Pharmacy and Pharmaceutical Sciences Commons^™

Expression Of Tryptophan 2,3-Dioxygenase In Metastatic Uveal Melanoma, Mizue Terai, Eric R Londin, Ankit Rochani, Emma Link, Bao Lam, Gagan Kaushal, Alok Bhushan, Marlana Orloff, Takami Sato

Kimmel Cancer Center Faculty Papers

Uveal melanoma (UM) is the most common primary eye malignancy in adults and up to 50% of patients subsequently develop systemic metastasis. Metastatic uveal melanoma (MUM) is highly resistant to immunotherapy. One of the mechanisms for resistance would be the immune-suppressive tumor microenvironment. Here, we have investigated the role of tryptophan 2,3-dioxygenase (TDO) in UM. Both TDO and indoleamine 2,3-dioxygenase (IDO) catalyze tryptophan and produce kynurenine, which could cause inhibition of T cell immune responses. We first studied the expression of TDO on tumor tissue specimens obtained from UM hepatic metastasis. High expression of TDO protein was confirmed in all …

A Real-World Analysis Of Patient Characteristics And Predictors Of Hospitalization Among Us Medicare Beneficiaries With Respiratory Syncytial Virus Infection, Veronique Wyffels, Furaha Kariburyo, Sandra Gavart, Roman Fleischhackl, Huseyin Yuce

Publications and Research

Introduction: Little has been published on respiratory syncytial virus (RSV) among Medicare patients at high risk (HR) of RSV complications due to age or comorbidity. Methods: Adult patients (at least 18 years of age) with at least 1 diagnostic code for RSV were identified using the 5% US Medicare database from 2011 through 2015. Patients were required to have continuous health plan enrollment for 180 days pre- and 180 days post-RSV diagnosis (baseline and follow-up periods, respectively). HR was defined as diagnosis of chronic lung disease, congestive heart failure, or weakened immune system for 180 days during the base-line period. …

Polymers For Extrusion‐Based 3d Printing Of Pharmaceuticals: A Holistic Materials–Process Perspective, Mohammad A. Azad, Deborah Olawuni, Georgia Kimbell, Abu Zayed Badruddoza, Md. Shahadat Hossain, Tasnim Sultana

Publications and Research

Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of ʹone size fits for allʹ. Using 3D printing, it is possible to design and develop complex dosage forms that can be suitable for tuning drug release. Polymers are the key materials that are necessary for 3D printing. Among all 3D printing processes, extrusion‐based (both fused deposition modeling (FDM) and pressure‐assisted microsyringe (PAM)) 3D printing is well researched for pharmaceutical manufacturing. It is important to understand which polymers are suitable for extrusion‐based 3D printing of pharmaceuticals …

Tobacco/Hiv-1-Induced Myeloid Cell-Derived Extracellular Vesicles In Hiv-1 Pathogenesis, Sanjana Haque

Theses and Dissertations (ETD)

Introduction. Smoking, which is highly prevalent in people living with HIV/AIDS, has been shown to exacerbate HIV-1 replication, in part via cytochrome P450 (CYP)-induced oxidative stress. CYP enzymes metabolize cigarette smoke condensate (CSC), causing oxidative stress and cytotoxicity. Our previous studies have demonstrated that CSC and specific CSC constituents, benzo(a)pyrene and nicotine, potentially induce CYPs, resulting in higher oxidative stress and subsequent exacerbation of HIV-1 replication in monocytes and macrophages. However, the exact mechanism behind tobacco-induced, oxidative stress-mediated enhancement of HIV-1 replication is still poorly understood. Extracellular vesicles (EVs) have recently gained attention for their unique nature as intercellular messengers …

Demarcation Of Sepsis-Induced Peripheral And Central Acidosis With Ph (Low) Insertion Cycle Peptide, Kelly E. Henry, Aisling M. Chaney, Veronica L. Nagle, Haley C. Cropper, Saghar Mozaffari, Chip Slaybaugh, Keykavous Parang, Oleg A. Andreev, Yana K. Reshetnyak, Michelle L. James, Jason S. Lewis

Pharmacy Faculty Articles and Research

Acidosis is a key driver for many diseases, including cancer, sepsis, and stroke. The spatiotemporal dynamics of dysregulated pH across disease remain elusive, and current diagnostic strategies do not provide localization of pH alterations. We sought to explore if PET imaging using hydrophobic cyclic peptides that partition into the cellular membrane at low extracellular pH (denoted as pH [low] insertion cycles, or pHLIC) can permit accurate in vivo visualization of acidosis. Methods: Acid-sensitive cyclic peptide c[E₄W₅C] pHLIC was conjugated to bifunctional maleimide-NO2A and radiolabeled with ⁶⁴Cu (half-life, 12.7 h). C57BL/6J mice were administered lipopolysaccharide (15 …

Pseudomonas And Bacillus As Potential Sources Of Novel Antibiotics, Cory Jayne, Dr. Lori Scott

Identifying and Characterizing Novel Antibiotic Producing Microbes From the Soil

With an increase in antibiotic resistance within the medical field the need for novel antibiotics is evident. Through collaboration with the Tiny Earth Project Initiative, we hope to find novel antibiotics through bacteria found in soil. We were able to successfully isolate two microbes that showed broad spectrum antibiotics against both Staphylococcus epidermis and Bacillus subtilis. Through further exploration and collaboration with the Tiny Earth Project Initiative, we might be able to discover novel antibiotics.

Identification Of Ebsulfur Analogues With Broad-Spectrum Antifungal Activity, Sylvie Garneau-Tsodikova, Huy X. Ngo, Sanjib K. Shrestha

Pharmaceutical Sciences Faculty Patents

The invention relates to novel ebsulfur analogues and novel pharmaceutical compositions comprising ebsulfur analogues. The invention also relates to novel methods of treating infections caused by fungal species comprising administration of ebselen, ebsulfur, and ebsulfur analogues.

Lavender Aromatherapy: Ready For Prime-Time Office Use?, Dennis J. Baumgardner

Journal of Patient-Centered Research and Reviews

The editor-in-chief of Journal of Patient-Centered Research and Reviews comments on the perioperative use of lavender aromatherapy and its potential to relieve pain and anxiety during minor primary care office procedures.

Δ9-Tetrahydrocannabinol Exposure During Rat Pregnancy Leads To Symmetrical Fetal Growth Restriction And Labyrinth-Specific Vascular Defects In The Placenta., Bryony V Natale, Katarina N Gustin, Kendrick Lee, Alison C Holloway, Steven R Laviolette, David R C Natale, Daniel B Hardy

Physiology and Pharmacology Publications

1 in 5 women report cannabis use during pregnancy, with nausea cited as their primary motivation. Studies show that (-)-△9-tetrahydrocannabinol (Δ9-THC), the major psychoactive ingredient in cannabis, causes fetal growth restriction, though the mechanisms are not well understood. Given the critical role of the placenta to transfer oxygen and nutrients from mother, to the fetus, any compromise in the development of fetal-placental circulation significantly affects maternal-fetal exchange and thereby, fetal growth. The goal of this study was to examine, in rats, the impact of maternal Δ9-THC exposure on fetal development, neonatal outcomes, and placental development. Dams received a daily intraperitoneal …

January 2020, Randy Curry, Cindy Brooks

RURAL ROCKS

Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy

Comprehensive Pharmacy Practice And Patient Care Php 548, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Antiproliferative And Apoptotic Effects Of Proteins From Black Seeds (Nigella Sativa) On Human Breast Mcf-7 Cancer Cell Line, Yamna Khursid, Basir Syed, Shabana U. Simjee, Obaid Beg, Aftab Ahmed

Pharmacy Faculty Articles and Research

Background

Nigella sativa (NS), a member of family Ranunculaceae is commonly known as black seed or kalonji. It has been well studied for its therapeutic role in various diseases, particularly cancer. Literature is full of bioactive compounds from NS seed. However, fewer studies have been reported on the pharmacological activity of proteins. The current study was designed to evaluate the anticancer property of NS seed proteins on the MCF-7 cell line.

Methods

NS seed extract was prepared in phosphate-buffered saline (PBS), and proteins were precipitated using 80% ammonium sulfate. The crude seed proteins were partially purified using gel filtration …

Medical Marijuana High On Drug Interaction, Shahrzad Ghanavi

All Publications

No abstract provided.

Postpartum Depression! One Iv And I Am Back To Happy!, Gabrielle Dubruille

All Publications

No abstract provided.

Lgbt – Gender Identification And Pharmacist Approach To Care Of The Patient, Alexandra Angel

All Publications

No abstract provided.

Updates On Human Immunodeficiency Virus (Hiv), Jose Ojeda

All Publications

No abstract provided.

Update On Oral Oncolytics, Elizabeth Osmon

All Publications

No abstract provided.

Update On Oral Oncolytics: A Focus On Hematology Drugs, Monica Tadros

All Publications

No abstract provided.

What A Blood Bath! Andexxa® Makes A Splash! Current Trends In Anticoagulation Reversal, Michael Pasqualicchio

All Publications

No abstract provided.

Oral Oncolytics, Gaines Kyna Gania

All Publications

No abstract provided.

Controlled Substance Validation, Claudia Martin Diaz, Jessica Hernandez, Laura Neubauer, Eduardo Guizan Corrales

All Publications

No abstract provided.

What A Blood Bath! Andexxa® Makes A Splash! Current Trends In Anticoagulation Reversal, Marianela Robainas

All Publications

No abstract provided.

Updates On Human Immunodeficiency Virus (Hiv), Eduardo Martinez Sanchez

All Publications

No abstract provided.

Precautions & Handling Of Hazardous Chemotherapeutic Agents, Paula Sayegh

All Publications

No abstract provided.

Clinical And Therapeutic Sciences Iv Php 528, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Study Of Cost Utilization Of Organophosphate And Zinc Phosphide Poisoning: A Prospective Observational Study, Girish P. Thunga Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Introduction and Aim: Pesticides and rodenticides have been useful for killing pests and rodents respectively but at the same time proven to be harmful to humans as well. They are easily available and accessible to the common people due to which they are often misused for self-harm predominantly in developing countries. There is a lot of burden on the healthcare system due to limited healthcare resources. This study aims to estimate the various costs incurred by the patients during the complete hospitalization period. Methodology: A prospective observational study was conducted in a tertiary care hospital. The patient related data was …

To Study The Treatment Pattern Of Paraquat Poisoning In A Tertiary Care Hospital: A Retrospective Analysis, Girish P. Thunga Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Introduction Paraquat poisoning is a major medical problem in many parts of Asia, Pacific nations, and America [1] . It is rapidly-acting, nonselective and relatively inexpensive due to which widespread use in the developing world is.An increased rate of morbidity and mortality is associated with Paraquat poisoning. General treatment includes gastrointestinal decontamination like treatment with activated charcoal and fuller's earth given to minimize the absorption Haemodialysis and Hemoperfusion also plays important role for elimination of poison. Immunosuppression is also widely practised with Dexamethasone, Cyclophosphamide and Methylprednisolone. Many evidences showed antioxidants such as N-Acetylcysteine also beneficial. However, there are no clear …

Effect Of Metformin In Wound Healing In Diabetic Foot Ulcer Patients –A Prospective Observational Study, Sonal M. Sekhar Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: Diabetic foot ulcers (DFUs) are one of the major complications of poorly controlled diabetes. The DFUs result due to the damage and breaking of the skin beneath it. The most commonly affected locations of DFUs are the extreme proximities of the toes. The wounds associated with foot ulcerations are the leading causes of the leg amputation. Metformin, a widely used anti- diabetic agent has a vital role in AMPK activation as well as plays an inhibitory effect on the mTOR, and Cyclin D1 pathways. Thereby causing a delay in the usual process of healing of wound in the patients. …

Evaluation Of Antimicrobial Agents With Potential To Develop Adverse Mental Health In Geriatrics, Sonal M. Sekhar Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: With advanced age, there is increased risk of various infections. Antimicrobial agents are majorly prescribed for management of these infections. Due to age-related physiological changes, many of the antimicrobial agents cause adverse mental health. Therefore, we evaluated the geriatric antimicrobial prescription to determine its potential to cause mental health issue. Objectives:  To prepare a checklist for antimicrobials which have the potential to cause adverse mental health.  Evaluate the geriatric antimicrobial prescription to determine its potential to cause mental health issue.  To determine antimicrobial-related mental health problems in geriatric patients. Methods: A prospective observational study was conducted …

Effectiveness Of Pictograms In Patients Or Caregivers In Healthcare Settings: A Systematic Review, Rajesh V Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: Pictograms are a graphical symbol that conveys a concept through its pictorial resemblance to a physical object, pictorial representation has shown to have a potential in enhancing patient knowledge. Methodology: The systematic review was conducted according to PRISMA guidelines. Randomized controlled trials including participants over 18 years older were included in the review. RCTs were included as it reduces certain type of bias by randomly allocating the participants. The risk of bias was assessed using Cochrane risk of bias tool, which assessed 5 different domains and scores were given according to their indication of low, high and unclear risk. …