Pharmacy and Pharmaceutical Sciences Commons^™

Amoxicillin-Clavulanate Related Liver Injury, Devin Vaishnani Md, Pratikkumar Vekaria Md, Ravish Patel Md, Megan White Md, Marvin Vaishnani Md

Gastroenterology

Introduction: Recognition of Drug-induced Liver Injury (DILI) may be challenging as it is often diagnosis of exclusion, unavailability of diagnostic test and variability in presentation. Many antibiotics can cause DILI but Amoxicillin-Clavulanate has rare adverse reaction causing mixed cholestatic-hepatocellular injury. Since amoxicillin alone does not induce liver injury, combination of amoxicillin and clavulanic acid could be responsible for this adverse reaction. It can be due to metabolic idiosyncrasy or hypersensitivity mechanism. Case Report: 64-year-old female with no pertinent PMH presented to ER with abdominal pain and jaundice. She had abdominal pain for 4-5 days. Abdominal pain was constant and located …

Co-Prescription Network Reveals Social Dynamics Of Opioid Doctor Shopping, Brea L. Perry, Kai Cheng Yang, Patrick Kaminski, Meltem Odabas, Jaehyuk Park, Michelle M. Martel, Carrie B. Oser, Patricia R. Freeman, Yong-Yeol Ahn, Jeffery C. Talbert

Psychology Faculty Publications

This paper examines network prominence in a co-prescription network as an indicator of opioid doctor shopping (i.e., fraudulent solicitation of opioids from multiple prescribers). Using longitudinal data from a large commercially insured population, we construct a network where a tie between patients is weighted by the number of shared opioid prescribers. Given prior research suggesting that doctor shopping may be a social process, we hypothesize that active doctor shoppers will occupy central structural positions in this network. We show that network prominence, operationalized using PageRank, is associated with more opioid prescriptions, higher predicted risk for dangerous morphine dosage, opioid overdose, …

A Review Of The Food And Drug Administration Adverse Event Reporting System For Tramadol-Related Hypoglycemia, Katherine Juba, Robbert Van Manen, Shawn E. Fellows

Pharmacy Faculty/Staff Publications

Background: Hypoglycemia is a rare adverse effect of tramadol that is described in the medical literature and package insert. Objective: The purpose of this study was to review reports of tramadol and hypoglycemia in the Food and Drug Administration Adverse Event Reporting System (FAERS) database to determine a potential association. Methods: Disproportionality analysis with Bayesian correction was used to compare tramadol and hypoglycemia with other medications in FAERS. The results were considered significant if the fifth percentile of the Empirical Bayesian geometric mean distribution (EB05) >2. Logistic regression odds ratios was used to determine if age, diabetes medications, and renal …

Good Publication Practice Guidelines: Integrity, Completeness, Transparency, Accountability And Responsibility, Anne F. Gentry

Pharmacy and Wellness Review

No abstract provided.

2103. Emergency Department (Ed) Stewardship: Stratifying Ed Sepsis Order Sets By Penicillin (Pcn) Allergy Severity, Mary L. Staicu, Maryrose Laguio-Vila, Allison Ramsey, Kelly Conn, Kristin Woodring

Pharmacy Faculty/Staff Publications

Background:

The Surviving Sepsis Campaign Guidelines recommends administration of broad-spectrum antibiotics within 1 hour of sepsis diagnosis; electronic order sets drive antibiotic selection with pre-populated regimens based on the suspected infectious indication. Given the low rate of cephalosporin cross-reactivity in patients with a PCN allergy, we modified our ED sepsis order set (Images 1 and 2) to include cephalosporin options in patients with reported mild-to-moderate PCN reaction histories. This was a single-center, retrospective analysis evaluating the impact of this change on antibiotic prescribing and associated outcomes.

Methods:

An electronic medical record (EMR) report identified patients ≥18 years of age with …

172. Risk Factors For 30-Day Mortality In Patients With Staphylococcus Aureus Bacteremia At A Community Hospital: A Prospective Case–Control Study, Charles Hoffmann, Gordon Watkins, Patrick Desimone, Peter Hallisey, David Hutchinson, Stephen Colodny, Jeffrey Burkey, Amanda Michael, Jo-Anne Klein, Christina Welc

Pharmacy Faculty/Staff Publications

Background:

Staphylococcus aureus bacteremia (SAB) is associated with 30-day all-cause mortality rates approaching 20–30%. The purpose of this case–control study was to evaluate risk factors for 30-day mortality in patients with SAB at a community hospital.

Methods:

As part of an antimicrobial stewardship program (ASP) initiative mandating Infectious Diseases consultation for episodes of SAB, our ASP prospectively monitored all cases of SAB at a 341-bed community hospital in Jefferson Hills, PA from April 2017–February 2019. Cases included patients with 30-day mortality from the initial positive blood culture. Only the first episode of SAB was included; patients were excluded if a …

Foundational Pharmaceutical Sciences I Bps 337, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Clinical And Therapeutic Sciences I Php 327, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Phenylethynyl-Substituted Benzenes And Heterocycles For The Treatment Of Cancer, David S. Watt, Chunming Liu, Vitaliy M. Sviripa, Wen Zhang, Markos Leggas

Molecular and Cellular Biochemistry Faculty Patents

Halogenated phenylethynyl-substituted heterocycles that possess either an N-alkylamino or N,N-dialkylamino group attached to the heterocycle or halogenated phenylethynyl-substituted benzenes that a nitrogen-containing heterocycle attached to the benzene inhibit the proliferation cancer cells and are useful antineoplastic agents.

Unused Medication Collection: An Emerging Service-Learning Experience For Pharmacy Students, Anne E. Packard, Maryam Noureldin, A. Carmine Colavecchia, Patricia L. Darbishire, Jennifer Colavecchia

Purdue Journal of Service-Learning and International Engagement

While the U.S. makes up around 5% of the world’s population, we consume approximately 75% of the world’s prescription drugs—well over 4 billion prescriptions per year. Approximately one third of those are never used, creating an array of public health challenges. These challenges include land and water pollution; unintentional inappropriate use and unintentional human, pet, and wildlife poisonings; and intentional drug abuse and diversion. Misuse of prescription drugs now exceeds that of all illegal drugs combined. Reducing the number of medications prescribed is of primary importance, as well as collecting unnecessary medications from households and disposing of them through environmentally …

The Role Of The Pharmacy Team In Atrial Fibrillation Detection In Nonclinical Settings, Brian C. Hazelrigg, Monica L. Miller, Sotiris Antoniou, Jagjot Chahal, Sadeer Fhadil

Purdue Journal of Service-Learning and International Engagement

Atrial Fibrillation (AF) is a common cardiac/heart disease that increases a person’s risk of death, making early identification significant in overall disease management. Throughout my time in pharmacy school, I [Brian] have developed an interest in cardiology and research. During my last year of pharmacy school, I spent eight weeks at St. Bartholomew’s Hospital, in London, England, one of the largest cardiac centers within Europe, on an experiential training experience. While there, I had the opportunity to study specifics about many cardiac illnesses, with a focus on atrial fibrillation, and provide education to patients living with this disease. In addition …

Safe Medication Disposal In Underserved Communities, Elaina Etter

Purdue Journal of Service-Learning and International Engagement

Of the 130 Americans who will die each day from opioid overdose, 46 will have overdosed on prescription opioid medications. The opioid epidemic has become one of our nation’s largest public health crises. Because many individuals may have access to prescription medications of family members or friends, responsible medication disposal has become increasingly important to prevent harm.

This fall, I worked on a professional project at local Federally Qualified Health Centers (FQHCs), which aimed to increase education about safe medication disposal. These clinics provide comprehensive healthcare services to underserved patients, many of whom live in rural areas or have limited …

Professional Leadership Development, Jena Schlabach, Meagan Brandt, Olivia Vanscoy, Kasie Bellmann, Jenelle Sobotka, Marianne F. Ivey

Pharmacy and Wellness Review

No abstract provided.

Healthcare Delivery And Pharmacy Workforce: Pharmacy (Wo)Manpower - 2016 And Beyond..., Crystal Zheng, Mariah Steele, Noori Lee, Sabrina Hamman, Stanley Kent

Pharmacy and Wellness Review

No abstract provided.

Population Health Management, Data And Technology, Helena Ladd, Cody Hepp, Anna Mccloud, Hannah Granger, Mary Ellen Hethcox, Samuel Calabrese

Pharmacy and Wellness Review

No abstract provided.

Discussing The Future Of Drug Development And The Pharmaceutical Marketplace, Brittiany Feher, Brady Giles, Gina Jones, Karen Kier, Chet Kaczor

Pharmacy and Wellness Review

No abstract provided.

Professional Priorities To Optimize Patient Outcomes, Megan Bishop, Joelle Hall, Mikayla Shea, Katherine Liu, Steven J. Martin, John Armistead

Pharmacy and Wellness Review

No abstract provided.

The Road To Provider Status: Legislative Obstacles And Precursors, Todd A. Tucker Jr., Sarah Turley, Kaila Bollinger, Lara Long, Jenelle Sobotka, Amy Fanous

Pharmacy and Wellness Review

No abstract provided.

Accountable Care Organizations: What Pharmacists Should Know, Kaitlin M. Horton, Rachel J. Pucel, Alison L. Streinbrunner, Lindsay A. Fleegle, Donald L. Sullivan

Pharmacy and Wellness Review

No abstract provided.

Metformin And Cancer: Pharmacoepidemiology Considerations, Sarah Kradel, Christina Spinaris, Victoria Pennington, Adam Trimble, Lara Long, Natalie Dipietro

Pharmacy and Wellness Review

No abstract provided.

Sterile Compounding: Regulations Addressed After The Meningitis Outbreak Of 2012, Kelly M. Dye, Tara M. Tokar, Halle M. Orlinski, Heather Helsel, Marcia M. Worley

Pharmacy and Wellness Review

No abstract provided.

Adderall®: Understanding And Preventing Its Abuse Amongst College-Aged Students, Adam Trimble, Cody Hay, Lindsay Mark, Heather Helsel, Tom Kier

Pharmacy and Wellness Review

No abstract provided.

Different Types Of Board Certified Pharmacists, Taylor Alane Beale, Megan Ruffner, Joanne Kien Tran, Lindsay A. Fleegle, Jennifer J. Kline, Pat Parteleno

Pharmacy and Wellness Review

No abstract provided.

Common Questions And Answers Regarding Oarrs For Pharmacists, Brittany M. Dye, Victoria S. Pennington, Rachel J. Pucel, Lindsay A. Fleegle, Donald L. Sullivan

Pharmacy and Wellness Review

No abstract provided.

How To Set Up An Outreach Event: A Guide For Pharmacists, Kimberly Baucher, Andrew Skouby, Tanya Wilsmann, Eric Stack, Kristen Finley Sobota

Pharmacy and Wellness Review

No abstract provided.

Prescription Drug Abuse: What Are We Doing About It?, Heather Helsel, Thomas Otroba, Juliana Zschoche, Brandon Haas

Pharmacy and Wellness Review

No abstract provided.

Genetic Predispositions To Opioid Addiction, Legislative Action And Implications To Pharmacy Practice, Adam N. Trimble, David N. Jones, Courtney L. Salvino, Michael M. Milks, David Kisor

Pharmacy and Wellness Review

Prescription pain-relievers can be powerfully effective agents in the treatment of moderate to severe pain; however, these drugs are also strongly associated with drug abuse and addiction. In the brain, opioid analgesics bind to various receptors in the mesocorticolimbic dopaminergic pathways, which play a multifaceted interaction of role in reward. Several specific single nucleotide polymorphisms (SNPs) have been identified as potential genetic factors that increase an individual's risk for addiction; however, confounding studies and lack of large trials prohibit definitive conclusions from being drawn. As a result of genetic testing, federal and state laws have been enacted to protect individuals …

Decoding The Prescription, Kim Baucher, Jessica Langhals, Ross Robison, Kristen Finley Sobota

Pharmacy and Wellness Review

No abstract provided.

The Role Of The Pharmacist In Patient-Centered Medical Homes, Eric Stack, Kevin Stack, Stelios Theophanous, Karen L. Kier

Pharmacy and Wellness Review

No abstract provided.

Pharmacogenetics: Where Are We Now?, Brittany Dye, Megan Meyer, Vincent Wu, Michael D. Kaine

Pharmacy and Wellness Review

No abstract provided.