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Full-Text Articles in Critical Care
Enteric Absorption Of Ciprofloxacin During Tube Feeding In The Critically Ill, Stephen M. Cohn, Mark D. Sawyer, Gerard A. Burns, Concertina Tolomeo, Kerry A. Milner
Enteric Absorption Of Ciprofloxacin During Tube Feeding In The Critically Ill, Stephen M. Cohn, Mark D. Sawyer, Gerard A. Burns, Concertina Tolomeo, Kerry A. Milner
Nursing Faculty Publications
To determine the pharmacokinetic properties of ciprofloxacin in the critically ill, we studied seven mechanically ventilated patients with pneumonia during entcral feedings. Subjects received ciprofloxacin 750 mg every 12 h via nasogastric tube and serial serum drug concentrations were measured after the first and fourth dose. After the initial dose, the maximum serum concentration ranged from 1.24–3.06 mg/L, and the area under the time curve from 0–12 h ranged from 3.2–19.65 mg.h/L. Similar levels were noted after dose four. Gastrointestinal absorption of ciprofloxacin in tube fed critically ill patients was decreased, but well above MIC values for many pathogenic bacteria.
Efficient Vasoactive Intestinal Polypeptide Hydrolyzing Autoantibody Light Chains Selected By Phage Display, Sonia Tyutyulkova, Qing-Sheng Gao, Austin Thompson, Stephen I. Rennard, Sudhir Paul
Efficient Vasoactive Intestinal Polypeptide Hydrolyzing Autoantibody Light Chains Selected By Phage Display, Sonia Tyutyulkova, Qing-Sheng Gao, Austin Thompson, Stephen I. Rennard, Sudhir Paul
Journal Articles: Pulmonary & Critical Care Med
An immunoglobulin light chain (L chain) library derived from the peripheral blood lymphocytes of a patient with asthma was cloned into a phagemid vector. Phage particles displaying L chains capable of binding vasoactive intestinal polypeptide (VIP) were isolated by affinity chromatography. Two VIP binding L chains were expressed in Escherichia coli in soluble form and purified to electrophoretic homogeneity by metal chelating and protein L affinity chromatography. Both L chains catalyzed the hydrolysis of [tyr10-125I]VIP substrate. The catalytic activity eluted at the molecular mass of the monomer form of the L chain (28 kDa) from a gel filtration column. The …
Endobronchial Tuberculosis--Manifesting By Coughing Up Of Bronchial Cartilage, A M. Memon, A Shafi, H Thawerani
Endobronchial Tuberculosis--Manifesting By Coughing Up Of Bronchial Cartilage, A M. Memon, A Shafi, H Thawerani
Section of Pulmonary & Critical Care
No abstract provided.