Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Sciences (20)
- Pediatrics (11)
- Diseases (10)
- Critical Care (6)
- Internal Medicine (4)
-
- Public Health (4)
- COVID-19 (2)
- Cardiology (2)
- Chemicals and Drugs (2)
- Clinical Epidemiology (2)
- Digestive System Diseases (2)
- Health Information Technology (2)
- Life Sciences (2)
- Pathological Conditions, Signs and Symptoms (2)
- Social and Behavioral Sciences (2)
- Surgery (2)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Bacterial Infections and Mycoses (1)
- Biochemical Phenomena, Metabolism, and Nutrition (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Bioethics and Medical Ethics (1)
- Biomedical Informatics (1)
- Cardiovascular Diseases (1)
- Dietetics and Clinical Nutrition (1)
- Economics (1)
- Emergency Medicine (1)
- Endocrinology, Diabetes, and Metabolism (1)
- Institution
- Publication
- Publication Type
Articles 31 - 31 of 31
Full-Text Articles in Nephrology
Effect Of Kidney Function On Drug Kinetics And Dosing In Neonates, Infants, And Children., Frederique Rodieux, Melanie Wilbaux, Johannes N. Van Den Anker, Marc Pfister
Effect Of Kidney Function On Drug Kinetics And Dosing In Neonates, Infants, And Children., Frederique Rodieux, Melanie Wilbaux, Johannes N. Van Den Anker, Marc Pfister
Pediatrics Faculty Publications
Neonates, infants, and children differ from adults in many aspects, not just in age, weight, and body composition. Growth, maturation and environmental factors affect drug kinetics, response and dosing in pediatric patients. Almost 80% of drugs have not been studied in children, and dosing of these drugs is derived from adult doses by adjusting for body weight/size. As developmental and maturational changes are complex processes, such simplified methods may result in subtherapeutic effects or adverse events. Kidney function is impaired during the first 2 years of life as a result of normal growth and development. Reduced kidney function during childhood …