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Full-Text Articles in Gastroenterology

Anticholinergic Toxicity Secondary To Overuse Of Topricin Cream, A Homeopathic Medication., M. Krzyzak, A. Regina, R. C. Jesin, L. Deeb, E. Steinberg, N. Majlesi Jan 2018

Anticholinergic Toxicity Secondary To Overuse Of Topricin Cream, A Homeopathic Medication., M. Krzyzak, A. Regina, R. C. Jesin, L. Deeb, E. Steinberg, N. Majlesi

Journal Articles

Adverse reactions from over-the-counter medications present a challenge to physicians. Homeopathic medicine is an alternative practice, originating in Germany and gaining popularity in the United States. It utilizes dilute preparations of substances in order to treat and cure disease. Patients may potentially suffer serious effects from the use of these products as the contents and concentrations are often unclear. Here, we describe a case of suspected atropine toxicity due to the overuse of a topical homeopathic cream, Topricin, which contains belladonna, a plant containing atropine.


Biliary And Pancreatic Lithotripsy Devices, R. R. Watson, M. A. Parsi, H. R. Aslanian, A. J. Goodman, D. R. Lichtenstein, J. Melson, U. Navaneethan, R. Pannala, A. J. Trindade, J. T. Maple, +4 Additional Authors Jan 2018

Biliary And Pancreatic Lithotripsy Devices, R. R. Watson, M. A. Parsi, H. R. Aslanian, A. J. Goodman, D. R. Lichtenstein, J. Melson, U. Navaneethan, R. Pannala, A. J. Trindade, J. T. Maple, +4 Additional Authors

Journal Articles

© 2018 Background and Aims: Lithotripsy is a procedure for fragmentation or destruction of stones to facilitate their removal or passage from the biliary or pancreatic ducts. Although most stones may be removed endoscopically using conventional techniques such as endoscopic sphincterotomy in combination with balloon or basket extraction, lithotripsy may be required for clearance of large, impacted, or irregularly shaped stones. Several modalities have been described, including intracorporeal techniques such as mechanical lithotripsy (ML), electrohydraulic lithotripsy (EHL), and laser lithotripsy, as well as extracorporeal shock-wave lithotripsy (ESWL). Methods: In this document, we review devices and methods for biliary and pancreatic …


Nitrous Oxide Cryotherapy Ablation For Refractory Gastric Antral Vascular Ectasia, A. A. Patel, A. J. Trindade, D. L. Diehl, H. S. Khara, T. Lee, C. Lee, A. Sethi Jan 2018

Nitrous Oxide Cryotherapy Ablation For Refractory Gastric Antral Vascular Ectasia, A. A. Patel, A. J. Trindade, D. L. Diehl, H. S. Khara, T. Lee, C. Lee, A. Sethi

Journal Articles

No abstract provided.


Functional Variants In The Lrrk2 Gene Confer Shared Effects On Risk For Crohn's Disease And Parkinson's Disease, K. Y. Hui, H. Fernandez-Hernandez, J. Hu, A. Schaffner, N. Pankratz, N. Hsu, L. Chuang, S. Katz, T. Lencz, I. Peter, +41 Additional Authors Jan 2018

Functional Variants In The Lrrk2 Gene Confer Shared Effects On Risk For Crohn's Disease And Parkinson's Disease, K. Y. Hui, H. Fernandez-Hernandez, J. Hu, A. Schaffner, N. Pankratz, N. Hsu, L. Chuang, S. Katz, T. Lencz, I. Peter, +41 Additional Authors

Journal Articles

No abstract provided.


From Bouveret's Syndrome To Gallstone Ileus: The Journey Of A Migrating Stone!, F. G. Haddad, W. Mansour, J. Mansour, L. Deeb Jan 2018

From Bouveret's Syndrome To Gallstone Ileus: The Journey Of A Migrating Stone!, F. G. Haddad, W. Mansour, J. Mansour, L. Deeb

Journal Articles

Bouveret's syndrome, first described in 1896, is an unusual cause of gastric outlet obstruction secondary to large gallstone impaction in the proximal duodenum after migration through a cholecystoduodenal fistula. Stone migration has been previously described after endoscopic or surgical fragmentation. However, this is the first reported case, in our knowledge, where the stone migrated after oral contrast administration a few days after the onset of symptoms, causing a distal gallstone ileus.


Hereditary Diffuse Gastric Cancer: One Family's Story, H. M. Zylberberg, K. Sultan, S. Rubin Jan 2018

Hereditary Diffuse Gastric Cancer: One Family's Story, H. M. Zylberberg, K. Sultan, S. Rubin

Journal Articles

No abstract provided.


Patient Considerations In The Management Of Ulcerative Colitis - Role Of Vedolizumab, M. Kothari, P. Mudireddy, A. Swaminath Jan 2015

Patient Considerations In The Management Of Ulcerative Colitis - Role Of Vedolizumab, M. Kothari, P. Mudireddy, A. Swaminath

Journal Articles

Ulcerative colitis (UC) is a subtype of inflammatory bowel disease which causes inflammation of the large intestine and affects approximately 7.6-24.6 per 100,000 persons. The therapeutic goal for UC patients is inducing remission, maintaining remission, and ideally, obtaining mucosal healing. Vedolizumab, approved by the US Food and Drug Administration in May 2014 for the treatment of moderate-to-severe UC and Crohn's disease, is a newly developed anti-integrin therapy. This review focuses on the preclinical development of vedolizumab and data from early trials, and details the results of the landmark trails that led to its approval in the USA with a specific …


Hepatic Manifestations Of Non-Steroidal Inflammatory Bowel Disease Therapy, R. Hirten, K. Sultan, A. Thomas, D. E. Bernstein Jan 2015

Hepatic Manifestations Of Non-Steroidal Inflammatory Bowel Disease Therapy, R. Hirten, K. Sultan, A. Thomas, D. E. Bernstein

Journal Articles

Inflammatory bowel disease (IBD) is composed of Crohn's disease and ulcerative colitis and is manifested by both bowel-related and extraintestinal manifestations. Recently the number of therapeutic options available to treat IBD has dramatically increased, with each new medication having its own mechanism of action and side effect profile. A complete understanding of the hepatotoxicity of these medications is important in order to distinguish these complications from the hepatic manifestations of IBD. This review seeks to evaluate the hepatobiliary complications of non-steroid based IBD medications and aide providers in the recognition and management of these side-effects.


Comparison Of The Diagnostic Yield And Outcomes Between Standard 8 H Capsule Endoscopy And The New 12 H Capsule Endoscopy For Investigating Small Bowel Pathology, M. Rahman, S. Akerman, B. Devito, L. Miller, M. Akerman, K. Sultan Jan 2015

Comparison Of The Diagnostic Yield And Outcomes Between Standard 8 H Capsule Endoscopy And The New 12 H Capsule Endoscopy For Investigating Small Bowel Pathology, M. Rahman, S. Akerman, B. Devito, L. Miller, M. Akerman, K. Sultan

Journal Articles

AIM: To evaluate the completion rate and diagnostic yield of the PillCam SB2-ex in comparison to the PillCam SB2. METHODS: Two hundred cases using the 8-h PillCam SB2 were retrospectively compared to 200 cases using the 12 h PillCam SB2-ex at a tertiary academic center. Endoscopically placed capsules were excluded from the study. Demographic information, indications for capsule endoscopy, capsule type, study length, completion of exam, clinically significant findings, timestamp of most distant finding, and significant findings beyond 8 h were recorded. RESULTS: The 8 and 12 h capsule groups were well matched respectively for both age (70.90 +/- 14.19 …


Clinical Markers Of Crohn's Disease Severity And Their Association With Opiate Use, M. Cheung, S. Khan, M. Akerman, C. K. Hung, K. Vennard, N. Hristis, K. Sultan Jan 2015

Clinical Markers Of Crohn's Disease Severity And Their Association With Opiate Use, M. Cheung, S. Khan, M. Akerman, C. K. Hung, K. Vennard, N. Hristis, K. Sultan

Journal Articles

BACKGROUND: The safety of opiate use for patients with Crohn's disease (CD) has long been a concern. The recent Crohn's therapy, resource, evaluation, and assessment tool (TREAT) registry update has added to these concerns by demonstrating an association of opiate use with an increased risk of infection and death in CD. While the association is clear, the relationship of opiates to these negative outcomes is not. It is unknown whether opiates are a contributing factor to these negative outcomes or if their use is merely a marker of more severe disease. We hypothesized that opiate use is not harmful in …


Comparison Of Endoscopic Ultrasound Guided 22-Gauge Core Needle With Standard 25-Gauge Fine-Needle Aspiration For Diagnosing Solid Pancreatic Lesions, M. Berzosa, N. Villa, H. B. El-Serag, D. V. Sejpal, K. K. Patel Jan 2015

Comparison Of Endoscopic Ultrasound Guided 22-Gauge Core Needle With Standard 25-Gauge Fine-Needle Aspiration For Diagnosing Solid Pancreatic Lesions, M. Berzosa, N. Villa, H. B. El-Serag, D. V. Sejpal, K. K. Patel

Journal Articles

Background and Objectives: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the standard modality for diagnosing pancreatic masses. We compared the diagnostic yield of a new EUS-guided 22-gauge core needle biopsy to a standard 25-gauge FNA in sampling the same pancreatic lesions during the same EUS. Patients and Methods: The main outcomes of the study were the sample adequacy of each method to provide a final pathological diagnosis, and the concordance in diagnosis between core and FNA specimens. The secondary outcomes were the sensitivity and specificity of the findings for each needle and the incremental yield of using both needles compared with …


Use Of Methotrexate In Inflammatory Bowel Disease In 2014: A User's Guide, A. Swaminath, R. Taunk, G. Lawlor Jan 2014

Use Of Methotrexate In Inflammatory Bowel Disease In 2014: A User's Guide, A. Swaminath, R. Taunk, G. Lawlor

Journal Articles

Methotrexate has been used an immunomodulator in many autoimmune diseases, including inflammatory bowel disease. However, many physicians are unfamiliar or uncomfortable with its use in the management of inflammatory bowel disease. We summarize the data for use of methotrexate in common clinical scenarios: (1) steroid dependant Crohn's disease (CD); (2) maintenance of remission in steroid free CD; (3) azathioprine failures in CD; (4) in combination therapy with Anti-TNF agents in CD; (5) decreasing antibody formation to Anti-TNF therapy in CD; (6) management of fistulizing disease in CD; and (7) as well as induction and maintenance of remission in ulcerative colitis. …


Enhanced Nicotinic Receptor Mediated Relaxations In Gastroesophageal Muscle Fibers From Barrett's Esophagus Patients, L. S. Miller, A. K. Vegesna, A. S. Braverman, M. F. Barbe, M. R. Ruggieri Jan 2014

Enhanced Nicotinic Receptor Mediated Relaxations In Gastroesophageal Muscle Fibers From Barrett's Esophagus Patients, L. S. Miller, A. K. Vegesna, A. S. Braverman, M. F. Barbe, M. R. Ruggieri

Journal Articles

No abstract provided.


Ethnic Disparities In The Risk Of Colorectal Adenomas Associated With Aspirin And Statin Use: A Retrospective Multiethnic Study, A. H. Davis-Yadley, S. Lipka, H. Shen, H. Shah, S. Swarup, A. Barnowsky, J. Silpe, A. Abraham, P. Viswanathan, B. Krishnamachari, +4 Additional Authors Jan 2014

Ethnic Disparities In The Risk Of Colorectal Adenomas Associated With Aspirin And Statin Use: A Retrospective Multiethnic Study, A. H. Davis-Yadley, S. Lipka, H. Shen, H. Shah, S. Swarup, A. Barnowsky, J. Silpe, A. Abraham, P. Viswanathan, B. Krishnamachari, +4 Additional Authors

Journal Articles

BACKGROUND: Although data on the inverse association between colorectal adenomas (CRA) and daily aspirin or statin therapy exists in white and black patients, scarce data exists on these associations in the Hispanic population. With a rapidly increasing Hispanic population in the United States, defining the association in Hispanics is crucial. METHODS: The study sample included 1,843 consecutive patients who underwent a colonoscopy (screening or diagnostic) from 2009 to 2011 at a community hospital in East Meadow, New York. Data was then extracted from patient charts regarding aspirin and/or statin use. Adjusted odds ratios (OR) and their 95% confidence intervals (CI) …


Histological Healing Favors Lower Risk Of Colon Carcinoma In Extensive Ulcerative Colitis, B. I. Korelitz, K. Sultan, M. Kothari, L. Arapos, J. Schneider, G. Panagopoulos Jan 2014

Histological Healing Favors Lower Risk Of Colon Carcinoma In Extensive Ulcerative Colitis, B. I. Korelitz, K. Sultan, M. Kothari, L. Arapos, J. Schneider, G. Panagopoulos

Journal Articles

AIM: To search for the answer in extensive ulcerative colitis as to whether histological inflammation persisting despite endoscopic mucosal healing serves to increase the risk of colon cancer (CC) or high grade dysplasia (HGD). METHODS: This is a single center (Lenox Hill Hospital) retrospective cohort and descriptive study of extensive ulcerative colitis (UC) for 20 years or more with a minimum of 3 surveillance colonoscopies and biopsies performed after the first 10 years of UC diagnosis. Data analyzed included: duration of UC, date of diagnosis of (CC) or (HGD), number of surveillance colonoscopies, and biopsies showing histological inflammation and its …


Interobserver Agreement For Single Operator Choledochoscopy Imaging: Can We Do Better?, A. Sethi, T. Doukides, D. V. Sejpal, D. K. Pleskow, A. Slivka, D. G. Adler, R. J. Shah, S. A. Edmundowicz, T. Itoi, M. Kahaleh, +3 Additional Authors Jan 2014

Interobserver Agreement For Single Operator Choledochoscopy Imaging: Can We Do Better?, A. Sethi, T. Doukides, D. V. Sejpal, D. K. Pleskow, A. Slivka, D. G. Adler, R. J. Shah, S. A. Edmundowicz, T. Itoi, M. Kahaleh, +3 Additional Authors

Journal Articles

Background. The SpyGlass Direct Visualization System (Boston Scientific, Natick, MA) is routinely used during single operator choledochoscopy (SOC) to identify biliary lesions or strictures with a diagnostic accuracy up to 88%. The objective of this study was to determine the interobserver agreement (IOA) of modified scoring criteria for diagnosing biliary lesions/strictures. Methods. 27 SPY SOC video clips were reviewed and scored by 9 interventional endoscopists based on published criteria that included the presence and severity of surface structure, vasculature visualization, lesions, and findings. Results. Overall IOA was "slight" for all variables. The K statistics are as follows: surface (K = …


Nodular Lymphoid Hyperplasia In A Patient Initially Believed To Have Familial Adenomatous Polyposis, S. Altafi, A. Volfson, M. J. Mckinley Jan 2014

Nodular Lymphoid Hyperplasia In A Patient Initially Believed To Have Familial Adenomatous Polyposis, S. Altafi, A. Volfson, M. J. Mckinley

Journal Articles

No abstract provided.


Perforation In A Patient With Stercoral Colitis And Diverticulosis: Who Did It?, V. R. Bhatt, S. Murukutla, J. Dipoce, S. Gustafson, D. Sarkany, K. Mody, W. D. Widmann, A. Gottesman Jan 2014

Perforation In A Patient With Stercoral Colitis And Diverticulosis: Who Did It?, V. R. Bhatt, S. Murukutla, J. Dipoce, S. Gustafson, D. Sarkany, K. Mody, W. D. Widmann, A. Gottesman

Journal Articles

Stercoral colitis with perforation of the colon is an uncommon, yet life-threatening cause of the acute abdomen. No one defining symptom exists for stercoral colitis; it may present asymptomatically or with vague symptoms. Diagnostic delay may result in perforation of the colon resulting in complications, even death. Moreover, stercoral perforation of the colon can also present with localized left lower quadrant abdominal pain masquerading as diverticulitis. Diverticular diseases and stercoral colitis share similar pathophysiology; furthermore, they may coexist, further complicating the diagnostic dilemma. The ability to decide the cause of perforation in a patient with both stercoral colitis and diverticulosis …


Resident Knowledge Of Colorectal Cancer Screening Assessed By Web-Based Survey, S. Akerman, S. L. Aronson, M. A. Cerulli, M. Akerman, K. Sultan Jan 2014

Resident Knowledge Of Colorectal Cancer Screening Assessed By Web-Based Survey, S. Akerman, S. L. Aronson, M. A. Cerulli, M. Akerman, K. Sultan

Journal Articles

BACKGROUND: To evaluate resident knowledge of colorectal cancer (CRC) screening guidelines and to define areas requiring attention. METHODS: A survey was created using three published guidelines for CRC screening. Program directors for internal medicine residency programs were contacted within the metro New York City area to have their residents participate. RESULTS: Five programs participated, and 115 responses were recorded. For the appropriate testing and interval to screen for CRC, 61/115 residents identified flexible sigmoidoscopy every 5 years, 108/115 identified colonoscopy every 10 years, 16/115 identified double contrast barium enema (DCBE) every 5 years and only 12/115 thought CT-colography every 5 …


Appendiceal Adenocarcinoma In A Patient With Chronic Ulcerative Colitis: What Is The Appropriate Surgical Procedure?, H. F. Shen, S. Lipka, S. Katz Jan 2014

Appendiceal Adenocarcinoma In A Patient With Chronic Ulcerative Colitis: What Is The Appropriate Surgical Procedure?, H. F. Shen, S. Lipka, S. Katz

Journal Articles

No abstract provided.


Capsule Endoscopy In Crohn's Disease: Are We Seeing Any Better?, D. Hudesman, J. Mazurek, A. Swaminath Jan 2014

Capsule Endoscopy In Crohn's Disease: Are We Seeing Any Better?, D. Hudesman, J. Mazurek, A. Swaminath

Journal Articles

Crohn's disease (CD) is a complex, immune-mediated disorder that often requires a multi-modality approach for optimal diagnosis and management. While traditional methods include ileocolonoscopy and radiologic modalities, increasingly, capsule endoscopy (CE) has been incorporated into the algorithm for both the diagnosis and monitoring of CD. Multiple studies have examined the utility of this emerging technology in the management of CD, and have compared it to other available modalities. CE offers a noninvasive approach to evaluate areas of the small bowel that are difficult to reach with traditional endoscopy. Furthermore, CE maybe favored in specific sub segments of patients with inflammatory …