Infectious Disease Commons^™

Risk-Stratified Treatment For Drug-Susceptible Pulmonary Tuberculosis., Vincent K. Chang, Marjorie Z. Imperial, Patrick P. J. Phillips, Gustavo E. Velásquez, Payam Nahid, Andrew Vernon, Ekaterina V. Kurbatova, Susan Swindells, Richard E. Chaisson, Susan E. Dorman, John L. Johnson, Marc Weiner, Amina Jindani, Thomas Harrison, Erin E. Sizemore, William Whitworth, Wendy Carr, Kia E. Bryant, Deron Burton, Kelly E. Dooley, Melissa Engle, Pheona Nsubuga, Andreas H. Diacon, Nguyen Viet Nhung, Rodney Dawson, Radojka M. Savic, Aids Clinical Trial Group, Tuberculosis Trials Consortium

Journal Articles: Infectious Diseases

The Phase 3 randomized controlled trial, TBTC Study 31/ACTG A5349 (NCT02410772) demonstrated that a 4-month rifapentine-moxifloxacin regimen for drug-susceptible pulmonary tuberculosis was safe and effective. The primary efficacy outcome was 12-month tuberculosis disease free survival, while the primary safety outcome was the proportion of grade 3 or higher adverse events during the treatment period. We conducted an analysis of demographic, clinical, microbiologic, radiographic, and pharmacokinetic data and identified risk factors for unfavorable outcomes and adverse events. Among participants receiving the rifapentine-moxifloxacin regimen, low rifapentine exposure is the strongest driver of tuberculosis-related unfavorable outcomes (HR 0.65 for every 100 µg∙h/mL increase, …

Pyrazinamide Safety, Efficacy, And Dosing For Treating Drug-Susceptible Pulmonary Tuberculosis: A Phase 3, Randomized Controlled Clinical Trial, Ava Y. Xu, Gustavo E. Velásquez, Nan Zhang, Vincent K. Chang, Patrick P. J. Phillips, Payam Nahid, Susan E. Dorman, Ekaterina V. Kurbatova, William C. Whitworth, Erin Sizemore, Kia Bryant, Wendy Carr, Nicole E. Brown, Melissa L. Engle, Nguyen Viet Nhung, Pheona Nsubuga, Andreas Diacon, Kelly E. Dooley, Richard E. Chaisson, Susan Swindells, Radojka M. Savic

Journal Articles: Infectious Diseases

Optimizing pyrazinamide dosing is critical to improve treatment efficacy while minimizing toxicity during tuberculosis treatment. Study 31/AIDS Clinical Trials Group A5349 represents the largest phase 3 randomized controlled therapeutic trial to date for such an investigation. Objectives: We sought to report pyrazinamide pharmacokinetic parameters, risk factors for lower pyrazinamide exposure, and relationships between pyrazinamide exposure and efficacy and safety outcomes. We aimed to determine pyrazinamide dosing strategies that optimize risks and benefits. Methods: We analyzed pyrazinamide steady-state pharmacokinetic data using population nonlinear mixed-effects models. We evaluated the contribution of pyrazinamide exposure to long-term efficacy using parametric time-to-event models and safety …

Preferences And Feasibility Of Long-Acting Technologies For Treatment Of Hepatitis C Virus In Low- And Middle-Income Countries: A Survey Of Providers And Policymakers, Neil Gupta, Susan Swindells, Kimberly Scarsi, Renae Furl, David L. Thomas, Ethel D. Weld, Joelle Dountio Ofimboudem, Hailemichael Desalegn, Saeed Hamid, Alethse De La Torre Rosas, Angelica E. Miranda, Andrew Owen, Steve Rannard, Lindsey Hiebert, Katherine Sun, John W. Ward

Journal Articles: Infectious Diseases

Long-acting technologies (LATs) for hepatitis C virus (HCV) are under development as a strategy to improve linkage to care, treatment adherence and outcomes. We conducted a survey of HCV treatment prescribers and HCV policymakers in low- and middle-income countries (LMICs) regarding acceptability and feasibility of HCV LATs. We included one-time intramuscular injection, subdermal implant and transdermal patch as potential LAT options. We surveyed participants regarding optimal health system and patient characteristics, concerns, potential barriers, overall feasibility and preferences for HCV LAT as compared to daily oral medication. Overall, 122 providers and 50 policymakers from 42 LMICs completed the survey. Among …

Unraveling The Effects Of The Covid-19 Pandemic On Staphylococcus Aureus Carriage: A Comparative Research Of Pre- And Post-Pandemic Samples, Catherine G. Johnston

Honors Undergraduate Theses

The COVID-19 pandemic brought about significant changes in the epidemiology of Staphylococcus aureus carriage and disease. This study aims to assess these changes by leveraging respiratory samples collected from a longstanding cohort, comparing the genomic characteristics of S. aureus isolates from pre- and post-pandemic periods. We analyzed S. aureus genomes and phenotypically determined macrolide resistance to characterize population structure, antibiotic resistance, and virulence profiles. Changes in S. aureus carriage rates, macrolide resistance, disease occurrence, and population structure between samples collected pre- and post-pandemic were examined. By using respiratory samples, chart reviews, and risk factor questionnaires of 498 children from a …

Tagalog: Sepsis Mga Dapat Mong Malaman - Sepsis What You Need To Know, Providence

All Sepsis Education Materials

SEPSIS Mga Dapat Mong Malaman SEPSIS What You Need to Know (Tagalog Language)

Spanish: Septicemia Todo Lo Que Necesita Saber - Sepsis What You Need To Know, Providence

All Sepsis Education Materials

SEPTICEMIA Todo lo que necesita saber SEPSIS What You Need to Know (Spanish Language)

Vietnamese: Nhiễm Khuẩn Huyết Những Điều Cần Biết - Sepsis What You Need To Know, Providence

All Sepsis Education Materials

NHIỄM KHUẨN HUYẾT Những Điều Cần Biết SEPSIS What You Need to Know (Vietnamese Language)

Russian: Сепсис Что Следует Знать - Sepsis What You Need To Know, Providence

All Sepsis Education Materials

СЕПСИС Что следует знать SEPSIS What You Need to Know (Russian Language)

English: Sepsis What You Need To Know, Providence

All Sepsis Education Materials

SEPSIS What You Need to Know (English Language)

Farsi, Persian: سپسیسآنچھ باید بدانید - Sepsis What You Need To Know, Providence

All Sepsis Education Materials

Sepsis What You Need to Know (Farsi, Persian Language) سپسیسآنچھ باید بدانید

Spanish: Understanding Your Sepsis Diagnosis, Providence

All Sepsis Education Materials

Graphic Novel: Understanding Your Sepsis Diagnosis (Spanish)

Japanese: Understanding Your Sepsis Diagnosis, Providence

All Sepsis Education Materials

Graphic Novel: Understanding Your Sepsis Diagnosis (Japanese)

Russian: Understanding Your Sepsis Diagnosis, Providence

All Sepsis Education Materials

Graphic Novel: Understanding Your Sepsis Diagnosis (Russian)

Chinese-Simplified: Understanding Your Sepsis Diagnosis, Providence

All Sepsis Education Materials

Graphic Novel: Understanding Your Sepsis Diagnosis (Chinese-Simplified)

Samoan: Understanding Your Sepsis Diagnosis, Providence

All Sepsis Education Materials

Graphic Novel: Understanding Your Sepsis Diagnosis (Samoan)

Korean: Understanding Your Sepsis Diagnosis, Providence

All Sepsis Education Materials

Graphic Novel: Understanding Your Sepsis Diagnosis (Korean)

Arabic: Understanding Your Sepsis Diagnosis, Providence

All Sepsis Education Materials

Graphic Novel: Understanding Your Sepsis Diagnosis (Arabic)

Tagalog: Understanding Your Sepsis Diagnosis, Providence

All Sepsis Education Materials

Graphic Novel: Understanding Your Sepsis Diagnosis (Tagalog)

English: Understanding Your Sepsis Diagnosis, Providence

All Sepsis Education Materials

Graphic Novel: Understanding Your Sepsis Diagnosis (English)

Tuberculous Myositis In The Leg Musculature, Tho Nguyen, Md

Books, Presentations, Posters, Etc.

Introduction - The majority of active Mycobacterium tuberculosis cases are pulmonary, but extrapulmonary tuberculosis (TB) can account for up to 30% of active cases. Cases of tuberculosis myositis are rare and account for less than three percent of active cases and diagnosis is often delayed due to its rarity. We present a case of TB myositis and discuss the difficulties in diagnosis Case - Patient is an 82-year-old Vietnamese speaking female with hypertension and hyperlipidemia who presented for acute onset of nausea and vomiting in setting of three-month history of recurrent left lower extremity (LLE) swelling without systemic symptoms such …

Ofatumumab Associated Legionella Pneumonia In A Young Multiple Sclerosis Patient, Jobe Ashby, Md, Omar Pandhair

Articles, Abstracts, and Reports

2024-2025 PGY2

Vietnamese: Understanding Your Sepsis Diagnosis, Providence

Sepsis Education Graphic Novels

Graphic Novel: Understanding Your Sepsis Diagnosis (Vietnamese)

Guardians Of The Catheters, Interprofessional Collaboration Reduced Cauti Rates At Phfh, Dawn Doud, Angela Shemwell, Stephanie Brown, Tobi Bryan, Georgia Gauron, Tasha Anisimov, Peter Weitzman, Emma Peterson, Tiffanie Rampley

Articles, Abstracts, and Reports

Abstract Title: A Quality Improvement Project to Reduce CAUTIs on Inpatient Units

Objectives:

1. Participants will be able to understand how interprofessional collaboration contributed to CAUTI reduction on inpatient acute care units.
2. Participants will be able to understand education nurses completed to reduce CAUTI rates on inpatient acute care units.

Purpose/Aims:

To reduce CAUTI rates for adult inpatients admitted to the acute care units: Progressive Care Unit (PCU), Surgical/Orthopedics, Medical/Oncology, and the Intensive Care Unit (ICU).

Background

An increase in CAUTI rates for adults admitted to inpatient units was identified in January of 2024. The CAUTI rate at that time was …