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Articles 211 - 240 of 278
Full-Text Articles in Psychiatry
A Randomized Trial Of Family Focused Therapy With Populations At Clinical High Risk For Psychosis: Effects On Interactional Behavior, M. P. O'Brien, D. J. Miklowitz, K. A. Candan, C. Marshall, I. Domingues, B. C. Walsh, J. L. Zinberg, S. D. De Silva, K. A. Woodberry, T. D. Cannon
A Randomized Trial Of Family Focused Therapy With Populations At Clinical High Risk For Psychosis: Effects On Interactional Behavior, M. P. O'Brien, D. J. Miklowitz, K. A. Candan, C. Marshall, I. Domingues, B. C. Walsh, J. L. Zinberg, S. D. De Silva, K. A. Woodberry, T. D. Cannon
Journal Articles
Objective: This study investigated whether family focused therapy (FFT-CHR), an 18-session intervention that consisted of psychoeducation and training in communication and problem solving, brought about greater improvements in family communication than enhanced care (EC), a 3-session psychoeducational intervention, among individuals at clinical high risk for developing psychosis. Method: This study was conducted within a randomized controlled trial across 8 sites. We examined 10-min problem-solving discussions at baseline and 6-month reassessment among 66 adolescents and young adults and their parents. Trained coders who were blind to treatment and time of assessment achieved high levels of interrater reliability when evaluating family discussions …
Managing Cardiovascular Disease Risk In Patients Treated With Antipsychotics: A Multidisciplinary Approach, M. Shulman, A. Miller, J. Misher, A. Tentler
Managing Cardiovascular Disease Risk In Patients Treated With Antipsychotics: A Multidisciplinary Approach, M. Shulman, A. Miller, J. Misher, A. Tentler
Journal Articles
BACKGROUND: The use of antipsychotic medication in the United States and throughout the world has greatly increased over the last fifteen years. These drugs have significant side effect burdens, many of them relating to cardiovascular health. OBJECTIVE: To review the available evidence on the major cardiovascular issues that arise in patients taking antipsychotic medication. METHOD: A PubMed literature review was performed to identify recent meta-analyses, review articles, and large studies. Further articles were identified through cited papers and based on expert consultation when necessary. RESULTS: CLINICAL GUIDANCE ON THE FOLLOWING ADVERSE EFFECTS AND ANTIPSYCHOTICS WAS REVIEWED: electrocardiogram (ECG) changes, (specifically, …
Serum Levels Of Brain-Derived Neurotrophic Factor At 4 Weeks And Response To Treatment With Ssris, R. Yoshimura, T. Kishi, H. Hori, A. Katsuki, A. Sugita-Ikenouchi, W. Umene-Nakano, K. Atake, N. Iwata, J. Nakamura
Serum Levels Of Brain-Derived Neurotrophic Factor At 4 Weeks And Response To Treatment With Ssris, R. Yoshimura, T. Kishi, H. Hori, A. Katsuki, A. Sugita-Ikenouchi, W. Umene-Nakano, K. Atake, N. Iwata, J. Nakamura
Journal Articles
Objective It is important to predict a response to an antidepressant in early time after starting the antidepressant. We previously reported that serum brain-derived neurotrophic factor (BDNF) levels in responders to treatment with antidepressants were increased, whereas, those in nonresponders were not. Therefore, we hypothesized that the changes in serum levels of BDNF from baseline (TO) to 4 weeks (T4) after treatment with selective serotonin reuptake inhibitors (SSRIs) predict the response to the treatment at 8 weeks (T8) in depressed patients. To confirm the hypothesis, we measured serum BDNF at TO, T4, and T8 during the treatment with SSRIs (paroxetine, …
High Rate Of Disease-Related Copy Number Variations In Childhood Onset Schizophrenia, K. Ahn, N. Gotay, P. Gochman, Y. Lee, S. Sanders, S. Guha, H. Hakonarson, T. Lencz, M. W. State, J. L. Rapoport, +5 Additional Authors
High Rate Of Disease-Related Copy Number Variations In Childhood Onset Schizophrenia, K. Ahn, N. Gotay, P. Gochman, Y. Lee, S. Sanders, S. Guha, H. Hakonarson, T. Lencz, M. W. State, J. L. Rapoport, +5 Additional Authors
Journal Articles
Copy number variants (CNVs) are risk factors in neurodevelopmental disorders, including autism, epilepsy, intellectual disability (ID) and schizophrenia. Childhood onset schizophrenia (COS), defined as onset before the age of 13 years, is a rare and severe form of the disorder, with more striking array of prepsychotic developmental disorders and abnormalities in brain development. Because of the well-known phenotypic variability associated with pathogenic CNVs, we conducted whole genome genotyping to detect CNVs and then focused on a group of 46 rare CNVs that had well-documented risk for adult onset schizophrenia (AOS), autism, epilepsy and/or ID. We evaluated 126 COS probands, 69 …
Resting-State Fmri Connectivity Impairment In Schizophrenia And Bipolar Disorder, Miklos Argyelan, T. Ikuta, P. Derosse, R. J. Braga, K. E. Burdick, M. John, P. B. Kingsley, A. K. Malhotra, P. R. Szeszko
Resting-State Fmri Connectivity Impairment In Schizophrenia And Bipolar Disorder, Miklos Argyelan, T. Ikuta, P. Derosse, R. J. Braga, K. E. Burdick, M. John, P. B. Kingsley, A. K. Malhotra, P. R. Szeszko
Journal Articles
Background: Schizophrenia and bipolar disorder share aspects of phenomenology and neurobiology and thus may represent a continuum of disease. Few studies have compared connectivity across the brain in these disorders or investigated their functional correlates. Methods: We used resting-state functional magnetic resonance imaging to evaluate global and regional connectivity in 32 healthy controls, 19 patients with bipolar disorder, and 18 schizophrenia patients. Patients also received comprehensive neuropsychological and clinical assessments. We computed correlation matrices among 266 regions of interest within the brain, with the primary dependent measure being overall global connectivity strength of each region with every other region. Results: …
Comparison Of Sga Oral Medications And A Long-Acting Injectable Sga: The Proactive Study, P. F. Buckley, N. R. Schooler, A. J. Mendelowitz, D. D. Miller, J. B. Severe, D. R. Wilson, D. Ames, J. Bustillo, J. Mintz, J. M. Kane, +5 Additional Authors
Comparison Of Sga Oral Medications And A Long-Acting Injectable Sga: The Proactive Study, P. F. Buckley, N. R. Schooler, A. J. Mendelowitz, D. D. Miller, J. B. Severe, D. R. Wilson, D. Ames, J. Bustillo, J. Mintz, J. M. Kane, +5 Additional Authors
Journal Articles
Until relatively recently, long-acting injectable (LAI) formulations were only available for first-generation antipsychotics and their utilization decreased as use of oral second-generation antipsychotics (SGA) increased. Although registry-based naturalistic studies show LAIs reduce rehospitalization more than oral medications in clinical practice, this is not seen in recent randomized clinical trials. PROACTIVE (Preventing Relapse Oral Antipsychotics Compared to Injectables Evaluating Efficacy) relapse prevention study incorporated efficacy and effectiveness features. At 8 US academic centers, 305 patients with schizophrenia or schizoaffective disorder were randomly assigned to LAI risperidone (LAI-R) or physician's choice oral SGAs. Patients were evaluated during the 30-month study by masked, …
Dopaminergic Influences On Emotional Decision Making In Euthymic Bipolar Patients, K. E. Burdick, R. J. Braga, C. B. Gopin, A. K. Malhotra
Dopaminergic Influences On Emotional Decision Making In Euthymic Bipolar Patients, K. E. Burdick, R. J. Braga, C. B. Gopin, A. K. Malhotra
Journal Articles
We recently reported that the D2/D3 agonist pramipexole may have pro-cognitive effects in euthymic patients with bipolar disorder (BPD); however, the emergence of impulse-control disorders has been documented in Parkinson's disease (PD) after pramipexole treatment. Performance on reward-based tasks is altered in healthy subjects after a single dose of pramipexole, but its potential to induce abnormalities in BPD patients is unknown. We assessed reward-dependent decision making in euthymic BPD patients pre- and post 8 weeks of treatment with pramipexole or placebo by using the Iowa Gambling Task (IGT). The IGT requires subjects to choose among four card decks (two risky …
Empirical Evidence For Discrete Neurocognitive Subgroups In Bipolar Disorder: Clinical Implications, K. E. Burdick, M. Russo, S. Frangou, K. Mahon, R. J. Braga, M. Shanahan, A. K. Malhotra
Empirical Evidence For Discrete Neurocognitive Subgroups In Bipolar Disorder: Clinical Implications, K. E. Burdick, M. Russo, S. Frangou, K. Mahon, R. J. Braga, M. Shanahan, A. K. Malhotra
Journal Articles
Background. Recent data suggest trait-like neurocognitive impairments in bipolar disorder (BPD), with deficits about 1 S.D. below average, less severe than deficits noted in schizophrenia. The frequency of significant impairment in BPD is approximately 60%, with 40% of patients characterized as cognitively spared. This contrasts with a more homogeneous presentation in schizophrenia. It is not understood why some BPD patients develop deficits while others do not. Method. A total of 136 patients with BPD completed the MATRICS Consensus Cognitive Battery and data were entered into hierarchical cluster analyses to: (1) determine the optimal number of clusters (subgroups) that fit the …
Reliability Of Neuroanatomical Measurements In A Multisite Longitudinal Study Of Youth At Risk For Psychosis, T. D. Cannon, L. J. Seidman, H. W. Thermenos, B. A. Cornblatt, D. M. Olvet, D. Perkins, M. L. Qiu, D. H. Mathalon, P. Thompson, A. W. Toga, +19 Additional Authors
Reliability Of Neuroanatomical Measurements In A Multisite Longitudinal Study Of Youth At Risk For Psychosis, T. D. Cannon, L. J. Seidman, H. W. Thermenos, B. A. Cornblatt, D. M. Olvet, D. Perkins, M. L. Qiu, D. H. Mathalon, P. Thompson, A. W. Toga, +19 Additional Authors
Journal Articles
Multisite longitudinal neuroimaging designs are used to identify differential brain structural change associated with onset or progression of disease. The reliability of neuroanatomical measurements over time and across sites is a crucial aspect of power in such studies. Prior work has found that while within-site reliabilities of neuroanatomical measurements are excellent, between-site reliability is generally more modest. Factors that may increase between-site reliability include standardization of scanner platform and sequence parameters and correction for between-scanner variations in gradient nonlinearities. Factors that may improve both between- and within-site reliability include use of registration algorithms that account for individual differences in cortical …
Clinical Predictors Of Therapeutic Response To Antipsychotics In Schizophrenia, M. Carbon, C. U. Correll
Clinical Predictors Of Therapeutic Response To Antipsychotics In Schizophrenia, M. Carbon, C. U. Correll
Journal Articles
The search for clinical outcome predictors for schizophrenia is as old as the field of psychiatry. However, despite a wealth of large, longitudinal studies into prognostic factors, only very few clinically useful outcome predictors have been identified. The goal of future treatment is to either affect modifiable risk factors, or use nonmodifiable factors to parse patients into therapeutically meaningful subgroups. Most clinical outcome predictors are nonspecific and/or nonmodifiable. Nonmodifiable predictors for poor odds of remission include male sex, younger age at disease onset, poor premorbid adjustment, and severe baseline psychopathology. Modifiable risk factors for poor therapeutic outcomes that clinicians can …
Sequencing An Ashkenazi Reference Panel Supports Population-Targeted Personal Genomics And Illuminates Jewish And European Origins, S. Carmi, K. Y. Hui, F. Grady, S. Guha, K. Upadhyay, D. Ben-Avraham, S. Mukherjee, B. M. Bowen, T. Lencz, I. Pe'er, +22 Additional Authors
Sequencing An Ashkenazi Reference Panel Supports Population-Targeted Personal Genomics And Illuminates Jewish And European Origins, S. Carmi, K. Y. Hui, F. Grady, S. Guha, K. Upadhyay, D. Ben-Avraham, S. Mukherjee, B. M. Bowen, T. Lencz, I. Pe'er, +22 Additional Authors
Journal Articles
The Ashkenazi Jewish (AJ) population is a genetic isolate close to European and Middle Eastern groups, with genetic diversity patterns conducive to disease mapping. Here we report high-depth sequencing of 128 complete genomes of AJ controls. Compared with European samples, our AJ panel has 47% more novel variants per genome and is eightfold more effective at filtering benign variants out of AJ clinical genomes. Our panel improves imputation accuracy for AJ SNP arrays by 28%, and covers at least one haplotype in approximate to 67% of any AJ genome with long, identical-by-descent segments. Reconstruction of recent AJ history from such …
Type And Duration Of Subsyndromal Symptoms In Youth With Bipolar I Disorder Prior To Their First Manic Episode, C. U. Correll, M. Hauser, J. B. Penzner, A. M. Auther, V. Kafantaris, E. Saito, D. Olvet, R. E. Carrion, M. Pavuluri, B. A. Cornblatt, +4 Additional Authors
Type And Duration Of Subsyndromal Symptoms In Youth With Bipolar I Disorder Prior To Their First Manic Episode, C. U. Correll, M. Hauser, J. B. Penzner, A. M. Auther, V. Kafantaris, E. Saito, D. Olvet, R. E. Carrion, M. Pavuluri, B. A. Cornblatt, +4 Additional Authors
Journal Articles
Objectives: The aim of the present study was to systematically evaluate the prodrome to mania in youth. Methods: New-onset/worsening symptoms/signs of >= moderate severity preceding first mania were systematically assessed in 52 youth (16.2 +/- 2.8 years) with a research diagnosis of bipolar I disorder (BD-I). Youth and/or caregivers underwent semi-structured interviews, using the Bipolar Prodrome Symptom Scale-Retrospective. Results: The mania prodrome was reported to start gradually in most youth (88.5%), with either slow (59.6%) or rapid (28.8%) deterioration, while a rapid-onset-and-deterioration prodrome was rare (11.5%). The manic prodrome, conservatively defined as requiring >= 3 symptoms, lasted 10.3 +/- 14.4 …
The Bipolar Prodrome Symptom Interview And Scale-Prospective (Bpss-P): Description And Validation In A Psychiatric Sample And Healthy Controls, C. U. Correll, D. M. Olvet, A. M. Auther, M. Hauser, T. Kishimoto, R. Carrion, S. Snyder, B. A. Cornblatt
The Bipolar Prodrome Symptom Interview And Scale-Prospective (Bpss-P): Description And Validation In A Psychiatric Sample And Healthy Controls, C. U. Correll, D. M. Olvet, A. M. Auther, M. Hauser, T. Kishimoto, R. Carrion, S. Snyder, B. A. Cornblatt
Journal Articles
Objective: The aim of the present study was to investigate the psychometric properties of the Bipolar Prodrome Symptom Interview and Scale-Prospective (BPSS-P), the first specific interview for emerging bipolar disorder (BD) symptoms. Methods: A total of 205 youth aged 12-23 years and/or their caregivers underwent BPSS-P interviews: 129 patients with mood spectrum disorders [ depression spectrum disorder (n = 77), mood disorder not otherwise specified (NOS) (n = 27), BD-NOS (n = 14), bipolar I disorder (BD-I)/bipolar II disorder (BD-II)/cyclothymia (n = 11), 34 with non-mood spectrum disorders, and 42 healthy controls (HCs)]. We used Cronbach's alpha to assess internal …
Adding Insult To Injury: Childhood And Adolescent Risk Factors For Psychosis Predict Lower Fractional Anisotropy In The Superior Longitudinal Fasciculus In Healthy Adults, P. Derosse, T. Ikuta, B. D. Peters, K. Karlsgodt, P. Szeszko, A. K. Malhotra
Adding Insult To Injury: Childhood And Adolescent Risk Factors For Psychosis Predict Lower Fractional Anisotropy In The Superior Longitudinal Fasciculus In Healthy Adults, P. Derosse, T. Ikuta, B. D. Peters, K. Karlsgodt, P. Szeszko, A. K. Malhotra
Journal Articles
Although epidemiological studies provide strong support for demographic and environmental risk factors in psychotic disorders, few data examine how these risk factors relate to the putative aberrant neurodevelopment associated with illness. The present study examined how the accumulation of risk factors including low IQ, low parental socioeconomic status (SES), history of adolescent cannabis use and childhood trauma, and high levels of subclinical psychotic-like experiences (PLEs) contributed to aberrant neurodevelopmental outcomes in 112 otherwise healthy adults recruited from the community. Participants were studied with diffusion tensor imaging (DTI), and voxel-wise statistical analysis of fractional anisotropy (FA) using tractbased spatial statistics (TBSS) …
The Relation Between Childhood Maltreatment And Psychosis In Patients With Schizophrenia And Non-Psychiatric Controls, P. Derosse, G. C. Nitzburg, B. Kompancaril, A. K. Malhotra
The Relation Between Childhood Maltreatment And Psychosis In Patients With Schizophrenia And Non-Psychiatric Controls, P. Derosse, G. C. Nitzburg, B. Kompancaril, A. K. Malhotra
Journal Articles
Several lines of evidence suggest that childhood maltreatment is associated with an increased risk for both psychotic disorders and subclinical psychotic-like experiences in the general population. Few studies, however, have sought to examine whether the strength of this relationship is comparable across patient and non-patient groups. The present study sought to compare the strength of the association between childhood maltreatment and self-reported psychotic symptoms in 447 healthy adult volunteers and 184 stable outpatients with schizophrenia or schizoaffective disorder. Strong positive correlations between childhood maltreatment and self-reported symptoms were observed in both groups. Although patients scored significantly higher than controls on …
Reliability Of Functional Magnetic Resonance Imaging Activation During Working Memory In A Multi-Site Study: Analysis From The North American Prodrome Longitudinal Study, J. K. Forsyth, C. E. Bearden, J. Addington, B. Goodyear, K. S. Cadenhead, H. Mirzakhanian, B. A. Cornblatt, D. M. Olvet, M. L. Qiu, T. D. Cannon, +13 Additional Authors
Reliability Of Functional Magnetic Resonance Imaging Activation During Working Memory In A Multi-Site Study: Analysis From The North American Prodrome Longitudinal Study, J. K. Forsyth, C. E. Bearden, J. Addington, B. Goodyear, K. S. Cadenhead, H. Mirzakhanian, B. A. Cornblatt, D. M. Olvet, M. L. Qiu, T. D. Cannon, +13 Additional Authors
Journal Articles
Multi-site neuroimaging studies offer an efficient means to study brain functioning in large samples of individuals with rare conditions; however, they present new challenges given that aggregating data across sites introduces additional variability into measures of interest. Assessing the reliability of brain activation across study sites and comparing statistical methods for pooling functional data are critical to ensuring the validity of aggregating data across sites. The current study used two samples of healthy individuals to assess the feasibility and reliability of aggregating multi-site functional magnetic resonance imaging (fMRI) data from a Sternberg-style verbal working memory task. Participants were recruited as …
Disease Variants In Genomes Of 44 Centenarians, Y. Freudenberg-Hua, J. Freudenberg, D. Oschwald, E. Christen, J. Koppel, B. Greenwald, R. B. Darnell, S. Germer, G. Atzmon, P. Davies, +5 Additional Authors
Disease Variants In Genomes Of 44 Centenarians, Y. Freudenberg-Hua, J. Freudenberg, D. Oschwald, E. Christen, J. Koppel, B. Greenwald, R. B. Darnell, S. Germer, G. Atzmon, P. Davies, +5 Additional Authors
Journal Articles
To identify previously reported disease mutations that are compatible with extraordinary longevity, we screened the coding regions of the genomes of 44 Ashkenazi Jewish centenarians. Individual genome sequences were generated with 30x coverage on the Illumina HiSeq 2000 and single-nucleotide variants were called with the genome analysis toolkit (GATK). We identified 130 coding variants that were annotated as "pathogenic" or "likely pathogenic" based on the ClinVar database and that are infrequent in the general population. These variants were previously reported to cause a wide range of degenerative, neoplastic, and cardiac diseases with autosomal dominant, autosomal recessive, and X-linked inheritance. Several …
Extension And Refinement Of The Predictive Value Of Different Classes Of Markers In Adni: Four-Year Follow-Up Data, J. J. Gomar, C. Conejero-Goldberg, P. Davies, T. E. Goldberg, Initi Alzheimer's Dis Neuroimaging
Extension And Refinement Of The Predictive Value Of Different Classes Of Markers In Adni: Four-Year Follow-Up Data, J. J. Gomar, C. Conejero-Goldberg, P. Davies, T. E. Goldberg, Initi Alzheimer's Dis Neuroimaging
Journal Articles
Background: This study examined the predictive value of different classes of markers in the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD) over an extended 4-year follow-up in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Methods: MCI patients were assessed for clinical, cognitive, magnetic resonance imaging (MRI), positron emission tomography-fluorodeoxyglucose (PET-FDG), and cerebrospinal fluid (CSF). markers at baseline and were followed on a yearly basis for 4 years to ascertain progression to AD. Logistic regression models were fitted in clusters, including demographics, APOE genotype, cognitive markers, and biomarkers (morphometric, PET-FDG, CSF, amyloid-beta, and tau). Results: The predictive model …
Apoe Genotype Modulates Proton Magnetic Resonance Spectroscopy Metabolites In The Aging Brain, J. J. Gomar, M. L. Gordon, P. B. Kingsley, A. M. Ulug, L. Keehlisen, S. Huet, J. J. Buthorn, J. Koppel, E. Christen, C. Conejero-Goldberg, P. Davies, T. E. Goldberg, +1 Additional Author
Apoe Genotype Modulates Proton Magnetic Resonance Spectroscopy Metabolites In The Aging Brain, J. J. Gomar, M. L. Gordon, P. B. Kingsley, A. M. Ulug, L. Keehlisen, S. Huet, J. J. Buthorn, J. Koppel, E. Christen, C. Conejero-Goldberg, P. Davies, T. E. Goldberg, +1 Additional Author
Journal Articles
Background: Proton magnetic resonance spectroscopy (H-1-MRS) studies on healthy aging have reported inconsistent findings and have not systematically taken into account the possible modulatory effect of APOE genotype. We aimed to quantify brain metabolite changes in healthy subjects in relation to age and the presence of the APOE E4 genetic risk factor for Alzheimer's disease. Additionally, we examined these measures in relation to cognition. Methods: We studied a cohort of 112 normal adults between 50 and 86 years old who were genotyped for APOE genetic polymorphism. Measurements of H-1-MRS metabolites were obtained in the posterior cingulate and precuneus region. Measures …
Independent Component Analysis Of Resting State Activity In Pediatric Obsessive-Compulsive Disorder, P. Gruner, A. Vo, M. Argyelan, T. Ikuta, A. J. Degnan, M. John, B. D. Peters, A. K. Malhotra, A. M. Ulug, P. Szeszko
Independent Component Analysis Of Resting State Activity In Pediatric Obsessive-Compulsive Disorder, P. Gruner, A. Vo, M. Argyelan, T. Ikuta, A. J. Degnan, M. John, B. D. Peters, A. K. Malhotra, A. M. Ulug, P. Szeszko
Journal Articles
Obsessive-compulsive disorder (OCD) is an often severely disabling illness with onset generally in childhood or adolescence. Little is known, however, regarding the pattern of brain resting state activity in OCD early in the course of illness. We therefore examined differences in brain resting state activity in patients with pediatric OCD compared with healthy volunteers and their clinical correlates. Twenty-three pediatric OCD patients and 23 healthy volunteers (age range 9-17), matched for sex, age, handedness, and IQ completed a resting state functional magnetic resonance imaging exam at 3T. Patients completed the Children's Yale Brown Obsessive Scale. Data were decomposed into 36 …
A Schizophrenia Risk Gene, Znf804a, Is Associated With Brain White Matter Microstructure, T. Ikuta, B. D. Peters, S. Guha, M. John, K. H. Karlsgodt, T. Lencz, P. R. Szeszko, A. K. Malhotra
A Schizophrenia Risk Gene, Znf804a, Is Associated With Brain White Matter Microstructure, T. Ikuta, B. D. Peters, S. Guha, M. John, K. H. Karlsgodt, T. Lencz, P. R. Szeszko, A. K. Malhotra
Journal Articles
Genome-wide association studies have provided strong evidence for association of the SNP rs1344706 in the ZNF804A gene with schizophrenia and bipolar disorder. Neuroimaging studies have suggested that variation at rs1344706 may be associated with neural endophenotypes such as white matter volumes and densities. However, analyses of white matter microstructure using diffusion tensor imaging (DTI) have produced conflicting results. We examined the association between rs1344706 and white matter microstructure in 107 healthy individuals using tract-based spatial statistics (TBSS). TBSS analysis showed significant association between the risk allele and lower fractional anisotropy in the corpus callosum, left forceps minor, and right parietal …
Subcortical Modulation Of Attentional Control By Second-Generation Antipsychotics In First-Episode Psychosis, T. Ikuta, D. G. Robinson, J. A. Gallego, B. D. Peters, P. Gruner, J. M. Kane, M. John, S. Sevy, A. K. Malhotra, P. R. Szeszko
Subcortical Modulation Of Attentional Control By Second-Generation Antipsychotics In First-Episode Psychosis, T. Ikuta, D. G. Robinson, J. A. Gallego, B. D. Peters, P. Gruner, J. M. Kane, M. John, S. Sevy, A. K. Malhotra, P. R. Szeszko
Journal Articles
Psychotic disorders are characterized by significant deficits in attentional control, but the neurobiological mechanisms underlying these deficits early in the course of illness prior to extensive pharmacotherapy are not well understood. Moreover, little is known regarding the symptom and brain changes associated with amelioration of attentional impairments through antipsychotic pharmacotherapy. In this study 14 male patients experiencing a first-episode of psychosis with minimal prior antipsychotic treatment completed an attentional control task while undergoing functional magnetic resonance imaging at the onset of treatment with a second generation antipsychotic (rispericlone or aripiprazole) in a double blind randomized clinical trial and then again …
Abnormal Cingulum Bundle Development In Autism: A Probabilistic Tractography Study, T. Ikuta, K. M. Shafritz, J. Bregman, B. D. Peters, P. Gruner, A. K. Malhotra, P. R. Szeszko
Abnormal Cingulum Bundle Development In Autism: A Probabilistic Tractography Study, T. Ikuta, K. M. Shafritz, J. Bregman, B. D. Peters, P. Gruner, A. K. Malhotra, P. R. Szeszko
Journal Articles
There is now considerable evidence that white matter abnormalities play a role in the neurobiology of autism. Little research has been directed, however, at understanding (a) typical white matter development in autism and how this relates to neurocognitive impairments observed in the disorder. In this study we used probabilistic tractography to identify the cingulum bundle in 21 adolescents and young adults with Autism Spectrum Disorder (ASD), and 21 age- and sex-matched healthy volunteers. We investigated group differences in the relationships between age and fractional anisotropy, a putative measure of white matter integrity, within the cingulum bundle. Moreover, in a preliminary …
Long-Acting Injectable Vs Oral Antipsychotics For Relapse Prevention In Schizophrenia: A Meta-Analysis Of Randomized Trials, Taishiro Kishimoto, A. Robenzadeh, C. Leucht, S. Leucht, K. Watanabe, M. Mimura, M. Borenstein, John Kane, Christoph Correll
Long-Acting Injectable Vs Oral Antipsychotics For Relapse Prevention In Schizophrenia: A Meta-Analysis Of Randomized Trials, Taishiro Kishimoto, A. Robenzadeh, C. Leucht, S. Leucht, K. Watanabe, M. Mimura, M. Borenstein, John Kane, Christoph Correll
Journal Articles
Background: While long-acting injectable antipsychotics (LAIs) are hoped to reduce high relapse rates in schizophrenia, recent randomized controlled trials (RCTs) challenged the benefits of LAIs over oral antipsychotics (OAPs). Methods: Systematic review/meta-analysis of RCTs that lasted = 6 months comparing LAIs and OAPs. Primary outcome was study-defined relapse at the longest time point; secondary outcomes included relapse at 3, 6, 12, 18, and 24 months, all-cause discontinuation, discontinuation due to adverse events, drug inefficacy (ie, relapse + discontinuation due to inefficacy), hospitalization, and nonadherence. Results: Across 21 RCTs (n = 5176), LAIs were similar to OAPs for relapse prevention at …
Psychotic Alzheimer's Disease Is Associated With Gender-Specific Tau Phosphorylation Abnormalities, Jeremy Koppel, C. Acker, P. Davies, O. L. Lopez, H. Jimenez, M. Azose, Blaine Greenwald, P. S. Murray, C. M. Kirkwood, J. Kofler, R. A. Sweet
Psychotic Alzheimer's Disease Is Associated With Gender-Specific Tau Phosphorylation Abnormalities, Jeremy Koppel, C. Acker, P. Davies, O. L. Lopez, H. Jimenez, M. Azose, Blaine Greenwald, P. S. Murray, C. M. Kirkwood, J. Kofler, R. A. Sweet
Journal Articles
Converging evidence suggests that psychotic Alzheimer's disease (AD + P) is associated with an acceleration of frontal degeneration, with tau pathology playing a primary role. Previous histopathologic and biomarker studies have specifically implicated tau pathology in this condition. To precisely quantify tau abnormalities in the frontal cortex in AD + P, we used a sensitive biochemical assay of total tau and 4 epitopes of phospho-tau relevant in AD pathology in a postmortem sample of AD + P and AD - P. Samples of superior frontal gyrus from 26 AD subjects without psychosis and 45 AD + P subjects with psychosis …
Cb2 Receptor Deficiency Increases Amyloid Pathology And Alters Tau Processing In A Transgenic Mouse Model Of Alzheimer's Disease, Jeremy Koppel, V. Vingtdeux, P. Marambaud, C. D'Abramo, H. Jimenez, M. Stauber, R. Friedman, P. Davies
Cb2 Receptor Deficiency Increases Amyloid Pathology And Alters Tau Processing In A Transgenic Mouse Model Of Alzheimer's Disease, Jeremy Koppel, V. Vingtdeux, P. Marambaud, C. D'Abramo, H. Jimenez, M. Stauber, R. Friedman, P. Davies
Journal Articles
The endocannabinoid CB2 receptor system has been implicated in the neuropathology of Alzheimer's disease (AD). In order to investigate the impact of the CB2 receptor system on AD pathology, a colony of mice with a deleted CB2 receptor gene, CNR2, was established on a transgenic human mutant APP background for pathological comparison with CB2 receptor-sufficient transgenic mice. J20 APP (PDGFB-APPSwInd) mice were bred over two generations with CNR2(-/-) (Cnr2(tm1Dgen)/J) mice to produce a colony of J20 CNR2(+/+) and J20 CNR2(-/-)mice. Seventeen J20 CNR2(+/+) mice (12 females, 5 males) and 16 J20 CNR2(-/-) mice (11 females, 5 males) were killed at …
Positive And Negative Subclinical Symptoms And Mccb Performance In Non-Psychiatric Controls, C. Korponay, G. C. Nitzburg, Anil Malhotra, P. Derosse
Positive And Negative Subclinical Symptoms And Mccb Performance In Non-Psychiatric Controls, C. Korponay, G. C. Nitzburg, Anil Malhotra, P. Derosse
Journal Articles
Considerable data support the phenomenological and temporal continuity between subclinical psychosis and psychotic disorders. In recent years, neurocognitive deficits have increasingly been recognized as a core feature of psychotic illness but there are few data seeking to elucidate the relationship between subclinical psychosis and neurocogntive deficits in non-clinical samples. The goal of the present study was to examine the relationship between subclinical positive and negative symptoms, as measured by the Community Assessment of Psychic Experiences (CAPE) and performance on the MATRICS Consensus Cognitive Battery (MCCB) in a large (n=303) and demographically diverse non-clinical sample. We found that compared to participants …
The Influence Of Neighborhood Characteristics On Police Officers' Encounters With Persons Suspected To Have A Serious Mental Illness, S. Krishan, R. Bakeman, B. Broussard, S. L. Cristofaro, D. Hankerson-Dyson, L. Husbands, A. C. Watson, Michael Compton
The Influence Of Neighborhood Characteristics On Police Officers' Encounters With Persons Suspected To Have A Serious Mental Illness, S. Krishan, R. Bakeman, B. Broussard, S. L. Cristofaro, D. Hankerson-Dyson, L. Husbands, A. C. Watson, Michael Compton
Journal Articles
Objective: Police officers' decisions and behaviors are impacted by the neighborhood context in which police encounters occur. For example, officers may use greater force and be more likely to make arrests in disadvantaged neighborhoods. We examined whether neighborhood characteristics influence police encounters with individuals suspected to have a serious mental illness, addictive disorder, or developmental disability. Method: We obtained data on 916 encounters from 166 officers in six jurisdictions in Georgia, USA and abstracted geographical data pertaining to the location of these encounters from United States Decennial Census data. Encounters were nested within 163 census tracts. Officer-reported data covered general …
Alpha 7 Nicotinic Acetylcholine Receptor Signaling Inhibits Inflammasome Activation By Preventing Mitochondrial Dna Release, B. Lu, K. Kwan, Y. A. Levine, P. S. Olofsson, H. Yang, J. H. Li, S. Joshi, H. C. Wang, U. Andersson, S. S. Chavan, K. J. Tracey
Alpha 7 Nicotinic Acetylcholine Receptor Signaling Inhibits Inflammasome Activation By Preventing Mitochondrial Dna Release, B. Lu, K. Kwan, Y. A. Levine, P. S. Olofsson, H. Yang, J. H. Li, S. Joshi, H. C. Wang, U. Andersson, S. S. Chavan, K. J. Tracey
Journal Articles
The mammalian immune system and the nervous system coevolved under the influence of cellular and environmental stress. Cellular stress is associated with changes in immunity and activation of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome, a key component of innate immunity. Here we show that alpha 7 nicotinic acetylcholine receptor (alpha 7 nAchR)-signaling inhibits inflammasome activation and prevents release of mitochondrial DNA, an NLRP3 ligand. Cholinergic receptor agonists or vagus nerve stimulation significantly inhibits inflammasome activation, whereas genetic deletion of alpha 7 nAchR significantly enhances inflammasome activation. Acetylcholine accumulates in macrophage cytoplasm after adenosine triphosphate (ATP) stimulation …
Genes And Schizophrenia: From A Festschrift Seminar Honoring William T. Carpenter Jr, Md, Anil Malhotra
Genes And Schizophrenia: From A Festschrift Seminar Honoring William T. Carpenter Jr, Md, Anil Malhotra
Journal Articles
Recent data have begun to elucidate the genetic architecture of schizophrenia, as well as provide new insights into the relationships of specific genetic factors across diagnostic boundaries, with specific symptom domains, and in the prediction of antipsychotic treatment response. Not surprisingly, work conducted at the Maryland Psychiatric Research Center (MPRC), led by Dr William Carpenter, has helped to guide the thinking behind much of this work, as well as contributed valuable data toward these efforts. In this article, I will briefly summarize some of the major findings emerging from these lines of research and highlight the role of the Dr …