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Articles 151 - 151 of 151
Full-Text Articles in Pathology
The Role Of Calcium Ions In Toxic Cell Injury., John L. Farber
The Role Of Calcium Ions In Toxic Cell Injury., John L. Farber
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Calcium ions have been increasingly implicated as a mediator of the mechanisms generating lethal cell injury under a variety of pathologic circumstances. An overview of the various roles suggested for such alterations in cellular calcium homeostasis is presented. The central role of plasma membrane damage in the genesis of irreversible cell injury is used to divide the postulated roles for calcium ions into two major mechanisms. On the one hand, calcium ions have been proposed as mediators of the functional consequences of plasma membrane injury. An influx of extracellular calcium ions across a damaged permeability barrier and down a steep …