Pharmacy and Pharmaceutical Sciences Commons^™

Evaluation Of Antimicrobial And Wound Healing Activities Of Jatropha Podagrica Extracts, Reawfang Sriyom, Arunporn Itharat, Onmanee Prajuabjinda, Sumalee Panthong, Pakakrong Thongdeeying, Metar Siriwattanasathorn, Maneewan Panthong, Neal M. Davies

The Thai Journal of Pharmaceutical Sciences

Background: Jatropha podagrica has been traditionally used to treat skin infections and promote wound healing. However, there is currently no scientific research validating its antimicrobial or wound-healing properties.
Objectives: This study aimed to evaluate the antimicrobial and wound-healing activities of various extracts from all parts of J. podagrica, using different solvents. In addition, the chemical composition of the most effective extract was analyzed by Gas Chromatography-Mass Spectrometry (GC-MS).

Materials and Methods: The leaves, stem, and root of J. podagrica were extracted using hexane, 95% ethanol, ethanol-soluble hexane residue, and aqueous decoction. The antimicrobial effects of the extracts were assessed …

Exploring The Link Between Physicians’ Familiarity And Biosimilar Prescribing In Thailand, Ekapong Kachai, Chaoncin Sooksriwong, Wanruchada Katchamart, Tuangrat Phodha

The Thai Journal of Pharmaceutical Sciences

Background: Despite the availability of various biosimilars in Thailand, the link between physicians’ familiarity and biosimilars prescribing practice remains still unclear.

Objectives: This study aimed to find the association between physicians’ familiarity and biosimilars prescribing practice among physicians in Thailand.

Methods: This research adopted an extended analysis framework, utilizing survey data from a pilot study on the surveillance of Thai physicians regarding biosimilar uptake. The familiarity with biosimilars among respondents was evaluated.

Results: The result showed that 82 respondents were included in the study. There was 79.3% of respondents indicated prescribing biosimilars. Overall, most respondents (75.6%) showed an “adequate” level …

Concurrent Use Of Skeletal Muscle Relaxants And Nsaids In Low Back Pain Management: A Critical Review Of Current Evidence And Future Directions, Rupesh A. Saindane, Nilima A. Thombre

The Thai Journal of Pharmaceutical Sciences

Low back pain (LBP) represents a leading cause of non-fatal disability globally. Its high prevalence and disabling nature highlight the urgent need for effective management strategies. The exact cause of LBP still remains unclear, and thus, its treatment remains symptomatic. LBP is commonly treated with non-steroidal anti-inflammatory drugs (NSAIDs) and skeletal muscle relaxants (SMRs). These agents are frequently used in combination to target both inflammation and muscle spasms. However, the clinical guidelines vary widely on the recommendation for the use of such combination therapy. The present review evaluates evidence from randomized clinical trials and systematic reviews on the concurrent use …

Pharmacogenetic-Guided Antiplatelet Therapy For Personalized Medicine In Patients With Stroke And Transient Ischemic Attack Without Cardioembolic Stroke: A Systematic Review Of Economic Evaluations, Nathapol Samprasit, Chamipa Phanudulkitti, Nattanichcha Kulthanachairojana, Jatapat Hemapanpairoa

The Thai Journal of Pharmaceutical Sciences

Background: Stroke is a major global public health burden. Ischemic stroke is the most common type of all stroke cases worldwide. Antiplatelet therapy is a key strategy for secondary prevention in patients with stroke and transient ischemic attacks (TIAs) without cardioembolic stroke. Dual antiplatelet therapy (DAPT) with clopidogrel is recommended in patients with early mild stroke or high-risk TIA, followed by long-term single antiplatelet therapy (SAPT). Clopidogrel is often used as an alternative for patients with aspirin resistance or intolerance. However, clopidogrel is a prodrug metabolized by the CYP2C19 enzyme, leading to variability in its effectiveness.

Objectives: This study aims …

A Review Of Overlapping Severe Cutaneous Adverse Reaction, Ploylarp Lertvipapath, Roongrat Piyananjaruhsri, Diana Karimee

The Thai Journal of Pharmaceutical Sciences

Severe cutaneous adverse reactions (SCARs) are life-threatening drug hypersensitivity reactions, including acute generalized exanthematous pustulosis (AGEP), drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). SCARs occur in approximately 0.1% of hospitalizations and have mortality rates ranging from 5% for AGEP to 5–35% for SJS/TEN. AGEP typically presents with acute erythematous areas, sterile pustules, fever, and neutrophilia within 48–72 h of drug exposure. In contrast, DRESS manifests as fever, facial edema, morbilliform rash, and exfoliative dermatitis, often accompanied by hematologic abnormalities and multi-organ involvement, including hepatitis, pneumonitis, and myocarditis. Moreover, SJS and TEN …

The Use Of Health And Herbal Products For Covid-19 Self-Prevention And Its Affecting Factors According To Theory Of Planned Behavior, Suppachai Insuk, Supanida Kittirattanasak, Mullika Sirithongkaset, Daranee Chiewchantanakit

The Thai Journal of Pharmaceutical Sciences

Introduction: Despite the World Health Organization’s recent declaration of the end of the COVID-19 pandemic, the lessons learned from the outbreak remain crucial for future public health responses. In Thailand, the pandemic’s impact led individuals to explore self-protection methods, including potentially ineffective health products. This study examined the prevalence of health and herbal products used for COVID-19 self-prevention, to identify the types of these products in use and to identify factors influencing their utilization.

Methods: A cross-sectional study surveyed 400 Thai participants aged 25–60 who had never contracted COVID-19. The study employed convenience sampling and self-administered online questionnaires based on …

Antituberculosis Potential Of Borrelidin Derivatives: An In Silico Molecular Docking And Molecular Dynamic Approach, Teni Ernawati, Donny Ramadhan, Faris Hermawan, Sasmito Wulyoadi, Bambang Marwoto, Ahmad Wibisana, Bambang Srijanto

The Thai Journal of Pharmaceutical Sciences

Background: The present tuberculosis (TB) treatment requires a significant time commitment, often lasting from 6 months to 2 years, with strict daily adherence. Non-compliance leads to drug resistance and suboptimal outcomes. Present research indicates that borrelidin shows potential activity against Mycobacterium tuberculosis, including strains that are resistant to first-line medications. Borrelidin has shown remarkable activity against M. tuberculosis H37Rv, with a minimum inhibitory concentration value of 3.12 μg/mL. Therefore, investigating the inhibition activity of borrelidin derivatives was essential for finding new anti-TB candidates. Objectives: This study aims to investigate the effects of 31 borrelidin derivative compounds …

Cost-Utility Analysis Of Riluzole Treatment Compared With Supportive Care For Patients With Amyotrophic Lateral Sclerosis, Thaiphat Rattana-Amonloet, Ampai Pimkrai, Piyameth Dilokthornsakul, Unchalee Permsuwan

The Thai Journal of Pharmaceutical Sciences

Background: In Thailand, riluzole, a drug used to treat amyotrophic lateral sclerosis (ALS), was costly and had not yet been included in the National List of Essential Medicines. In addition, no studies have been conducted on the cost-effectiveness of the drug. Objective: This study aimed to evaluate the cost-utility of riluzole in treating patients with ALS compared with supportive care from the perspective of societal and health-care providers. Methods: A Markov model was employed to analyze costs and benefits from a societal and the health-care provider’s perspective. Outcomes were measured in quality-adjusted life years (QALYs). The analysis calculated an incremental …

Preparation And Evaluation Of Mesoporous Celecoxib For Improved Antiarthritic Activity In Rodents, Reena I. Fernandaes, Sayani Bhattacharyya

The Thai Journal of Pharmaceutical Sciences

Background: Celecoxib, a model anti-inflammatory drug, used in the management of arthritis exhibits limited oral bioavailability and slow onset of action due to its poor solubility. Objective: The present study explores a mesoporous drug delivery of celecoxib to investigate the efficacy of its antiarthritic activity in animal models, and develops a low-oral dose therapy. Materials and Methods: The solvent evaporation method was employed for the preparation of mesoporous delivery of celecoxib, using Syloid^®, and Neusilin^®, at a molar ratio of silica/ drug 1:2.5. The formulations were characterized for drug loading, in vitro drug release, and material …

The Antioxidant And Antiaging Activity Of Fig (Ficus Carica Linn) Leaf Ethanolic Extract In Vitro, Aji Winanta, Novita Zulaekhah, Perdana Priya Haresmita, Annisa Krisridwany, Rifki Febriansah, Inka Aprissa

The Thai Journal of Pharmaceutical Sciences

Background: Human organ systems can experience the aging process, one of which is the aging of the skin, characterized by dry, rough, or scaly skin, dullness, dark spots, and wrinkles. Previous studies have found that fig leaves contain compounds that have the potential to be anti-aging.
Objectives: This study aimed to determine the potential of fig leaves (Ficus carica Linn) as an anti-aging agent by examining their antioxidant activity, elastase inhibition, and antioxidative stress activity against hydrogen peroxide (H₂O₂). Materials and Methods: The phytochemicals in fig leaf ethanol extract were identified using phytochemical screening tests, …

Enhancing Topical Drug Delivery Of Apremilast Through Niosomal Gel Formulation: Ex Vivo Skin Permeation And In Vivo Evaluation For Psoriasis, Megha Shyam Matlapudi, Anka Rao Areti, Yukti Jaiswal, Veeresh Bantal, Raghavender Medishetti

The Thai Journal of Pharmaceutical Sciences

Background: Psoriasis is a dynamic and chronic disease characterized by inflammatory changes and an increased rate of keratinocyte proliferation leading to the formation of erythematous scleroderma plaques with a silvery sheen. The existing therapies come with shortcomings in terms of effectiveness and leave behind a trail of side effects. Hence, there is a need of alternative therapeutic measures. Objectives: This study aimed to assess the therapeutic potential of Apremilast Niosomal Gel (APR Nio Gel) in treating psoriasis, comparing its effectiveness with conventional gel (APR Gel) and oral suspension (APR Oral) formulations. Materials and Methods: Apremilast niosomes were prepared by thin …

Study Of Laws And Regulations Related To The Management Of Florfenicol Detection Cases In Swine, Shinnawat Saengungsumalee

The Thai Journal of Pharmaceutical Sciences

Background: Florfenicol, an antibiotic permitted in veterinary medicine, currently lacks an established maximum residue limit (MRL) in meat products in Thailand, effectively mandating undetectable residue levels. In May 2024, Thailand Pesticide Alert Network reported florfenicol residues in swine, raising concerns about consumer safety, rational veterinary drug use, and the potential for antimicrobial resistance (AMR). Addressing these issues involves multiple laws, decrees, and regulations across various agencies. Objectives: To analyze laws and regulations managing florfenicol residue detection in swine. Materials and Methods: This documentary research examines relevant laws, regulations, and measures for florfenicol in livestock and compares Thailand’s regulations with those …

Evaluating Asthma Education: A Comparison Of Whatsapp-Based Digital Interventions And Traditional Techniques, Rama Parthasarathy, Jayakumar Rajagopal, Sona Primuha Sugumaran, Sharon Angelin Johnson, Sai Shyam Kumar Nappa Selvam, Karthikeyan Ramaraju

The Thai Journal of Pharmaceutical Sciences

Background and Aims: Asthma is a chronic lung disease affecting people of all age group, which is characterized by inflammation and muscle tightening around the airway. Coughing, wheezing, and shortness of breath are the symptoms. The main complication faced by asthma patient is poor medication adherence; to overcome this patient counseling was performed. In this patient education was given through both digital and direct approaches. It is important to find out whether the above-mentioned approaches improve medication adherence. This research specifically investigates whether digital approaches through WhatsApp can directly improve asthma control compared to traditional methods. Methods: A prospective …

Antioxidant And Chemotherapeutic Synergy: Triphala Enhances Doxorubicin Cytotoxicity In Breast Cancer Cells And Reduces Toxicity In Non-Tumorigenic Cells, Supamas Charucharana, Poonlarp Cheepsunthorn Ph.D., Chalisa Louicharoen Cheepsunthorn Ph.D.

Chulalongkorn Medical Journal

Background: The combining of antioxidants with chemotherapy is increasingly explored to minimize toxicity in non-cancerous cells during breast cancer treatment. Triphala (TPL), a Thai herbal compound rich in antioxidants, shows potential as a complementary candidate for breast cancer chemotherapy.

Objective: This study investigated the combined effects of TPL and low-dose doxorubicin (DOX) on human breast cancer and non-tumorigenic mammary epithelial cells.

Methods: TPL’s bioactive compounds were analyzed via high-performance liquid chromatography (HPLC). Cell viability and reactive oxygen species (ROS) levels were assessed in breast cancer (MDA-MB-231, MCF-7) and epithelial (MCF-10A) cells using thiazolyl blue tetrazolium bromide (MTT) and chloromethyl 2′,7′-dichlorodihydrofluorescein …

Cytotoxic Constituents From Cylindrolobus Mucronatus Against Glioblastoma Cells, Shune Lae Yee Soe

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study reported the phytochemical investigation of Cylindrolobus mucronatus Lindl., a member of the Orchidaceae family, focusing on its chemical constituents and cytotoxic potential against glioblastoma cells. Eleven compounds were successfully isolated and structurally characterized, including new phenanthrene derivatives, cymucronins A-D, along with seven known compounds comprising confusarin , nudol, erianthridin, coelonin, bleformin I, (2,3-trans)-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-10-methoxy-2,3,4,5-tetrahydrophenanthro [2,1-b] furan-7-ol, and blestriarene C. Structural elucidation was accomplished using NMR, MS, IR and UV-Vis spectroscopic techniques, supported by comparison with literature data. Eight compounds were evaluated for their cytotoxic activity against U-87 human glioblastoma cells and three non-cancerous human cell lines: HEK293 (embryonic kidney), …

Antimicrobial Activity Of Silver Nanoparticles Synthesized Using Thai Herbal Extracts, Charuwan Pradabsang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Synthesis of silver nanoparticles (SNP) using Thai herbal plants, namely Garcinia cowa Roxb. ex Choisy (S1), Boesenbergia rotunda (L.) Mansf. (S2), Curcuma mangga Valeton & Zijp (S3), Momordica charantia L. forma abbreviata (Ser.) W. J. de Wilde & Duyfjes (S4), Persicaria odorata (Lour.) Soják (S5), Litsea elliptica Blume (S6), Gnetum gnemon Linn. var. tenerum Markgr (S7), Phaleria macrocarpa (Scheff.) Boerl. (S8), Salacia chinensis Linn. (S9) and Brachypterum scandens (Roxb.) Miq. (S10), is considerably economical and safe. Plants and preparation methods can affect properties and bioactivity such as controlled temperature of SNP. This study aimed to assess the ability of aqueous …

The Development Of Surveillance And Monitoring Tools For Pharmaceutical Supply Chain Management System For Public Health Emergencies, Kakanang Tosanguan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Thailand frequently experiences public health emergencies (PHEs) that severely disrupt pharmaceutical supply chain (PSC) management. This study addresses the urgent need for a specialized assessment tool to identify system weaknesses, support timely risk management, and enhance national preparedness planning.Methods: Utilizing a sequential exploratory mixed-methods design (July 2022–July 2024), the study began with a scoping review to identify existing frameworks. Following this, in-depth interviews with 36 key stakeholders synthesized conceptual domains. The draft tool underwent rigorous content validity assessment by 63 experts and was then pilot tested with 62 participants to confirm reliability (Cronbach’s alpha).Results: The evidence synthesis resulted in …

Optimization And Efficacy Of Car T Cells Derived From Newly Generated Anti-Cd22 Monoclonal Antibody For Blood Cancer Treatment, Wipawadee Ruengdej

Chulalongkorn University Theses and Dissertations (Chula ETD)

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of B-cell malignancies. Nevertheless, relapse due to loss of CD19 expression remains a major clinical challenge. CD22 serves as an alternative target because of its consistent expression on malignant B cells, even in CD19-negative disease. Optimization of CD22-directed CAR design is therefore critical to enhance antitumor potency and persistence. Two novel anti-CD22 CAR constructs were generated from monoclonal antibody clones 24A7G6 and 29H9C8, each incorporating either a 4-1BB or CD28 costimulatory domain. The resulting CAR T cells were evaluated for proliferation, phenotype, and cytotoxicity against CD22-positive (Raji, Nalm-6) and CD22-negative …

Comparison Of Efficacy Between Thai Herbal Anti-Hemorrhoid Formula And Micronized Purified Flavonoid Fraction In Patients With Internal Hemorrhoids, Darunee Rattanawongsamathakul, Varut Lohsiriwat, Suksalin Booranasubkajorn, Angkana Apichartvorakit, Pravit Akarasereenont

Journal of Health Research

Background: Hemorrhoids are a common anorectal condition. In Thai traditional medicine, the Bantaoridsidwangthawan formula (BRF) has been used to treat hemorrhoids. We aimed to evaluate the clinical efficacy and satisfaction of BRF versus Micronized purified flavonoid fraction (MPFF) in patients with internal hemorrhoids grades 1 and 2.

Methods: This was a single-blind, randomized control noninferiority trial. Twenty-seven participants were randomly assigned to BRF (n=13) or MPFF (n=14). The BRF group received 5 pills 3 times daily for 14 days. The MPFF group received 2 tablets 3 times daily for 4 days, and then 2 tablets 2 times daily …

Preventive Effects Of Quercetin On The Leaky Gut By Suppression Of Il-1beta-Induced Transcription Factors Involved In An Inflammatory Pathway In Colonic Epithelial Cells, Wannaporn Chayalak, Sumpun Thammacharoen, Chatsri Deachapunya, Sutthasinee Poonyachoti

The Thai Journal of Veterinary Medicine

Flavonol quercetin (Q), found in vegetables and fruits, demonstrates the most potent anti-inflammatory effect. The preventive effect and cellular mechanisms of Q (Q1, Q10, and Q100 µM) on IL-1β induced leaky gut via the signaling molecules of inflammatory pathway, NF-κB p65-iκB/or p38/ERK1/2/MLCK/phospho(p)-MLC were investigated in Caco-2 cells. The cytotoxic effect of Q was initially determined by MTT assay. Transepithelial electrical resistance (TER) and apical-to-basolateral fluorescein isothiocyanate-labeled dextran (FD-4) flux were used to determine paracellular permeability. The protein expression of signaling molecules was examined by Western blot analysis, and their target MLCK mRNA expression was determined using real-time PCR. All Q …

Beyond Mitragynine: Composition Survey And Stability Assessment Of Kratom Tea Ordered Via Food Delivery Platforms In Bangkok, Thailand, Yuta Tokuda, Apinya Tubtimrattana, Nat Tansrisawad, Kornvalee Meesilpavikkai, Parath Thirati

Chulalongkorn Medical Journal

Background: Kratom is a native tree to Southeast Asia. Kratom leaves have long been used medicinally and recreationally due to their stimulative and opioid-like effects attributed to high endogenous levels of mitragynine and related alkaloids. Kratom is widely consumed as tea and is now publicly sold, including on food delivery platforms, after recent decriminalization despite selling of kratom products being still considered illegal by other acts.

Objectives: To assess the formulas of kratom teas sold on Thai food delivery platform together with their consistency and the stability of refrigerated teas.

Methods: Kratom alkaloids, mitragynine and 7-hydroxymitragynine, and additive contents of …

Zinc Chloride Molten Salt Carbonization And Activation For Conversion Of Plastic Waste Into Porous Carbon, Theerawat Waiyaka

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research focuses on the development of a prototype of a continuous molten salt carbonization and activation process to convert plastic waste into porous carbon by improving the immersion of zinc chloride molten at 350°C under atmospheric conditions. The plastic wastes used in the study include polypropylene (PP) from plastic cups, polylactic acid (PLA) from plastic glasses, and polyethylene terephthalate (PET) from plastic bottles with a ZnCl2 to plastic waste ratio of 10:1 by mass. The experimental results showed that PET plastic yielded the highest amount of mesoporous carbon yield of 14.1% of the initial mass, followed by PLA at …

Regulation Amendment To Improve Thai Drug Importation Control System, Neeranart Potiyanon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Drug importation is critical for ensuring access to essential medicines in Thailand. However, the current system faces significant challenges, including outdated regulations, inefficient processes, and limited use of modern technology. This study aimed to identify regulatory and operational gaps and propose improvements to enhance the effectiveness of Thailand’s drug importation control. Methods: A two-phase mixed-methods study was conducted in Bangkok from 2019 to 2021. Phase 1 employed the Context, Input, Process, and Product (CIPP) model to analyze content from semi-structured interviews with 19 key informants representing both government and private sectors. In Phase 2, the Multi-Criteria Decision Analysis (MCDA) …

Thermally Conductive Adhesive Based On Carbon Quantum Dots/Graphene Nanoplatelets-Epoxy Composites For Electronic Packaging, Thanayuth Jongrungrotbaworn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Conventional bottom-up synthesis of carbon quantum dots (CQDs) often requires extended reaction times, high energy input, and specialized equipment, limiting scalability and sustainability. In this study, we present an eco-friendly and energy-efficient method for synthesizing CQDs using H₂CO₃ as a carbon precursor at just 72 °C for 1 hour—representing one of the lowest reported synthesis temperatures and shortest reaction times using simple apparatus. Graphene oxide vacancies act as catalytic and nucleation sites, promoting the formation of CQDs under these mild conditions. The resulting CQD solution exhibits strong yellow photoluminescence, with a maximum emission at 533 nm and excitation-independence across the …

Antibacterial And Anti-Inflammatory Activities Of Herbal Formulas And Its Components: Ya-Kao Formula And The Formula Of Propolis Extract And Hemp Extract, Naruemon Perstwong

Chulalongkorn University Theses and Dissertations (Chula ETD)

The COVID-19 pandemic has prompted the Thai government to explore herbal medicines grounded in Traditional Thai Medicine (TTM) knowledge and review literature. Highlighted herbs formula, including Ya-Kao formula and propolis extract, have been recommended as supportive treatments for non-symptomatic COVID-19 patients. Additionally, Cannabis sativa (C. sativa) has gained recognition for its pharmacological properties, such as analgesic effects, pain relief, and anti-SARS-CoV-2 activity. One formula, Ya-Kao, traditionally used for fever relief, is documented in TTM textbook. The second formula is propolis extract (PE) was combined with C. sativa extract (CS). However, the efficacy and effectiveness require further scientific investigation. This study …

Safety And Efficacy Of Bispecific Antibodies In Hematologic Neoplasms: A Systematic Review, Khanittha Lommuang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: The global burden of hematologic neoplasms is rising. Despite advances in therapy, relapse, resistance, and limited options persist. Bispecific antibodies (BsAbs) offer a novel approach by targeting multiple antigens. This systematic review assesses their efficacy and safety. Methods: We conducted this systematic review following the PRISMA 2020 guidelines. Articles published up to 1 February 2025 were searched across PubMed, Scopus, Web of Science, and Embase. The clinical trials, focusing on SAEs, grade ≥ 3 AEs, hematologic and non-hematologic toxicities, and efficacy outcomes (ORR, CR, OS, and PFS), were included. Results were summarized qualitatively. Results: Twenty-three studies evaluating fifteen different …

Developemnt Of Hyaluronic Acid Grafted With Poly N-Isopropyl Acrylamide Nanogel Incorporating Hemp Extract Containing Cbd, May Thu Thu Kyaw

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cannabidiol (CBD), a major phytocannabinoid present in Cannabis sativa, possesses multiple effective pharmacological activities, such as neuroprotective, cardioprotective and anti-inflammatory properties. However, its hydrophobic nature and rapid degradation mechanisms limit its clinical usefulness. Encapsulation of lipophilic compounds inside modified polymers with hydrophilic properties can improve the aqueous solubility and stability of drugs in specific environments. Therefore, this study focused on self-assembled poly N-isopropyl acrylamide (pNIPAM) grafted hyaluronic acid (HA) nanogels for encapsulating CBD. At the highest concentration 0.25 % w/w of HA-g-pNIPAM, encapsulation efficiency (% EE) of CBD 87.57 % was achieved compared to other two formulations 0.15 % w/w …

การประเมินคุณภาพชีวิตด้านสุขภาพ คุณภาพชีวิตด้านการใช้ยา และความเต็มใจที่จะจ่ายในผู้ป่วยโรคเพมฟิกัสและผู้ป่วยโรคบูลลัสเพมฟิกอยด์, อริสรา เหลืองสุขฤกษ์

Chulalongkorn University Theses and Dissertations (Chula ETD)

วัตถุประสงค์: เพื่อประเมินคุณภาพชีวิตด้านสุขภาพ คุณภาพชีวิตด้านการใช้ยา และความเต็มใจที่จะจ่าย รวมถึงศึกษาปัจจัยที่มีความสัมพันธ์กับคุณภาพชีวิตด้านสุขภาพ คุณภาพชีวิตด้านการใช้ยา และความเต็มใจที่จะจ่ายในผู้ป่วยโรคเพมฟิกัสและผู้ป่วยโรคบูลลัสเพมฟิกอยด์ วิธีการศึกษา: การศึกษาวิจัยเชิงวิเคราะห์แบบภาคตัดขวางในผู้ป่วยโรคเพมฟิกัสและผู้ป่วยโรคบูลลัสเพมฟิกอยด์ที่มีอายุ 18-90 ปีที่เข้ารับการรักษาในสถาบันโรคผิวหนัง ระหว่างเดือนมกราคมถึงพฤษภาคม 2568 จำนวน 178 ราย โดยใช้แบบสอบถามคุณภาพชีวิตด้านสุขภาพ EQ-5D-5L และ Dermatology Life Quality Index (DLQI) แบบสอบถามคุณภาพชีวิตด้านการใช้ยา Patient-Reported Outcomes Measure of Pharmaceutical Therapy (PROMPT) และแบบสอบถามความเต็มใจที่จะจ่าย ผลการศึกษา: ผู้ป่วยส่วนใหญ่มีคุณภาพชีวิตด้านสุขภาพและด้านการใช้ยาในระดับดี โดยมิติที่มีผู้ป่วยรายงานปัญหามากที่สุดในแบบสอบถาม EQ-5D-5L คือ มิติอาการเจ็บปวดหรือไม่สบายตัว ขณะที่มิติอาการและความรู้สึกในแบบสอบถาม DLQI เป็นมิติที่ได้รับผลกระทบมากที่สุด สำหรับแบบสอบถาม PROMPT พบว่ามิติผลกระทบทางด้านจิตใจของการใช้ยามีคะแนนต่ำที่สุด ปัจจัยที่มีความสัมพันธ์กับคุณภาพชีวิตด้านสุขภาพ ได้แก่ อายุ ระดับการศึกษา ระดับความรุนแรงของโรค และจำนวนโรคร่วม ส่วนเพศ อายุ ระดับการศึกษา และสภาวะโรคปัจจุบันสัมพันธ์กับคุณภาพชีวิตด้านการใช้ยา ขณะที่รายได้ต่อเดือนและระดับการศึกษามีความสัมพันธ์กับมูลค่าความเต็มใจที่จะจ่ายอย่างมีนัยสำคัญทางสถิติ สรุปผล: ผู้ป่วยโรคเพมฟิกัสและผู้ป่วยโรคบูลลัสเพมฟิกอยด์ได้รับผลกระทบต่อคุณภาพชีวิตในหลายมิติ ทั้งจากตัวโรค การรักษา และการใช้ยา ข้อมูลที่ได้สามารถใช้ประโยชน์ในการวางแผนการรักษา การให้คำปรึกษาด้านยา และสนับสนุนการกำหนดนโยบายเพื่อเพิ่มการเข้าถึงยาที่จำเป็นให้แก่ผู้ป่วยมากยิ่งขึ้น

In Silico And In Vitro Studies On Ha-G-Pnipam Modified Liposomal Curcumin For Cancer Treatment, Abd. Umar

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cancer remains the leading cause of global mortality, with conventional chemotherapy drugs often limited by poor selectivity, side effects, and drug resistance. As a promising alternative and adjuvant, curcumin offers potent anticancer properties, but its low bioavailability highlights the need for targeted delivery systems to enhance its therapeutic potential. This study designs a targeted delivery system for curcumin using hyaluronic acid-grafted pNIPAM (HA-g-pNIPAM) modified liposomes, characterized both experimentally and computationally. The results show that the nanoparticle system has a size range of 80-120 nm, a PDI of 0.12-0.3, a zeta potential of -13.2 to -50.8 mV, and an absorption efficiency …

Bioactive Extracts Of The Roots Of Cannabis Sativa L. Against Dental Pathogens, Pattarapol Udomlarp

Chulalongkorn University Theses and Dissertations (Chula ETD)

The roots of Cannabis sativa L. are often underutilized and regarded as agricultural waste, despite reports of bioactive compounds with potential pharmaceutical applications. This study focused on developing an ecofriendly method for extracting triterpenoids and investigating the oral antimicrobial activity of cannabis root extracts. The primary objectives were to optimize an extraction process yielding high triterpenoid content and evaluate the potential of extracts to inhibit dental pathogens, thereby promoting the value of cannabis roots for future applications.The efficiency of Soxhlet solvent extraction, ultrasonic-assisted extraction (UAE), subcritical water extraction, and subcritical dimethyl ether extraction (SDMEE) was compared for yielding triterpenoids, particularly …