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Articles 361 - 362 of 362
Full-Text Articles in Neurology
Potential Roles Of Extracellular Vesicles In The Pathophysiology, Diagnosis, And Treatment Of Autoimmune Diseases., Jing Tian, Giacomo Casella, Yuan Zhang, Abdolmohamad Rostami, Xing Li
Potential Roles Of Extracellular Vesicles In The Pathophysiology, Diagnosis, And Treatment Of Autoimmune Diseases., Jing Tian, Giacomo Casella, Yuan Zhang, Abdolmohamad Rostami, Xing Li
Department of Neurology Faculty Papers
Since extracellular vesicles (EVs) were discovered in 1983 in sheep reticulocytes samples, they have gradually attracted scientific attention and become a topic of great interest in the life sciences field. EVs are small membrane particles, released by virtually every cell that carries a variety of functional molecules. Their main function is to deliver messages to the surrounding area in both physiological and pathological conditions. Initially, they were thought to be either cell debris, signs of cell death, or unspecific structures. However, accumulating evidence support a theory that EVs are a universal mechanism of communication. Thanks to their biological characteristics and …
Emerging Regenerative Medicine And Tissue Engineering Strategies For Parkinson's Disease., James P Harris, Justin C Burrell, Laura A Struzyna, H Isaac Chen, Mijail D Serruya, John A Wolf, John E Duda, D Kacy Cullen
Emerging Regenerative Medicine And Tissue Engineering Strategies For Parkinson's Disease., James P Harris, Justin C Burrell, Laura A Struzyna, H Isaac Chen, Mijail D Serruya, John A Wolf, John E Duda, D Kacy Cullen
Department of Neurology Faculty Papers
Parkinson's disease (PD) is the second most common progressive neurodegenerative disease, affecting 1-2% of people over 65. The classic motor symptoms of PD result from selective degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc), resulting in a loss of their long axonal projections to the striatum. Current treatment strategies such as dopamine replacement and deep brain stimulation (DBS) can only minimize the symptoms of nigrostriatal degeneration, not directly replace the lost pathway. Regenerative medicine-based solutions are being aggressively pursued with the goal of restoring dopamine levels in the striatum, with several emerging techniques attempting to reconstruct the …