Open Access. Powered by Scholars. Published by Universities.®
Pharmacy and Pharmaceutical Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Pharmacy Administration, Policy and Regulation (28)
- Public Health (13)
- Chemicals and Drugs (10)
- Medicinal and Pharmaceutical Chemistry (10)
- Natural Products Chemistry and Pharmacognosy (10)
-
- Other Pharmacy and Pharmaceutical Sciences (9)
- Life Sciences (8)
- Medical Sciences (6)
- Social and Behavioral Sciences (5)
- Alternative and Complementary Medicine (4)
- Community Health and Preventive Medicine (4)
- Diseases (4)
- Medical Education (4)
- Medical Specialties (4)
- Other Public Health (4)
- Pharmaceutical Preparations (4)
- Chemistry (3)
- Health Services Administration (3)
- Interprofessional Education (3)
- Mental and Social Health (3)
- Other Chemicals and Drugs (3)
- Physical Sciences and Mathematics (3)
- Public Health Education and Promotion (3)
- Biochemistry (2)
- Biochemistry, Biophysics, and Structural Biology (2)
- Bioethics and Medical Ethics (2)
- Biology (2)
- Heterocyclic Compounds (2)
- Institution
- Keyword
-
- Pharmacy (7)
- Mississippi (5)
- CBD (3)
- Cannabinoids (3)
- Cannabis (3)
-
- Community pharmacy (3)
- Pharmacist (3)
- Zebrafish (3)
- Aging (2)
- Asthma (2)
- Behavior (2)
- Cannabidiol (2)
- Development (2)
- FDA (2)
- Fluorescence (2)
- HIV (2)
- Inflammation (2)
- Marijuana (2)
- Medicaid (2)
- Medicine (2)
- Mental health (2)
- Pain (2)
- Pharmaceuticals (2)
- Research (2)
- Social media (2)
- Sphingolipids (2)
- 24-hour recall (1)
- 340B (1)
- ADHA (1)
- Academic strain (1)
Articles 61 - 90 of 116
Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Modification Of Hiv-1 Protease Inhibitor Pharmacophore To Assess Anti-Malarial Properties, Margaret Ann Street
Modification Of Hiv-1 Protease Inhibitor Pharmacophore To Assess Anti-Malarial Properties, Margaret Ann Street
Honors Theses
For years, the human immunodeficiency virus type 1 (HIV-1) and malarial parasites have both been prevalent in sub-Saharan Africa. Coinfections of HIV-1 and malaria are common in areas of geographic overlap as both infections seem to increase the severity of the other. HIV-1 treatments have shown to decrease the Plasmodium infections resulting in a lower malarial incidence. HIV-1 protease inhibitors target a crucial step in the life cycle required for viral maturation and have demonstrated a lower level of resistance compared with other therapies. Recent studies have shown the treatment of HIV-1 with protease inhibitors has resulted in inhibitory effects …
A Comprehensive Examination Of University Of Mississippi Early Entry Students’ Perceptions Of Mental Illness, Brianna Gray
A Comprehensive Examination Of University Of Mississippi Early Entry Students’ Perceptions Of Mental Illness, Brianna Gray
Honors Theses
Mental disorders affect nearly 1 in 5 adults in the United States in a given year, and that number is steadily increasing. Pharmacists, being some of the most accessible and frequently contacted health care professionals, must be prepared to provide support for these patients. They can play a key role in whether or not there is a positive patient outcome. Education can play a role in pharmacists’ comfort with and knowledge of mental illness. The primary objective of this study was to determine if University of Mississippi early-entry pharmacy students’ mental illness knowledge, familiarity, and acceptable social distance affected their …
Neurotoxic Effects Of Hiv-1 Gp120 And Interaction With Allopregnanolone, Kimberly A. Thornton
Neurotoxic Effects Of Hiv-1 Gp120 And Interaction With Allopregnanolone, Kimberly A. Thornton
Honors Theses
With increasing incidence of HIV and its associated neurocognitive disorders, there has emerged a need for an antiviral with improved delivery to the CNS. In searching for drug candidates that meet these criteria, some have noted that certain steroid hormones like estrogen and progesterone that naturally accumulate in the CNS show neuroprotective effects in cells exposed to HIV proteins. This investigation focused on testing the potential protective effects of the progesterone metabolite, allopregnanolone (AlloP), against HIV protein gp120-mediated neurotoxicity. Experiments were conducted using SH-SY5Y neuroblastoma cells that were exposed to varying concentrations of AlloP (0-100 nM) in conjunction with one …
Predator Diet Affects Perceived Oviposition Site Quality For Mosquitoes, Brandon Mcdaniel
Predator Diet Affects Perceived Oviposition Site Quality For Mosquitoes, Brandon Mcdaniel
Honors Theses
Ovipositing freshwater organisms rely primarily on cues to determine site quality (Silberbush and Blaustein 2008) and to select an ideal habitat for their offspring (Resetarits 2014). Characteristics of high quality oviposition sites that yield the greatest fitness for offspring include the absence of predators and high resource availability that allows for optimal growth and development (Kershenbaum et al. 2012). It has been shown that predator presence is a large deterrent of oviposition due to threats of offspring survival, however, there is a little information about the predatory cues mosquitoes experience before ovipositing (Angelon and Petranka 2002). One hypothesis is that …
A New Consultation Service For Community Pharmacies? An Investigation Of Pharmacists' Perspective On Implementing A Weight Management Program, Shelby N. Strength
A New Consultation Service For Community Pharmacies? An Investigation Of Pharmacists' Perspective On Implementing A Weight Management Program, Shelby N. Strength
Honors Theses
Pharmacists are capable and interested in providing a targeted weight management intervention addressing the high rates, and associated risk, of obesity. A series of in-depth phone interviews with Mississippi community pharmacists were used to gain their perspective on a systematic approach for delivering a weight and obesity management service to patients. Using qualitative content analysis, three themes were identified and analyzed. These themes included: pharmacist’s perceptions of patient’s needs, program structural components, and pharmacist’s implementational needs. These findings can be used to expand the role of pharmacists, serve as a model for the development of other consultation services, improve health …
State And Regional Comparisons Of Breastfeeding Policies And Rates: A National Study, Erin Johnson
State And Regional Comparisons Of Breastfeeding Policies And Rates: A National Study, Erin Johnson
Honors Theses
State legislation focused on promoting and supporting breastfeeding is relatively new, beginning in the 1990s. The purpose of this study is to determine if there is an association between state breastfeeding rates and state breastfeeding legislation and other institutional policies. The Centers for Disease Control and Prevention releases breastfeeding report cards with the most up-to-date state breastfeeding rates. These reports are used to examine the relationship between state breastfeeding rates and number of breastfeeding policies passed by a state. Government initiatives, such as Healthy People Initiative, and organizational practices, such as Baby-Friendly USA Inc., are also studied to determine their …
Geographical Variability In Antibacterial Chemical Defenses Of The Caribbean Sponge Xestospongia Muta, Coleman Sisson
Geographical Variability In Antibacterial Chemical Defenses Of The Caribbean Sponge Xestospongia Muta, Coleman Sisson
Honors Theses
Coral reefs are important and diverse marine ecosystems, and sponges represent the majority of species in Caribbean reefs. Xestospongia muta is a giant barrel sponge that is one of the most abundant and visible sponges on Caribbean reefs, and has been the subject of many studies. Xestospongia muta produces a diversity of secondary metabolites that have various ecological functions including allelopathy, anti-fouling, predation deterrence, and antibacterial activity. The chemical defenses produced by a sponge can change in response to various biotic and abiotic stressors, including water temperature, sedimentation, nutrient runoff, and predation. This study compared the antibacterial activity of X. …
The Protective Role Of Estrogen On Hiv-1 Mediated Neurotoxicity, Macklin Licamied
The Protective Role Of Estrogen On Hiv-1 Mediated Neurotoxicity, Macklin Licamied
Honors Theses
The prevalence of HIV among men have been in a steady inclination over the last several decades, yet the accelerated infection rate among older women is considerably concerning. Not only does the HIV virus affect the immune system but it also affects the central nervous system. One of its viral proteins, Tat, acts as an excitotoxin and disrupts the cell’s membrane potential by increasing the concentration of Ca2+ inside the cell. This influx of calcium ions leads to apoptosis and secretion of the cell’s contents into the surrounding area. Macrophages, along with other innate immune components, gather and induce the …
Method Development And Pharmacokinetic Study Of Jy08, A Dual Opioid-Npff Receptor Ligand, Sydney Harrison
Method Development And Pharmacokinetic Study Of Jy08, A Dual Opioid-Npff Receptor Ligand, Sydney Harrison
Honors Theses
Within the United States and worldwide, a rapidly developing public health crisis is at hand due to the abuse of opioids. With high percentages of Americans experiencing both acute and chronic pain and limited treatment routes, opioid analgesics are highly prescribed in clinical practice. These drugs act on central nervous system to activate opioid receptors in regions of the brain regulating pain and reward. However, these compounds are associated with many unwanted adverse effects including tolerance, dependence, hyperalgesia, and addiction. Thus, there is a need to for the development of new drug candidates that can serve as analgesics for long-term …
A Comprehensive Examination Of The Pharmacist's Role In Mental Illness, Kaleb D. Barnes
A Comprehensive Examination Of The Pharmacist's Role In Mental Illness, Kaleb D. Barnes
Honors Theses
The number of people receiving mental illness diagnoses has increased in the last two decades. As one of the most accessible healthcare professionals, pharmacists need to be prepared to assist in the management of patients with mental illness. In this study, the objective was to see how pharmacists' mental illness knowledge, acceptable social distance, familiarity, and perceived barriers may predict pharmacists' attitude toward patients with mental illness and also their willingness to provide care to patients with mental illness. The secondary objectives of this study were to test for differences in knowledge, attitude, perceived barriers, and willingness to provide care …
The Role Of Cannabinoids And Terpenes In Cannabis Mediated Analgesia In Rats, Margaret A. Rousseau
The Role Of Cannabinoids And Terpenes In Cannabis Mediated Analgesia In Rats, Margaret A. Rousseau
Honors Theses
Objective: This research examined the contributions of terpenes (volatile oil) and cannabinoids in cannabis mediated analgesia in rats. Methods: In experiment 1, separate groups of rats received IP administration of either vehicle, 5, 10, or 15 mg/kg cannabis extract, one of three concentrations of volatile oil alone in these cannabis extracts, one of three concentrations of these extracts with volatile oils removed, 2.5, 5, or 7.5 mg/kg Δ9-THC, or 10 or 18 mg/kg morphine 30 m before hotplate and tail-flick tests of thermal nociception. One week later, separate groups of rats received a second administration of these test articles IP …
Evaluation Of New Antimalarial Drug Combinations, Robert Tyrone Higginbotham
Evaluation Of New Antimalarial Drug Combinations, Robert Tyrone Higginbotham
Honors Theses
Malaria is a disease that has affected people throughout the world for centuries and is still responsible for over 200 million clinical cases per year. While a number of developed countries have eradicated the disease, its prevalence in tropical regions poses a significant global health challenge. The disease is caused by the Plasmodium genus, an obligate, intracellular parasite that is carried by the female Anopheles mosquito. While there are effective antimalarial drugs in clinical use, Plasmodium's resilient nature has allowed it to develop resistance to multiple drugs. This fact makes it imperative to seek out novel drugs to combat resistant …
An Evaluation Of Mobile Apps For The Collation Of Materials To Propose An App For Type-2 Diabetes Self-Management, Sydney Watson
An Evaluation Of Mobile Apps For The Collation Of Materials To Propose An App For Type-2 Diabetes Self-Management, Sydney Watson
Honors Theses
This study is an evaluation of mobile application (apps) with the intention to collate materials appropriate for the proposal of a mobile app for type 2 diabetes self-management. In order to decipher the most vital aspects to be included in the app, an evaluation of mobile apps pertaining to nutrition and diabetes management were investigated. It was found that there is a lack of mobile apps that have all-encompassing features regarding the management of the disease. Future app developers looking to develop a mobile app that is efficient in type 2 diabetes self-management should include each feature as follows: blood …
Synthesis Of (2r,6r)-Hydroxy-Norketamine For Evaluation Of Antidepressant Effects, Savannah Fairley
Synthesis Of (2r,6r)-Hydroxy-Norketamine For Evaluation Of Antidepressant Effects, Savannah Fairley
Honors Theses
Major Depressive Disorder, colloquially known as depression, is a devastating mental illness that affects a large portion of today's population. Following a drug side-effect that caused depression, the monoamine theory of depression was created, stating that depressive symptoms were caused by a decrease in concentrations of vital monoamine neurotransmitters at the synaptic cleft. Pharmaceutical remedies to combat depression were first introduced in the 1950s and to this date, most available drugs follow the monoamine theory. These drugs have a large loading dose lag time, numerous negative side effects, and still many patients do not experience relief from symptoms. In 2000, …
Development And Evaluation Of Quercetin Nanoparticles And Hot Melt Cast Films For Retinal Neuroprotection, Chau Truong
Development And Evaluation Of Quercetin Nanoparticles And Hot Melt Cast Films For Retinal Neuroprotection, Chau Truong
Honors Theses
The aim of this study was to prepare optimized nanoparticles and hot melt cast films of quercetin and to investigate the release and permeability profile across corneal membranes. The results demonstrate that all formulations can be successfully employed for delivery of quercetin into the eye through the topical route of administration, with films showing significantly better transcorneal permeability.
Knowledge Of Epilepsy In Students Attending The University Of Mississippi Oxford Campus, Alyssa Reid
Knowledge Of Epilepsy In Students Attending The University Of Mississippi Oxford Campus, Alyssa Reid
Honors Theses
Epilepsy is thought to be a very rare condition, and therefore many people do not know how to react or what to do when a person has a seizure. Epilepsy is in fact twice as common as cerebral palsy, muscular dystrophy, multiple sclerosis, and cystic fibrosis combined. Furthermore, there is not a cure to stop the seizures for many people. Attending college is a challenging experience, but managing epilepsy while in college can be even more difficult. Hence it is important for all students to learn the basics of epilepsy and especially how to help a person having a seizure. …
Needs Assessment Of Healthcare Services For Transitioning College Students, Victoria M. Miller
Needs Assessment Of Healthcare Services For Transitioning College Students, Victoria M. Miller
Honors Theses
Investigators measured students' needs for healthcare services during their transition from pediatric to adult healthcare at The University of Mississippi. Also, investigators examined chronically ill students' adherence to their conditions needs and measured a baseline of college freshman's knowledge about healthcare. Data was collected using a self-administered cross-sectional survey online through Qualtrics. This study was divided into four focuses in order to assess the subject's health status, health knowledge, healthcare practices, and barriers to transitioning. The investigator found that most of the students' health status compares to the national average with minor differences, a number of students have little knowledge …
525,600 Minutes: A Study On The Knowledge And Perceptions Of College Students About Hiv/Aids, Olivia Griffis
525,600 Minutes: A Study On The Knowledge And Perceptions Of College Students About Hiv/Aids, Olivia Griffis
Honors Theses
Human Immunodeficiency Virus (HIV), which subsequently leads to the disease Acquired Immune Deficiency Syndrome (AIDS), is a highly prevalent virus throughout the world, yet it is a commonly misunderstood disease. HIV/AIDS comes with a stigma that can hinder the prevention, diagnosis, and treatment of the disease. This study evaluated the knowledge and perceptions of the students at the University of Mississippi. A sample of University of Mississippi students was randomly selected and asked through email to participate in a 26-item survey assessing their knowledge, awareness, and empathy towards people with HIV/AIDS through true/false, multiple choice, and Likert scale questions. The …
Intravenous Solution Wastage In Hospital Pharmacy At Baptist Memorial Hospital-North Mississippi (Oxford), Yujing Zhang
Intravenous Solution Wastage In Hospital Pharmacy At Baptist Memorial Hospital-North Mississippi (Oxford), Yujing Zhang
Honors Theses
Introduction: IV solution wastage refers to IV medications made for a patient that remain unused by that patient for a variety of reasons, and have subsequently expired, or for other reasons cannot be used for another patient (recycled), and therefore must be disposed of. This problem is widespread across hospital pharmacies in the U.S. and the world. BMH-NM (Oxford) pharmacy utilizes many waste reduction strategies but has never monitored its IV solution wastage. Therefore, the objective of this study was to identify the number of IV solutions wasted in a month and the subsequent financial loss in terms of drug …
Effects Of Dioscin On Dna Methyltransferase 1 Protein Expression In Human Breast Cancer Cell Lines, David Andrew Means
Effects Of Dioscin On Dna Methyltransferase 1 Protein Expression In Human Breast Cancer Cell Lines, David Andrew Means
Honors Theses
In previous experiments, the steroidal saponin, dioscin, which was extracted from the roots of the wild yam (Dioscorea villosa), was observed to have potent anti-proliferative effects on the human breast cancer cell lines MCF-7 and MDA-MB-231. Dioscin was also able to activate the transcription of tumor suppressor genes GATA3 and CDH1 in these cell lines. We hypothesize that the anti-proliferative effect of dioscin on human breast cancer cells could be mediated through the epigenome. Consequently, in order to explore this hypothesis, we have analyzed the expression of DNA methyltransferase 1 (DNMT1) protein in these cells. MCF-7 and MDA-MB-231 cells were …
Mississippi Pharmacists' Knowledge And Perceptions Of Adhd In Children, Anna Crider
Mississippi Pharmacists' Knowledge And Perceptions Of Adhd In Children, Anna Crider
Honors Theses
Attention-deficit/hyperactivity disorder (ADHD) is a condition that has garnered more attention in the profession of pharmacy in recent years as a result of being more commonly diagnosed in both adult and pediatric populations. With new medications available, pharmacists need to be knowledgeable about how these products may affect patients, especially children. It is crucial to understand pharmacists' perceptions and knowledge of ADHD and its treatments to optimize their provision of treatment for these patients. Due to the lack of literature dedicated to pharmacists' knowledge, familiarity, confidence, and perceptions as it relates the condition of ADHD and its treatments, the objectives …
Healthcare Professionals Knowledge And Attitudes Regarding Biosimilars In Northern Mississippi, Amanda Seals
Healthcare Professionals Knowledge And Attitudes Regarding Biosimilars In Northern Mississippi, Amanda Seals
Honors Theses
The emergence of biologics over the past the past few decades has led to a new interest in the production of a classification of drugs known as biosimilars. The vast complexity involved in the discovery, development, and manufacturing of biologics and biosimilars has made researching the knowledge and perceptions among healthcare professionals important. Healthcare professionals must have an understanding of biologics, as these medications are used for some of the most rare diseases. Healthcare professionals in northern Mississippi were surveyed on their knowledge of and attitudes towards biologics and biosimilars in order to gain insight on the current status of …
Pharmacists' Perceptions Of Rapid Diagnostic Testing In Community Pharmacies In Mississippi: A Diffusion Of Innovations Approach, Erin Ann Hoevelmann
Pharmacists' Perceptions Of Rapid Diagnostic Testing In Community Pharmacies In Mississippi: A Diffusion Of Innovations Approach, Erin Ann Hoevelmann
Honors Theses
Objectives: The broad purpose of this study is to describe community pharmacists' perceptions of rapid diagnostic tests (RDTs) in community pharmacies in Mississippi. The focused goal of this study is to determine the correlation between Everett M. Rogers' attributes of the diffusion of innovations (including relative advantage, compatibility, complexity, trialability, and observability) and the willingness of community pharmacists to offer RDTs in community pharmacies in Mississippi. Methods: This study was approved by the University of Mississippi IRB. A list of licensed pharmacists was obtained from the Mississippi Board of Pharmacy. An email with study details and a link to the …
Differences In Amphetamine/Dextroamphetamine Prescriptions In Areas With & Without Large Universities, Heather Bacon
Differences In Amphetamine/Dextroamphetamine Prescriptions In Areas With & Without Large Universities, Heather Bacon
Honors Theses
This investigative study is examining trends in stimulant prescribing for several Michigan counties. An ex-post facto design was used to determine trends in the amount of amphetamine/dextroamphetamine dispensed in four Michigan counties containing large universities and two Michigan counties not containing large universities over the years 2007-2012. The study found suggestive evidence that there is an increasing trend of amphetamine/dextroamphetamine prescriptions filled in both counties with and without large universities. Suggestive evidence was also found that counties with large universities display a greater average amount of amphetamine/dextroamphetamine dispensed than counties without large universities for the years 2007-2012. Because the study …
Global Reach, Local Markets: The Challenges Of Leading Global Innovation, Sarah Higgins
Global Reach, Local Markets: The Challenges Of Leading Global Innovation, Sarah Higgins
Honors Theses
This Global Studies honors thesis addresses how managers and leaders of global firms manage innovation across multiple markets. Current research on multinational corporations provides an understanding of different kinds of innovation and the ways to attend to multiple markets. However, there is less documentation of how these innovation strategies are actually implemented on the ground and the tensions that these efforts might produce. Therefore, my research focuses in particular on the challenges and tensions faced by leaders of global firms as they implement transnational innovation strategies. This study is based upon in-depth interviews with 20 participants who held positions in …
Redox-Sensitive Block Copolymer Nanoparticle Preparation And Characterization, Mary Virginia Portera
Redox-Sensitive Block Copolymer Nanoparticle Preparation And Characterization, Mary Virginia Portera
Honors Theses
The purpose of the research conducted in this project was to add to a wealth of knowledge concerning chemotherapy. Although chemotherapy has been used since Paul Ehrlich's discover of Salvarsan's ability to kill Treponema pallidum (the bacterium that causes syphilis), today the term chemotherapy is mostly used in conjunction with cancer treatment. There have been many successful chemotherapy drugs produced throughout the years, but a constant problem with chemotherapy is the fact that it also affects noncancerous cells. The topic of this research investigated targeted drug delivery systems that incorporate paclitaxel, a hydrophobic chemotherapy drug. This research mainly focused on …
Students' And Pharmacists' Perspectives On The Issue Of Adhd Prescription Medication Abuse At The University Of Mississippi, Meghan Wagner
Students' And Pharmacists' Perspectives On The Issue Of Adhd Prescription Medication Abuse At The University Of Mississippi, Meghan Wagner
Honors Theses
No abstract provided.
Patient Experiences With Small-Scale Pharmacy Compounding, Morgan Cawthon
Patient Experiences With Small-Scale Pharmacy Compounding, Morgan Cawthon
Honors Theses
Investigators examined patients' use, knowledge and perceptions of pharmacy compounding at an independent compounding pharmacy in Mandeville, Louisiana. Data were collected using a self-administered survey that patients could complete in hard-copy in the pharmacy or at home, or online using Qualtrics. Investigators found that, in some instances, patients who use compounded medications, or have a member of their household who uses compounded medications, may be more knowledgeable or have more positive perceptions of compounded medications. However, patients who did not have experience with compounds were not unknowledgeable about the practice and did not report any negative perceptions of compounding. These …
Terpenes And Flavonoids From Salvia Apiana And Their Affinities To Cannabinoid And Opioid Receptors, Taylor Hayes
Terpenes And Flavonoids From Salvia Apiana And Their Affinities To Cannabinoid And Opioid Receptors, Taylor Hayes
Honors Theses
Salvia apiana (white sage, Lamiacae family) plant is native to southern California and parts of Mexico. Some Native American tribes local to this region consider S. apiana to be sacred and burn the leaves as incense for purification ceremonies. The plant has been used to treat sore throats, coughs, chest colds, upper respiratory infections, and poison oak rashes. Native Americans widely used this plant in traditional Chumash healing. Infusion of the leaves is used as a diaphoretic and diuretic. The aqueous ethanolic extract of S. apiana showed moderate activity towards the CB1 receptor (58.3% displacement). The extract was fractionated on …
Exploration In The Effectiveness Of Solid Lipid Nanoparticle Formulations In Enhancing Ocular Delivery Of Win 55, 212 In The Management Of Glaucoma, Emily Ann Nesbit
Exploration In The Effectiveness Of Solid Lipid Nanoparticle Formulations In Enhancing Ocular Delivery Of Win 55, 212 In The Management Of Glaucoma, Emily Ann Nesbit
Honors Theses
Glaucoma is a progressive and degenerative ocular disease which, without proper treatment, can result in permanent blindness. Due to a complex organization of lipophilic and hydrophilic ocular membranes, topical delivery of therapeutic agents has also proved to be a challenging task. Cannabinoids, such as Δ9-Tetrahydrocannabinol (THC), have intraocular pressure (IOP) lowering and neuroprotective capabilities. Due to the unfavorable physiochemical characteristics of these molecules, delivery into the eye through a topical route is very difficult. Previous research has shown that prodrug derivatization and formulations such as solid lipid nanoparticles (SLNs) improve the physiochemical characteristics and ocular bioavailability of such molecules. WIN …