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Honors Theses

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Articles 91 - 116 of 116

Full-Text Articles in Pharmacy and Pharmaceutical Sciences

Variability In Antibacterial Chemical Defenses In Caribbean Sponges Of The Genus Aplysina, Savannah Stockton Jan 2016

Variability In Antibacterial Chemical Defenses In Caribbean Sponges Of The Genus Aplysina, Savannah Stockton

Honors Theses

Coral reefs represent one of the most diverse ecosystems on earth, providing habitat for at least 25% of all marine species. Coral ecosystems are faced with many stressors, both physical and biological, that are causing their continuing decline. Understanding the impacts of these stressors, and the resilience of coral reefs, is important to the long-term survival of these critical ecosystems. As a major constituent of marine communities, sponges are an important phylum contributing to the ecology of coral reefs. Like other components of coral reef habitats, sponges also face a wide variety of biological stressors including pathogens, predators, and competitors. …

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Identification Of Inhibitors Of Fxii, Alexandra C. Bensel Jan 2016

Identification Of Inhibitors Of Fxii, Alexandra C. Bensel

Honors Theses

Hereditary angioedema is characterized by recurrent swelling of the extremities, larynx, and gastrointestinal tract. While type I and type II hereditary angioedema result from a C1-inhibitor deficiency, a new variant of the disease, type III hereditary angioedema, was recently discovered in individuals with functioning levels of the C1-inhibitor. Ongoing research has postulated that increased activity of factor XII is responsible for this new form of hereditary angioedema because it causes overproduction of bradykinin. The purpose of the experiment was to identify inhibitors of factor XII. One hundred and seventy six molecules were screened through a dose response using Human Factor …

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Evaluation Of The Prevalence And Treatment Trends Of Diabetic Peripheral Neuropathy Among Patients With Diabetes In A Rural Population, Lauren Daigle Jan 2016

Evaluation Of The Prevalence And Treatment Trends Of Diabetic Peripheral Neuropathy Among Patients With Diabetes In A Rural Population, Lauren Daigle

Honors Theses

Evidence for adherence to the American Diabetes Association's (ADA) screening and treatment guidelines for various health complications of diabetes in rural populations is limited. The ADA recommends annual foot and eye exams and supports the use of the Semmes-Weinstein monofilament (SWM) to detect signs of diabetic peripheral neuropathy (DPN). This study evaluated the prevalence and treatment trends of DPN among patients with diabetes in a rural population. Fifty-two individuals over the age of 18, with known Type 1 or Type 2 diabetes mellitus, were recruited to participate. Participants were asked to respond to a 29-item, multiple choice and freeform question …

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Evaluation Of Dual-Activity Opioid-Npff Ligands For Antinociception, Jason N. Teng Jan 2015

Evaluation Of Dual-Activity Opioid-Npff Ligands For Antinociception, Jason N. Teng

Honors Theses

Opioids have become a staple in the medical world as an analgesic used to treat acute and chronic pain. However, there are many issues associated with the frequent use of opioids including tolerance, constipation, and opioid-induced hyperalgesia. Fortunately, recent discoveries of neuropeptide FF (NPFF) antagonists, have led to the understanding that tolerance and hyperalgesia caused by opioids can be greatly reduced. This discovery eventually led to the creation of dual ligands with both opioid agonist and NPFF antagonist activity. These dual ligands have been shown to prevent tolerance and opioid-induced hyperalgesia while maintain analgesic qualities in mice. However, these studies …

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Student Involvement And Satisfaction With And Through The School Of Pharmacy, Katherine Bruchman Jan 2015

Student Involvement And Satisfaction With And Through The School Of Pharmacy, Katherine Bruchman

Honors Theses

Pharmacy students are often defined by their tests scores and grade point averages with too few people willing to acknowledge students' feelings of satisfaction and involvement that may or may not be related to their performance in school. A desire to increase students' test scores often surpasses the desire to increase their satisfaction despite satisfaction being directly related to student success. This cross-sectional study therefore serves to determine how Students of Pharmacy are spending their time both in and out of the School of Pharmacy and whom they're choosing to spend it with, in hopes of identifying contributing factors to …

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Immunization Perception And Education, Katie Day Jan 2015

Immunization Perception And Education, Katie Day

Honors Theses

With vaccination rates in the United States falling, there is now a growing need for immunization education. This study aimed to survey a large group of students to determine the most beneficial method of educating the public and to evaluate the locations that individuals are more likely to receive vaccinations. The survey highlights the increasing demand for physicians and pharmacists to improve immunization education to prevent individuals from dying each year due to vaccine preventable diseases.

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Evaluation Of Purkinje Neurons And Endocannabinoid Receptors As A Potential Target Of Alcoholism Using Japanese Medaka (Oryzias Latipes) As An Animal Model, J. Ford Franklin Jan 2015

Evaluation Of Purkinje Neurons And Endocannabinoid Receptors As A Potential Target Of Alcoholism Using Japanese Medaka (Oryzias Latipes) As An Animal Model, J. Ford Franklin

Honors Theses

Purkinje cells (PK) are neurons with large cell bodies found in the central nervous system and are mostly distributed in the cerebellar region of the hindbrain. Several novel markers for PK cells have been developed and are used for characterization of neurobehavioral disorders. The present study was aimed to identify endocannabinoid receptor 1 (CB1) as a potential marker of PK cells and evaluate them as a molecular target of alcohol and cerebellar functions using Japanese medaka (Oryzias latipes) as an animal model. Previously, we have observed that medaka genome consist three CB receptor paralogs; two of them (cnr1a and cnr1b) …

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Discovery Of Resistance-Reversing Agents In Antibiotic Resistant Strains Of Escherichia Coli And Klebsiella Pneumoniae From Natural Product Libraries, Andrew B. Watkins Jan 2015

Discovery Of Resistance-Reversing Agents In Antibiotic Resistant Strains Of Escherichia Coli And Klebsiella Pneumoniae From Natural Product Libraries, Andrew B. Watkins

Honors Theses

Objective: The objective of this exploratory research is to discover compounds, particularly from natural products, that inhibit ESBL, KPC, and NDM-1 mechanisms of antibiotic resistance in the Gram negative bacteria Escherichia coli and Klebsiella pneumoniae. Methods: This objective will be accomplished utilizing a high-volume bioassay testing natural product samples from the National Center for Natural Products Research. This assay tests samples against 6 different strains of bacteria known to express β-lactamases in the presence and absence of sub-inhibitory concentrations of the test antibiotic. By structuring the assay in this way, differentiation may be made between the inherent antibacterial activity of …

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Dereplication And Prioritization Of Natural Product Extracts For Antifungal Drug Discovery, Kara Fowler Jan 2014

Dereplication And Prioritization Of Natural Product Extracts For Antifungal Drug Discovery, Kara Fowler

Honors Theses

The prevalence of opportunistic fungal infections in hospital settings are at alarming rates. Through technological advances in natural product research, plants have become a useful source for antifungal drug discovery. More samples can be screened at once, fractionated in less time, and biologically tested at smaller quantities. However, isolating antifungal compounds from these plant extracts and determining their specific chemical makeup can still take up a significant amount of time. Therefore, this thesis presents a prioritization technique to prevent the need to isolate every compound within an active fraction. With the guidance of literature research on the genus and species …

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Mississippi Pharmacists' Knowledge And Attitudes About Pharmacy Compounding Safety And Regulation, Kimberly Allen Jan 2014

Mississippi Pharmacists' Knowledge And Attitudes About Pharmacy Compounding Safety And Regulation, Kimberly Allen

Honors Theses

Introduction: Pharmacy compounding, which is defined by The Food and Drug Administration (FDA) as a practice in which a licensed pharmacist combines, mixes, or alters ingredients in response to a prescription to create a medication tailored to the medical needs of an individual patient,1 has gained recent attention at both national and state levels. Outbreaks of adverse events associated with pharmacy compounding have led to many proposed and enacted changes in how to appropriately and best regulate traditional compounding pharmacies and those that act as manufacturers. Given such recent controversies and potential confusion as to exactly how compounding is regulated, …

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Reproductive And Multigenerational Effects Of Dietary Benzo[A]Pyrene Exposure In Zebrafish, Mallory White Jan 2014

Reproductive And Multigenerational Effects Of Dietary Benzo[A]Pyrene Exposure In Zebrafish, Mallory White

Honors Theses

Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that is a known carcinogen that also acts as an endocrine disruptor. Multigenerational impacts of PAH exposure are suggested in human cohort studies. To investigate mechanisms and developmental phenotypes associated with a dietary BaP exposure, zebrafish (Danio rerio) were used. We hypothesized that BaP exposure would cause: 1) phenotypic malformations in the gonad that would affect reproductive success; 2) developmental deformities in the offspring that would lead to decreased survival and ability to reproduce without additional BaP exposure; and 3) changes in gene expression that would be conserved across generations and related …

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Roles And Regulations For Pharmacists In State-Level Disaster Relief Efforts, Rachel Lowe Jan 2014

Roles And Regulations For Pharmacists In State-Level Disaster Relief Efforts, Rachel Lowe

Honors Theses

Objective: The purpose of this study is to determine what expanded roles have been identified for pharmacists by the states in disaster relief efforts, what regulations currently exist for pharmacists in disaster relief efforts in each state, and whether or not disaster relief and public health training should be added to the pharmacy school curriculum. Methods: A cross-sectional, descriptive design was used to survey fifty-three boards of pharmacy via email and Qualtrics Survey Software. Results: Analysis of the survey results showed that most states lack a disaster preparedness plan and expanded roles for pharmacists in disaster relief efforts, and most …

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The Potential Success Of The F.D.A.'S New Paradigm Based On Community Pharmacists' Opinons, Anna Blair Brown Jan 2014

The Potential Success Of The F.D.A.'S New Paradigm Based On Community Pharmacists' Opinons, Anna Blair Brown

Honors Theses

For the past 40 years the F. D. A. (Food and Drug Administration) has considered creating a third class of drugs in the United States of America that would be a pharmacist-only class which could only be sold with the approval of a pharmacist. Several things have inhibited its creation, the main one being the Durham-Humphrey Amendment which states that there are only two classes of drugs: prescription and over-the-counter. This has culminated into the development of the F.D.A.'s new paradigm, which is an expansion of the over-the-counter class of drugs to create and O.T.C.+ category. Community Pharmacists were interviewed …

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Parent Satisfaction With Diabetes Technology In Children With Type 1 Diabetes Mellitus, Laura Brooke Carter Jan 2014

Parent Satisfaction With Diabetes Technology In Children With Type 1 Diabetes Mellitus, Laura Brooke Carter

Honors Theses

Purpose: To increase glucose control, advanced technologies are being integrated into diabetes self-management in children with Type 1 Diabetes Mellitus (T1DM). Two technologies being adopted is Continuous Subcutaneous Insulin Infusion (CSII), more commonly known as insulin pumps (pumps) and Continuous Glucose Monitoring (CGM). The purpose of the study was to better understand the experiences of parents whose T1DM child is using insulin pumps and CGM devices in diabetes self-management. Methods: This study was approved by the University of Mississippi IRB. A cross-sectional study was conducted using a sample of parents in the Mid-South region of the U.S. The local chapters …

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Patient Perceptions Of Medication Therapy Management Targeted For Adherence Following The Provision Of Influenza Immunizations By Student Pharmacists: Preliminary Findings, Logan H. Ramsey Jan 2014

Patient Perceptions Of Medication Therapy Management Targeted For Adherence Following The Provision Of Influenza Immunizations By Student Pharmacists: Preliminary Findings, Logan H. Ramsey

Honors Theses

Objective: To examine patients' opinions of clinical pharmacy services, especially Medication Therapy Management (MTM), following the administration of influenza immunization. Methods: The McLean Institute for Public Service and Community Engagement at the University of Mississippi funded a service-learning project for student pharmacists to administer influenza immunizations to medically underserved patients. The project was conducted at a clinic for uninsured patients in Southaven, Mississippi but was open to the public. Patients (n=52) received an influenza immunization followed by a personal medication record during the observation period. Students, under the supervision of a licensed pharmacist, then provided a medication review and Drug …

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A Comprehensive Review Of Malaria With An Emphasis On Plasmodium Resistance, Lindsay O. Thomas Jan 2014

A Comprehensive Review Of Malaria With An Emphasis On Plasmodium Resistance, Lindsay O. Thomas

Honors Theses

Malaria is a disease that is caused by the Plasmodium genus. It is endemic in tropical areas. There are multiple drugs used for prophylaxis and treatment. However, the parasites have developed resistance towards most antimalarial pharmaceuticals. The pharmaceutical industry is generating new antimalarial pharmaceuticals, but the rate of new Plasmodium resistance is much faster.

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Cardiovascular Protective Agents And Their Biochemical Role In Endothelial Cell Senescence, Nicholas Boullard Jan 2014

Cardiovascular Protective Agents And Their Biochemical Role In Endothelial Cell Senescence, Nicholas Boullard

Honors Theses

Cellular senescence is a slow, biological process of aging that involves the accumulation of various changes to the internal environment of a cell, most notably the buildup of acidic B-galactosidase. These changes, both structural and molecular in nature, disable metabolism of many cellular processes and eventually induce apoptosis. As cells divide, the ends of chromosomes, telomeres, slowly shorten. Once telomere shortening reaches critical levels, those chromosomes may no longer replicate properly, leading to cellular process complication and apoptosis. Telomerase is a reverse transcriptase that adds nucleotides to telomeres, elongating them and successfully delaying endothelial cell senescence. Endothelial cells serve an …

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Dieting For Diabetes: A Mobile 'App'roach, Alaina Brooks Darby Jan 2014

Dieting For Diabetes: A Mobile 'App'roach, Alaina Brooks Darby

Honors Theses

Diabetes mellitus, being a prevalent disease in modern society, is moderately influenced by one's nutrition. Due to this, mobile programs created especially for tracking food intake can be an important aid for diabetics. The objective of this project was to analyze eight of the most prominent of these applications — MyNetDiary, GoMeals, MyFitnessPal, Fooducate, Lose It!, The Carrot, Diabetes In Check, and Daily Carb — to determine the subsets of diabetics that would benefit most from the utilization of each. Data was obtained through testing of each app and through the information provided by users on iTunes and Google Play …

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University Of Mississippi Prepharmacy And Early Entry Students' Professional Commitment And Perceptions Of The Professional Role Of Pharmacists, Blake A. Williams Jan 2014

University Of Mississippi Prepharmacy And Early Entry Students' Professional Commitment And Perceptions Of The Professional Role Of Pharmacists, Blake A. Williams

Honors Theses

Introduction: The profession of pharmacy is now largely focused on patient-centered care, rather than the drug-centered focus of the past. Schools of pharmacy have a vested interest in recruiting student pharmacists who are patient-focused. The purpose of this study is to assess University of Mississippi prepharmacy and Early Entry students' perceptions of the professional role of pharmacists, and to determine if these perceptions are related to student characteristics. Methods: This cross-sectional, descriptive study utilized an online, self-administered survey, administered to prepharmacy and Early Entry students enrolled at the University of Mississippi. The survey included constructs of the theory of planned …

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Perceptions Of Health Information On General And Medical Social Media Sites, Brea Hope Rich Jan 2014

Perceptions Of Health Information On General And Medical Social Media Sites, Brea Hope Rich

Honors Theses

The goal of this thesis is to identify and discuss the public's perception on health information found on general and medical social media sites. To discover this information, a survey was sent to employees of South Tippah School District. It was found that people are more likely to use general social media sites compared to medical social media sites. People are more likely to share medical information than receive information on either type of site. Most people doubt or are uncertain of the credibility of health information on social media sites. The benefit found most in reading or sharing medical …

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Crizotinib: A Tyrosine Kinase Inhibitor, Graham Mclaren Apr 2013

Crizotinib: A Tyrosine Kinase Inhibitor, Graham Mclaren

Honors Theses

Crizotinib is a small molecule tyrosine kinase inhibitor that is currently being marketed by Pfizer under the trade name Xalkori®. After its development in 2005, an appropriate target was discovered in 2007. By 2011 the FDA had approved crizotinib for use in patients with ALK+ non small cell lung cancer (NSCLC). ALK+ NSCLC is caused by a genetic mutation that truncates and flips a section of the EML4 gene and attaches it to a section of the ALK gene. The result is the EML4-ALK oncogene. The resulting protein from this mutation is capable of undergoing ligand independent dimerization, …

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Precision And Accuracy: Omnipod Pdm® (O-Pdm) Versus Freestyle Lite Meter® (Fsl Meter) Utilizing Freestyle Lite (Fsl)® Test Strips In Multiple Patient Situations, Christine M. Hayden Jan 2013

Precision And Accuracy: Omnipod Pdm® (O-Pdm) Versus Freestyle Lite Meter® (Fsl Meter) Utilizing Freestyle Lite (Fsl)® Test Strips In Multiple Patient Situations, Christine M. Hayden

Honors Theses

Today, diabetes mellitus affects 8.3% of the people in the United States and is having detrimental effects on patient populations as well as health care. To this date, there are numerous monitors that all meet specific requirements and industry standards in order to aid patients in self-monitoring of blood glucose (SMBG). There is currently a large market for these monitors and efforts have been made to devise the monitors to be accurate and precise. Through this study, accuracy and precision were studied by evaluating the difference between the O-PDM and FSL meter monitoring systems. It was hypothesized that a difference …

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Synthesis Of A New Scytovirin Protein Derivative, Sd1-Sd2-Sd2, To Decrease Hiv-1 Binding Affinity, Alexandra M. Wood Jan 2013

Synthesis Of A New Scytovirin Protein Derivative, Sd1-Sd2-Sd2, To Decrease Hiv-1 Binding Affinity, Alexandra M. Wood

Honors Theses

Scytovirin is a novel anti-viral protein isolated from the cyanobacterium Scytonema varium. This protein has produced great scientific interest for its anti-human immunodeficiency virus (HIV) activity. Scytovirin disrupts the mechanism of HV infection by binding to HIV-1 proteins glycoprotein 120, glycoprotein 160, and glycoprotein 41. It does not bind to the CD4 receptor on human immune cells. The wild-type protein consists of a single 95 amino acid chain. When folded, Scytovirin's amino acid sequence is arranged into two distinct domains, each with a high degree of sequence conservation. This implicates the importance of both domains in anti-HIV activity. Primers were …

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Mechanism Of Action Of A Novel Antifungal Compound, Amber Ward Jan 2012

Mechanism Of Action Of A Novel Antifungal Compound, Amber Ward

Honors Theses

Opportunistic fungal infections have become problematic in recent years. There has been an emergence of new fungal pathogens, development of antifungal resistance, and increasing prevalence. In addition, toxicity, resistance, and lack of efficacy as a single agent limit the effectiveness of current antifungal drugs. Therefore, new drugs targeting new pathways are greatly needed. An analog derived from the marine natural product phloeodictine, analog PHL5-34A, was identified as having strong in vitro antifungal activity. In this study, its mechanism of action (MOA) was investigated in the model yeast, Saccharomyces cerevisiae. This study made use of a collection of 166 yeast mutants …

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Antibiotics, Herbs, And Magic: Health Practices In Contemporary St. Petersburg, Christine Shu Jan 2009

Antibiotics, Herbs, And Magic: Health Practices In Contemporary St. Petersburg, Christine Shu

Honors Theses

In St. Petersburg, Russia, two seemingly conflicting health doctrines, western medicine and alternative medicine, play significant roles in residents' health culture. I define alternative medicine as all health practices that use such natural products as herbs, natural honey, water, seeds, berries, and even animal products, and as such unobtrusive body therapies as acupuncture, massage, yoga, or animal therapies. I define western medicine as all treatments that involve the manipulation of ingredients in a chemistry laboratory (such as antibiotics, antiviral drugs, antihistamines. or pain killers) and all body therapies intrusive to the body (such as operations). Through interviews with St. Petersburg …

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Pharmacists' Perceptions Of Practice Roles: Opportunities And Challenges Facing Pharmacy With Respect To Expanding The Scope Of Practice In Mississippi, Peter John Pattridge Jr. Jan 2002

Pharmacists' Perceptions Of Practice Roles: Opportunities And Challenges Facing Pharmacy With Respect To Expanding The Scope Of Practice In Mississippi, Peter John Pattridge Jr.

Honors Theses

Title: Pharmacists' Perceptions of Practice Roles: Opportunities and Challenges Facing Pharmacy with Respect to Expanding the Scope of Practice in Mississippi Objective: To provide objective evidence as to the opportunities and challenges that pharmacists will encounter when implementing an expanded role in the health care system from the perspective of the practicing pharmacist. Methods: Questionnaires were mailed to Mississippi licensed pharmacists. The first section contained questions dealing with the demography of the respondent including a utilization of skills scale and several domains of job satisfaction. The second section contained the health care activities inventory. Respondents were asked to report which …

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