Neurology Commons^™

Bilateral Cervical Radiculopathy As A Presentation Of Spinal Tuberculosis: Report Of Two Cases, G R. Sharma, Rashid Jooma

Section of Neurosurgery

No abstract provided.

Giant Hypothalamic Hamartoma And Associated Seizure Types, M K. Chishti, Ashfaq A. Razzaq

Section of Neurosurgery

No abstract provided.

Neoplastic Growth Of Cerebral Cavernous Malformation Presenting With Impending Cerebral Herniation: A Case Report And Review Of The Literature On De Novo Growth Of Cavernomas, Arshad A. Siddiqui, Rashid Jooma

Section of Neurosurgery

Background: Cerebral cavernomas are rare vascular anomalies and their expansile growth has been considered to be mainly due to recurrent hemorrhages. They are not generally reported to show aggressive behavior.
Case description: A 27-year-old male presented with headache, visual disturbances, and a 17-year history of seizures. He was known to have a temporal lobe lesion on CT scan, consistent with a diagnosis of cavernous malformation but with no relevant family history. Serial clinical and radiological follow-up revealed a progressive increase in the size of the lesion with formation of a growing cyst of 7 cm in diameter, which produced mass …

Prediction Of Long-Term Intellectual And Neuropsychological Effects Of Closed Head Injury In Infants And Children, Tamara Sue Brenner

Loma Linda University Electronic Theses, Dissertations & Projects

The ability to predict long-term intellectual and neuropsychological outcome (1-7 years post-injury) in children (ages 1 week - 14 years at injury) with a history of closed head injury were investigated. Clinical indicators of injury severity including EEG reading and age at injury as well as ’H-MRS variables of NAA/Ch, Ch/Cr, and lactate presence accurately classified 100% of children as functioning either within or above the average range or below the average range for most outcome measures. Combined clinical and H-MRS variables accounted for approximately 50% of the variance in outcome confirming the validity of their predictive use and also …

Histological Pattern Of Central Nervous System Neoplasms, Z. Ahmed, S. Muzaffar, Naila Kayani, Shahid Pervez, A. S. Husainy, S. H. Hasan

Department of Pathology and Laboratory Medicine

Objective:

To see in a large series of patients the histological pattern of CNS neoplasms and to provide a comprehensive data about the frequency of CNS neoplasms in Pakistani patients and to give a clearer idea about their prevalence.

Method:

Retrospective study of all consecutive cases of CNS neoplasms diagnosed at The Aga Khan University Hospital (AKUH) between 1st January 1994 and 31st December, 1999.

Setting:

The section of Histopathology, AKUH, Karachi.

Observation:

Our series included a large number of cases i.e., 1110 . There are very few local studies on CNS tumours and none so large . Our data …

Estrogen Protects Against The Synergistic Toxicity By Hiv Proteins, Methamphetamine And Cocaine, Jadwiga Turchan, Caroline Anderson, Kurt F. Hauser, Qinmiao Sun, Jiayou Zhang, Ying Liu, Phyllis M. Wise, Inna Kruman, William Maragos, Mark P. Mattson, Rosemarie Booze, Avindra Nath

Neurology Faculty Publications

BACKGROUND: Human immunodeficiency virus (HIV) infection continues to increase at alarming rates in drug abusers, especially in women. Drugs of abuse can cause long-lasting damage to the brain and HIV infection frequently leads to a dementing illness. To determine how these drugs interact with HIV to cause CNS damage, we used an in vitro human neuronal culture characterized for the presence of dopaminergic receptors, transporters and estrogen receptors. We determined the combined effects of dopaminergic drugs, methamphetamine, or cocaine with neurotoxic HIV proteins, gp120 and Tat.

RESULTS: Acute exposure to these substances resulted in synergistic neurotoxic responses as measured by …

Vestibular Schwannomas: Clinical Presentation, Management And Outcome, M S. Awan, H U. Qureshi, A A. Sheikh, M M. Ali

Section of Neurosurgery

Objective: To review the demographic trends clinical spectrum, diagnosis, management and outcome of patients with vestibular Schwannoma and to identify areas where improvements are needed.
Methods: All patients with vestibular schwannoma admitted to the Aga Khan University Hospital over the past 11 years were reviewed retrospectively.
Results: The age range of majority of 22 patients analyzed, was 41-50 years (23%). Hearing loss was the most common presenting symptom (96%). Other clinical features included cranial nerve palsies (59%) and headache (55%). Fifty percent had signs of raised intracranial pressure. Neuroimaging revealed "Stage IV b" (tumor distorting the brainstem and compressing the …

Functions Of The Rat's Temporal Association Cortex In Higher Perceptual Functions, Summer L. Maki

The Corinthian

The role of the rodent temporal cortex in relational perception was investigated. Eighteen Long Evans rats were separated into three surgical groups (sham, partial striate, and Te2/3) and trained on a preoperative and postoperative discrimination task. The rats were then presented a series of relational judgement trials consisting of both between category judgments and within category judgments. It was hypothesized that the rats with Te2/3 lesions would perform as well as controls on the preoperative and postoperative discrimination task, but show a considerable behavioral dysfunction on the tests of visual relational perception. The results showed no differences across groups in …

The Concentration Of Three Anti-Seizure Medications In Hair: The Effects Of Hair Color, Controlling For Dose And Age, Tom Mieczkowski, Aristidis M. Tsatsakis, Michael Kruger, Thanasis Psillakis

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

This paper assess the relationship between the quantity of three anti-seizure medications in hair and the color of the analyzed hair, while controlling for the effects of dose, dose duration, and patient age for 140 clinical patients undergoing anti-seizure therapy. Three drugs are assessed: carbamazepine (40 patients), valproic acid (40 patients), and phenytoin (60 patients). The relationship between hair assay results, hair color, dose, dose duration, and age is modeled using an analysis of covariance. The covariance model posits the hair assay results as the dependent variable, the hair color as the qualitative categorical independent variable, and dose, …