Oncology Commons^™

Oncolog, Volume 58, Number 10, October 2013, Bryan Tutt, Sunni Hosemann, C. Wilcox

OncoLog MD Anderson's Report to Physicians (All issues)

• Sentinel Lymph Node Dissection After Neoadjuvant Chemotherapy for Node-Positive Breast Cancer May replace Axillary Dissection for Some Patients: Sentinel lymph node dissection has become a standard staging tool for breast cancer patients with no clinical eveidence of disease in the lymph nodes
• INBRIEF: miR-200 MicroRNAs Slow Tumor Growth
• Compass: Resectable or Borderline Resectable Pancreatic Adenocarcinoma: Initial Treatment Options-Neoadjuvent chemoradiation may benefit patients with resectable disease
• HOUSE CALL: Hereditary Cancers: Genetic screening can give valuable information

Tgf-Beta Suppresses Vegfa-Mediated Angiogenesis In Colon Cancer Metastasis., Liying Geng, Anathbandhu Chaudhuri, G. Talmon, James L. Wisecarver, J. Wang

Journal Articles: Eppley Institute

The FET cell line, derived from an early stage colon carcinoma, is non-tumorigenic in athymic nude mice. Engineered FET cells that express TGF-α (FETα) display constitutively active EGFR/ErbB signaling. These cells readily formed xenograft tumors in athymic nude mice. Importantly, FETα cells retained their response to TGF-beta-mediated growth inhibition, and, like the parental FET cells, expression of a dominant negative TGF-beta type II receptor (DNRII) in FETα cells (FETα/DNRII) abrogated responsiveness to TGF-beta-induced growth inhibition and apoptosis under stress conditions in vitro and increased metastatic potential in an orthotopic model in vivo, which indicates metastasis suppressor activity of TGF-beta signaling …