Pharmacy and Pharmaceutical Sciences Commons^™

Options For Breast Cancer Prevention In High-Risk Patients, Ashley M. Overy, Lacey A. Shumate, Sarah M. Webb, Ashley E. Lehnert, Monica A. Weisenberger, Whitney N. Detillion, Andrew M. Roecker

Pharmacy and Wellness Review

Breast cancer is the most frequently diagnosed non-skin cancer in women, and one in eight women will develop breast cancer within their Iifetimes. Unfortunately, the strongest risk factors for breast cancer (i.e. age, family history, hormonal factors) are not easily modified. There is some evidence that chemopreventative drugs may be able to prevent breast cancer in high-risk patients. Tamoxifen and raloxifene have been shown to reduce the risk of breast cancer in high-risk women but may be associated with several serious adverse events. Clinical trials are currently in progress to determine if aromatase inhibitors are a viable alternative for breast …

A Review Of Dabigatran, An Oral Anticoagulant, Lindsey A. Hallman, Chad A. Rounds, Rebecca A. Carey, Nicole R. Hume, Karen L. Kier, James Spicer

Pharmacy and Wellness Review

Serious clinical complications associated with venous thrombotic embolism (VTE) necessitate prophylaxis in patient groups who are at high risk of VTE, specifically those recovering from orthopedic surgery with atrial fibrillation, with mechanical heart valves, at increased risk for stroke, or recovering post-MI. Currently, prophylaxis with warfarin, enoxaparin, or fondaparinux has been the standard of therapy, but these therapies each have their limitations. Dabigatran etexilate is an orally available pro-drug of dabigatran, a competitive, reversible, direct inhibitor thrombin (Factor lla). The agent is converted by esterases, and, thus, not associated with the complications of the CYP enzyme system. Dabigatran follows a …

Introduction & Medical Communications And Writing, Maggie Allen, Kate Klyczek, Anne F. Gentry

Pharmacy and Wellness Review

No abstract provided.

A Real World Assessment Of The Efficacy And Safety Of Switching From Tdf To Taf In Treatment Experienced Patients With Hiv Infection, Jaclyn O'Connor, Pharmd Candidate, Kaitlin N. Sassa, Pharmd, Jason J. Schafer, Pharmd, Mph, Bcps Aq-Id, Bcidp, Aahivp

College of Pharmacy Posters

Objective

• The primary objective of this study was to determine if patients maintain viral suppression after switching from TDF to TAF
• The secondary objective was to assess changes in renal function and serum cholesterol levels

Off-Label, On Brand: How Psychiatric Drugs Reached Unsuspecting Youths, Charles J. May, Danielle Hyams, Larisa Karr

Capstones

This capstone project takes a deep dive into the world of off-label medicine, specifically focusing on psychiatric drugs for children. Off-label medicine is common practice, but not many people understand the potential dangers of this practice if doctors are not forthcoming and honest with their patients about potential side effects. Throughout this report, we detail the experiences of youths who took antipsychotics and antidepressants for off-label purposes, and the life-changing side effects the experienced as a result.

https://medium.com/@charlie.may/off-label-on-brand-how-psychiatric-drugs-reached-unsuspecting-youths-cdcb22315789

Clinical And Therapeutic Sciences Ii Php 328, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Clinical And Therapeutic Sciences Iii Php 427, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Clinical And Therapeutic Sciences V Php 527, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Clinical And Therapeutic Sciences Iv Php 428, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Expanding Services Of A Pharmacist-Led Rural Mobile Health Clinic To School-Aged Children And Working Class Parents, Megan Stephan, Karen Kier, Michael Rush

Pharmacy Faculty Scholarship

No abstract provided.

Implementation Of Liberate Protocol With Focus On Delirium In An Acute Care Community Hospital’S Medical And Cardiovascular Intensive Care Units, Jasmine M. Hossler, Emily A. Sedio, Karen L. Kier

Pharmacy Faculty Scholarship

No abstract provided.

Evaluation Of A Perioperative Multi-Modal Analgesia Approach In Regards To Enhanced Recovery After Surgery, Seth Wollenhaupt, Jeremy Ebert, Karen Kier

Pharmacy Faculty Scholarship

No abstract provided.

Implementation Of A Pharmacist-Driven Prescription Delivery And Home Visitation Service In A Rural Community, Clayton L. Miller, Katie Westgerdes, Michael Rush, Karen L. Kier, Megan Stephan

Pharmacy Faculty Scholarship

No abstract provided.

Analysis Of Ashp Pgy1 Residency Placement Rates With Student Pharmacist Characteristics, Bradley S. Troyer, Karen L. Kier, Heather P. Roecker

Pharmacy Student Scholarship

No abstract provided.

Integrating Pharmacist Involvement Into A Student-Led, Peer-Reviewed Journal, Crystal Zheng, Nicole A. Mcelroy, Karen L. Kier

Pharmacy Student Scholarship

No abstract provided.

Development And Validation Of A High-Performance Thin-Layer Chromatographic Method For The Quantitative Analysis Of Vitexin In Passiflora Foetida Herbal Formulations, Ahmed Ibrahim Foudah, Prawez Alam, Y. T. Kamal, Saleh Ibrahim Alqasoumi, Mohammed Hamed Alqarni, Samir A. Ross, Hasan Soliman Yusufoglu

Faculty and Student Publications

© 2019 Dehon et al. Introduction: Formative evaluations of clinical teaching for emergency medicine (EM) faculty are limited. The goal of this study was to develop a behaviorally-based tool for evaluating and providing feedback to EM faculty based on their clinical teaching skills during a shift. Methods: We used a three-phase structured development process. Phase 1 used the nominal group technique with a group of faculty first and then with residents to generate potential evaluation items. Phase 2 included separate focus groups and used a modified Delphi technique with faculty and residents, as well as a group of experts to …

Evaluating The Effects Of Pre-Treatment With Diltiazem Bolus In Acute Atrial Fibrillation, Marwah Dabaja, Tara Jellison Pharmd, Mba, Fashp

Parkview Pharmacy Department

Presented at: American Society of Health-System Pharmacists Midyear Clinical Meeting, Las Vegas, NV. December 2019

Objective: Evaluate the impact of administering a diltiazem bolus for the initial treatment of atrial fibrillation at Parkview Regional Medical Center (PRMC)

Working Together To Improve Outcomes: Physician-Pharmacist Collaborative Agreement For Uncontrolled Type 2 Diabetes, Frank Sperrazza Do, Laura M. Mauro Bs, Pharmd, Bcps, Lauren Geerlof Bcps, Jennifer Cicconetti Pharmd, Bcps, Bcgp, Michelle Omari-Okyere Bs, Pharmd, Bcps, Bcgp

Department of Pharmacy

No abstract provided.

Clinical Interventions Documented By Appe Students: Results From A Pilot Study, Elizabeth Laughlin, Bsps, Danielle Mayer, Pharmd, Bcacp, Sarah Lynch, Pharmd, Bcacp

College of Pharmacy Posters

Primary Objective: Evaluate the types of drug therapy problems identified by student pharmacists and the results of these interventions.

Secondary Objective: Evaluate trends in trends of what type of interventions are identified and how they are defined.

Pharmacy Newsletter : December 2019, Pharmacy Department

Department of Pharmacy Archives

Content:

• FDA Safety Alert | Ranitidine Recall & AKUH Approaches
• Truth About Patients with Penicillin Allergies
• House Hold Poisoning | How to Keep Your Child Safe
• Protective effect of Co-Enzyme Q10 administration on propofol infusion syndrome (PRIS)
• Antibiotic Prophylaxis in Animal Bite
• Role of Vitamin E In Non-Alcoholic Fatty Liver Disease

Preserving Ancient Cultures Through Medicinal Narratives, Mckenzie Jewel Moss

Honors Projects

“Preserving Ancient Cultures through Medicinal Narratives” is a comprehensive project that takes an interdisciplinary approach to understanding the effects that culture has on health. The project as a whole includes the initial work and readings I performed to better understand differences in healing between the cultures found throughout South America, where Inca culture is still prevalent, and that of the Unites States, as well as an independent documentary. The documentary contains my own personal commentary complemented by video clips of interviews I performed with individuals living in South America.

A Recombinant Cholera Toxin B Subunit Variant (Ctb-Kdel) Exhibits Unique Colon Mucosal Healing Effects That Have Therapeutic Implications For Inflammatory Bowel Disease., Joshua Mark Royal

Electronic Theses and Dissertations

This dissertation uncovers the mechanism and explores the utility of a recombinant cholera toxin B subunit (CTB) variant containing a KDEL endoplasmic reticulum (ER) retention motif (CTB-KDEL) as a drug candidate for the treatment of inflammatory bowel disease (IBD). CTB is a mucosal immunomodulatory protein that induces robust mucosal and systemic antibody responses. This well-known biological activity has been exploited in cholera prevention (as a component of Dukoral® vaccine) and vaccine development for decades. On the other hand, several studies have investigated CTB’s immunotherapeutic potential in the treatment of inflammatory diseases such as Crohn’s disease and asthma. Here, we reveal …

Expert Search For "Antibiotics For The Urgent Management Of Symptomatic Irreversible Pulpitis, Symptomatic Apical Periodontitis, And Localized Acute Apical Abscess", Kelly K. O'Brien

Expert Search Strategies

This search strategy was constructed to support the research for the peer reviewed article listed above. Full article abstract:

Background

Patients with pulpal and periapical conditions often seek treatment for pain, intraoral swelling, or both. Even when definitive, conservative dental treatment (DCDT) is an option, antibiotics are often prescribed. The purpose of this review was to summarize available evidence regarding the effect of antibiotics, either alone or as adjuncts to DCDT, to treat immunocompetent adults with pulpal and periapical conditions, as well as additional population-level harms associated with antibiotic use.

Type of Studies Reviewed

The authors updated 2 preexisting systematic …

The Discovery And Development Of Thienopyrimidines As Inhibitors Of Helicobacter Pylori, Alex Kagabo Mugengana

Theses and Dissertations (ETD)

The rate of successful treatment for Helicobacter pylori infections, with the clarithromycin triple therapy, is only 75%. The triple therapy, which consists of a proton pump inhibitor and two broad-spectrum antibiotics such as clarithromycin and amoxicillin, is becoming less effective due to the rise of strains with resistance against these antibiotics. In the search for narrow spectrum drugs for the treatment of H. pylori infections, a high-throughput screen was performed to identify selective compounds against H. pylori. This screen revealed two selective and structurally related thienopyrimidines. Structure-activity relationship of the thienopyrimidines against H. pylori was examined through the synthesis of …

Structure Elucidation Of A Pyrrolobenzodiazepine Alkaloid And A Biologically Active Polyketide Produced By Rhodococcus Sp. Mtm3w5.2 Via Two-Dimensional Nmr Spectroscopy, Garrett Johnson

Electronic Theses and Dissertations

As the battle against ever-increasing drug resistence bacteria rages on, novel and sometimes more complex natural products can be used to combat this. In this study, two-dimensional NMR techniques were utilized to collect a complete spectral data set for two natural products. The first structure, a synthesized Pyrrolobenzodiazepine alkaloid natural product was confirmed through these methods. The second, a strain of Rhodococcus, MTM3W5.2, produces a novel antibacterial molecule in broth cultures and the active compound was fractionated using a Sephedex LH-20 column. Chromatographic purification yielded a pure sample at 58.90 minutes, RT.58. HRMS data deduced an exact mass of …

Retrospective Review Of Ticagrelor And Clopidogrel Use In Adult Patients Receiving Dual Antiplatelet Therapy After Percutaneous Coronary Intervention In A Community Hospital, Jessica Hernandez, Laura Neubauer, Radhan Gopalani, Heidi Clarke, Marcus St. John

All Publications

No abstract provided.

Cangrelor Use In Patients Undergoing Percutaneous Coronary Intervention Or Neurointervention With Stent Placement In A Community Hospital, Radhan Gopalani, Jessica Justiz, Monica Tadros, Stephanie Palma, Andrea Marr-Peralto

All Publications

No abstract provided.

Timing Of Anticoagulation Therapy In Patients Admitted With A Primary Diagnosis Of Ischemic Stroke Or Transient Ischemic Attack Due To Non-Valvular Atrial Fibrillation, Claudia Martin Diaz, Eduardo Guizan Corrales, Felipe De Los Rios La Rosa, Heidi Clarke, Jonatha Kline, Sylvia Marrero, Radhan Gopalani, Star Belnap

All Publications

No abstract provided.

Evaluating Antipsychotic Prescribing In The Intensive Care Unit And Across The Continuum Of Care, Michael Pasqualicchio, Heidi Clarke

All Publications

Purpose/Background: The 2018 Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU (PADIS) recommend against both typical and atypical antipsychotic use for delirium in critically ill patients. This recommendation is based on evidence showing that these medications are not associated with shorter durations of delirium, mechanical ventilation, intensive care unit (ICU) length of stay, or reduced mortality. There are many long term complications associated with the use of antipsychotics including QTc prolongation, extrapyramidal symptoms, metabolic abnormalities, and anticholinergic effects. Regardless, antipsychotics remain the most common medication used …

Impact Of Serial Blood Glucose Monitoring And Treatment In Patients With Corticosteroid-Induced Hyperglycemia In The Inpatient Setting, Monica Tadros, Heidi Clarke, Radhan Gopalani, Stephanie Palma, Moe Shwin

All Publications

No abstract provided.