Psychiatry Commons^™

Premenstrual Syndrome: Existence, Knowledge, And Attitude Among Female University Students In Karachi, Aleena Mohib, Amara Zafar, Areeba Najam, Hafsa Tanveer, Rehana Rehman

Department of Biological & Biomedical Sciences

Objective: The aim of this study was to investigate the existence, knowledge, and the attitude of female students towards premenstrual syndrome (PMS).
Methods: This cross-sectional study was conducted in three universities in Karachi, Pakistan. A total of 448 female students participated in the study. The clinical criterion of American College of Obstetricians and Gynecologists (ACOG) for PMS was used to assess the prevalence of PMS in the participants. The questionnaire was set in four parts, one each to assess the knowledge, the attitude, and practices regarding PMS and one to assess the gap between self-perceived PMS and actual PMS. Data …

Canadian Network For Mood And Anxiety Treatments (Canmat) And International Society For Bipolar Disorders (Isbd) 2018 Guidelines For The Management Of Patients With Bipolar Disorder., Lakshmi N Yatham, Sidney H Kennedy, Sagar V Parikh, Ayal Schaffer, David J Bond, Robert M Post, +Several Additional Authors

Psychiatry and Behavioral Sciences Faculty Publications

The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published treatment guidelines for bipolar disorder in 2005, along with international commentaries and subsequent updates in 2007, 2009, and 2013. The last two updates were published in collaboration with the International Society for Bipolar Disorders (ISBD). These 2018 CANMAT and ISBD Bipolar Treatment Guidelines represent the significant advances in the field since the last full edition was published in 2005, including updates to diagnosis and management as well as new research into pharmacological and psychological treatments. These advances have been translated into clear and easy to use recommendations for first, …

Demographic And Clinical Correlates Of Seizure Frequency: Findings From The Managing Epilepsy Well Network Database, Martha Sajatovic, Ashley Bukach, Curtis Tatsuoka

Faculty Scholarship

Background and Purpose Epilepsy is a chronic neurological disease that represents a tremendous burden on both patients and society in general. Studies have addressed how demographic variables, socioeconomic variables, and psychological comorbidity are related to the quality of life (QOL) of people with epilepsy (PWE). However, there has been less focus on how these factors may differ between patients who exhibit varying degrees of seizure control. This study utilized data from the Managing Epilepsy Well (MEW) Network of the Centers for Disease Control and Prevention with the aim of elucidating differences in demographic variables, depression, and QOL between adult PWE. …

Suicide And Deliberate Self-Harm In Pakistan: A Scoping Review, Sualeha S. Shekhani, Shagufta Perveen, Dur-E-Sameen Hashmi, Khawaja Akbar, Sara Bachani, Murad M. Khan Dr.

Department of Psychiatry

Background: Suicide is a major global public health problem with more than 800,000 incidents worldwide annually. Seventy-five percent of the global suicides occur in low and middle-income countries (LMICs). Pakistan is a LMIC where information on suicidal behavior is limited. The aim of the review is to map available literature on determinants, risk factors and other variables of suicidal behavior in Pakistan.
Method: This study was based on Arksey and O'Malley's methodological framework of scoping review, combining peer reviewed publications with grey literature. Ten databases including Applied Social Sciences Index and Abstracts (ASSIA), Cochrane Trials Register (CRG), Cumulative Index to …

Maternal Mental Health Priorities, Help-Seeking Behaviors, And Resources In Post-Conflict Settings: A Qualitative Study In Eastern Uganda., Wietse A Tol, Breeona Ebrecht, Rebecca Aiyo, Sarah M Murray, Amanda J Nguyen, Brandon A Kohrt, Sheila Ndyanabangi, Stephen Alderman, Seggane Musisi, Juliet Nakku

Psychiatry and Behavioral Sciences Faculty Publications

BACKGROUND: Limited knowledge exists to inform the selection and introduction of locally relevant, feasible, and effective mental health interventions in diverse socio-cultural contexts and health systems. We examined stakeholders' perspectives on mental health-related priorities, help-seeking behaviors, and existing resources to guide the development of a maternal mental health component for integration into non-specialized care in Soroti, eastern Uganda.

METHODS: We employed rapid ethnographic methods (free listing and ranking; semi-structured interviews; key informant interviews and pile sorting) with community health workers (n = 24), primary health workers (n = 26), perinatal women (n = 24), traditional and religious healers (n = …

Self-Reported Academic Performance In Relation To Health Behaviours Among Bahria University Students, Rehana Rehman, Amara Zafar, Aleena Mohib, Mehwish Hussain, Rabiya Ali

Department of Biological & Biomedical Sciences

Objective: To find an association between self-reported academic performance with different socio-demographic factors, health behaviours and mental health amongst university students.
Methods: This cross-sectional study was conducted at Bahria University, Karachi, from January 2012 to December 2013, and comprised university students of different disciplines. An anonymous, self-reported questionnaire was distributed among the subjects. Convenient sampling technique was used. Demographic information, including age, gender and field of study, were obtained. Depresion was evaluated via Centre for Epidemiological Studies Depression Scale. SPSS 22 was used to analyse data.
Results: Of the 813 respondents, 334(41.1%) were males and 479(58.9%) females. The mean age …

Chasing The Dragon, Daniel Young Cho, Hani Nazha, Kalin Fisher

Marshall Journal of Medicine

Abstract: Although rare, toxic leukoencephalopathy (TLE) associated with heroin inhalation have been reported. ‘Chasing the dragon’ may lead to progressive spongiform degeneration of the brain and presents with a large range of neuropsychological sequelae. A thorough social history and clinical suspicion are paramount in recognizing the diagnosis. This case is an example of TLE in a middle-aged white male with a history of polysubstance abuse. He presented with a three week history of progressive neuropsychological symptoms, including abulia, bradyphrenia, hyperreflexia, and visual hallucinations. He was initially suspected to have progressive multifocal leukoencephalopathy, however, JCV PCR was negative. MRI showed diffuse …

Objective Coding Of Content And Techniques In Workplace-Based Supervision Of An Ebt In Public Mental Health, Shannon Dorsey, Suzanne E U Kerns, Leah Lucid, Michael D Pullmann, Julie P Harrison, Lucy Berliner, Kelly Thompson, Esther Deblinger

Rowan-Virtua School of Osteopathic Medicine Departmental Research

BACKGROUND: Workplace-based clinical supervision as an implementation strategy to support evidence-based treatment (EBT) in public mental health has received limited research attention. A commonly provided infrastructure support, it may offer a relatively cost-neutral implementation strategy for organizations. However, research has not objectively examined workplace-based supervision of EBT and specifically how it might differ from EBT supervision provided in efficacy and effectiveness trials.

METHODS: Data come from a descriptive study of supervision in the context of a state-funded EBT implementation effort. Verbal interactions from audio recordings of 438 supervision sessions between 28 supervisors and 70 clinicians from 17 public mental health …

Childhood Interpersonal Violence And Adult Alcohol, Cannabis, And Tobacco Use Disorders: Variation By Race/Ethnicity?, Jacquelyn Meyers, Carolyn Sartor, Kimberly Werner, Karestan Koenen, Bridget Grant, Deborah Hasin

Nursing Faculty Works

No abstract provided.

Reducing Stigma Among Healthcare Providers To Improve Mental Health Services (Reshape): Protocol For A Pilot Cluster Randomized Controlled Trial Of A Stigma Reduction Intervention For Training Primary Healthcare Workers In Nepal., Brandon A Kohrt, Mark J D Jordans, Elizabeth L Turner, Kathleen J Sikkema, Nagendra P Luitel, Sauharda Rai, Daisy R Singla, Jagannath Lamichhane, Crick Lund, Vikram Patel

Psychiatry and Behavioral Sciences Faculty Publications

Background

Non-specialist healthcare providers, including primary and community healthcare workers, in low- and middle-income countries can effectively treat mental illness. However, scaling-up mental health services within existing health systems has been limited by barriers such as stigma against people with mental illness. Therefore, interventions are needed to address attitudes and behaviors among non-specialists. Aimed at addressing this gap, REducing Stigma among HealthcAre Providers to ImprovE mental health services (RESHAPE) is an intervention in which social contact with mental health service users is added to training for non-specialist healthcare workers integrating mental health services …

Interpersonal Violence And Suicidality Among Former Child Soldiers And War-Exposed Civilian Children In Nepal., Anvita Bhardwaj, Christine Bourey, Sauharda Rai, Ramesh Prasad Adhikari, Carol M Worthman, Brandon A Kohrt

Psychiatry and Behavioral Sciences Faculty Publications

Background: Suicide risk reduction is crucial for 15-29-year-old youth, who account for 46% of suicide deaths in low- and middle-income countries. Suicide predictors in high-resource settings, specifically depression, do not adequately predict suicidality in these settings. We explored if interpersonal violence (IPV) was associated with suicidality, independent of depression, in Nepal.

Methods: A longitudinal cohort of child soldiers and matched civilian children, enrolled in 2007 after the People's War in Nepal, were re-interviewed in 2012. The Depression Self-Rating Scale and Composite International Diagnostic Interview assessed depression and suicidality, respectively. Non-verbal response cards were used to capture experiences of sexual and …

Neural Correlates Of Taste Reactivity In Autism Spectrum Disorder., Jason A Avery, John E Ingeholm, Sophie Wohltjen, Meghan Collins, Cameron D Riddell, Stephen J Gotts, Lauren Kenworthy, Gregory L Wallace, W Kyle Simmons, Alex Martin

Psychiatry and Behavioral Sciences Faculty Publications

Selective or 'picky' eating habits are common among those with autism spectrum disorder (ASD). These behaviors are often related to aberrant sensory experience in individuals with ASD, including heightened reactivity to food taste and texture. However, very little is known about the neural mechanisms that underlie taste reactivity in ASD. In the present study, food-related neural responses were evaluated in 21 young adult and adolescent males diagnosed with ASD without intellectual disability, and 21 typically-developing (TD) controls. Taste reactivity was assessed using the Adolescent/Adult Sensory Profile, a clinical self-report measure. Functional magnetic resonance imaging was used to evaluate hemodynamic responses …

Erratum: Specificity Of Incident Diagnostic Outcomes In Patients At Clinical High Risk For Psychosis (Schizophrenia Bulletin (2015) 41 (1066-1075) Doi: 10.1093/Schbul/Sbv091), J. R. Webb, J. Addington, D. O. Perkins, C. E. Bearden, K. S. Cadenhead, T. D. Cannon, B. A. Cornblatt, R. K. Heinssen, L. J. Seidman, S. W. Woods, +4 Additional Authors

Journal Articles

© The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. An error in statistical syntax defining baseline disorder led to misidentification of baseline anxiety disorder in five cases in one of the two reported samples (PREDICT). NAPLS-1 data and previous publications of PREDICT data were not affected. The error affected rows in Table 1 labeled 'DSM-IV anxiety' and 'Any mood/anx disorder' and rows in Table 3 labeled 'Baseline Anxiety Excluded' and 'Any Baseline Mood/ Anxiety Excluded.' Corrected Tables are shown below with corrected numbers in bold. Tables S1-S5 in the …

Preliminary Findings Of Altered Functional Connectivity Of The Default Mode Network Linked To Functional Outcomes One Year After Pediatric Traumatic Brain Injury, J. A. Stephens, C. F. Salorio, A. D. Barber, S. R. Risen, S. H. Mostofsky, S. J. Suskauer

Journal Articles

© 2018, © 2018 Taylor & Francis. Purpose and Method: This study examined functional connectivity of the default mode network (DMN) and examined brain–behavior relationships in a pilot cohort of children with chronic mild to moderate traumatic brain injury (TBI). Results: Compared to uninjured peers, children with TBI demonstrated less anti-correlated functional connectivity between DMN and right Brodmann Area 40 (BA 40). In children with TBI, more anomalous less anti-correlated) connectivity between DMN and right BA 40 was linked to poorer performance on response inhibition tasks. Conclusion: Collectively, these preliminary findings suggest that functional connectivity between DMN and BA 40 …

Investigation Of Superior Longitudinal Fasciculus Fiber Complexity In Recent Onset Psychosis, P. R. Szeszko, E. T. Tan, A. M. Ulug, P. B. Kingsley, J. A. Gallego, K. Rhindress, A. K. Malhotra, D. G. Robinson, L. Marinelli

Journal Articles

No abstract provided.

Latent Class Cluster Analysis Of Symptom Ratings Identifies Distinct Subgroups Within The Clinical High Risk For Psychosis Syndrome, A. T. Ryan, J. Addington, C. E. Bearden, K. S. Cadenhead, B. A. Cornblatt, D. H. Mathalon, T. H. Mcglashan, D. O. Perkins, L. J. Seidman, E. F. Walker, +3 Additional Authors

Journal Articles

© 2017 The clinical-high-risk for psychosis (CHR-P) syndrome is heterogeneous in terms of clinical presentation and outcomes. Identifying more homogenous subtypes of the syndrome may help clarify its etiology and improve the prediction of psychotic illness. This study applied latent class cluster analysis (LCCA) to symptom ratings from the North American Prodrome Longitudinal Studies 1 and 2 (NAPLS 1 and 2). These analyses produced evidence for three to five subgroups within the CHR-P syndrome. Differences in negative and disorganized symptoms distinguished among the subgroups. Subgroup membership was found to predict conversion to psychosis. The authors contrast the methods employed within …

A Collaborative, Network-Based Approach To Advance Women's Depression Research In The United States: Preliminary Findings, H. A. Flynn, C. Spino, C. Guille, K. M. Deligiannidis, P. Maki, J. Jahnke, K. L. Rosenblum, C. N. Epperson, S. J. Weiss

Journal Articles

No abstract provided.

Improved Estimation Of Subject-Level Functional Connectivity Using Full And Partial Correlation With Empirical Bayes Shrinkage, A. F. Mejia, M. B. Nebel, A. D. Barber, A. S. Choe, J. J. Pekar, B. S. Caffo, M. A. Lindquist

Journal Articles

© 2018 Reliability of subject-level resting-state functional connectivity (FC) is determined in part by the statistical techniques employed in its estimation. Methods that pool information across subjects to inform estimation of subject-level effects (e.g., Bayesian approaches) have been shown to enhance reliability of subject-level FC. However, fully Bayesian approaches are computationally demanding, while empirical Bayesian approaches typically rely on using repeated measures to estimate the variance components in the model. Here, we avoid the need for repeated measures by proposing a novel measurement error model for FC describing the different sources of variance and error, which we use to perform …

Smri Biomarkers Predict Electroconvulsive Treatment Outcomes: Accuracy With Independent Data Sets, R. Jiang, C. C. Abbott, T. Jiang, Y. Du, R. Espinoza, K. L. Narr, B. Wade, M. Argyelan, G. Petrides, V. D. Calhoun, +6 Additional Authors

Journal Articles

No abstract provided.

The Evolution Of Cultural Psychiatry, R. S. Shim

Journal Articles

No abstract provided.

Stress-Dependent Association Between Polygenic Risk For Schizophrenia And Schizotypal Traits In Young Army Recruits, A. Hatzimanolis, D. Avramopoulos, D. E. Arking, A. Moes, P. Bhatnagar, T. Lencz, A. K. Malhotra, S. G. Giakoumaki, P. Roussos, N. C. Stefanis, +2 Additional Authors

Journal Articles

No abstract provided.

Efficacy Of Guided Icbt For Depression And Mediation Of Change By Cognitive Skill Acquisition, N. R. Forand, J. G. Barnett, D. R. Strunk, M. U. Hindiyeh, J. E. Feinberg, J. R. Keefe

Journal Articles

No abstract provided.

Measuring Cognition And Function In The Preclinical Stage Of Alzheimer's Disease, S. Weintraub, M. C. Carrillo, S. T. Farias, T. E. Goldberg, J. A. Hendrix, J. Jaeger, D. S. Knopman, J. B. Langbaum, D. C. Park, C. Randolph, +9 Additional Authors

Journal Articles

© 2018 The Authors The Alzheimer's Association's Research Roundtable met in November 2016 to explore how best to measure changes in cognition and function in the preclinical stage of Alzheimer's disease. This review will cover the tools and instruments currently available to identify populations for prevention trials, and measure subtle disease progression in the earliest stages of Alzheimer's disease, and will include discussions of suitable cognitive, behavioral, functional, composite, and biological endpoints for prevention trials. Current prevention trials are reviewed including TOMMOROW, Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Trial, the Alzheimer's Prevention Initiative Generation Study, and the Anti-Amyloid Treatment …

Predictors Of Aggression In 3.322 Patients With Affective Disorders And Schizophrenia Spectrum Disorders Evaluated In An Emergency Department Setting, E. A. Blanco, L. M. Duque, V. Rachamallu, E. Yuen, J. M. Kane, J. A. Gallego

Journal Articles

No abstract provided.

The Genetics Of Endophenotypes Of Neurofunction To Understand Schizophrenia (Genus) Consortium: A Collaborative Cognitive And Neuroimaging Genetics Project, G. A. Blokland, E. C. Del Re, R. I. Mesholam-Gately, J. Jovicich, J. Trampush, M. S. Keshavan, L. E. Delisi, A. K. Malhotra, T. Lencz, T. L. Petryshen, +64 Additional Authors

Journal Articles

No abstract provided.

Identifying Patients And Clinical Scenarios For Use Of Long-Acting Injectable Antipsychotics - Expert Consensus Survey Part I, M. Sajatovic, R. Ross, S. N. Legacy, C. U. Correll, J. M. Kane, F. Dibiasi, H. Fitzgerald, M. Byerly

Journal Articles

No abstract provided.

Networks Of Blood Proteins In The Neuroimmunology Of Schizophrenia, C. D. Jeffries, D. O. Perkins, M. Fournier, K. Q. Do, M. Cuenod, I. Khadimallah, E. Domenici, J. Addington, B. A. Cornblatt, S. W. Woods, +8 Additional Authors

Journal Articles

© 2018 The Author(s). Levels of certain circulating cytokines and related immune system molecules are consistently altered in schizophrenia and related disorders. In addition to absolute analyte levels, we sought analytes in correlation networks that could be prognostic. We analyzed baseline blood plasma samples with a Luminex platform from 72 subjects meeting criteria for a psychosis clinical high-risk syndrome; 32 subjects converted to a diagnosis of psychotic disorder within two years while 40 other subjects did not. Another comparison group included 35 unaffected subjects. Assays of 141 analytes passed early quality control. We then used an unweighted co-expression network analysis …

Erratum To: Specificity Of Incident Diagnostic Outcomes In Patients At Clinical High Risk For Psychosis, J. R. Webb, J. Addington, D. O. Perkins, C. E. Bearden, K. S. Cadenhead, T. D. Cannon, B. A. Cornblatt, R. K. Heinssen, L. J. Seidman, S. W. Woods, +4 Additional Authors

Journal Articles

© The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. An error in statistical syntax defining baseline disorder led to misidentification of baseline anxiety disorder in five cases in one of the two reported samples (PREDICT). NAPLS-1 data and previous publications of PREDICT data were not affected. The error affected rows in Table 1 labeled 'DSM-IV anxiety' and 'Any mood/anx disorder' and rows in Table 3 labeled 'Baseline Anxiety Excluded' and 'Any Baseline Mood/ Anxiety Excluded.' Corrected Tables are shown below with corrected numbers in bold. Tables S1-S5 in the …

A Longitudinal Human Phantom Reliability Study Of Multi-Center T1-Weighted, Dti, And Resting State Fmri Data, C. Hawco, J. D. Viviano, S. Chavez, E. W. Dickie, N. Calarco, P. Kochunov, M. Argyelan, J. A. Turner, A. K. Malhotra, A. N. Voineskos, +1 Additional Author

Journal Articles

© 2018 Multi-center MRI studies can enhance power, generalizability, and discovery for clinical neuroimaging research in brain disorders. Here, we sought to establish the utility of a clustering algorithm as an alternative to more traditional intra-class correlation coefficient approaches in a longitudinal multi-center human phantom study. We completed annual reliability scans on ‘travelling human phantoms’. Acquisitions across sites were harmonized prospectively. Twenty-seven MRI sessions were available across four participants, scanned on five scanners, across three years. For each scan, three metrics were extracted: cortical thickness (CT), white matter fractional anisotropy (FA), and resting state functional connectivity (FC). For each metric, …

The Early Psychosis Screener (Eps): Quantitative Validation Against The Sips Using Machine Learning, B. B. Brodey, R. R. Girgis, O. Favorov, J. Addington, D. O. Perkins, C. E. Bearden, S. W. Woods, E. F. Walker, B. A. Cornblatt, I. S. Brodey, +3 Additional Authors

Journal Articles

No abstract provided.