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Full-Text Articles in Integrative Medicine
Comparison Of Biological Measurement And Physical Estimates Of Space Radiation In The International Space Station, Kayo Yoshida, Megumi Hada, Akane Kizu, Kohei Kitada, Kiyomi Eguchi-Kasai, Toshiaki Kokubo, Takeshi Teramura, Sachiko Yano, Hiromi Hashizum Suzuki, Hitomi Watanabe, Gen Kondoh, Aiko Nagamatsu, Premkumar Saganti, Francis A. Cucinotta, Takashi Morita
Comparison Of Biological Measurement And Physical Estimates Of Space Radiation In The International Space Station, Kayo Yoshida, Megumi Hada, Akane Kizu, Kohei Kitada, Kiyomi Eguchi-Kasai, Toshiaki Kokubo, Takeshi Teramura, Sachiko Yano, Hiromi Hashizum Suzuki, Hitomi Watanabe, Gen Kondoh, Aiko Nagamatsu, Premkumar Saganti, Francis A. Cucinotta, Takashi Morita
Integrated Health Sciences Faculty Research
Nowadays, ordinary people can travel in space, and the possibility of extended durations in an environment such as moon of the Earth and Mars with higher space radiation exposures compared to past missions, is increasing. Until now, the physical doses of space radiation have been measured, but measurement of direct biological effects has been hampered by its low dose and low dose-rate effect. To assess the biological effects of space radiation, we launched and kept frozen mouse embryonic stem (ES) cells in minus eighty degree Celsius freezer in ISS (MELFI) on the International Space Station (ISS) for a maximum of …
Diabetes: Risk Factor And Translational Therapeutic Implications For Alzheimer's Disease, Jeffrey Cummings, Andrew Ortiz, Janelle Castellino, Jefferson Kinney
Diabetes: Risk Factor And Translational Therapeutic Implications For Alzheimer's Disease, Jeffrey Cummings, Andrew Ortiz, Janelle Castellino, Jefferson Kinney
Integrated Health Sciences Faculty Research
Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) commonly co-occur. T2DM increases the risk for AD by approximately twofold. Animal models provide one means of interrogating the relationship of T2DM to AD and investigating brain insulin resistance in the pathophysiology of AD. Animal models show that persistent hyperglycaemia results in chronic low-grade inflammation that may contribute to the development of neuroinflammation and accelerate the pathobiology of AD. Epidemiological studies suggest that patients with T2DM who received treatment with specific anti-diabetic agents have a decreased risk for the occurrence of AD and all-cause dementia. Agents such as metformin ameliorate T2DM …