Oncology Commons^™

Nfkb Disrupts Tissue Polarity In 3d By Preventing Integration Of Microenvironmental Signals, Sabine Becker-Weimann, Gaofeng Xiong, Saori Furuta, Ju Han, Irene Kuhn, Uri-David Akavia, Dana Pe'er, Mina J. Bissell, Ren Xu

Markey Cancer Center Faculty Publications

The microenvironment of cells controls their phenotype, and thereby the architecture of the emerging multicellular structure or tissue. We have reported more than a dozen microenvironmental factors whose signaling must be integrated in order to effect an organized, functional tissue morphology. However, the factors that prevent integration of signaling pathways that merge form and function are still largely unknown. We have identified nuclear factor kappa B (NFkB) as a transcriptional regulator that disrupts important microenvironmental cues necessary for tissue organization. We compared the gene expression of organized and disorganized epithelial cells of the HMT-3522 breast cancer progression series: the non-malignant …

Oncolog, Volume 58, Number 11-12, November - December 2013, Amelia Scholtz, Bryan Tutt, Luanne Jorewicz, K Stuyck

OncoLog MD Anderson's Report to Physicians (All issues)

• Paget Disease of the Breast: A Rare, Often Misdiagnosed Malignancy: A small, scaling rash around the nipple may not be just another case of eczema or dermatitis. Paget disease of the breast, a rare malignancy, is often mistaken for a benign dermatological condition. But Paget disease typically indicates underlying ductal carcinoma in situ or invasive breast cancer
• New Partial-Breast Radiation Therapy Regimen Uses Protons: Whole-or partial-breast radiation therapy can reduce a patient's chance of brest cancer recurrence after lumpectomy, but this benefit must be weighed against the risk of damage to healthy tissue
• Managing Dental Complications in Patients with Head …

Coupling S100a4 To Rhotekin Alters Rho Signaling Output In Breast Cancer Cells, Min Chen, Anne R. Bresnick, Kathleen L. O'Connor

Markey Cancer Center Faculty Publications

Rho signaling is increasingly recognized to contribute to invasion and metastasis. In this study, we discovered that metastasis-associated protein S100A4 interacts with the Rho-binding domain (RBD) of Rhotekin, thus connecting S100A4 to the Rho pathway. Glutathione S-transferase pull-down and immunoprecipitation assays demonstrated that S100A4 specifically and directly binds to Rhotekin RBD, but not the other Rho effector RBDs. S100A4 binding to Rhotekin is calcium-dependent and uses residues distinct from those bound by active Rho. Interestingly, we found that S100A4 and Rhotekin can form a complex with active RhoA. Using RNA interference, we determined that suppression of both S100A4 and …

Circulating Tumor Dna To Monitor Metastatic Breast Cancer., Massimo Cristofanilli, Paolo Fortina

Kimmel Cancer Center Faculty Papers

No abstract provided.

Altered Drainage Patterns In Patients With Melanoma And Previous Axillary Dissection., Caitlyn M. Johnson, Charles Intenzo, Michael Mastrangelo, Kendra Feeney, Adam C. Berger

Department of Surgery Faculty Papers

The incidence of melanoma is increasing rapidly in the United States. Sentinel lymph node biopsy is an important diagnostic tool in the treatment and staging of melanoma. However, many patients with melanoma will have had lymph node surgery for previous melanoma or breast cancer. We set out to examine alterations in drainage patterns in patients with previous axillary dissection for breast cancer. We reviewed four patients with truncal and/or extremity melanomas and examined their lymphoscintigraphy and drainage patterns. Three patients with truncal melanoma mapped to cervical lymph nodes and a fourth patient with an arm melanoma mapped to her previously …

Oncolog, Volume 58, Number 06, June 2013, Joe Munch, Amelia Scholtz, Luanne Jorewicz

OncoLog MD Anderson's Report to Physicians (All issues)

• Addressing Emerging Survivorship Issues in Glioblastoma Patients: An increasing number of glioblastoma patients are becoming '' long-term'' survivors-living 3 or more years after diagnosis
• Prediction Tool Helps Determine Whether Older Breast Cancer Patients will benefit from Radiation: A statistical tool is now available to predict the likely individual benefit of radiation therapy for older women who have undergone breast-conserving surgery for breast cancer
• Sequential Multidrug Regiman May Offer an Alternative to Standard Cisplatin-Based Therapy for Urothelial Cancer: Cisplatin-based chemotherapy is the standard neoadjuvant treatment for high-risk, surgically resectable, invasive urothelial cancer. But some patients are not good candidates for this …

Prognostic Factors For Male Breast Cancer: Similarity To Female Counterparts, Edward Yu, Larry Stitt, Olga Vujovic, Kurian Joseph, Avi Assouline, Joseph Au, Jawaid Younus, Francisco Perera, Patricia Tai

Edward Yu

Abstract. Aim: To assess whether prognostic factors in male (MBC) and female (FBC) breast cancer have similar impact on survival. Patients and Methods: Charts for men and women diagnosed with breast cancer referred to the London Regional Cancer Program (LRCP) were reviewed. Patients with distant metastatic diseases were excluded. Data on prognostic factors including age, nodal status, resection margin, use of hormonal therapy, chemotherapy with/without hormone and radiation therapy (RT), overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS) were analyzed. Survival estimates were obtained using Kaplan-Meier methodology. The Cox regression interaction was used to compare male and female …

Oncolog, Volume 58, Number 04, April 2013, Kathryn L. Hale, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues)

• Preventing and Treating Graft-Versus-Host Disease After Stem Cell Transplantation: Each year, thousands of patients with hematologic malignancies undergo allogeneic (donor) stem cell transplantation (SCT), which offers a chance at cure. Graft-versus-host disease (GHVD) is a potentially deadly complication of this therapy and occurs in 25%-60% of patients. However, clinicians and researchers are continually working to reduce the rate of GVHD occurrance and improve patient outcomes
• Compass: Breast cancer Risk Reduction: Women at increased risk have multiple options
• HOUSE CALL: Benefits of In-Person Support Groups- Face-to-face contact helps people cope with chronic illness

Oncolog, Volume 58, Number 01, January 2013, Joe Munch, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues)

• Emerging Vaccines Take Aim at Preventing Recurrent Breast Cancer: Myriad advances have been made in the treatment of breast cancer, and cures are achieved in many patients. However, there are still patients whose cancer recurs, and most of these patients will die of their disease. This indicates a need for other therapies that can be used to prevent recurrent disease. One potential option is breast cancer vaccines.
• Compass: Hepatocellular Carcinoma: Concomitant liver disease affects treatment options
• HOUSE CALL: Music Therapy-Music therapists help cancer patients manage stress and side effects