Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Sciences (21)
- Medical Immunology (16)
- Diseases (13)
- Life Sciences (13)
- Public Health (13)
-
- Microbiology (11)
- Virus Diseases (11)
- Genetics and Genomics (10)
- Medical Pathology (10)
- Virology (10)
- Biological Phenomena, Cell Phenomena, and Immunity (9)
- Cell and Developmental Biology (9)
- Community Health and Preventive Medicine (7)
- Medical Microbiology (7)
- Epidemiology (5)
- Health Law and Policy (5)
- Law (5)
- Clinical Epidemiology (4)
- Influenza Virus Vaccines (4)
- International Public Health (4)
- Public Health Education and Promotion (4)
- Bacterial Infections and Mycoses (3)
- Influenza Humans (3)
- Nursing (3)
- Public Health and Community Nursing (3)
- Bacteria (2)
- Biotechnology (2)
- Institution
- Publication Year
- Publication
-
- Nebraska Center for Virology: Faculty Publications (9)
- All Faculty Scholarship (5)
- Dartmouth Scholarship (3)
- Advances in Clinical Medical Research and Healthcare Delivery (2)
- Department of Microbiology and Immunology Faculty Papers (2)
-
- The University of Louisville Journal of Respiratory Infections (2)
- Ateneo School of Medicine and Public Health Publications (1)
- Biology: Student Scholarship & Creative Works (1)
- Capstone Showcase (1)
- Department of Paediatrics and Child Health (1)
- Doctor of Nursing Practice Scholarly Projects (1)
- Emerging Writers (1)
- MCB Articles (1)
- Medical College Documents (1)
- Natural & Applied Sciences Faculty Publications (1)
- Population Health, East Africa (1)
- School of Graduate Studies Faculty Publications (1)
- Publication Type
Articles 31 - 34 of 34
Full-Text Articles in Infectious Disease
Long-Term Immunity To Lethal Acute Or Chronic Type Ii Toxoplasma Gondii Infection Is Effectively Induced In Genetically Susceptible C57bl/6 Mice By Immunization With An Attenuated Type I Vaccine Strain, Jason P. Gigley, Barbara A. Fox, David J. Bzik
Long-Term Immunity To Lethal Acute Or Chronic Type Ii Toxoplasma Gondii Infection Is Effectively Induced In Genetically Susceptible C57bl/6 Mice By Immunization With An Attenuated Type I Vaccine Strain, Jason P. Gigley, Barbara A. Fox, David J. Bzik
Dartmouth Scholarship
C57BL/6 (B6) mice are genetically highly susceptible to chronic type II Toxoplasma gondii infections that invariably cause lethal toxoplasmic encephalitis. We examined the ability of an attenuated type I vaccine strain to elicit long-term immunity to lethal acute or chronic type II infections in susceptible B6 mice. Mice immunized with the type I cps1-1 vaccine strain were not susceptible to a lethal (100-cyst) challenge with the type II strain ME49. Immunized mice challenged with 10 ME49 cysts exhibited significant reductions in brain cyst and parasite burdens compared to naive mice, regardless of the route of challenge infection. Remarkably, cps1-1 strain-immunized …
Transcutaneous Immunization With Toxin-Coregulated Pilin A Induces Protective Immunity Against Vibrio Cholerae O1 El Tor Challenge In Mice, Julianne E. Rollenhagen, Anuj Kalsy, Francisca Cerda, Manohar John
Transcutaneous Immunization With Toxin-Coregulated Pilin A Induces Protective Immunity Against Vibrio Cholerae O1 El Tor Challenge In Mice, Julianne E. Rollenhagen, Anuj Kalsy, Francisca Cerda, Manohar John
Dartmouth Scholarship
Toxin-coregulated pilin A (TcpA) is the main structural subunit of a type IV bundle-forming pilus of Vibrio cholerae, the cause of cholera. Toxin-coregulated pilus is involved in formation of microcolonies of V. cholerae at the intestinal surface, and strains of V. cholerae deficient in TcpA are attenuated and unable to colonize intestinal surfaces. Anti-TcpA immunity is common in humans recovering from cholera in Bangladesh, and immunization against TcpA is protective in murine V. cholerae models. To evaluate whether transcutaneously applied TcpA is immunogenic, we transcutaneously immunized mice with 100 mug of TcpA or TcpA with an immunoadjuvant (cholera toxin [CT], …
Prophylaxis And Therapy Of Inhalational Anthrax By A Novel Monoclonal Antibody To Protective Antigen That Mimics Vaccine-Induced Immunity, Laura Vitale, Diann Blanset, Israel Lowy, Thomas O'Neill, Joel Goldstein, Stephen F. Little, Gerard P. Andrews, Gary Dorough, Ronald K. Taylor, Tibor Keler
Prophylaxis And Therapy Of Inhalational Anthrax By A Novel Monoclonal Antibody To Protective Antigen That Mimics Vaccine-Induced Immunity, Laura Vitale, Diann Blanset, Israel Lowy, Thomas O'Neill, Joel Goldstein, Stephen F. Little, Gerard P. Andrews, Gary Dorough, Ronald K. Taylor, Tibor Keler
Dartmouth Scholarship
The neutralizing antibody response to the protective antigen (PA) component of anthrax toxin elicited by approved anthrax vaccines is an accepted correlate for vaccine-mediated protection against anthrax. We reasoned that a human anti-PA monoclonal antibody (MAb) selected on the basis of superior toxin neutralization activity might provide potent protection against anthrax. The fully human MAb (also referred to as MDX-1303 or Valortim) was chosen from a large panel of anti-PA human MAbs generated using transgenic mice immunized with recombinant PA solely on the basis of in vitro anthrax toxin neutralization. This MAb was effective in prophylactic and postsymptomatic treatment of …
Orally Delivered, Plant-Produced Tat Protein Primes Mice For A Challenge Dna Vaccine Expressing Tat, A V. Karasev, S Foulke, C Wellens, I Zwierzynski, R Baldwin, H Koprowski, M S. Reitz Jr
Orally Delivered, Plant-Produced Tat Protein Primes Mice For A Challenge Dna Vaccine Expressing Tat, A V. Karasev, S Foulke, C Wellens, I Zwierzynski, R Baldwin, H Koprowski, M S. Reitz Jr
Department of Microbiology and Immunology Faculty Papers
Oral Presentation.