Neurology Commons^™

Role Of Slit2 In Reducing Complications After Surgical Brain Injury, Prativa Sherchan

Loma Linda University Electronic Theses, Dissertations & Projects

Surgical brain injury (SBI) is the inadvertent injury to brain tissue at the perisurgical site which occurs due to neurosurgical maneuvers such as incision, retraction, and electrocoagulation that can result in post-operative complications. Blood brain barrier (BBB) disruption and neuroinflammation are major pathophysiological consequences after neurosurgical injury. Blood brain barrier dysfunction leads to increased influx of water and plasma proteins as well as peripheral immune cell infiltration into the brain parenchyma that further potentiates brain edema and worsens post-operative neurological function. Activated resident immune cells and infiltrated peripheral immune cells release inflammatory mediators and promote oxidative stress and cell death …

Role Of Astrocyte Network In Edema After Juvenile Traumatic Brain Injury, Andrew Minoru Fukuda

Loma Linda University Electronic Theses, Dissertations & Projects

Juvenile traumatic brain injury (jTBI) is the leading cause of death and disability in young children and adolescents. Despite its lasting detrimental effects on the developing brain, no pharmacological treatment exists. One of the pathological hallmarks of jTBI is edema. Astrocytes play a key role in the edema process, and have been hypothesized that numerous astrocyte networks allow communication and propagation of edema and secondary injury spread. Two key astrocyte proteins are hypothesized to have a central role in the edema process: Aquaporin 4 (AQP4) and Connexin 43 (Cx43). AQP4 is expressed extensively in astrocyte endfeet, which surrounds the blood …

Caveolins And Njks Influence Brain Endothelial Permeability After Juvenile Tbi, David Olufemi Ajao

Loma Linda University Electronic Theses, Dissertations & Projects

Disruption of blood-brain barrier (BBB) is a key secondary event that exacerbates brain damage following traumatic brain injury (TBI). BBB disruption is particularly damaging to the developing brain – which is highly vulnerable to various stress stimuli, resulting in increased brain swelling, disrupted cerebral blood flow (CBF) autoregulation, long-term disabilities and death following TBI in young demographic. Unsurprisingly, BBB disruption and the resultant cerebral edema have emerged as therapeutic targets in juvenile TBI. It is therefore important to understand the molecular players and mechanisms involved in TBI-induced BBB disruption in the juvenile brain. To this end, the endothelial caveolins and …

Prediction Of Long-Term Intellectual And Neuropsychological Effects Of Closed Head Injury In Infants And Children, Tamara Sue Brenner

Loma Linda University Electronic Theses, Dissertations & Projects

The ability to predict long-term intellectual and neuropsychological outcome (1-7 years post-injury) in children (ages 1 week - 14 years at injury) with a history of closed head injury were investigated. Clinical indicators of injury severity including EEG reading and age at injury as well as ’H-MRS variables of NAA/Ch, Ch/Cr, and lactate presence accurately classified 100% of children as functioning either within or above the average range or below the average range for most outcome measures. Combined clinical and H-MRS variables accounted for approximately 50% of the variance in outcome confirming the validity of their predictive use and also …

Research Notebook, G. Austin

The Dr. George M. Austin Neurology Research Collection

Book cover inscription:

G. Austin M.D. Research Notebook, Oct. 1 1995-Aug. '96, Brash Aneurysm Research Sources Notebook, P1-20; Paris - P. 121

Descriptive Enlargement Of Intracranial Aneurysms To A Critical Thickness For Rupture, G. Austin, X. Gong, Z. Suo

The Dr. George M. Austin Neurology Research Collection

''lntracranial Aneurysm: A model of expansion to critical thinning," Poster Presentation Annual Meeting of Biophysical Society, Wash., D.C., 1993, 9 p.

Most intracranial aneurysms (IA) are thinner at the apex; and 84% rupture at the apex. (Weir, 1987, Crompton, 1966). Minimum thickness of an unruptured aneurysm is reported 20 microns (Suzuki, et al 1980). We have developed a computer model of aneurysm enlargement starting from a vascular wall using the membrane elasticity equations of Green and Adkins, 1960 and Bogen & McMahon, 1978, and a computer solution with a new Fortran program by X. Gong. The relatively homogeneous wall (Austin, …

Middle Cerebral Artery Aneurysm: A Computer Model, G. Austin, R. Gaskell

The Dr. George M. Austin Neurology Research Collection

Middle Cerebral Artery Aneurysm: A Computer Model, Program Abstract, 8th Int. Congress of Neurological Surgery - Toronto, Canada, July 7-11, 1985

Computer Model Of Anterior Communicating Artery Aneurysm And Vasospasm, G. Austin

The Dr. George M. Austin Neurology Research Collection

Computer Model of Anterior Communicating Artery Aneurysm and Vasospasm. G. Austin and R. Gaskell. Typed manuscript, 3 p. plus 4 pages of handwritten notes. See additional file. Poster boards used in the presentation are also held in the Department of Archives and Special Collections at Loma Linda University. Presentation date unknown.

Anterior Communicating Artery Aneurysm And Vasospasm - A Computer Model, G. Austin, R. Gaskell

The Dr. George M. Austin Neurology Research Collection

Anterior Communicating Artery Aneurysm and Vasospasm – A Computer Model. G. Austin, R. Gaskell. Poster presentation. Annual Meeting of American Association of Neurological Surgeons, Atlanta, CA. 1985. 8 pg

Anterior Communicating Artery Aneurysm And Vasospasm – A Computer Model., G. Austin, R. Gaskell

The Dr. George M. Austin Neurology Research Collection

Anterior Communicating Artery Aneurysm and Vasospasm – A Computer Model. G. Austin, R. Gaskell. Poster presentation. Annual Meeting of American Association of Neurological Surgeons, Atlanta, CA. 1985. 8 pg.

Environmental Enrichment And Nursing Therapy With Comatose Patients : Two Case Studies, Marilyne R. Sayler

Loma Linda University Electronic Theses, Dissertations & Projects

As a part of a larger research project with comatose patients the problem stated for this portion of the research study was to investigate the potential for identifying whether or not the quality of nursing care for comatose patients could be improved by nursing therapy with environmental enrichment and meaningful systematic orienting stimuli given by professional nurse clinicians and a patient's significant others. The effects of the orienting stimuli were measured by observable changes in arousal patterns in serial electroencephalograms (EEGs) , level of arousal as scored on the Glasgow Coma Scale (GCS), and selected measures of recovery outcome (RO). …

Technical Consideration Regarding Direction And Perfusion Of Blood Flow In Patients Undergoing Sta-Mca Anastomosis, G. Austin, J. Thompson, D. Laffin, W. Hayward

The Dr. George M. Austin Neurology Research Collection

Technical Consideration Regarding Direction and Perfusion of Blood Flow in Patients Undergoing STA-MCA Anastomosis. G. Austin, M.D., J. Thompson, M.D., D. Laffin, W. Hayward. Presented at Neurol. Surgeons International Association, St. Louis, Missouri, April 21-25, 197[4], 9 pg.

Effects Of Vasospasm On Cerebral Blood Flow Measured By An Intravenous Isotope Technique, G. Austin, S. Rouhe, L. Dayes, D. Laffin, W. Hayward

The Dr. George M. Austin Neurology Research Collection

Effects of Vasospasm on Cerebral Blood Flow Measured by an Intravenous Isotope Technique. G. Austin, S. Rouhe, L. Dayes, D. Laffin and W. Hayward. Conference presentation. American Association of Neurosurgeons, Boston, Massachusetts, April 16-20, 1972. Typewritten manuscript, 5 pg.

Early Detection And Follow-Up Measurement Of Rcbf In Vasospasm And Occlusive Disease By I.V. Radioisotope Method, George Austin, Niall Horn, Stan Rouhe, Wm. Hayward

The Dr. George M. Austin Neurology Research Collection

Early Detection and Follow-up Measurement of rCBF in Vasospasm and Occlusive Disease by I.V. Radioisotope Method. George Austin, Niall Horn, Stan Rouhe, and William Hayward. Conference presentation. International CBF Symposium. Roma-Siena. October 28-31, 1971. 1 typed manuscript., 3 pg. with author’s note on verso pg. 3

Factors Which Deterred Twenty-Three Selected Patients From Utilizing Public Health Nursing Services, Lora Wood Welch

Loma Linda University Electronic Theses, Dissertations & Projects

A study was conducted to identify factors which deterred twenty-three selected epileptic patients from utilizing public health nursing services. The literature was reviewed in areas relating to factors which may contribute to or deter patients use of clinic or public health services.

The descriptive survey approach employing an interview guide was used. Data on the guide were classified in two areas: (1) personal characteristics and (2) participant responses. The participant responses were further categorized according to (1) perception of the public health department and public health nursing services, (2) perception of the needs of the epileptic patient and his parents, …

Electroencephalography In A Teaching Hospital, Guy M. Hunt Jr.

Loma Linda University Electronic Theses, Dissertations & Projects

Electroencephalography may be defined as a study of the electrical activity of the brain. This activity was first recorded and reported by Caton in 1875. However, it was the work of Hans Berger, confirmed by Adrian and Matthews in 1935, which opened the way for the rapid advancement of knowledge in this field. The arrival of the age of electronics made possible development of the sensitive, accurate, and dependable amplifiers available in modern electroencephalography, which has in turn made possible the rapid advancements in this field. Techniques have been perfected and standardized, personnel have been trained, and laboratories have been …

The Neuropsychiatric Factor In Allergic Disease, Norman Shure, M Coleman Harris

Medical Arts and Sciences: A Scientific Journal of the College of Medical Evangelists

A concept of the causation of allergic disease herewith is presented in which, in addition to the allergic factors, emotional states and psychic stimuli are introduced as integral parts of every case. The adoption of the terms "intrinsic" for the neuropsychiatric factors and "extrinsic" for the organic factors in the production of allergic disease is suggested.

Intracranial Surgery, William T. Grant

Medical Arts and Sciences: A Scientific Journal of the College of Medical Evangelists

No abstract provided.

Inherited Disorders, George Austin

The Dr. George M. Austin Neurology Research Collection

A manuscript outline of possible inherited disorders presumably created by Dr. Austin. No date.

Cerebral Co2 Reactivity And Autoregulation In Patients Undergoing Microanastomosis, David Zinke, William Hayward, Neil Poll, George Austin

The Dr. George M. Austin Neurology Research Collection

Cerebral CO₂ Reactivity and Autoregulation in Patients Undergoing Microanastomosis. David Zinke, M.D., William Hayward, BSc, Neil Poll, MSC, and George Austin, M.D., From the Section of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, California. Typewritten manuscript with several handwritten notes, 3 pg.