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Articles 61 - 89 of 89
Full-Text Articles in Emergency Medicine
Loperamide-Induced Torsades De Pointes: A Case Series (Poster)., Kenneth D. Katz Md, Robert D. Cannon Do, Matthew D. Cook Do, Alexandra Amaducci, Ryan Day, Joshua Enyart Do, Glenn Burket, Jennifer Janssen Ms, Karl E. Williams Md, Mph
Loperamide-Induced Torsades De Pointes: A Case Series (Poster)., Kenneth D. Katz Md, Robert D. Cannon Do, Matthew D. Cook Do, Alexandra Amaducci, Ryan Day, Joshua Enyart Do, Glenn Burket, Jennifer Janssen Ms, Karl E. Williams Md, Mph
Department of Emergency Medicine
No abstract provided.
Impact Of Smartphone Digital Photography, Email, And Media Communication On Emergency Room Visits Post-Hypospadias Repair., Michael E. Chua, Megan A. Saunders, Paul R. Bowlin, Jessica M. Ming, Roberto Iglesias Lopes, Walid A. Farhat, Joana Dos Santos
Impact Of Smartphone Digital Photography, Email, And Media Communication On Emergency Room Visits Post-Hypospadias Repair., Michael E. Chua, Megan A. Saunders, Paul R. Bowlin, Jessica M. Ming, Roberto Iglesias Lopes, Walid A. Farhat, Joana Dos Santos
Manuscripts, Articles, Book Chapters and Other Papers
INTRODUCTION: Advances in communication technology are shaping our medical practice. To date, there is no clear evidence that this mode of communication will have any effect on unnecessary postoperative emergency room (ER) visits. We aim to evaluate the effect of email and media communication with application of smartphone digital photography on post-hypospadias repair ER visit rates.
METHODS: This prospective cohort study included all patients who underwent hypospadias repair performed by a single surgeon from October 2014 to November 2015. Patients were categorized into two groups: Group A consented for smartphone photography and email communication and Group B declined. Reason for …
Dysuria: An Uncommon Presentation In Emergency Department Following Bladder Neck Disruption., Ali Pourmand, Assya Abdallah, Hamid Shokoohi, Mindy Park, Marie White, Francis O'Connell
Dysuria: An Uncommon Presentation In Emergency Department Following Bladder Neck Disruption., Ali Pourmand, Assya Abdallah, Hamid Shokoohi, Mindy Park, Marie White, Francis O'Connell
Emergency Medicine Faculty Publications
Prostate cancer is the most common life-threatening cancer diagnosed in men. Complications of prostatectomies vary and often include urinary incontinence, erectile dysfunction and pain, while other complications go unreported. While emergency physicians are already familiar with the more common post-operative complications presenting to their departments, including urinary retention, ileus, surgical site infections, venous thromboembolisms and urinary tract infections, they must have a high index of suspicion for rarer complications. We report a case of posterior bladder neck disruption as a complication of a robotic assisted laparoscopic prostatectomy that presented to the emergency department as dysuria and abdominal pain following urination.
Does Mental Status Impact Therapist And Patient Communication In Emergency Department Brief Interventions Addressing Alcohol Use?, Brian Borsari, Timothy R. Apodaca, Ali Yurasek, Peter M. Monti
Does Mental Status Impact Therapist And Patient Communication In Emergency Department Brief Interventions Addressing Alcohol Use?, Brian Borsari, Timothy R. Apodaca, Ali Yurasek, Peter M. Monti
Manuscripts, Articles, Book Chapters and Other Papers
Motivational interviewing (MI) is often incorporated into screening, brief intervention, and referral to treatment (SBIRT) interventions in critical care settings to address alcohol and other drug use. However, cognitive status has been linked to differential response to MI sessions in emergency department (ED) settings. The current study examined one possible explanation for this differential response: whether higher versus lower mental status impacts patient response to clinician statements during MI sessions conducted in an ED. Participants were 126 patients receiving an MI-based single-session alcohol brief intervention, and 13 therapists who provided treatment. Participants completed a mental status exam (MSE) as part …
Academic Primer Series: Five Key Papers For Consulting Clinician Educators., Teresa M. Chan, Michael Gottlieb, Antonia Quinn, Kory S. London, Lauren W. Conlon, Felix Ankel
Academic Primer Series: Five Key Papers For Consulting Clinician Educators., Teresa M. Chan, Michael Gottlieb, Antonia Quinn, Kory S. London, Lauren W. Conlon, Felix Ankel
Department of Emergency Medicine Faculty Papers
INTRODUCTION: Clinician educators are often asked to perform consultations for colleagues. Invitations to consult and advise others on local problems can help foster great collaborations between centers, and allows for an exchange of ideas between programs. In this article, the authors identify and summarize several key papers to assist emerging clinician educators with the consultation process.
METHODS: A consensus-building process was used to generate a list of key papers that describe the importance and significance of educational consulting, informed by social media sources. A three-round voting methodology, akin to a Delphi study, determined the most impactful papers from the larger …
Associations Of Emergency Department Length Of Stay With Publicly Reported Quality-Of-Care Measures., Anna Marie Chang, Amber Lin, Rongwei Fu, K. John Mcconnell, Benjamin Sun
Associations Of Emergency Department Length Of Stay With Publicly Reported Quality-Of-Care Measures., Anna Marie Chang, Amber Lin, Rongwei Fu, K. John Mcconnell, Benjamin Sun
Department of Emergency Medicine Faculty Papers
OBJECTIVE: The Institute of Medicine identified emergency department (ED) crowding as a critical threat to patient safety. We assess the association between changes in publicly reported ED length of stay (LOS) and changes in quality-of-care measures in a national cohort of hospitals.
METHODS: Longitudinal analysis of 2012 and 2013 data from the American Hospital Association (AHA) Survey, Center for Medicare and Medicaid Services (CMS) Cost Reports, and CMS Hospital Compare. We included hospitals reporting Hospital Compare timeliness measure of LOS for admitted patients. We used AHA and CMS data to incorporate hospital predictors of interest. We used the method of …
T-Cadherin Deficiency Increases Vascular Vulnerability In T2dm Through Impaired No Bioactivity., Han Wang, Ling Tao, Anastasia Ambrosio, Wenjun Yan, Ross Summer, Wayne Bond Lau, Yajing Wang, Xin-Liang Ma
T-Cadherin Deficiency Increases Vascular Vulnerability In T2dm Through Impaired No Bioactivity., Han Wang, Ling Tao, Anastasia Ambrosio, Wenjun Yan, Ross Summer, Wayne Bond Lau, Yajing Wang, Xin-Liang Ma
Department of Emergency Medicine Faculty Papers
BACKGROUND: Endothelial dysfunction plays a critical role in the development of type 2 diabetes (T2DM). T-cadherin (T-cad) has gained recognition as a regulator of endothelial cell (EC) function. The present study examined whether T-cad deficiency increases vascular vulnerability in T2DM.
METHODS: Vascular segments were isolated from WT or T-cad knockout mice. Endothelial function, total NO accumulation, and the expression of T-cad related proteins were determined.
RESULTS: Ach and acidified NaNO2 induced similar vasorelaxation in WT groups. T-cad KO mice exhibited normal response to acidified NaNO2, but manifested markedly reduced response to Ach. NO accumulation was also decreased in T-cad KO …
Gender Disparity In Clinical Trials: Research Professionals’ Perspective Regarding Their Own Female Patient's Barriers, V1, 2015, Anita Kurt Phd, Rn, Lauren Semler Ms, Matthew Meyers Bs, Samantha Myles Rn, Bernadette Glenn-Porter Bs, Tyler Adams Bs, Micaela Wilson Ba, Jeanne L. Jacoby Md, John C. Smulian Md, Mph
Gender Disparity In Clinical Trials: Research Professionals’ Perspective Regarding Their Own Female Patient's Barriers, V1, 2015, Anita Kurt Phd, Rn, Lauren Semler Ms, Matthew Meyers Bs, Samantha Myles Rn, Bernadette Glenn-Porter Bs, Tyler Adams Bs, Micaela Wilson Ba, Jeanne L. Jacoby Md, John C. Smulian Md, Mph
Department of Emergency Medicine
No abstract provided.
A Systematic Review Of Diagnostic Methods To Differentiate Acute Lung Injury/Acute Respiratory Distress Syndrome From Cardiogenic Pulmonary Edema, Kosaku Komiya, Tomohiro Akaba, Yuji Kozaki, Jun-Ichi Kadota, Bruce K. Rubin
A Systematic Review Of Diagnostic Methods To Differentiate Acute Lung Injury/Acute Respiratory Distress Syndrome From Cardiogenic Pulmonary Edema, Kosaku Komiya, Tomohiro Akaba, Yuji Kozaki, Jun-Ichi Kadota, Bruce K. Rubin
Emergency Medicine Publications
Background
Discriminating acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) from cardiogenic pulmonary edema (CPE) is often challenging. This systematic review examines studies using biomarkers or images to distinguish ALI/ARDS from CPE.
Methods
Three investigators independently identified studies designed to distinguish ALI/ARDS from CPE in adults. Studies were identified from PubMed, and the Cochrane Central Register of Controlled Trials database until July 3, 2017.
Results
Of 475 titles and abstracts screened, 38 full texts were selected for review, and we finally included 24 studies in this systematic review: 21 prospective observational studies, two retrospective observational studies, and one …
Risk Assessment And Comparative Effectiveness Of Left Ventricular Assist Device And Medical Management In Ambulatory Heart Failure Patients The Roadmap Study 2-Year Results, Randall C. Starling, Jerry D. Estep, Douglas A. Horstmanshof, Carmelo A. Milano, Josef Stehlik, Keyur B. Shah, Brian A. Bruckner, Sangjin Lee, James W. Long, Craig H. Selzman, Vigneshwar Kasirajan, Donald C. Haas, Andrew J. Boyle, Joyce Chuang, David J. Farrar, Joseph G. Rogers
Risk Assessment And Comparative Effectiveness Of Left Ventricular Assist Device And Medical Management In Ambulatory Heart Failure Patients The Roadmap Study 2-Year Results, Randall C. Starling, Jerry D. Estep, Douglas A. Horstmanshof, Carmelo A. Milano, Josef Stehlik, Keyur B. Shah, Brian A. Bruckner, Sangjin Lee, James W. Long, Craig H. Selzman, Vigneshwar Kasirajan, Donald C. Haas, Andrew J. Boyle, Joyce Chuang, David J. Farrar, Joseph G. Rogers
Emergency Medicine Publications
OBJECTIVES The authors sought to provide the pre-specified primary endpoint of the ROADMAP (Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients) trial at 2 years.
BACKGROUND The ROADMAP trial was a prospective nonrandomized observational study of 200 patients (97 with a left ventricular assist device [LVAD], 103 on optimal medical management [OMM]) that showed that survival with improved functional status at 1 year was better with LVADs compared with OMM in a patient population of ambulatory New York Heart Association functional class IIIb/IV patients.
METHODS The primary composite endpoint was …
Feasibility And Usability Of Tele-Interview For Medical Residency Interview, Ali Pourmand, Hayoung Lee, Malika Fair, Kaylah Maloney, Amy Caggiula
Feasibility And Usability Of Tele-Interview For Medical Residency Interview, Ali Pourmand, Hayoung Lee, Malika Fair, Kaylah Maloney, Amy Caggiula
Emergency Medicine Faculty Publications
Every year in the United States, medical students and residency programs dedicate millions of dollars to the residency matching process. On-site interviews for training positions involve tremendous financial investment, and time spent detracts from educational pursuits and clinical responsibilities. Students are usually required to fund their own travel and accommodations, adding additional financial burdens to an already costly medical education. Similarly, residency programs allocate considerable funds to interview-day meals, tours, staffing, and social events. With the rapid onslaught of innovations and advancements in the field of telecommunication, technology has become ubiquitous in the practice of medicine. Internet applications have aided …
Does The Normal Four Steps Weight-Bearing Rule Predict The Need For Radiography In Cases Of Blunt Ankle Trauma?, Hassan Amiri, Samad Shams Vahdati, Mehdi Gharehkhani, Radin Maheronnaghsh, Hamid Shokoohi, Vafa Rahimi-Movaghar
Does The Normal Four Steps Weight-Bearing Rule Predict The Need For Radiography In Cases Of Blunt Ankle Trauma?, Hassan Amiri, Samad Shams Vahdati, Mehdi Gharehkhani, Radin Maheronnaghsh, Hamid Shokoohi, Vafa Rahimi-Movaghar
Emergency Medicine Faculty Publications
Background: Ankle injuries are one of the most common complaints of patients presenting to emergency departments (ED). The Ottawa ankle rules (OAR) was introduced to help physicians to decide who may require x-ray for blunt injuries. The present study aimed at validating the four steps weight-bearing rule of OAR as a sole criterion.
Methods: This prospective observational study was conducted on 214 patients with acute ankle injury who referred to 3 emergency departments over a 7-months period in 2008. Main outcome measures of this survey included the sensitivity, specificity, positive and negative predictive values, and the likelihood ratios (positive and …
Staff Perceptions Toward Emergency Clinical Pharmacists In A Saudi Arabian Academic Emergency Department, Jameel Abualenain, Hussain Talal Bakhsh
Staff Perceptions Toward Emergency Clinical Pharmacists In A Saudi Arabian Academic Emergency Department, Jameel Abualenain, Hussain Talal Bakhsh
Emergency Medicine Faculty Publications
Introduction:
In Saudi Arabia, the establishment of pharmacy services as a part of the emergency department is relatively new and has been run by non-residency-trained pharmacists and limited to non-emergency services. We sought to explore emergency department staff members’ perceptions of clinical emergency pharmacy services in an academic emergency department.
Method:
In this survey study, 24 questions were sent to all emergency department staff 9 months after establishing an emergency pharmacist program with the goal of improving medication safety and quality of care.
Results:
Most, 122 out of 145 (84%), emergency department staff members responded to the survey. All 41 …
Developing And Implementing A Multisource Feedback Tool To Assess Competencies Of Emergency Medicine Residents In The United States., J. Lamantia, L. M. Yarris, K. Sunga, M. Weizberg, D. Hart, G. Farina, E. Rodriguez, R. Lucas, Z. Mahmooth, J. Lockyear, +1 Additional Author
Developing And Implementing A Multisource Feedback Tool To Assess Competencies Of Emergency Medicine Residents In The United States., J. Lamantia, L. M. Yarris, K. Sunga, M. Weizberg, D. Hart, G. Farina, E. Rodriguez, R. Lucas, Z. Mahmooth, J. Lockyear, +1 Additional Author
Journal Articles
Objectives: Multisource feedback (MSF) has potential value in learner assessment, but has not been broadly implemented nor studied in emergency medicine (EM). This study aimed to adapt existing MSF instruments for emergency department implementation, measure feasibility, and collect initial validity evidence to support score interpretation for learner assessment. Methods: Residents from eight U.S. EM residency programs completed a self-assessment and were assessed by eight physicians, eight nonphysician colleagues, and 25 patients using unique instruments. Instruments included a five-point rating scale to assess interpersonal and communication skills, professionalism, systems-based practice, practice-based learning and improvement, and patient care. MSF feasibility was measured …
An Echocardiography Training Program For Improving The Left Ventricular Function Interpretation In Emergency Department; A Brief Report, Mary Jacob, Hamid A. Shokoohi, Fabith Moideen, Amelia Pousson, Keith S. Boniface
An Echocardiography Training Program For Improving The Left Ventricular Function Interpretation In Emergency Department; A Brief Report, Mary Jacob, Hamid A. Shokoohi, Fabith Moideen, Amelia Pousson, Keith S. Boniface
Emergency Medicine Faculty Publications
Introduction: Focused training in transthoracic echocardiography enables emergency physicians (EPs) to accurately estimate the left ventricular function. This study aimed to evaluate the efficacy of a brief training program utilizing standardized echocardiography video clips in this regard.
Methods: A before and after design was used to determine the efficacy of a 1 hour echocardiography training program using PowerPoint presentation and standardized echocardiography video clips illustrating normal and abnormal left ventricular ejection fraction (LVEF) as well as video clips emphasizing the measurement of mitral valve E-point septal separation (EPSS). Pre- and post-test evaluation used unique video clips and asked trainees to …
Protocol Based Screening Tools To Identify Sepsis Patients Transported By Emergency Medical Services, Isaiah Moser
Protocol Based Screening Tools To Identify Sepsis Patients Transported By Emergency Medical Services, Isaiah Moser
Honors Undergraduate Theses
Sepsis is a complicated disorder in which an infection has reached the bloodstream and caused a cascade of events that in time will lead to death. Interventions aimed at identifying sepsis early in its progression are imperative to stopping the process. The purpose of this study is to examine the current state of the literature regarding sepsis screening tools utilized by emergency medical services. A literature review exploring the various tools in place was conducted to see their value in predicting sepsis and secondary what the initiation of a sepsis alert has on the patients’ outcome. Results found included that …
Uchunguzi (Journal Watch/ Montre De Journal) June 2017, Benjamin Wachira
Uchunguzi (Journal Watch/ Montre De Journal) June 2017, Benjamin Wachira
Emergency Medicine, East Africa
The purpose of an effective emergency care system is to provide universal emergency care to all regardless of socioeconomic status, to stabilise patients who have a life-threatening illness or injury, and to reduce consequences of preventable mortality, morbidity and disability. Unfortunately, the limited availability of resources remains a significant barrier to the development and implementation of emergency care systems in low- and middle-income countries (LMICs). In this recent study from Cameroon, of 3201 participants from 619 households surveyed, 1113 (34.8%) had experienced one or more emergency conditions in the previous year. Despite this high incidence of emergency conditions, only 7% …
First 100 Cases Of Bls First Responder A Dministered Naloxone In A Statewide Ems System, Joshua Mastenbrook, James Markman, Tyler Koedam, William Fales
First 100 Cases Of Bls First Responder A Dministered Naloxone In A Statewide Ems System, Joshua Mastenbrook, James Markman, Tyler Koedam, William Fales
Research Day
Abstract Title: FIRST 100 CASES OF BLS FIRST RESPONDER ADMINISTERED NALOXONE IN A STATEWIDE EMS SYSTEM Abstract ID: 240 Abstract Category: Clinical Research BACKGROUND: In October 2015, a midwestern state law mandated that all BLS first responder (FR) agencies be trained and equipped to administer naloxone to suspected opioid-overdose patients. Although well intentioned, several questions have arisen: does naloxone use displace emphasis on early positive pressure ventilation (PPV), is naloxone being appropriately administered, and does the mandate affect patient outcome. The purpose of this study is to evaluate the first 100 cases of FR administered naloxone (FR-naloxone) for administration appropriateness …
Why Is Education Important In Ems?, Adriana Goad
Why Is Education Important In Ems?, Adriana Goad
A with Honors Projects
In EMS, education is vital. As prehospital healthcare providers, we must constantly be educating ourselves on the advances and changes that are made within our protocols and by research. Frequent renewal deadlines for the licenses we hold are put in place so that we remain competent in our skills and are up to date to the most current of standards. There is another factor to our professional need for education, and that is community education. By educating those around us, we can be a means of prevention. While EMS is our career and passion, we want nothing more than to …
Emergency Medical Services (Ems) Training In Kenya: Findings And Recommendations From An Educational Assessment, Benjamin Nicholson, Chelsea Mccollough, Benjamin Wachira, Nee-Kofi Mould-Millman
Emergency Medical Services (Ems) Training In Kenya: Findings And Recommendations From An Educational Assessment, Benjamin Nicholson, Chelsea Mccollough, Benjamin Wachira, Nee-Kofi Mould-Millman
Emergency Medicine, East Africa
Background: Over the past twenty years, Kenya has been developing many important components of a prehospital emergency medical services (EMS) system. This is due to the ever-increasing demand for emergency medical care across the country. To better inform the next phase of this development, we undertook an assessment of the current state of EMS training in Kenya.
Methods: A group of international and Kenyan experts with relevant EMS and educational expertise conducted an observational qualitative assessment of Kenyan EMS training institutions in 2016. Three assessment techniques were utilised: semi-structured interviews, document review, and structured observations. Recommendations were reached through a …
Community Collaboration To Decrease Atypical Emergency Department Utilization, Becky Wilkinson
Community Collaboration To Decrease Atypical Emergency Department Utilization, Becky Wilkinson
Articles, Abstracts, and Reports
No abstract provided.
Patient Characteristics Of The Accident And Emergency Department Of Kenyatta National Hospital, Nairobi, Kenya: A Cross-Sectional, Prospective Analysis, Justin Guy Myers, Katherine M. Hunold, Karen Ekernas, Ali Wangara, Alice Maingi, Vincent Mutiso, Stephen Dunlop, Ian B K Martin
Patient Characteristics Of The Accident And Emergency Department Of Kenyatta National Hospital, Nairobi, Kenya: A Cross-Sectional, Prospective Analysis, Justin Guy Myers, Katherine M. Hunold, Karen Ekernas, Ali Wangara, Alice Maingi, Vincent Mutiso, Stephen Dunlop, Ian B K Martin
Faculty & Staff Scholarship
Background Resource-limited settings are increasingly experiencing a ‘triple burden’ of disease, composed of trauma, non-communicable diseases (NCDs) and known communicable disease patterns. However, the epidemiology of acute and emergency care is not well characterised and this limits efforts to further develop emergency care capacity.
Objective To define the burden of disease by describing the patient population presenting to the Accident and Emergency Department (A&E) at Kenyatta National Hospital (KNH) in Kenya.
Methods We completed a prospective descriptive assessment of patients in KNH’s A&E obtained via systematic sampling over 3 months. Research assistants collected data directly from patients and their charts. …
Development Of A Health Care Systems Curriculum., Zachary Pruitt, Rahul Mhaskar, Bryan G. Kane Md, Robert D. Barraco Md, Mph, Deborah J Dewaay, Alexander M. Rosenau Do, Kristin A. Bresnan Md, Marna R. Greenberg Do, Mph, Facep
Development Of A Health Care Systems Curriculum., Zachary Pruitt, Rahul Mhaskar, Bryan G. Kane Md, Robert D. Barraco Md, Mph, Deborah J Dewaay, Alexander M. Rosenau Do, Kristin A. Bresnan Md, Marna R. Greenberg Do, Mph, Facep
Department of Emergency Medicine
Background: There is currently no gold standard for delivery of systems-based practice in medical education, and it is challenging to incorporate into medical education. Health systems competence requires physicians to understand patient care within the broader health care system and is vital to improving the quality of care clinicians provide. We describe a health systems curriculum that utilizes problem-based learning across 4 years of systems-based practice medical education at a single institution.
Methods: This case study describes the application of a problem-based learning approach to system-based practice medical education. A series of behavioral statements, called entrustable professional activities, was created …
Characteristics Of Real-Time, Non-Critical Incident Debriefing Practices In The Emergency Department., Nur-Ain Nadir, Suzanne Bentley, Dimitrios Papanagnou, Komal Bajaj, Stephan Rinnert, Richard Sinert
Characteristics Of Real-Time, Non-Critical Incident Debriefing Practices In The Emergency Department., Nur-Ain Nadir, Suzanne Bentley, Dimitrios Papanagnou, Komal Bajaj, Stephan Rinnert, Richard Sinert
Department of Emergency Medicine Faculty Papers
INTRODUCTION: Benefits of post-simulation debriefings as an educational and feedback tool have been widely accepted for nearly a decade. Real-time, non-critical incident debriefing is similar to post-simulation debriefing; however, data on its practice in academic emergency departments (ED), is limited. Although tools such as TeamSTEPPS® (Team Strategies and Tools to Enhance Performance and Patient Safety) suggest debriefing after complicated medical situations, they do not teach debriefing skills suited to this purpose. Anecdotal evidence suggests that real-time debriefings (or non-critical incident debriefings) do in fact occur in academic EDs;, however, limited research has been performed on this subject. The objective of …
Teaching The Emergency Department Patient Experience: Needs Assessment From The Cord-Em Task Force., Kory S. London, Jeffrey Druck, Matthew Silver, Douglas Finefrock
Teaching The Emergency Department Patient Experience: Needs Assessment From The Cord-Em Task Force., Kory S. London, Jeffrey Druck, Matthew Silver, Douglas Finefrock
Department of Emergency Medicine Faculty Papers
INTRODUCTION: Since the creation of Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) patient satisfaction (PS) scores, patient experience (PE) has become a metric that can profoundly affect the fiscal balance of hospital systems, reputation of entire departments and welfare of individual physicians. While government and hospital mandates demonstrate the prominence of PE as a quality measure, no such mandate exists for its education. The objective of this study was to determine the education and evaluation landscape for PE in categorical emergency medicine (EM) residencies.
METHODS: This was a prospective survey analysis of the Council of Emergency Medicine Residency …
Design And Challenges Of A Randomized Clinical Trial Of Medical Expulsive Therapy (Tamsulosin) For Urolithiasis In The Emergency Department., Pamela K. Burrows, Judd E. Hollander, Allan B. Wolfson, Michael C. Kurz, Lorna Richards, Sara Difiore, Phillip Watts, Nivedita Patkar, Jeremy Brown, Stephen Jackman, Ziya Kirkali, John W. Kusek, Chloe Michel, Andrew C. Meltzer
Design And Challenges Of A Randomized Clinical Trial Of Medical Expulsive Therapy (Tamsulosin) For Urolithiasis In The Emergency Department., Pamela K. Burrows, Judd E. Hollander, Allan B. Wolfson, Michael C. Kurz, Lorna Richards, Sara Difiore, Phillip Watts, Nivedita Patkar, Jeremy Brown, Stephen Jackman, Ziya Kirkali, John W. Kusek, Chloe Michel, Andrew C. Meltzer
Department of Emergency Medicine Faculty Papers
Urolithiasis or urinary stone disease has been estimated to affect about 1 in 11 Americans. Patients with urinary stone disease commonly present to the emergency department for management of their acute pain. In addition to providing analgesia, administration of drug (medical expulsive therapy) is often prescribed to assist passage of the urinary stone. In this methodology paper, we describe the design of a prospective, multi-center, randomized, double-blind placebo controlled clinical trial of the alpha-adrenergic blocker, tamsulosin, to evaluate its effectiveness as medical expulsive therapy. In addition, we describe the unique challenges of conducting a trial of this type within the …
Targeting The Nrf2-Heme Oxygenase-1 Axis After Intracerebral Hemorrhage., Jing Chen-Roetling, Raymond F. Regan
Targeting The Nrf2-Heme Oxygenase-1 Axis After Intracerebral Hemorrhage., Jing Chen-Roetling, Raymond F. Regan
Department of Emergency Medicine Faculty Papers
BACKGROUND: Injury to cells adjacent to an intracerebral hemorrhage (ICH) is likely mediated at least in part by toxins released from the hematoma that initiate complex and interacting injury cascades. Pharmacotherapies targeting a single toxin or pathway, even if consistently effective in controlled experimental models, have a high likelihood of failure in a variable clinical setting. Nuclear factor erythroid-2 related factor 2 (Nrf2) regulates the expression of heme oxygenase-1 (HO-1) and multiple other proteins with antioxidant and antiinflammatory effects, and may be a target of interest after ICH.
METHODS: Studies that tested the effect of HO and Nrf2 in models …
Factors Associated With Post-Arrest Withdrawal Of Life-Sustaining Therapy., Anne V. Grossestreuer, David F. Gaieski, Benjamin S. Abella, Douglas J. Wiebe, Ari Moskowitz, Daniel J. Ikeda, Jason S. Haukoos, Sarah M. Perman
Factors Associated With Post-Arrest Withdrawal Of Life-Sustaining Therapy., Anne V. Grossestreuer, David F. Gaieski, Benjamin S. Abella, Douglas J. Wiebe, Ari Moskowitz, Daniel J. Ikeda, Jason S. Haukoos, Sarah M. Perman
Department of Emergency Medicine Faculty Papers
INTRODUCTION: Most successfully resuscitated cardiac arrest patients do not survive to hospital discharge. Many have withdrawal of life sustaining therapy (WLST) as a result of the perception of poor neurologic prognosis. The characteristics of these patients and differences in their post-arrest care are largely unknown.
METHODS: Utilizing the Penn Alliance for Therapeutic Hypothermia Registry, we identified a cohort of 1311 post-arrest patients from 26 hospitals from 2010 to 2014 who remained comatose after return of spontaneous circulation. We stratified patients by whether they had WLST post-arrest and analyzed demographic, arrest, and post-arrest variables.
RESULTS: In our cohort, 565 (43%) patients …
Adiponectin Partially Rescues High Glucose/High Fat-Induced Impairment Of Mitochondrial Biogenesis And Function In A Pgc-1Α Dependent Manner., H. Wang, W.-J. Yan, J.-L. Zhang, F.-Y. Zhang, C. Gao, Y.-J. Wang, W.B. Lau, L. Tao
Adiponectin Partially Rescues High Glucose/High Fat-Induced Impairment Of Mitochondrial Biogenesis And Function In A Pgc-1Α Dependent Manner., H. Wang, W.-J. Yan, J.-L. Zhang, F.-Y. Zhang, C. Gao, Y.-J. Wang, W.B. Lau, L. Tao
Department of Emergency Medicine Faculty Papers
OBJECTIVE: Plasma adiponectin (APN) levels are decreased in diabetic patients. Dysfunctional mitochondrial biogenesis is involved in type 2 diabetes (T2DM) pathogenesis, by unclear mechanisms. The present study determined (1) whether myocardial mitochondrial biogenesis was impaired in cardiomyocytes exposed to a high glucose/high fat (HGHF) medium (a T2DM in vitro model), (2) the effects of APN administration upon mitochondrial biogenesis in cardiomyocytes affected by HGHF incubation, and 3) the involved underlying mechanisms.
MATERIALS AND METHODS: Neonatal rat ventricular myocytes (NRVMs) were isolated and incubated in HGHF medium. Mitochondrial function was assessed by ATP content, and fluorescent microscopic analysis of myocardial apoptosis …