Psychiatry Commons^™

Potentially Important Periods Of Change In The Development Of Social And Role Functioning In Youth At Clinical High Risk For Psychosis, E. Velthorst, J. Zinberg, J. Addington, K. S. Cadenhead, T. D. Cannon, R. E. Carrion, A. Auther, B. A. Cornblatt, T. H. Mcglashan, C. E. Bearden, +7 Additional Authors

Journal Articles

No abstract provided.

Prospective Relationships Between Motivation And Functioning In Recovery After A First Episode Of Schizophrenia, D. Fulford, D. Piskulic, J. Addington, J. M. Kane, N. R. Schooler, K. T. Mueser

Journal Articles

No abstract provided.

Effectiveness Of Long-Acting Injectable Vs Oral Antipsychotics In Patients With Schizophrenia: A Meta-Analysis Of Prospective And Retrospective Cohort Studies, T. Kishimoto, K. Hagi, M. Nitta, S. Leucht, M. Olfson, J. M. Kane, C. U. Correll

Journal Articles

No abstract provided.

A Daily Diary Study Of Stressful And Positive Events, Alcohol Use, And Addiction Severity Among Heavy Drinking Sexual Minority Men, E. H. Mereish, A. Kuerbis, J. Morgenstern

Journal Articles

© 2018 Elsevier B.V. Background: The purpose of this study is to examine the conditions under which daily stressful and positive events are associated with alcohol use among heavy drinking sexual minority men (SMM). Specifically, we examined the moderating effects of two indicators of alcohol addiction severity (i.e., alcohol dependence severity and negative drinking consequences) on the associations between daily stressful events and alcohol use and between daily positive events and alcohol use among heavy drinking SMM. Procedures: Secondary data analyses were performed using data from a randomized controlled trial of heavy drinking and treatment seeking SMM who were assigned …

Correlation Of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns With Outcome Following Neoadjuvant Chemoradiation, J. M. Kane, A. Magliocco, Q. Zhang, D. Wang, A. Klimowicz, J. Harris, J. Simko, T. Delaney, W. Kraybill, D. G. Kirsch

Journal Articles

© 2018 John M. Kane III et al. Background. Sarcoma mortality remains high despite adjuvant chemotherapy. Biomarker predictors of treatment response and outcome could improve treatment selection. Methods. Tissue microarrays (TMAs) were created using pre- and posttreatment tumor from two prospective trials (MGH pilot and RTOG 9514) of neoadjuvant/adjuvant MAID chemotherapy and preoperative radiation. Biomarkers were measured using automated computerized imaging (AQUA or ACIS). Expression was correlated with disease-free survival (DFS), distant disease-free survival (DDFS), and overall survival (OS). Results. Specimens from 60 patients included 23 pretreatment (PRE), 40 posttreatment (POST), and 12 matched pairs (MPs). In the MP set, …

White Matter Integrity In Medication-Free Women With Peripartum Depression: A Tract-Based Spatial Statistics Study, M. Silver, C. M. Moore, V. Villamarin, N. Jaitly, J. E. Hall, A. J. Rothschild, K. M. Deligiannidis

Journal Articles

No abstract provided.

Treatment Of Tardive Dyskinesia With Vmat-2 Inhibitors: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, M. Solmi, G. Pigato, J. M. Kane, C. U. Correll

Journal Articles

No abstract provided.

Accounting For Group Differences In Study Retention In A Randomized Trial Of Specialized Treatment For First Episode Psychosis, K. Sint, R. Rosenheck, D. G. Robinson, N. R. Schooler, P. Marcy, J. M. Kane, K. T. Mueser, H. Lin

Journal Articles

No abstract provided.

Prevalence And Predictors Of Hair Pulling Disorder And Excoriation Disorder In Tourette Syndrome, E. Greenberg, E. S. Tung, C. Gauvin, L. Osiecki, K. G. Yang, E. Curley, A. Essa, C. Illmann, C. L. Budman, J. M. Scharf, +10 Additional Authors

Journal Articles

No abstract provided.

Malignant Adnexal Tumors Of The Skin: A Single Institution Experience, T. Oyasiji, W. Tan, J. Kane, J. Skitzki, V. Francescutti, K. Salerno, N. I. Khushalani

Journal Articles

© 2018 The Author(s). Background: Malignant adnexal tumors of the skin (MATS) are rare. We aimed to measure the survival of patients with MATS and identify predictors of improved survival. Methods: A retrospective review of MATS treated at our institution from 1990 to 2012. Results: There were 50 patients within the time period. Median age was 59.5 years (range 22-95); primary site was the head and neck (52%); most common histologic subtypes were skin appendage carcinoma (20%) and eccrine adenocarcinoma (20%); and the vast majority were T1 (44%). Most patients (98%) underwent surgical treatment. Chemotherapy and radiation were administered to …

What Is The Risk-Benefit Ratio Of Long-Term Antipsychotic Treatment In People With Schizophrenia?, C. U. Correll, J. M. Rubio, J. M. Kane

Journal Articles

No abstract provided.

Comparison Of Early Intervention Services Vs Treatment As Usual For Early-Phase Psychosis A Systematic Review, Meta-Analysis, And Meta-Regression, C. U. Correll, B. Galling, A. Pawar, A. Krivko, C. Bonetto, M. Ruggeri, T. J. Craig, M. Nordentoft, D. G. Robinson, J. M. Kane, +16 Additional Authors

Journal Articles

No abstract provided.

Initiating/Maintaining Long-Acting Injectable Antipsychotics In Schizophrenia/Schizoaffective Or Bipolar Disorder - Expert Consensus Survey Part 2, M. Sajatovic, R. Ross, S. N. Legacy, M. Byerly, J. M. Kane, F. Dibiasi, H. Fitzgerald, C. U. Correll

Journal Articles

No abstract provided.

Impact Of Paliperidone Palmitate One-Month Formulation On Relapse Prevention In Patients With Schizophrenia: A Post-Hoc Analysis Of A One-Year, Open-Label Study Stratified By Medication Adherence, T. Si, N. Li, H. Lu, S. Cai, J. Zhuo, C. U. Correll, L. Zhang, Y. Feng

Journal Articles

No abstract provided.

Law Enforcement Officers' Perceptions Of And Responses To Traumatic Events: A Survey Of Officers Completing Crisis Intervention Team Training, M. H. Fleischmann, P. Strode, B. Broussard, M. T. Compton

Journal Articles

No abstract provided.

Genome-Wide Association Study Of Cognitive Flexibility Assessed By The Wisconsin Card Sorting Test, H. Zhang, H. Zhou, T. Lencz, L. A. Farrer, H. R. Kranzler, J. Gelernter

Journal Articles

No abstract provided.

Gene Discovery And Polygenic Prediction From A Genome-Wide Association Study Of Educational Attainment In 1.1 Million Individuals, J. J. Lee, R. Wedow, A. Okbay, E. Kong, O. Maghzian, M. Zacher, A. N. Tuan, T. Lencz, A. K. Malhotra, D. Cesarini, +67 Additional Authors

Journal Articles

No abstract provided.

Shared Polygenicity Detection Using Elastic Nets: Sharpen, M. John, T. Lencz

Journal Articles

Current research suggests that hundreds to thousands of single nucleotide polymorphisms (SNPs) with modest effect sizes contribute to the genetic basis of many disorders, a phenomenon labeled as polygenicity. Additionally, many such disorders demonstrate polygenic overlap, in which risk alleles are shared at associated genetic loci. However, there are currently no well-developed statistical methods that can be utilized to detect specific subsets of SNPs involved in the shared polygenicity of phenotypes. In this paper, we illustrate how elastic nets, with appropriate adaptation in selecting the penalty parameter, can be utilized for narrowing the range of SNPs involved in shared polygenicity. …

Tardive Dyskinesia Risk With First- And Second-Generation Antipsychotics In Comparative Randomized Controlled Trials: A Meta-Analysis, M. Carbon, J. M. Kane, S. Leucht, C. U. Correll

Journal Articles

No abstract provided.

What's In A Name? Moving To Neuroscience-Based Nomenclature In Pediatric Psychopharmacology, R. S. Sultan, C. U. Correll, J. Zohar, G. Zalsman, J. Veenstra-Vanderweele

Journal Articles

© 2018 American Academy of Child and Adolescent Psychiatry Our traditional names for psychotropic medication classes lead to unnecessary confusion. As clinicians, we have grown comfortable with idiosyncratic names of psychotropic medications and have forgotten how unclear and misleading they can be. For example, evidence shows that serotonin reuptake inhibitors help in pediatric anxiety disorders, but a parent with an anxious child might ask, “If you diagnosed my son with separation anxiety, why are you giving him an antidepressant?” Another parent might object to the use of a “stimulant” medication, “My daughter never slows down, the last thing she needs …

National Patterns Of Commonly Prescribed Psychotropic Medications To Young People, R. S. Sultan, C. U. Correll, M. Schoenbaum, M. King, J. T. Walkup, M. Olfson

Journal Articles

No abstract provided.

Grk5 Is Associated With The Regulation Of Methadone Dosage In Heroin Dependence, S. C. Wang, R. H. Chung, H. W. Kuo, T. H. Liu, C. P. Fang, S. C. Liu, C. C. Liu, H. H. Tsou, A. C. Chen, Y. L. Liu

Journal Articles

© The Author(s) 2018. Background There is no countable biomarker for opioid dependence treatment responses thus far. In this study, we recruited Taiwanese methadone maintenance treatment patients to search for genes involving the regulatory mechanisms of methadone dose by genome-wide association analyses. Methods A total of 344 Taiwanese methadone maintenance treatment patients were included in a genome-wide association study. The involvement of GRK5 in opioid dependence was then further confirmed by gene expression study on lymphoblastoid cell lines derived from 3 independent age- and gender-matched groups: Methadone maintenance treatment patients, medication-free former heroin abusers, and normal controls. Results The results …

Lack Of Diagnostic Pluripotentiality In Patients At Clinical High Risk For Psychosis: Specificity Of Comorbidity Persistence And Search For Pluripotential Subgroups., S. W. Woods, A. R. Powers, J. H. Taylor, C. A. Davidson, J. K. Johannesen, J. Addington, D. O. Perkins, C. E. Bearden, B. A. Cornblatt, T. H. Mcglashan, +5 Additional Authors

Journal Articles

More than 20 years after the clinical high risk syndrome for psychosis (CHR) was first articulated, it remains controversial whether the CHR syndrome predicts onset of psychosis with diagnostic specificity or predicts pluripotential diagnostic outcomes. Recently, analyses of observational studies, however, have suggested that the CHR syndrome is not pluripotential for emergent diagnostic outcomes. The present report conducted additional analyses in previously reported samples to determine (1) whether comorbid disorders were more likely to persist in CHR patients compared to a comparison group of patients who responded to CHR recruitment efforts but did not meet criteria, termed help-seeking comparison subjects …

Parsing Cyclothymic Disorder And Other Specified Bipolar Spectrum Disorders In Youth, A. Van Meter, B. I. Goldstein, T. R. Goldstein, S. Yen, H. Hower, M. Strober, J. A. Merranko, M. K. Gill, R. S. Diler, B. Birmaher, +3 Additional Authors

Journal Articles

© 2018 Elsevier B.V. Objective: Most studies of pediatric bipolar disorder (BP) combine youth who have manic symptoms, but do not meet criteria for BP I/II, into one “not otherwise specified” (NOS) group. Consequently, little is known about how youth with cyclothymic disorder (CycD) differ from youth with BP NOS. The objective of this study was to determine whether youth with a research diagnosis of CycD (RDCyc) differ from youth with operationalized BP NOS. Method: Participants from the Course and Outcome of Bipolar Youth study were evaluated to determine whether they met RDCyc criteria. Characteristics of RDCyc youth and BP …

Psychopharmacological Treatment In The Raise-Etp Study: Outcomes Of A Manual And Computer Decision Support System Based Intervention, D. G. Robinson, N. R. Schooler, C. U. Correll, M. John, B. T. Kurian, P. Marcy, A. L. Miller, R. Pipes, M. H. Trivedi, J. M. Kane

Journal Articles

No abstract provided.

Reminder Duration Determines Threat Memory Modification In Humans, J. Hu, W. Wang, P. Homan, P. Wang, X. Zheng, D. Schiller

Journal Articles

© 2018 The Author(s). Memory reminders can return a memory into an unstable state such that it will decay unless actively restabilized into long-term memory through reconsolidation. Exposure to a memory reminder, however, does not always lead to destabilization. The 'trace dominance' principle posits that the extent of exposure to memory reminders governs memory susceptibility to disruption. Here, we provide a first systematic investigation of reminder duration effects on threat memory modification in humans. Reminder duration was parametrically varied across 155 participants in a three-day protocol. We found that short reminders (1 s and 4 s) made the memory prone …

Statewide Cross-Sectional Survey Of Emergency Departments’ Adoption And Implementation Of The Ohio Opioid Prescribing Guidelines And Opioid Prescribing Practices, Jonathan Penm, Neil J. Mackinnon, Rebecca Mashni, Michael S. Lyons, Edmond A. Hooker, Erin L. Winstanley, Steve Carlton-Ford, Chloe Connelly, Erica Tolle, Jill Boone, Kathleen Koechlin, Jolene Defiore-Hyrmer

Faculty & Staff Scholarship

study objective: To evaluate the implementation of the Ohio Emergency and Acute Care Facility Opioids and Other Controlled Substances Prescribing Guidelines and their perceived impact on local policies and practice.

Methods: The study design was a cross-sectional survey of emergency department (ED) medical directors, or appropriate person identified by the hospital, perception of the impact of the Ohio ED Opioid Prescribing Guidelines on their departments practice. All hospitals with an ED in Ohio were contacted throughout October and November 2016. Distribution followed Dillman’s Tailored Design Method, augmented with telephone recruitment. Hospital chief executive officers were contacted when necessary to encourage …

The Role Of Genetics In Advancing Precision Medicine For Alzheimer's Disease-A Narrative Review., Y. Freudenberg-Hua, W. Li, P. Davies

Journal Articles

Alzheimer's disease (AD) is the most common type of dementia, which has a substantial genetic component. AD affects predominantly older people. Accordingly, the prevalence of dementia has been rising as the population ages. To date, there are no effective interventions that can cure or halt the progression of AD. The only available treatments are the management of certain symptoms and consequences of dementia. The current state-of-the-art medical care for AD comprises three simple principles: prevent the preventable, achieve early diagnosis, and manage the manageable symptoms. This review provides a summary of the current state of knowledge of risk factors for …

Suicidal Ideation Assessment In Individuals With Premanifest And Manifest Huntington Disease., Melissa Wesson, Nicholas R Boileau, Joel S Perlmutter, Jane S Paulsen, Stacey K Barton, Michael K Mccormack, Noelle E Carlozzi

Rowan-Virtua School of Osteopathic Medicine Departmental Research

BACKGROUND: Huntington disease (HD) is associated with increased risk of suicide.

OBJECTIVE: This study compares suicide ideation in HD to the general population, assesses factors associated with increased prevalence of suicidal thoughts, and compares clinician-rated to self-reported assessments of suicidal ideation.

METHODS: We examined 496 participants with premanifest or manifest HD. Clinician-rated suicidal ideation was measured using the Problem Behaviors Assessment - short form. Self-reported ideation was measured using two items from the HDQLIFE Concern with Death and Dying item bank. Independent sample t-tests were conducted to compare the prevalence of suicidal thoughts between our HD sample and the U.S. …

Benzodiazepines I: Upping The Care On Downers: The Evidence Of Risks, Benefits And Alternatives, Jeffrey Guina, Brian Merrill

Psychiatry Faculty Publications

Benzodiazepines are some of the most commonly prescribed medications in the world. These sedative-hypnotics can provide rapid relief for symptoms like anxiety and insomnia, but are also linked to a variety of adverse effects (whether used long-term, short-term, or as needed). Many patients take benzodiazepines long-term without ever receiving evidence-based first-line treatments (e.g., psychotherapy, relaxation techniques, sleep hygiene education, serotonergic agents). This review discusses the risks and benefits of, and alternatives to benzodiazepines. We discuss evidence-based indications and contraindications, and the theoretical biopsychosocial bases for effectiveness, ineffectiveness and harm. Potential adverse effects and drug-drug interactions are summarized. Finally, both fast-acting/acute …