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Articles 1 - 3 of 3
Full-Text Articles in Hepatology
Clinical Practice Guidelines On Hemochromatosis: Asian Pacific Association For The Study Of The Liver, Darrell H. G. Crawford, Grant A. Ramm, Kim R. Bridle, Amanda J. Nicoll, Martin B. Delatycki, John K. Olynyk
Clinical Practice Guidelines On Hemochromatosis: Asian Pacific Association For The Study Of The Liver, Darrell H. G. Crawford, Grant A. Ramm, Kim R. Bridle, Amanda J. Nicoll, Martin B. Delatycki, John K. Olynyk
Research outputs 2022 to 2026
Hereditary hemochromatosis is the result of pathogenic variants in multiple genes that can result in increased body iron stores with excess iron deposited in various organs, including the liver, pancreas, and heart. The two most important advances in the field over the past 30 years have been the identification of the HFE gene (and the associated p.Cys282Tyr substitution), and the discovery of the hormone hepcidin, which is inappropriately low in this condition and is the pathophysiological basis of the increased iron absorption. The identification of mutations in the HFE gene and subsequent studies have reshaped diagnostic algorithms resulting in a …
Liver Disease In Aboriginal And Torres Strait Islander People, Yasmina Tashkent, John K. Olynyk, Alan J. Wigg
Liver Disease In Aboriginal And Torres Strait Islander People, Yasmina Tashkent, John K. Olynyk, Alan J. Wigg
Journal of the Australian Indigenous HealthInfoNet
Aboriginal and Torres Strait Islander people have a substantially higher prevalence of liver disease than non-Indigenous Australians. Cirrhosis and its complications were the sixth leading cause of mortality for Aboriginal and Torres Strait Islander people in 2020. Liver disease has been estimated to be the third leading cause of the mortality gap between Aboriginal and Torres Strait Islander and non-Indigenous people due to chronic disease, accounting for 11% of this gap. While current trends show reducing mortality rates for Aboriginal and Torres Strait Islander people for conditions including circulatory disease, diabetes and kidney disease, there are no data to suggest …
Insulin Therapy And Autoimmune Disease With Relevance To Non Alcoholic Fatty Liver Disease, Ian James Martins
Insulin Therapy And Autoimmune Disease With Relevance To Non Alcoholic Fatty Liver Disease, Ian James Martins
Research outputs 2014 to 2021
The diabetes epidemic is now expected by the year 2050 to become a global pandemic with approx. 592 million affected in both the developed and developing world. The treatment of diabetes by insulin therapy has been the focus for many diabetics with the improvement and prevention of various diseases such as cardiovascular disease, kidney disease and neurodegeneration. The global nonalcoholic fatty liver disease (NAFLD) epidemic has now become of major concern to diabetes with critical interest in insulin therapy to reverse and stabilize autoimmune disease with relevance to NAFLD and the diabetes pandemic. Dietary components that activate anti-aging genes improve …