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Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Efficacy Of Betaprone With Ultraviolet Irradiation On Hepatitis B Antigen In Human Plasma Pools (A Retrospective Study), Gerald A. Logrippo, Hajime Hayashi

Henry Ford Hospital Medical Journal

In a retrospective study, hepatitis B antigen (HB Ag) was found in 14 lots of human plasma pools (16-20 liters each) that had been treated by the combined Betaprone (BPL) with ultraviolet (UV) irradiation procedure. No evidence of clinical hepatitis was found during a six-month follow-up after 185.2 liters of HB Ag positive plasma were Infused into 257 patients. Since HB Ag positive blood products treated by BPL with UV produced no clinical hepatitis, it is evident that our treatment is efficacious against hepatitis virus agents.

Surgical Treatment Of Liver Trauma: Technical Considerations And Case Reports, C. Grodsinsky, T. A. Fox Jr., B. E. Brush

Henry Ford Hospital Medical Journal

The incidence of abdominal trauma, and thus that of liver trauma, has been increasing in the past few years. Improvements in the understanding of the anatomy of the liver and improvements in diagnostic techniques have resulted in shorter and better operations with less delay between injury and surgery. Improvements in transportation to adequate hospital facilities and vigorous resuscitative measures have also contributed to lowering the mortality rate for this type of injury. Suggestions are made for the surgical management of liver injuries, together with illustrative case reports.

Near Basal Blood Pressure: A Method Applicable To Clinical Practice, John R. Caldwell

Henry Ford Hospital Medical Journal

A method is described for determining near basal blood pressure (NBBP) measurements that is applicable to outpatient clinic or office use in daily practice. In our clinic, patients' mean casual pressure was significantly higher than the NBBP, the difference being 40 mm Hg systolic (p < .001) and 18 mm Hg diastolic (p < .001). In hospitalized patients the casual blood pressure was higher than the fourth to sixth day hospital average, and the hospital average was higher than NBBP. The difference between the last two was 15 mm Hg systolic (p <. 005) and 9 mm Hg diastolic (p < .005). In patients recording blood pressure readings at home the average weekly home-recorded blood pressure was not significantly different from NBBP during the same week, -1 mm Hg systolic (p > .80) and 4 mm Hg diastolic (p > .10). NBBP by this method offers a practical way to estimate the average daily blood pressure.

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Henry Ford Hospital Medical Journal

No abstract provided.

The Effects Of Atropine On The Growth And Respiration Of Two Species Of Bacteria Normally Inhabiting The Human Gastro-Intestinal System, Mary M. Ramos

Theses & Dissertations

It is the purpose of this study to determine whether the drug atropine has an effect on bacteria found normally inhabiting the human body, most specifically the gastrointestinal system. Atropine is one of the oldest drugs in medicine. It is derived from the roots and leaves of solanaceous plants such as henbane and Jimson weed. Atropine is often termed a belladonna alkaloid because it can also be found in the deadly nightshade plant, Atropa belladonna. Atropine is a highly competitive antagonist of acetylcholine at receptor sites in smooth muscles, cardiac muscle, and various glandular cells (5). Therefore, its effects are …

Localization Of Deep Abscesses With Radioactive Isotopes: An Experimental Study, H. M. Allen, R. Berguer, L. A. Dusault, M. A. Block

Henry Ford Hospital Medical Journal

Life-endangering effects of deep abscesses make early and precise identification and localization important to permit adequate surgical drainage. An experiment was undertaken to study the feasibility of detecting abscesses by using leucocytes tagged with radioactive isotopes. For the labeling, 51chromium appeared preferable to 131iodine or 99technetium. Leucocytes so labelled will concentrate sufficiently in abscesses to permit identification of abscesses by scintillation scanning. For clinical application, techniques require further simplification and refinement to eliminate interference by collection of radioactive isotopes in the liver and spleen.

Statistics For Clinical Research, W. R. Mccrum

Henry Ford Hospital Medical Journal

The purpose of this paper is to make understandable the use of statistics in the field of medicine, and to introduce to the clinician some new methods of statistics for drawing some reasonable conclusions based on the meager data usually available. There is, after all, only one valid use of statistics: to enable oneself to make a personal decision based on the information available.

Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Primary Biliary Cirrhosis With Systemic Sclerosis, Pedro A. Diaz, Bernard M. Schuman

Henry Ford Hospital Medical Journal

Two patients with combinedbilian/ cirrhosis and scleroderma are described. Both patients also presented features of the CRST syndrome, namely Raynaud's phenomenon, and telangiectasiae. Nine previously reported cases are reviewed and the clinical data suggest that a common underlying immunologic basis may account for both clinical conditions.

A Clinical Trial Of Tobramycin With Pharmacological And Microbiological Studies, Keith Burch, Richard D. Nichols, Edward L. Quinn, Frank Cox, Evelyn J. Fisher, T. Madhavan, Donald Pohlod

Henry Ford Hospital Medical Journal

Tobramycin, a new aminoglycoside antibiotic, was shown to be effective in vitroagainst Pseudomonas, Klebsiella, Staphylococcus aureus, Enterobacter, Proteus mirabilis, indole-positive Proteus, and Eshcherichia coli. It was shown to produce serum and urine concentrations similar to gentamicin when administered intramuscularly. Preliminary animal studies showed this agent to have nephrotoxic and ototoxic effects similar to gentamicin. In our studies, tobramycin was well tolerated and produced only two transient elevations in serum creatinine and no abnormalities in audiograms and vestibular function tests. It was effective in 10 of 12 susceptible infections, including 2 of 4 with Pseudomonas endocarditis. Tobramycin compared favorably with gentamicin …

Haversian And Endosteal Bone Formation Rates In Rib Biopsies Of 50 Patients With Senile And Postmenopausal Osteoporosis, Kent K. Wu

Henry Ford Hospital Medical Journal

Eleventh rib biopsies of 50 patients with senile and postmenopausal osteoporosis, studied by means of tetracycline bone labeling, revealed significant and similar although modest decreases In bone formation on the cortical-endosteal and haversian surfaces of the biopsies.

Frank J. Sladen 1882-1973, Enisse Chimes

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Complications Of Treated Cushing's Syndrome, Lewis B. Morrow, Raymond C. Mellinger, M. Saeed Zafar, Richmond W. Smith Jr.

Henry Ford Hospital Medical Journal

Fifty-two patients with Cushing's syndrome are reported with emphasis on post treatment complications. Seven patients, cured of their disease following appropriate therapy, had a recurrence of adrenal hypersecretion from one to ten years later. This occurred after all modalities of treatment, but was more common after sub-total adrenalectomy. Pituitary adenomas were found in two cases. Pseudotumor cerebri, psychiatnc complications, hyperthyroidism and hyperpigmentation were observed. One patient developed progressive hyperplgmentation despite pituitary radiation. Thirteen of fifty-two patients had malignant disease including three endometrial carcinomas, one rectal carcinoma and one adenocarcinoma of the mandible. Despite the remarkable improvement In the prognosis for …

Toxic Megacolon In Granulomatous Colitis, K. Anselm, S. A. Rosenblum, V. De Marco

Henry Ford Hospital Medical Journal

Acute, toxic dilatation of the colon in granulomatous colitis occurs more frequently than heretofore reported, and is a more serious complication than its counterpart in ulcerative colitis. Twenty-six patients who had toxic megacolon were seen at the Henry Ford Hospital between 1961 and 1971. Fourteen of these had ulcerative colitis and 12 had granulomatous colitis. Coricosteroids were relatively ineffective in these 12 patients and all but two needed surgical intervention. Postoperative complications occurred in two cases, with two deaths. Although the initial clinical picture between the two conditions is identical, the clinical course In those with granulomatous colitis is more …

The Scanning Electron Microscope: Applications At The Edsel B. Ford Institute For Medical Research, John H. L. Watson

Henry Ford Hospital Medical Journal

The Henry Ford Hospital with its research partner, The Edsel B. Ford Institute for Medical Research, was the first private medical center in the State of Michigan to purchase a scanning electron microscope and to begin to apply it, a year ago, to the study of medical and biological problems in both the animal and the human. This article briefly describes how the instrument works and shows some samples of micrographs produced.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

The Involvement Of Urinary Kallikrein In The Renal Escape From The Sodium Retaining Effect Of Mineralocorticoids, M. Marin-Grez, N. B. Oza, Oscar A. Carretero

Henry Ford Hospital Medical Journal

It is well known that the normal kidney "escapes" the sodium retaining effect of mineralocorticoids. However, the mechanism that mediates this "escape" is not understood. The possible role of kallikrein in this "escape" phenomenon was investigated by placing seven dogs in metabolic cages and giving them a constant sodium diet. After they had been on this diet three days, urine was collected for two 24-hour periods. DOCA (25 mg/day) was then given intramuscularly for five days. Urine was collected daily during this DOCA period and for two additional 24- hour periods. Urine volume, sodium, potassium, protein, and kallikrein excretion were …

Experience With Cleft Lip And Palate At The Henry Ford Hospital, W. Peter Mccabe

Henry Ford Hospital Medical Journal

A detailed analysis is presented of 321 patients with clefts of the lip and/or palate treated at Henry Ford Hospital. Comments are made on past and future trends in the management of these complex entities.

Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.

A Method Of Analyzing Mandibular Movement, Richard B. Mccoy

Loma Linda University Electronic Theses, Dissertations & Projects

Mandibular movement is considered to be a fundamental factor in the study, analysis, and treatment of occlusion. For many years, dentists have realized that dental health depends upon the compatibility of mandibular movements and occlusion. This realization has led to the development of new methods and techniques for recording accurately and scientifically the movements of the mandible. In order for this data to be of scientific value, it must be stored in a usable form which is easily available for analysis.

The purpose of this research project was to develop a procedure for storing and recalling mandibular-movement information. Before such …

Role Of Membrane-Associated Components Of Mycoplasma Arthritidis On The Biosynthesis Of Humoral Antibodies And Arthritogenic Properties In Experimental Animals, Lois M. Bergquist

Loma Linda University Electronic Theses, Dissertations & Projects

The virulence of animal-passaged Mycoplasma arthritidis (158) was demonstrated to be enhanced in rats by growth in oleic acid-enriched broth. The virulence of a laboratory-maintained culture of the same strain was unaffected by similar growth conditions. No differences either in the immune response as measured by complement-fixing (CF) antibodies or in the histogenesis of the disease were detected when rats were injected with animal-passaged M. arthritidis grown either in the presence or in the absence of oleic acid. All tests for metabolism-inhibiting (MI) antibodies in the rat were negative.

A Mycoplasma-associated immunosuppression of the primary and of the secondary hemagglutinin …

Author Index, 1953-1972

Henry Ford Hospital Medical Journal

No abstract provided.

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Henry Ford Hospital Medical Journal

No abstract provided.

Subject Index, 1953-1972

Henry Ford Hospital Medical Journal

No abstract provided.

The Effect Of Psyllium Hydrocolloid And Cholestyramine On Hepatic Bile Lipid Composition In Man, W. T. Beher, B. M. Schuman, M. A. Block, G. J. Lin, K. K. Casazza

Henry Ford Hospital Medical Journal

The effects of a mucoid - psyllium hydrocolloid - and an anion exchange polymercholestryamine - on the total cholesterol, total phospholipid, total bile salt, cholate, chenodeoxycholate, and deoxycholate concentrations of hepatic bile were determined in six post-cholecystectomy patients. Bile was obtained by drainage through an indwelling T-tube, which was clamped except during bile collection. Psyllium hydrocolloid treatment (12 gm/day) for 6 to 29 days had little or no effect on the cholesterol or phospholipid concentration of hepatic bile, but increased the total bile salt pool by gradually increasing the concentration of deoxycholate. Cholestyramine treatment (12 gm/day) for 8 to 12 …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.