Internal Medicine Commons^™

A Unique Presentation Of Libman-Sacks: Non-Bacterial Tricuspid Valve Endocarditis, August Rakutt, Lauren Hampton, Johnathan Frunzi

West Florida Division GME Research Day 2023

No abstract provided.

A Case Of Coxsackievirus Type B-Induced Myocarditis Presenting With Gi Symptoms, Daniel Karpel, Jason Nguyen, Cristina Benites, Mohammed Akram, Francini Alcocer-Guzman, Evelyn Garcia, Shany Quevedo, Ambar Sekulits, Livasky Concepcion Perez

East Florida Division GME Research Day 2023

Please see supplemental content for full abstract with references.

Myocarditis affects 1.5 million people worldwide and in chronic forms can lead to heart failure. This inflammatory disorder is a primary cause of dilated cardiomyopathy globally and is frequently a complication of viral infections. Although Coxsackievirus B3 continues to be a prominent causative agent, further exploration has discovered a number of Coxsackie serotypes responsible for myocarditis. Despite being a well-known contributor to congestive heart failure, there is a lack of conventional techniques available to aid in diagnosis, making diagnosing acute viral myocarditis a complex and tedious process. We discuss the case …

A Young Case Of Giant Cell Arteritis, Tricia O'Brien, Philip Mesquita, Zahid Chaudhry

East Florida Division GME Research Day 2023

Introduction: Giant Cell Arteritis is condition that commonly affects patients between the ages of 70 and 80 years old. It rarely affects those younger than 50 years of age.

Description: A 40-year-old African American woman, who had previously been diagnosed with Giant Cell Arthritis via temporal artery biopsy at age 33, presented to the emergency department due to facial and arm numbness and throbbing headache. Her ESR was markedly elevated and she was placed on prednisone.

Discussion: The incidence of Giant Cell Arthritis is between 5.8 to 31.3 per 100,000 in the population. This disease affects women 2-3 times more …

A Stiff Lower Lip, Tricia O'Brien, Philip Mesquita, Zahid Chaudry

East Florida Division GME Research Day 2023

No abstract available.

An Intersting Presentation Of Angina Due To Left Posterolateral To Right Posterolateral Coronary Artery Fistula, Vivek Nadipalli, Ahmed Mahmood, Muhammad Uzair Lodhi, Bilal Hussain, Sohail Khan, Christel Cuevas, Thomas Alexander

Gulf Coast Division GME Research Day 2023

No abstract provided.

A Rare Case Of Right Atrial Appendage Mass In Patient With Recurrent Methicillin-Resistant Staphylococcus Aureus Bacteremia, Vivek Nadipalli, Ahmed Mahmood, Thomas Alexander

Gulf Coast Division GME Research Day 2023

No abstract provided.

Intracerebral Hemorrhage And Reversible Cerebral Vasoconstriction Syndrome Ina Patient With Covid-19, Matthew Bear, Branden Wilson, Aswin Srinivasan, Amar Hasan, Salman Alim, Mohamad Ezzeldin

Gulf Coast Division GME Research Day 2023

No abstract provided.

Fatal Atrio-Esophageal Fistula Presenting As New Onset Seizures, Hytham Rashid, Jonathan Brown, Eryn Percenti, Justin Saunders, Sivatej Sarva

Gulf Coast Division GME Research Day 2023

No abstract provided.

Rare Case Of Chylopericardium Status Post Coronary Artery Bypass Graft, Hytham Rashid, Harris R. Khawaja, Ashley Charales, Essam Girgawy, Ramesh Kesavan, Michael Daniel

Gulf Coast Division GME Research Day 2023

No abstract provided.

A Rare Educational Case Of Idiopathic Cutaneous Leukocytoclastic Vasculitis, Shruthi Vijayalakshmi, Shreyan A. Patel, Admir Syla

Capital Division GME Research Day 2023

No abstract provided.

Heart Failure With Preserved Ejection Fraction Management Current Literature Review, Gregory Carbonella, Peter Dourdoufis

Capital Division GME Research Day 2023

No abstract provided.

Incidence And Risk Factors Leading To Stress Test And Coronary Intervention In The Patient Presenting With Atrial Fibrillation In The Ed, Ali Mohsin Choudhry, Srikanth Tadepali, Bernard Dankyi, Sandi Dunn, Rakesh Prashad

North Florida Division GME Research Day 2023

No abstract provided.

Emphasis On Need To Develop Strategies To Prevent Drug-Induced Qtc Prolongation: Case Based Study Following Azithromycin Use, Shruti Verma, Emadeldeen Elgwairi, Marcarthur Limpiado, William Zvagelsky, Naresh Kodwani

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Moyamoya Disease: Classic Imaging With Atypical Presentation, Amanda Fahrenbruck, Holly Fleming, Elena Salikhova-Neace, Dmitriy Scherbak

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Anticoagulation Resumption In A Patient With Sdh And Mechanical Aortic Valve, Humberto Torres, Marines Faya, Ali Mohsin Choudhry, Abdul Mheir, Ramy Abdelmaseih, Rakesh Prashad

North Florida Division GME Research Day 2023

No abstract provided.

Endovascular Stroke Intervention: A Retrospective Analysis Of Functional Outcomes In Elderly Stroke Patients Undergoing Endovascular Therapy, Anvita Anne, Sandi Dunn, Humberto Torres, Scott Simon, Victoria Rallens, Cristobal Cintron, Chandan Mitra, Iraj Nikfarjam

North Florida Division GME Research Day 2023

No abstract provided.

Endobronchial Ultrasound Diagnosis Of A Malignant Superior Vena Cava Tumor Thrombus Extending Into The Right Atrium: An Unusual Cause Of Recurrent Syncope., Larissa Check, Ariba Naz, Richard Duff

South Atlantic Division GME Research Day 2023

No abstract provided.

Efficacy And Safety Of Mavacamten In The Treatment Of Hypertrophic Cardiomyopathy: A Systematic Review, Daniel Bishev, Stephanie Fabara, Isaac Loseke, Akankcha Alok, Hashim Al-Ani, Yvette Bazikian

North Florida Division GME Research Day 2023

No abstract provided.

Noncompaction Cardiomyopathy: A Catastrophic Cause Of Heart Failure, William Zvagelsky, Ajay Iyer, Rebecca Kurian, Brent Wu, Minar Rane, Rajendran Sabapathy

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Efficacy Of Apixaban In Nonhemorrhagic Stroke Prevention In Morbid Obesity, Jason Findlay, Kruten Patel, Justin Chen, Jared Krainin

West Florida Division GME Research Day 2023

No abstract provided.

Percutaneous Closure Of Aorto-Right Fistula: An Interesting Case Of Marfan's Syndrome And Fistula Formation, Ahmed Mahmood, Vivek Nadipalli, Muhammad Uzair Lodhi, Bilal Hussain, Carlos E. Vargas, Sohail Khan, Christel Cuevas, Thomas Alexander

Gulf Coast Division GME Research Day 2023

No abstract provided.

Post-Covid Baroreflex Failure, Khaled Elkholey, Cyndya A. Shibao, Italo Biaggioni

TriStar Division Research Day 2023

No abstract provided.

Chiari’S Network: What Is The Clinical Significance?, Emadeldeen Elgwairi, Ajay Iyer, William Zvagelsky, Shruti Verma, Marcarthur Limpiado, Minar Rane, Kiranmayi Chilappa

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Analysis Of Transthoracic Echocardiogram Findings In Stroke And Tia Patients, Connor Petrovich, Anne Annvita, Robyn Meadows, Cristobal Cintron, Anand Venkatraman, Chandan Mitra, Rakesh Prashad

North Florida Division GME Research Day 2023

No abstract provided.

When You Are Not Able To Engage The Right Coronary Artery, Emadeldeen Elgwairi, Ajay Iyer, William Zvagelsky, Shruti Verma, Marcarthur Limpiado, Minar Rane, David Rios

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Endothelial Activation And Fibrotic Changes Are Impeded By Laminar Flow-Induced Chk1-Senp2 Activity Through Mechanisms Distinct From Endothelial-To-Mesenchymal Cell Transition, Minh T H Nguyen, Masaki Imanishi, Shengyu Li, Khanh Chau, Priyanka Banerjee, Loka Reddy Velatooru, Kyung Ae Ko, Venkata S K Samanthapudi, Young J Gi, Ling-Ling Lee, Rei J Abe, Elena Mcbeath, Anita Deswal, Steven H Lin, Nicolas L Palaskas, Robert Dantzer, Keigi Fujiwara, Mae K Borchrdt, Estefani Berrios Turcios, Elizabeth A Olmsted-Davis, Sivareddy Kotla, John P Cooke, Guangyu Wang, Jun-Ichi Abe, Nhat-Tu Le

Faculty, Staff and Student Publications

BACKGROUND: The deSUMOylase sentrin-specific isopeptidase 2 (SENP2) plays a crucial role in atheroprotection. However, the phosphorylation of SENP2 at T368 under disturbed flow (D-flow) conditions hinders its nuclear function and promotes endothelial cell (EC) activation. SUMOylation has been implicated in D-flow-induced endothelial-to-mesenchymal transition (endoMT), but the precise role of SENP2 in counteracting this process remains unclear.

METHOD: We developed a phospho-specific SENP2 S344 antibody and generated knock-in (KI) mice with a phospho-site mutation of SENP2 S344A using CRISPR/Cas9 technology. We then investigated the effects of SENP2 S344 phosphorylation under two distinct flow patterns and during hypercholesteremia (HC)-mediated EC activation.

RESULT: …

Cardiovascular Hemodynamics In Mice With Tumor Necrosis Factor Receptor-Associated Factor 2 Mediated Cytoprotection In The Heart, Andrea G Marshall, Kit Neikirk, Zer Vue, Heather K Beasley, Edgar Garza-Lopez, Larry Vang, Taylor Barongan, Zoe Evans, Amber Crabtree, Elsie Spencer, Josephs Anudokem, Remi Parker, Jamaine Davis, Dominique Stephens, Steven Damo, Thuy T Pham, Jose A Gomez, Vernat Exil, Dao-Fu Dai, Sandra A Murray, Mark L Entman, George E Taffet, Antentor O Hinton, Anilkumar K Reddy

Faculty, Staff and Students Publications

INTRODUCTION: Many studies in mice have demonstrated that cardiac-specific innate immune signaling pathways can be reprogrammed to modulate inflammation in response to myocardial injury and improve outcomes. While the echocardiography standard parameters of left ventricular (LV) ejection fraction, fractional shortening, end-diastolic diameter, and others are used to assess cardiac function, their dependency on loading conditions somewhat limits their utility in completely reflecting the contractile function and global cardiovascular efficiency of the heart. A true measure of global cardiovascular efficiency should include the interaction between the ventricle and the aorta (ventricular-vascular coupling, VVC) as well as measures of aortic impedance and …

More On The Magic Of Metformin, Efstratios Koutroumpakis, Claire Huang-Lucas, Heinrich Taegtmeyer

Faculty, Staff and Student Publications

No abstract provided.

Tnik Regulation Of Interferon Signaling And Endothelial Cell Response To Virus Infection, Khanh M Chau, Abishai Dominic, Eleanor L Davis, Sivareddy Kotla, Estefani Turcios Berrios, Arsany Fahim, Ashwin Arunesh, Shengyu Li, Dongyu Zhao, Kaifu Chen, Alan R Davis, Minh T H Nguyen, Yongxing Wang, Scott E Evans, Guangyu Wang, John P Cooke, Jun-Ichi Abe, David P Huston, Nhat-Tu Le

Faculty, Staff and Student Publications

BACKGROUND: Traf2 and Nck-interacting kinase (TNIK) is known for its regulatory role in various processes within cancer cells. However, its role within endothelial cells (ECs) has remained relatively unexplored.

METHODS: Leveraging RNA-seq data and Ingenuity Pathway Analysis (IPA), we probed the potential impact of TNIK depletion on ECs.

RESULTS: Examination of RNA-seq data uncovered more than 450 Differentially Expressed Genes (DEGs) in TNIK-depleted ECs, displaying a fold change exceeding 2 with a false discovery rate (FDR) below 0.05. IPA analysis unveiled that TNIK depletion leads to the inhibition of the interferon (IFN) pathway [-log (

SUMMARY: Our findings suggest that …

The Gastrointestinal-Brain-Microbiota Axis: A Promising Therapeutic Target For Ischemic Stroke, Yan-Hao Wei, Ren-Tang Bi, Yan-Mei Qiu, Chun-Lin Zhang, Jian-Zhuang Li, Ya-Nan Li, Bo Hu

Faculty, Staff and Student Publications

Ischemic stroke is a highly complex systemic disease characterized by intricate interactions between the brain and gastrointestinal tract. While our current understanding of these interactions primarily stems from experimental models, their relevance to human stroke outcomes is of considerable interest. After stroke, bidirectional communication between the brain and gastrointestinal tract initiates changes in the gastrointestinal microenvironment. These changes involve the activation of gastrointestinal immunity, disruption of the gastrointestinal barrier, and alterations in gastrointestinal microbiota. Importantly, experimental evidence suggests that these alterations facilitate the migration of gastrointestinal immune cells and cytokines across the damaged blood-brain barrier, ultimately infiltrating the ischemic brain. …