanding Of Pharmacy Students Towards Antibiotic Use, Antibiotic Resistance And Antibiotic Stewardship Programs: A Cross-Sectional Study From Punjab, Pakistan, Khezar Hayat, Shazia Jamshed, Meagen Rosenthal, Noman Ul Haq

Faculty and Student Publications

Antibiotic resistance (ABR) is a significant issue for public health globally. An adequate understanding of ABR and the approaches used to tackle ABR, including antibiotic stewardship programs, are vital. This study aimed to get an insight into antibiotic use, ABR, and antibiotic stewardship programs among pharmacy students of Punjab, Pakistan. This multicenter study was undertaken among final (fifth) year undergraduate pharmacy students of 7 universities of Punjab, Pakistan. A paper-based self-administered questionnaire comprising 48-items was utilized for data collection. Descriptive and inferential statistics were employed for data analysis. This study included a total of 296 respondents with a response rate …

A Modified Delphi Involving Laboratory Faculty To Define Essential Skills For Pharmacy Graduates, Jeanne E. Frenzel, Brandon T. Nuziale, Courtney L. Bradley, Jordan M. Ballou

Faculty and Student Publications

Objective. To define essential skills for Doctor of Pharmacy (PharmD) graduates that are needed in the four most common sectors of pharmacy practice as determined by expert faculty who instruct within pharmacy skills laboratories. Methods. A three-round Delphi method was used to establish consensus. In the first round, participants were asked what skills were needed by students at entry to practice in community, health-system, ambulatory care, and managed care pharmacy settings. In rounds two and three, participants were asked to rate each skill with a level of importance using a 10-point Likert scale (1=not important to 10=very important). Results. In …

Expression Of Trefoil Factor 3 Is Decreased In Colorectal Cancer, Ingrid Espinoza, Sumit Agarwal, Amit Reddy, Veena Shenoy

Faculty and Student Publications

In colorectal cancer (CRC), high expression of trefoil factor 3 (TFF3) is associated with tumor progression and reduced patient survival; however, bioinformatics analyses of public 'omics' databases show low TFF3 expression in CRCs as compared to normal tissues. Thus, we examined TFF3 expression in CRCs and matching normal tissues to evaluate its role in CRC progression. TFF3 gene expression was char- acterized using the bioinformatics portal UALCAN (http:// ualcan.path.uab.edu). Tissue microarrays (TMAs) of archival CRC specimens (n=96) were immunostained with anti-human TFF3 antibodies. Immunohistochemical (IHC) staining intensity was semi-quantitatively scored. For this cohort, the median follow-up was 5.4 years. Associations …

Exploring The Chemical Space Of 1,2,3-Triazolyl Triclosan Analogs For Discovery Of New Antileishmanial Chemotherapeutic Agents, Julia Fernández De Luco, Alejandro I. Recio-Balsells, Diego G. Ghiano, Ana Bortolotti

Faculty and Student Publications

Triclosan and isoniazid are known antitubercular compounds that have proven to be also active againstLeishmaniaparasites. On these grounds, a collection of 37 diverse 1,2,3-triazoles based on the antitubercular molecules triclosan and 5-octyl-2-phenoxyphenol (8PP) were designed in search of novel structures with leishmanicidal activity and prepared using different alkynes and azides. The 37 compounds were assayed againstLeishmania donovani, the etiological agent of leishmaniasis, yielding some analogs with activity at micromolar concentrations and againstM. tuberculosisH37Rv resulting in scarce active compounds with an MIC of 20 μM. To study the mechanism of action of these catechols, we analyzed the inhibition activity of the …

Multisite Study Assessing The Effect Of Cognitive Test Anxiety On Academic And Standardized Test Performance, Adam N. Pate, Stephen Neely, Daniel R. Malcom, Kimberly K. Daugherty

Faculty and Student Publications

Objective. To evaluate the degree of cognitive test anxiety (CTA) present in student pharmacists at multiple pharmacy programs in the United States and to determine if there are associations between self-reported CTA and relevant academic outcomes. Methods. All 2018-2019 advanced pharmacy practice experience (APPE) students from three US Doctor of Pharmacy (PharmD) programs (N=260) were invited to participate in the study. Participants completed a validated 37-question survey that included the Cognitive Test Anxiety Scale-2 (CTAS-2) along with demographics-related questions. Responses were analyzed using analysis of variance (ANOVA), Kruskal Wallace, and multiple linear regression where appropriate. Results. One hundred twenty-four students …

The Impact Of Two Longitudinal Professionalism Courses On Student Pharmacists’ Empathy, Brent N. Reed, Stuart T. Haines, Erin R. Holmes

Faculty and Student Publications

Objective. To determine whether empathy increased in first-year student pharmacists after completing longitudinal professionalism courses at two schools of pharmacy, identify potential moderators, and assess whether students’ conceptualization of empathy changed with time. Methods. Surveys to assess empathy and other variables were administered to student pharmacists at baseline and at the end of two professionalism courses. Baseline and follow-up scores were compared to detect changes over time. Multivariable analysis was used to identify predictors of empathy scores. Factor analysis was performed to ascertain changes in the dimensionality of empathy. Results. Students’ demographics and baseline empathy scores differed between the two …

Oligodendroglioma, Bala Seshank Akshit Reddy Mettu Dr, Rudresh Hiremath Dr, Vinay Raj Dr

Radiology Teaching Files

CLINICAL HISTORY:

A 39 year old male patient presented to our institute with one episode of GTCS and post-ictal headache. No other relevant history was present, no similar complaints were present in the past and no comorbidities. On examination, neurological examination was within normal limits. Blood-work up was also within normal limits.

Post Primary Pulmonary Tuberculosis: A Case Report, Abhigna S. Moudgalya Dr, Vikram Patil Dr

Radiology Teaching Files

No abstract provided.

Splenic Artery Pseudoaneurysm Secondary To Necrotizing Pancreatitis – A Rare Lethal Complication, Vinay Raj Dr, Divya Vishwanatha Kini Dr

Radiology Teaching Files

CLINICAL HISTORY:

A 35-year-old male patient presented with history of massive hemoptysis associated with pain abdomen and breathlessness since the past 3 days. Patient had no prior co-morbidities; however was a chronic alcoholic and smoker since the past 15 years. No hospital admissions in the past.

Structure Based Optimization Of Benzimidazole 4-Carboxamide Scaffold Led To Picomolar Poly(Adp-Ribose) Polymerase Inhibitors, Griffin J. Coate

Theses and Dissertations

Poly(ADP-ribose) polymerase 1 (PARP1) is one of several proteins in the PARP superfamily consisting of 17 proteins with a conserved ART domain. Out of the 17 total proteins, 6 show clear evidence of catalytic activity. These 6 proteins are comprised of PARP1 through PARP4 as well as TNKS1 and TNKS2. PARP1 is thoroughly characterized and has been implicated for its role in various forms of cancer. Due to the role PARP1 plays in the DNA repair pathway, targeting PARP1 for inhibition has led to two distinct anticancer strategies. The first focusing on combinatorial drug therapy with a DNA damaging anticancer …

Characterization Of Cardiovascular Function In Adult Offspring Following Prenatal Exposure To Methamphetamine, Hasitha Chavva

Theses, Dissertations and Capstones

Methamphetamine (meth) is a synthetic stimulant, and its abuse is a significant public health concern in the United States and all over the world. Methamphetamine is a highly addictive drug, and its abuse is widespread among women of child-bearing age. The consequences of methamphetamine abuse are not only of relevance to pregnant women, but also their unborn children, as amphetamine type substances can cross the placental barrier and effect the fetus during gestation. Most previous studies investigating the impact of prenatal methamphetamine exposure on the offspring have focused on neurological and behavioral effects. The goal of this study was to …

Mechanisms Of Apoptosis Induced By Actinomycin D In Aerodigestive Tract Cancers, Adeoluwa Ayodeji Adeluola

Theses, Dissertations and Capstones

Upper aerodigestive tract cancers including cancers of the oral cavity, pharynx, larynx, esophagus, and lungs are the most prevalent cancers and leading causes of cancer-related deaths. Collectively, over 300,000 new cases and 146,500 deaths are projected within the US in the year 2021. Drug-associated toxicities, as well as resistance to therapy (intrinsic and acquired), are big challenges for successfully treating these cancers. Recent studies have shown that combining low-dose actinomycin D with existing therapies is a promising strategy to reduce toxicity (cyclotherapy) and to overcome resistance. The development of these treatment strategies however requires an understanding of the molecular mechanisms …

Structural Characterization And In Vitro Antiproliferative Activity Of Non-Specific Lipid Transfer Protein 1 (Nsltp1) From Fennel (Foeniculum Vulgare) Seeds, Mekdes Megeressa

Pharmaceutical Sciences (PhD) Dissertations

Non-specific lipid transfer proteins (nsLTPs) are cationic proteins involved in intracellular lipid shuttling, in growth and reproduction, as well as in defense against pathogenic microbes. Even though the primary and spatial structures of some nsLTPs from different plants indicate their similar features, they exhibit distinct lipid-binding specificities signifying their various biological roles that dictate further structural study. The present study determined the complete amino acid sequence, in silico 3D structure modeling, and in vitro antiproliferative activity of nsLTP1 from fennel (Foeniculum vulgare) seeds.

Fennel is a member of the family Umbelliferae (Apiaceae) native to southern Europe and the …

School Of Pharmacy Intellectual Property Report, Fy22, First Quarter Report, Soumyajit Majumdar

U. S. Patents, School of Pharmacy

No abstract provided.

Pharmacist Impact On Cardiology Bundle Payments For Care Improvement And Patient Outcomes, Megan Wagner Pharmd, Jordan Holder Pharmd, Priya Verma Pharmd, Bcacp

Parkview Pharmacy Department

2021 ASHP Midyear Clinical Meeting - Poster ID:1127833

Background: The Medicare Bundle Payments for Care Improvement (BPCI) Initiative was created to better the transitions of care process, incentivize hospitals to reduce readmission rates, and improve overall care in hospitals nationwide.• As this payment structure has incorporated additional diagnoses, it has become a popular focus of research into interprofessional and pharmacy-based interventions to reduce readmission rates. • Data shows that pharmacist-led interventions during transitions of care can significantly contribute to decreased readmission rates. • This study examines the review process of the ambulatory-based cardiology pharmacists at Parkview Health in evaluating cardiology …

Equity For All: Providing Accessible Healthcare For Patients Living With Disabilities, Michelle L. Blakely, Sharon E. Connor, Jennifer Ko

Pharmacy Faculty Books and Book Chapters

At the end of this activity, students will be able to:

• Identify relevant resources to assist patients living with disabilities
• Recommend appropriate patient-specific resources to minimize barriers to health
• Identify strategies to enhance the healthcare experience of patients living with disabilities
• Describe the policies that currently exist to enhance care for patients living with disabilities

Let Your Pharmacist Be Your Guide: Navigating Barriers To Pharmaceutical Access, Jennifer Ko, Miranda Steinkopf, Sharon E. Connor

Pharmacy Faculty Books and Book Chapters

At the end of this case, students will be able to: • Describe policy, organizational, and individual factors that contribute to barriers to accessing medications and pharmaceutical care • Identify resources to improve access to affordable medications for uninsured and underinsured patients • Recommend appropriate resources for obtaining affordable medications

New Benzoxazole Derivatives As Antiprotozoal Agents: In Silico Studies, Synthesis, And Biological Evaluation, Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Mohamed A. Zaki, Enas I.A. Mohamed

Faculty and Student Publications

Background. Benzoxazole derivatives have different biological activities. In pursuit of designing novel chemical entities with antiprotozoal and antimicrobial activities, benzoxazolyl aniline was utilized as a privileged scaffold of a series of (3-benzoxazole-2-yl) phenylamine derivatives, 3-benzoxazoloyl acetamide, and butyramide derivatives. Methods. These novel analogs were synthesized in straightforward simple chemistry without any quantitative chromatographic separations in reasonable yields. The biological evaluation of all target compounds as potential antimalarial, antileishmanial, antitrypanosomal, and antimicrobial agents was performed by various well-established cell-based methods. Results. Compounds 6d and 5a showed promising biological screening data. The amidation of 3-benzoxazolyl aniline 1 with the chloroacetyl functional group …

Effect Of Lutrol® F Grades (Poloxamer) On Dissolution Of Hot-Melt Extruded Kollidon® Va64-Felodipine Matrices, Saad M. Alshahrani, Abdullah Alshetaili, Bjad K. Almutairy, Michael A. Repka

Faculty and Student Publications

The objective of this study was to assess the potential of Lutrol® F grades as polymeric surfactants for dissolution enhancement of Kollidon®VA64-drug matrices produced by hot-melt extrusion (HME). The poorly soluble model drug felodipine (FEL) with a medium melting point was selected for this study. Two different grades of Lutrol® F (also called Kolliphor® P grades) were added into the HME systems to investigate their influence on the drug-incorporated matrices. Two grades of Lutrols i.e., Lutrol® F 68 (Kolliphor®P 188) and Lutrol® F 127 (Kolliphor®P 407) were studied as polymeric solubilizers. FEL was mixed with Kollidon®VA64, with or without Lutrol®F …

Use Of Adaptive Learning Technology To Promote Self-Directed Learning In A Pharmacists’ Patient Care Process Course, Jennifer Toth, Meagen Rosenthal, Kristen Pate

Faculty and Student Publications

Objective. To evaluate student changes in self-directed learning (SDL) in a Pharmacists’ Patient Care Process (PPCP) course using adaptive learning technology (ALT). Methods. The Pharmacists’ Patient Care Process was delivered using traditional teaching methods in fall 2018 and ALT in spring 2019. First-year student pharmacists were surveyed three times throughout the academic year on SDL factors. Focus groups were conducted at the end of the spring semester to identify perceptions of course delivery. Multilevel linear modeling and qualitative content analysis were used to evaluate survey responses and focus group feedback, respectively. Results. Ninety-two of 106 students completed all three surveys. …

Evaluation Of Benefits Associated With Chemotherapy Dose-Banding Practices, Alexis Mann Pharmd, Mba, Kyle Becker Pharmd, Mba, Bcop, Jesse Christman Pharmd, Bcop

Parkview Pharmacy Department

2021 ASHP Midyear Clinical Meeting / Virtual Meeting / Poster # 1130014

The objective of this study was to evaluate the benefit of applying a 10% rounding strategy with predetermined dose-bands to the current chemotherapy dosing policy at Parkview Health.

The Place And Role Of Pharmacy Benefit Management (Pbm) Companies In Us Healthcare System, George Mattis Ii

Electronic Theses and Dissertations

On average, prescription drugs cost US consumers more than any other developed country in the world. US drug makers claim that intermediaries in the prescription drug supply chain, companies called pharmacy benefit managers (PBM), are forcing them to increase their drug prices. PBMs counter that the discounts they receive from drug makers are channeled to insurers. This thesis will examine the role that PBMs play in the prescription drug supply chain and determine what effect they have on drug prices. This thesis will utilize a comparative static model, Structure, Conduct, Performance (SCP) framework to analyze the pharmaceutical manufacturing and the …

Selective Toxicity Of Mx106-4c, A Survivin Inhibitor, To Abcb1 Positive Multidrug Resistant Colon Cancer, Zining Lei

Theses and Dissertations

Multidrug resistance (MDR) is a major challenge in colon cancer chemotherapy, which is typically mediated by the overexpression of ATP-binding cassette (ABC) transporters, particularly ABCB1 (P-gp, MDR1). The application of ABCB1 inhibitors to overcome ABCB1-mediated MDR has been disappointing in the clinical settings. As an alternative approach, a synthetic analog of survivin inhibitor MX106, MX106-4C, was identified as a potent collateral sensitivity (CS) agent that selectively exerted more than 10-fold cytotoxicity on ABCB1 positive MDR colon cancer cell lines compared to cell lines with low ABCB1 expression. Biochemical assays revealed that MX106-4C did not affect the ATPase activity or the …

Self-Emulsified Nanoemulsion As Permeation Enhancer And Its Application For Intranasal Delivery Of Insulin, Kanyaphat Bunchongprasert

Theses and Dissertations

This study aimed to investigate the permeation enhancing property and safety of self-emulsified nanoemulsion (SEN) and use these findings to enhance insulin absorption through the nasal route.

The first part of the project was to identify the factors affecting cytotoxicity and permeation enhancement of SEN on Madin-Darby Canine Kidney (MDCK) cells, a widely used paracellular model. Twenty-six fatty acid esters (FAEs) commonly used in SEN were investigated. Among the FAEs (mono-, di-, and triesters), fatty acid monoesters (FAME) are the main excipient causing cytotoxicity and opening tight junction. The cytotoxicity of FAME in SEN was reduced with the presence of …

Particle Shape Engineering For Improved Drug Delivery To Peripheral Lungs By Non-Invasive Route, Snehal Shukla

Theses and Dissertations

Inhalation of therapeutics has been gaining importance owing to immense advantages offered by pulmonary route and have attracted significant advancements in the pharmaceutical field. However, pulmonary drug delivery has been challenging because of the complexity of the respiratory tract and the existing defense mechanism. The pulmonary drug delivery has experienced advances in approaches and strategies to combat the existing challenges by tailoring the physicochemical properties of the delivery carriers and enabling both localized as well as systemic delivery. Pulmonary drug delivery is governed by several biophysical parameters of the delivery carriers such as particle size, shape, density, charge, and surface …