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Articles 61 - 90 of 118
Full-Text Articles in Emergency Medicine
Deep Neck Space Infections-A Study In Diabetic Population In A Tertiary Care Centre, K. Sharma, D. Das, M. Joshi, D. Barman, A. J. Sarma
Deep Neck Space Infections-A Study In Diabetic Population In A Tertiary Care Centre, K. Sharma, D. Das, M. Joshi, D. Barman, A. J. Sarma
Journal Articles
© 2017, Association of Otolaryngologists of India. This study is intended to analyze the clinical profile and outcomes of deep neck space infection in diabetic patients in our tertiary care centre. A prospective study of 1 year duration from 30th September 2015 to 30th September 2016 at department of Otorhinolaryngology, Gauhati Medical College and Hospital, Guwahati. A total of 45 diabetic patients who presented with DNSI are included in this study. Their demographic profile, etiology, bacteriology, treatment, duration of hospital stay, complications and outcomes have been analyzed. 45 patients were recorded; 32 (71.11%) were men, and 13 (45%) were women, …
Retrospective Chart Review Of Synthetic Cannabinoid Intoxication With Toxicologic Analysis, P. Sud, M. Gordon, L. Tortora, M. Stripp, D. Borg, A. Berman
Retrospective Chart Review Of Synthetic Cannabinoid Intoxication With Toxicologic Analysis, P. Sud, M. Gordon, L. Tortora, M. Stripp, D. Borg, A. Berman
Journal Articles
© 2018 Sud et al. Introduction: Use of synthetic cannabinoids (SC) has recently emerged as a new drug epidemic. Our emergency departments (EDs) received a surge of SC users presenting with lethargy and bradycardia, contrasting prior reports of SC-induced tachycardia and agitation.Our goal was to describe these novel presentations and characterize the compounds. Methods: We present a case series of patients with SC intoxication who presented to our toxicology service covering two tertiary care EDs between 2/11/2015 and 6/23/2015. A retrospective chart review recorded initial vital signs, chief complaint and clinical course. Urine, blood and xenobiotic samples were analyzed using …
Developing And Implementing A Multisource Feedback Tool To Assess Competencies Of Emergency Medicine Residents In The United States., J. Lamantia, L. M. Yarris, K. Sunga, M. Weizberg, D. Hart, G. Farina, E. Rodriguez, R. Lucas, Z. Mahmooth, J. Lockyear, +1 Additional Author
Developing And Implementing A Multisource Feedback Tool To Assess Competencies Of Emergency Medicine Residents In The United States., J. Lamantia, L. M. Yarris, K. Sunga, M. Weizberg, D. Hart, G. Farina, E. Rodriguez, R. Lucas, Z. Mahmooth, J. Lockyear, +1 Additional Author
Journal Articles
Objectives: Multisource feedback (MSF) has potential value in learner assessment, but has not been broadly implemented nor studied in emergency medicine (EM). This study aimed to adapt existing MSF instruments for emergency department implementation, measure feasibility, and collect initial validity evidence to support score interpretation for learner assessment. Methods: Residents from eight U.S. EM residency programs completed a self-assessment and were assessed by eight physicians, eight nonphysician colleagues, and 25 patients using unique instruments. Instruments included a five-point rating scale to assess interpersonal and communication skills, professionalism, systems-based practice, practice-based learning and improvement, and patient care. MSF feasibility was measured …
Crhbp Polymorphisms Predict Chronic Pain Development Following Motor Vehicle Collision, S. D. Linnstaedt, A. V. Bortsov, A. C. Soward, R. Swor, D. A. Peak, J. Jones, N. Rathlev, D. C. Lee, R. Domeier, P. L. Hendry, S. A. Mclean
Crhbp Polymorphisms Predict Chronic Pain Development Following Motor Vehicle Collision, S. D. Linnstaedt, A. V. Bortsov, A. C. Soward, R. Swor, D. A. Peak, J. Jones, N. Rathlev, D. C. Lee, R. Domeier, P. L. Hendry, S. A. Mclean
Journal Articles
Musculoskeletal pain (MSP) is a common sequela of traumatic stress exposure. While biologic factors contributing to chronic MSP after motor vehicle collision (MVC) have traditionally focused on tissue injury, increasing evidence suggests that neuro/stress/immune processes mediated by stress system activation may play a more dominant role. In a previous study we found that genetic variants in the hypothalamic-pituitary-adrenal (HPA) axis-related gene FKBP5 influence vulnerability to persistent MSP 6 weeks after MVC. In the present cohort study (n = 855) we evaluated whether genetic variants in several other important HPA axis-related genes, including the glucocorticoid receptor (NR3C1), corticotropin-releasing hormone receptor R1 …
Simulation For Operational Readiness In A New Freestanding Emergency Department: Strategy And Tactics, R L. Kerner, K Gallo, M Cassara Do, J D'Angelo, A Egan, J G. Simmons
Simulation For Operational Readiness In A New Freestanding Emergency Department: Strategy And Tactics, R L. Kerner, K Gallo, M Cassara Do, J D'Angelo, A Egan, J G. Simmons
Journal Articles
© 2016 by the Society for Simulation in Healthcare. Statement Simulation in multiple contexts over the course of a 10-week period served as a core learning strategy to orient experienced clinicians before opening a large new urban freestanding emergency department. To ensure technical and procedural skills of all team members, who would provide care without on-site recourse to specialty backup, we designed a comprehensive interprofessional curriculum to verify and regularize a wide range of competencies and best practices for all clinicians. Formulated under the rubric of systems integration, simulation activities aimed to instill a shared culture of patient safety among …
High-Density Lipoprotein (Hdl) Counter-Regulates Serum Amyloid A (Saa)-Induced Spla(2)-Iie And Spla(2)-V Expression In Macrophages, S. Zhu, Y. Wang, W. Chen, W. Li, A. Wang, J. Li, H. Yang, K. J. Tracey, J. D'Angelo, H. Wang, +2 Additional Authors
High-Density Lipoprotein (Hdl) Counter-Regulates Serum Amyloid A (Saa)-Induced Spla(2)-Iie And Spla(2)-V Expression In Macrophages, S. Zhu, Y. Wang, W. Chen, W. Li, A. Wang, J. Li, H. Yang, K. J. Tracey, J. D'Angelo, H. Wang, +2 Additional Authors
Journal Articles
No abstract provided.
A Massive Overdose Of Dalfampridine, L. J. Fil, P. Sud, S. Sattler
A Massive Overdose Of Dalfampridine, L. J. Fil, P. Sud, S. Sattler
Journal Articles
Multiple sclerosis (MS) is an immune mediated inflammatory disease that attacks myelinated axons in the central nervous system. Dalfampridine (4-aminopyridine) was approved by the Food and Drug Administration in January 2010 for treatment of MS. Our patient was a 34-year-old male with a history of MS, who was brought to the emergency department after being found unresponsive. His current medications were valacyclovir, temazepam, dalfampridine (4-AP) and a tysabri intravenous (IV) infusion. Fifteen minutes after arrival the patient seized. The seizures were refractory to benzodiazepines, barbiturates and phenytoin. The 4-AP level was 530ng/mL (25ng/mL and 49ng/mL). The patient stopped seizing on …
Bleb Point: Mimicker Of Pneumothorax In Bullous Lung Disease, C. Gelabert, M. Nelson
Bleb Point: Mimicker Of Pneumothorax In Bullous Lung Disease, C. Gelabert, M. Nelson
Journal Articles
In patients presenting with severe dyspnea, several diagnostic challenges arise in distinguishing the diagnosis of pneumothorax versus several other pulmonary etiologies like bullous lung disease, pneumonia, interstitial lung disease, and acute respiratory distress syndrome. Distinguishing between large pulmonary bullae and pneumothorax is of the utmost importance, as the acute management is very different. While multiple imaging modalities are available, plain radiographs may be inadequate to make the diagnosis and other advanced imaging may be difficult to obtain. Ultrasound has a very high specificity for pneumothorax. We present a case where a large pulmonary bleb mimics the lung point and therefore …
Not Just Painless Bleeding: Meckel's Diverticulum As A Cause Of Small Bowel Obstruction In Children-Two Cases And A Review Of The Literature, K. Itriyeva, M. Harris, J. Rocker, R. Gochman
Not Just Painless Bleeding: Meckel's Diverticulum As A Cause Of Small Bowel Obstruction In Children-Two Cases And A Review Of The Literature, K. Itriyeva, M. Harris, J. Rocker, R. Gochman
Journal Articles
Physicians are educated with the classical teaching that symptomatic patients with Meckel's diverticulum (MD) most often present with painless rectal bleeding. However, a review of the literature reveals that young patients with MD will most commonly present with signs of intestinal obstruction, an etiology not frequency considered in patients presenting to the emergency department with obstruction. We present two cases of intestinal obstruction diagnosed in our emergency department, with Meckel's diverticulum being the etiology.
Managing The Inherent Patient Safety Risks Of Electronic Health Records, G.S. Rudolph
Managing The Inherent Patient Safety Risks Of Electronic Health Records, G.S. Rudolph
Journal Articles
No abstract provided.
Hspb1 As A Novel Regulator Of Ferroptotic Cancer Cell Death, X. Sun, Z. Ou, M. Xie, R. Kang, Y. Fan, X. Niu, H. Wang, L. Cao, D. Tang
Hspb1 As A Novel Regulator Of Ferroptotic Cancer Cell Death, X. Sun, Z. Ou, M. Xie, R. Kang, Y. Fan, X. Niu, H. Wang, L. Cao, D. Tang
Journal Articles
Ferroptosis is an iron-dependent form of non-apoptotic cell death, but its molecular mechanism remains largely unknown. Here, we demonstrate that heat shock protein beta-1 (HSPB1) is a negative regulator of ferroptotic cancer cell death. Erastin, a specific ferroptosis-inducing compound, stimulates heat shock factor 1 (HSF1)-dependent HSPB1 expression in cancer cells. Knockdown of HSF1 and HSPB1 enhances erastin-induced ferroptosis, whereas heat shock pretreatment and overexpression of HSPB1 inhibits erastin-induced ferroptosis. Protein kinase C-mediated HSPB1 phosphorylation confers protection against ferroptosis by reducing iron-mediated production of lipid reactive oxygen species. Moreover, inhibition of the HSF1-HSPB1 pathway and HSPB1 phosphorylation increases the anticancer activity …
Single-Portal Arthroscopy Of The Central Compartment Of The Hip, S. Mannava, E. A. Howse, T. J. Kelsey, R. H. Barnes, A. Antunes, A. J. Stubbs
Single-Portal Arthroscopy Of The Central Compartment Of The Hip, S. Mannava, E. A. Howse, T. J. Kelsey, R. H. Barnes, A. Antunes, A. J. Stubbs
Journal Articles
Since hip arthroscopy has become a standard of orthopaedic practice, the indications have continued to expand as it has proved to be a helpful diagnostic, as well as therapeutic, tool. Access to the hip joint, however, remains challenging for the orthopaedic surgeon who does not routinely perform hip arthroscopy. We present a single-portal arthroscopic technique, showing the feasibility of single-portal arthroscopic access to the hip joint, as well as describing basic indications and instrumentation for single-portal hip arthroscopy. Single-portal hip arthroscopy is ideal for the patient who needs to undergo diagnostic hip arthroscopy or for treatment in patients with simple …
What Is The Prevalence And Success Of Remediation Of Emergency Medicine Residents?, M. Silverberg, M. Weizberg, T. Murano, J. L. Smith, J. C. Burkhardt, S. A. Santen
What Is The Prevalence And Success Of Remediation Of Emergency Medicine Residents?, M. Silverberg, M. Weizberg, T. Murano, J. L. Smith, J. C. Burkhardt, S. A. Santen
Journal Articles
INTRODUCTION: The primary objective of this study was to determine the prevalence of remediation, competency domains for remediation, the length, and success rates of remediation in emergency medicine (EM). METHODS: We developed the survey in Surveymonkey with attention to content and response process validity. EM program directors responded how many residents had been placed on remediation in the last three years. Details regarding the remediation were collected including indication, length and success. We reported descriptive data and estimated a multinomial logistic regression model. RESULTS: We obtained 126/158 responses (79.7%). Ninety percent of programs had at least one resident on remediation …
Arthroscopic Excision Of Acetabular Osteoid Osteoma: Computer Tomography-Guided Approach, C. Tamam, E. A. Howse, M. Tamam, R. H. Barnes, T. J. Kelsey, B. Perry, A. J. Stubbs
Arthroscopic Excision Of Acetabular Osteoid Osteoma: Computer Tomography-Guided Approach, C. Tamam, E. A. Howse, M. Tamam, R. H. Barnes, T. J. Kelsey, B. Perry, A. J. Stubbs
Journal Articles
Osteoid osteoma is a benign osteoblastic tumor that occurs in the subcortical shaft and metaphysis of the long bones of the lower extremities; however, intra-articular lesions are also possible. Intra-articular osteoid osteomas are rare, and clinical symptoms are often less specific and, thereby, may lead to misdiagnosis. The definitive treatment for osteoid osteoma is the excision of the nidus. We present the case of a 23-year-old man with a 4-year history of right anterior hip pain, subsequently diagnosed with a subarticular osteoid osteoma located in the right anterior acetabulum. Hip arthroscopic excision of the juxta-articular osteoid osteoma is presented as …
An Ongoing Search For Potential Targets And Therapies For Lethal Sepsis, G. Q. Bao, L. He, D. Lee, J. D'Angelo, H. C. Wang
An Ongoing Search For Potential Targets And Therapies For Lethal Sepsis, G. Q. Bao, L. He, D. Lee, J. D'Angelo, H. C. Wang
Journal Articles
Sepsis, which refers to a systemic inflammatory response syndrome resulting from a microbial infection, represents the leading cause of death in intensive care units. The pathogenesis of sepsis remains poorly understood although it is attributable to dysregulated immune responses orchestrated by innate immune cells that are sequentially released early (e.g., tumor necrosis factor(TNF), interleukin-1(IL-1), and interferon-gamma(IFN-gamma)) and late (e.g., high mobility group box 1(HMGB1)) pro-inflammatory mediators. As a ubiquitous nuclear protein, HMGB1 can be passively released from pathologically damaged cells, thereby converging infection and injury on commonly dysregulated inflammatory responses. We review evidence that supports extracellular HMGB1 as a late …
Bedside Echocardiography For Undifferentiated Hypotension: Diagnosis Of A Right Heart Thrombus, J. F. Kenny, X. Zhong, C. Brown, D. Das, B. Royall, M. Kapoor
Bedside Echocardiography For Undifferentiated Hypotension: Diagnosis Of A Right Heart Thrombus, J. F. Kenny, X. Zhong, C. Brown, D. Das, B. Royall, M. Kapoor
Journal Articles
A free-floating right heart thrombus is often a harbinger of a massive pulmonary embolism and must be diagnosed and treated rapidly in order to avoid significant adverse sequelae. We present the case of an 84-year-old female who presented with two days of dyspnea and was hypotensive on arrival. Bedside ultrasound was performed by the emergency physician and showed a large, mobile right heart thrombus leading to immediate administration of a thrombolytic. In this case, bedside ultrasound was utilized to help further delineate clinical care in a progressively worsening patient, leading to a potentially lifesaving treatment.
Serum Amyloid A Stimulates Pkr Expression And Hmgb1 Release Possibly Through Tlr4/Rage Receptors, W. Li, S. Zhu, J. Li, J. D'Amore, J. D'Angelo, H. Yang, P. Wang, K. J. Tracey, H. Wang
Serum Amyloid A Stimulates Pkr Expression And Hmgb1 Release Possibly Through Tlr4/Rage Receptors, W. Li, S. Zhu, J. Li, J. D'Amore, J. D'Angelo, H. Yang, P. Wang, K. J. Tracey, H. Wang
Journal Articles
Serum amyloid A proteins (SAAs) have been suggested as surrogate markers of sepsis, but their pathogenic roles remain poorly elucidated. Here we provide evidence to support a possible role of SAA as a pathogenic mediator of lethal sepsis. In a subset of septic patients whose serum HMGB1 levels paralleled with the clinical scores, some anti-HMGB1 antibodies detected a 12 kDa protein belonging to the SAA family. In contrast to the most abundant SAA1, human SAA induced PKR expression and HMGB1 release in the wild-type, but not TLR4/RAGE-deficient, macrophages. Pharmacological inhibition of PKR phosphorylation blocked SAA-induced HMGB1 release, suggesting an important …
Cannabinoid Cb2 Receptors In A Mouse Model Of A Beta Amyloidosis: Immunohistochemical Analysis And Suitability As A Pet Biomarker Of Neuroinflammation, A. V. Savonenko, T. Melnikova, Y. C. Wang, H. Ravert, Y. J. Gao, J. Koppel, D. Lee, P. Davies, M. G. Pomper, A. G. Horti, +6 Additional Authors
Cannabinoid Cb2 Receptors In A Mouse Model Of A Beta Amyloidosis: Immunohistochemical Analysis And Suitability As A Pet Biomarker Of Neuroinflammation, A. V. Savonenko, T. Melnikova, Y. C. Wang, H. Ravert, Y. J. Gao, J. Koppel, D. Lee, P. Davies, M. G. Pomper, A. G. Horti, +6 Additional Authors
Journal Articles
In Alzheimer's disease (AD), one of the early responses to A beta amyloidosis is recruitment of microglia to areas of new plaque. Microglial receptors such as cannabinoid receptor 2 (CB2) might be a suitable target for development of PET radiotracers that could serve as imaging biomarkers of A beta-induced neuroinflammation. Mouse models of amyloidosis (J20APPswe/ind and APPswe/PS1 Delta E9) were used to investigate the cellular distribution of CB2 receptors. Specificity of CB2 antibody (H60) was confirmed using J20APPswe/ind mice lacking CB2 receptors. APPswe/PS1 Delta E9 mice were used in small animal PET with a CB2-targeting radiotracer, [C-11]A836339. These studies revealed …
Achilles Tendon Rupture, S. P. Stickles, L. Friedman, M. Demarest, C. Raio
Achilles Tendon Rupture, S. P. Stickles, L. Friedman, M. Demarest, C. Raio
Journal Articles
No abstract provided.
Choledochal Cyst Mimicking Gallbladder With Stones In A Six-Year-Old With Right-Sided Abdominal Pain, R. Subramony, N. Kittisarapong, I. Barata, M. Nelson
Choledochal Cyst Mimicking Gallbladder With Stones In A Six-Year-Old With Right-Sided Abdominal Pain, R. Subramony, N. Kittisarapong, I. Barata, M. Nelson
Journal Articles
Choledochal cysts are rare but serious bile duct abnormalities are found in young children, usually during the first year of life.1 They require urgent surgical intervention due to the risk of developing cholangiocarcinoma.2 Clinicians should consider this diagnosis and perform a point-of-care ultrasound (POCUS) when a child presents to the emergency department (ED) with findings of jaundice, abdominal pain, and the presence of an abdominal mass. We present the case of a six-year-old child presenting only with abdominal pain upon arrival to our ED and was ultimately diagnosed by POCUS to have a choledochal cyst.
Have First-Year Emergency Medicine Residents Achieved Level 1 On Care-Based Milestones?, M. Weizberg, M. C. Bond, M. Cassara, C. Doty, J. Seamon
Have First-Year Emergency Medicine Residents Achieved Level 1 On Care-Based Milestones?, M. Weizberg, M. C. Bond, M. Cassara, C. Doty, J. Seamon
Journal Articles
BACKGROUND: Residents in Accreditation Council for Graduate Medical Education accredited emergency medicine (EM) residencies were assessed on 23 educational milestones to capture their progression from medical student level (Level 1) to that of an EM attending physician (Level 5). Level 1 was conceptualized to be at the level of an incoming postgraduate year (PGY)-1 resident; however, this has not been confirmed. OBJECTIVES: Our primary objective in this study was to assess incoming PGY-1 residents to determine what percentage achieved Level 1 for the 8 emergency department (ED) patient care-based milestones (PC 1-8), as assessed by faculty. Secondary objectives involved assessing …
Novel Mechanisms Of Herbal Therapies For Inhibiting Hmgb1 Secretion Or Action, A. H. Wu, L. He, W. Long, Q. Zhou, S. Zhu, P. Wang, S. Fan, H. Wang
Novel Mechanisms Of Herbal Therapies For Inhibiting Hmgb1 Secretion Or Action, A. H. Wu, L. He, W. Long, Q. Zhou, S. Zhu, P. Wang, S. Fan, H. Wang
Journal Articles
High mobility group box 1 (HMGB1) is an evolutionarily conserved protein and is constitutively expressed in virtually all types of cells. In response to microbial infections, HMGB1 is secreted from activated immune cells to orchestrate rigorous inflammatory responses. Here we review the distinct mechanisms by which several herbal components inhibit HMGB1 action or secretion, such as by modulating inflammasome activation, autophagic degradation, or endocytic uptake. In light of the reciprocal interactions between these cellular processes, it is possible to develop more effective combinational herbal therapies for the clinical management of inflammatory diseases.
High Mobility Group Box Protein 1 (Hmgb1): The Prototypical Endogenous Danger Molecule, Huan Yang, H. Wang, Sangeeta S. Chavan, Ulf Andersson
High Mobility Group Box Protein 1 (Hmgb1): The Prototypical Endogenous Danger Molecule, Huan Yang, H. Wang, Sangeeta S. Chavan, Ulf Andersson
Journal Articles
No abstract provided.
Milk Fat Globule Epidermal Growth Factor-Factor 8-Derived Peptide Attenuates Organ Injury And Improves Survival In Sepsis, W. L. Yang, A. Sharma, F. Zhang, S. Matsuo, Z. Wang, H. Wang, P. Wang
Milk Fat Globule Epidermal Growth Factor-Factor 8-Derived Peptide Attenuates Organ Injury And Improves Survival In Sepsis, W. L. Yang, A. Sharma, F. Zhang, S. Matsuo, Z. Wang, H. Wang, P. Wang
Journal Articles
INTRODUCTION: Sepsis involves overwhelming inflammatory responses with subsequent immune-suppression that can lead to multiple organ dysfunction and ultimately death. Milk fat globule epidermal growth factor-factor 8 (MFG-E8) is a secretory protein found to have multiple biological activities against autoimmune and inflammatory diseases. MFG-E8 contains an Arg-Gly-Asp (RGD) motif involved in cell-cell and cell-matrix interactions. In sepsis, excessive neutrophils migration through endothelial cells and matrix to sites of inflammation results in organ damage. We hypothesized that MFG-E8-derived short peptides (MSP) flanking its RGD motif could provide protection against organ injury in sepsis. METHODS: The differentiated human neutrophil-like HL-60 cells (dHL60) were …
Hmgb1: A Novel Protein That Induced Platelets Active And Aggregation Via Toll-Like Receptor-4, Nf-Kappab And Cgmp Dependent Mechanisms, X. Yang, H. Wang, M. Zhang, J. Liu, B. Lv, F. Chen
Hmgb1: A Novel Protein That Induced Platelets Active And Aggregation Via Toll-Like Receptor-4, Nf-Kappab And Cgmp Dependent Mechanisms, X. Yang, H. Wang, M. Zhang, J. Liu, B. Lv, F. Chen
Journal Articles
BACKGROUND: Thrombotic diseases are a group of prevalent and life-threatening diseases. Selective inhibition of pathological thrombosis holds the key to treat variety of thrombotic diseases. The pathological thrombosis can be induced by either tissue necrosis and deregulated inflammation. HMGB1, as an important proinflammatory cytokine and a late mediator, also involves on thrombosis disease. However, the underlying mechanisms are not fully understood. METHODS: Immunofluorescence, ELISA assay, Platelet Aggregation, Thromboelastogram (TEG) analyzes. Flow cytometric analysis and Western blot analysis were used to investigated the role of HMGB1 in platelet aggregation and obtained following observations. RESULTS: By doing so, we obtained the following …
Mitochondrial Dysfunction In Peripheral Blood Mononuclear Cells In Pediatric Septic Shock, S. L. Weiss, M. A. Selak, F. Tuluc, J. Perales Villarroel, V. M. Nadkarni, C. S. Deutschman, L. B. Becker
Mitochondrial Dysfunction In Peripheral Blood Mononuclear Cells In Pediatric Septic Shock, S. L. Weiss, M. A. Selak, F. Tuluc, J. Perales Villarroel, V. M. Nadkarni, C. S. Deutschman, L. B. Becker
Journal Articles
OBJECTIVES: Mitochondrial dysfunction in peripheral blood mononuclear cells has been linked to immune dysregulation and organ failure in adult sepsis, but pediatric data are limited. We hypothesized that pediatric septic shock patients exhibit mitochondrial dysfunction within peripheral blood mononuclear cells which in turn correlates with global organ injury. DESIGN: Prospective observational study. SETTING: Academic PICU. PATIENTS: Thirteen pediatric patients with septic shock and greater than or equal to two organ failures and 11 PICU controls without sepsis or organ failure. INTERVENTIONS: Ex vivo measurements of mitochondrial oxygen consumption and membrane potential (DeltaPsim) were performed in intact peripheral blood mononuclear cells …
Prescription For Antidepressant In Reducing Future Alcohol-Related Readmission In Patients Suffering From Depression And Alcohol Use Disorder: A Retrospective Medical Record Review, P. Chan, K. Yomen, J. Turcios, M. Richman
Prescription For Antidepressant In Reducing Future Alcohol-Related Readmission In Patients Suffering From Depression And Alcohol Use Disorder: A Retrospective Medical Record Review, P. Chan, K. Yomen, J. Turcios, M. Richman
Journal Articles
BACKGROUND: Patients suffering from major depressive disorder are more likely to suffer from alcohol use disorder. The data is inconclusive for the effectiveness of antidepressant treatment of patients suffering from both illnesses in regards to improving sobriety and reducing alcohol-related healthcare expenses such as hospitalizations. The objective of this study is to determine if a new prescription of an antidepressant upon inpatient discharge is associated with a reduction in the number of future acute alcohol-related hospital readmissions to the same institution in patients suffering from major depressive disorder and alcohol-use disorder. METHODS: A retrospective, medical record review study was conducted …
Mu-Opioid Receptor Gene A118 G Variants And Persistent Pain Symptoms Among Men And Women Experiencing Motor Vehicle Collision, S. D. Linnstaedt, J. M. Hu, A. V. Bortsov, A. C. Soward, R. Swor, J. Jones, D. Lee, R. Domeier, P. Hendry, S. A. Mclean, +2 Additional Authors
Mu-Opioid Receptor Gene A118 G Variants And Persistent Pain Symptoms Among Men And Women Experiencing Motor Vehicle Collision, S. D. Linnstaedt, J. M. Hu, A. V. Bortsov, A. C. Soward, R. Swor, J. Jones, D. Lee, R. Domeier, P. Hendry, S. A. Mclean, +2 Additional Authors
Journal Articles
The mu-opioid receptor 1 (OPRM1) binds endogenous opioids. Increasing evidence suggests that endogenous OPRM1 agonists released at the time of trauma may contribute to the development of posttraumatic musculoskeletal pain (MSP). In this prospective observational study, we evaluated the hypothesis that individuals with an AG or GG genotype at the OPRM1 A118 G allele, which results in a reduced response to opioids, would have less severe MSP 6 weeks after motor vehicle collision (MVC). Based on previous evidence, we hypothesized that this effect would be sex-dependent and most pronounced among women with substantial peritraumatic distress. European American men and women …
Genetic Polymorphisms In The Dopamine Receptor 2 Predict Acute Pain Severity After Motor Vehicle Collision, Y. J. Qadri, A. V. Bortsov, D. C. Orrey, R. A. Swor, D. A. Peak, J. S. Jones, N. K. Rathlev, D. C. Lee, P. L. Hendry, S. A. Mclean, +1 Additional Author
Genetic Polymorphisms In The Dopamine Receptor 2 Predict Acute Pain Severity After Motor Vehicle Collision, Y. J. Qadri, A. V. Bortsov, D. C. Orrey, R. A. Swor, D. A. Peak, J. S. Jones, N. K. Rathlev, D. C. Lee, P. L. Hendry, S. A. Mclean, +1 Additional Author
Journal Articles
Objectives:Dopaminergic signaling is implicated in nociceptive pathways. These effects are mediated largely through dopamine receptors and modulated in part by dopamine transporters. This study tested the hypothesis that genetic variants in the genes encoding dopamine receptor 2 (DRD2) and the dopamine active transporter (SLC6A3) influence acute pain severity after motor vehicle collision.Materials and Methods:European Americans presenting to the emergency department after motor vehicle collision were recruited. Overall pain intensity in emergency department was assessed using a 0 to 10 numeric rating scale. DNA was extracted from blood samples and genotyping of single-nucleotide polymorphisms (SNPs) in the DRD2 and SLC6A3 gene …
Sideline Coverage: When To Get Radiographs? A Review Of Clinical Decision Tools, S. J. Gould, D. A. Cardone, J. Munyak, P. J. Underwood, S. A. Gould
Sideline Coverage: When To Get Radiographs? A Review Of Clinical Decision Tools, S. J. Gould, D. A. Cardone, J. Munyak, P. J. Underwood, S. A. Gould
Journal Articles
CONTEXT: Sidelines coverage presents unique challenges in the evaluation of injured athletes. Health care providers may be confronted with the question of when to obtain radiographs following an injury. Given that most sidelines coverage occurs outside the elite level, radiographs are not readily available at the time of injury, and the decision of when to send a player for radiographs must be made based on physical examination. Clinical tools have been developed to aid in identifying injuries that are likely to result in radiographically important fractures or dislocations. EVIDENCE ACQUISITION: A search for the keywords x-ray and decision rule along …