Medical Specialties Commons^™

Skin Lesions Associated With E. Coli Sepsis In A Patient With Acute Leukemia, Robert A. Chapman, Ellis J. Van Slyck, Tom Madhavan

Henry Ford Hospital Medical Journal

The clinical course of a patient with acute leukemia and metastatic intradermal abscesses secondary to Escherichia coli sepsis is described. E. coli organisms, cultured first from the blood and later from the lesions, had an identical antibiotic susceptibility and biotyping profile. This complication has not been previously described. Granulocytopenia and varicose veins may have been critical predisposing factors. With more widespread use of progressive immunosuppressive regimens, unusual manifestations of common infections will be recognized more frequently.

Hypomagnesemia-Lnduced Cardiac Arrhythmia, Robert Chapman, Jan Rival

Henry Ford Hospital Medical Journal

A case of life-threatening cardiac arrhythmia associated with magnesium deficiency is described. The patient had no history of any cardiac disease, was not taking any medication and had no other accompanying electrolyte disorder. His arrhythmia was refractory to conventional treatment but responded to parenteral magnesium therapy. The role of hypomagnesemia in the predisposition to cardiac arrhythmia is discussed. To our knowledge, there are only two well-documented cases of ventricular irritability which responded to magnesium as the sole treatment. As awareness of such a relationshp increases and magnesium determinations become more available, this entity may be more commonly recognized, and the …

Dissecting Aneurysm Of Aorta Complicating Coarctation Of The Aorta: Case Report And Brief Literature Review, Remigio Garcia, Julius M. Ohorodnik, Donald J. Magilligan Jr.

Henry Ford Hospital Medical Journal

The incidence of dissecting thoracic aorta aneurysm complicating coarctation of the aorta ranges from 1.7 to 23% in large series of coarctation of the aorta reported. In a review of 95 cases of dissection of the aorta, we found only one case with associated coarctation of the aorta. The presence of this anomaly, although rare, should be suspected and searched for in younger patients with dissection, in view of the surgical implications at the time of correction.

Use Of The Intraocular Lens In The Aphakic Eye - Part 1: The Anterior Chamber Intraocular Lens, Philip C. Hessburg

Henry Ford Hospital Medical Journal

Th;s paper reviews some reasons why many ophthalmic surgeons do not implant intraocular lenses. It presents some parameters of a theoretically "ideal" lens, some of the disadvantages and advantages of the currently available anterior chamber intraocular lenses, and lastly, it offers designs for a new anterior chamber intraocular lens. While preserving the advantages of currently available anterior chamber intraocular lenses, the new designs may have certain advantages. Currently under investigation, the new lenses may be available for use in man within the next year.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

1979 Publications Of The Staff Of Henry Ford Hospital

Henry Ford Hospital Medical Journal

No abstract provided.

Cumulative Index, 1973-1979

Henry Ford Hospital Medical Journal

No abstract provided.

The Synthesis And Evaluation Of The Potential Antineoplastic Activity Of The Semicarbazone And The Thiosemicarbazone Derivatives Of The Di-2-Pyridyl Ketone And The 1,8-Diazafluorenone Ring Systems, Adriene Y. Principe

Chemistry & Biochemistry Theses & Dissertations

A number of' a-(N)-heterocyclic thiosemicarbazones have been synthesized and evaluated for potential antineoplastic activity since Brockman and colleagues2 reported the antineoplastic activity of' 2-f'ormylpyridine thiosemicarbazone (1). The primary objective of' this research project has been the synthesis and characterization of' the semicarbazone and the thiosemicarbazone derivatives of' the di-2-pyridyl ketone, (9-a) and (9-b), and the 1,8-diazaf'luorenone, (10-a) and (10-b), ring systems, as well as the evaluation of' these compounds for both in vitro and in vivo antineoplastic activity against Ehrlich ascites tumor cells in mice. These studies have suggested that di-2-pyridyl ketone thiosemicarbazone (9-b) is as effective as 2-formylpyridine …

A Method Of Studying Leukocytic Functions In Vivo, John W. Rebuck, James H. Crowley

Henry Ford Hospital Medical Journal

No abstract provided.

Lymphocytes: 1979, Sudhir Gupta, Robert A. Good

Henry Ford Hospital Medical Journal

Rapid progress has been made in understanding the complexity of the immune system. The current status of lymphocyte subpopulations with regard to ontogenic development, their surface and intracellular markers, and functions in various Immunologic phenomena has been reviewed. Heterogeneity of T lymphocytes as defined by receptors for immunoglobulin isotypes is discussed in detail. Various cell types and their products involved in immunoregulatlon are also presented.

A Method For Evaluating The Platelet Surface Response By Using Electron Microscopy, Jeanne M. Riddle

Henry Ford Hospital Medical Journal

Our method for evaluating the surface response of any given platelet population, which has evolved over the past two decades, provides a measure of both the adhesive and cohesive qualities of platelets. General morphologic features of the adherent, whole platelets can be assessed by transmission electron microscopy, and the results are reproducible when serial samples are collected on normal subjects and patient groups. With this technique, different metabolites and drugs can be combined with platelet populations that are either normoresponsive or hyperactive to determine if these substances trigger or inhibit the platelet response. To date, the results from in vitro …

Contributions Of Electron Microscopy To The Study Of Platelets, J. W. Rebuck, Jeanne M. Riddle, S. A. Johnson, R. W. Monto, Ruth M. Sturrock

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

John W. Rebuck Md, Phd, Raymond W. Monto

Henry Ford Hospital Medical Journal

No abstract provided.

Functions And Interrelationships Of Leukocytes In Inflammation As Elucidated By The Rebuck Skin Window Technique, Sheikh M. Saeed

Henry Ford Hospital Medical Journal

This article provides an overview of the functions of human leukocytes in inflammation as elucidated by the Rebuck skin window technique. The migration sequence of various leukocytes into the field of inflammation is described, as well as cytologic, cytochemical, and transformational changes, and the interrelationships of responding leukocytes. Since it was introduced in 1955, the Rebuck skin window technique has provided an excellent means of studying in vivo inflammatory response to different phlogistic agents in normal individuals and in various disease states. This simple technique continues to prove fruitful to further study and to monitoring of many disease states.

Igg Lymphoplasmacytic Intestinal Lymphoma: A Case Report, Heidrun Z. Rotterdam, Sheldon C. Sommers

Henry Ford Hospital Medical Journal

We describe a rare case of a localized primary small intestinal lymphoma with features of both the Mediterranean and the Western type. This case demonstrates the need to regard intestinal lymphoma as a spectrum of diseases with the Mediterranean and the Western types at opposite ends and many variants in between. The role of the plasma cell infiltrate has been interpreted as reactive as well as neoplastic. In our case, both lymphocytic and plasmacytic proliferations spread widely in the intestinal submucosa, extended into muscularis propria and subserosal fat, and involved mesenteric lymph nodes. Direct immunofluorescence demonstrated IgG-kappa both in plasma …

Sequential Electron Micrography Of Sickling, J. W. Rebuck, R. M. Sturrock, R. W. Monto

Henry Ford Hospital Medical Journal

No abstract provided.

The Role Of High Molecular Weight Kininogen (Fitzgerald Factor) In The Activation Of Various Plasma Proteolytic Enzyme Systems, R. Waldmann, A. G. Scicli, J. Guimaraes, G. Scicli, Oscar A. Carretero, H. Kato, Y. N. Han, S. Iwanaga

Henry Ford Hospital Medical Journal

Bovine high molecular weight kininogen (bHMWK) partially corrects the aPTT of Fitzgerald-trait plasma, which is congenitally deficient in HMWK. The relationship between the structure and activity of HMWK was clarified by studying the effects of different fragments of bHMWK on the aPTT of Fitzgerald-trait plasma. The peptides studied, all in equimolar concentrations, were lys-bradykinin-free HMWK, bradyk In In-fragment 1-2-tree HMWK, heavy chain, fragment 1 -2-Hght chain, and light chain. Bradykinin- fragment 1-2-free HMWK, heavy chain, and light chain have little or no correcting activity upon Eitzgeraldtrait plasma aPTT. Fragment 1-2 light chain has the same correcting activity as intact bHMWK, …

Acute Inflammatory Response In Experimental Skin Lesions Of Patients With Ankylosing Spondylitis, Gilbert H. Bluhm, Honora H. Mcelroy, Jeanne M. Riddle, John W. Sigler

Henry Ford Hospital Medical Journal

Two different stimuli, tetanus toxoid (TT) and autologous fibrin (AF), were used to investigate the inflammatory response in ten patients with ankylosing spondylitis (AS); in seven persons who had a family history of AS and were HLA-627 positive but had no clinical signs of AS; and in eight nonarthritic controls. The purpose was to determine whether the leukocytic response in an experimental Rebuck skin window lesion was the same or different from that seen in the synovial fluid of AS patients when in vivo-formed fibrin flakes were present. Four lesions were produced on each subject, with TT added to one …

Functional And Biochemical Alterations Of Platelets In Atherosclerosis And Thromboembolism, Orhan N. Ulutin

Henry Ford Hospital Medical Journal

In atherosclerosis, platelets appear to circulate in an activated state. Our findings are based on results obtained from 240 patients. These platelets demonstrated an increased degree of surface activation and an increased amount of aggregation. Platelet aggregation was also demonstrated by a heightened sensitivity to adrenalin and ADP. Greater than normal secretion of ADP, PF-4, platelet fibrinogen, and platelet antiplasmin was noted. Platelet antiplasmin was increased, whereas platelet antithrombin III was decreased. Membrane transport of glucose was found to be defective in atherosclerosis. There appears to be no alteration in the phospholipid distribution, although the amount of phospholipids increases. The …

The Chediak-Higashi Syndrome: Spectrum Of Giant Organelles In Peripheral Blood Cells, James G. White, C. C. Clawson

Henry Ford Hospital Medical Journal

The presence of giant organelles in the cytoplasm of peripheral blood elements is diagnostic for the Chediak-Higashi syndrome. These abnormal cytoplasmic inclusions are found within neutrophils, eosinophils, basophils, lymphocytes, monocytes, and platelets. Their fine structural characteristics differ. Neutrophils demonstrate striking variability in the size, shape, and internal features of their giant organelles. Lymphocytes contain two different types of giant inclusions, one with a smoothly homogeneous substructure, the other with structures resembling microtubules. Emphasizing the ultrastructural similarities and differences of these anomalous granulations may provide valuable clues for understanding the basic defect of this inherited disorder.

The Role Of Exercise And Nutrition In The Rehabilitation Of The Geriatric, Robert R. Ladd

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract not included]

Detection Of Unique Tumor-Associated Proteins In The Urine Of Patients With Transitional Cell Carcinoma By High Resolution Two-Dimensional Polyacrylamide Gel Electrophoresis, Robert David Lehman

Biological Sciences Theses & Dissertations

A two-dimensional polyacrylamide gel electrophoretic technique was developed for the detection of unique tumor-associated proteins in urine of patients with transitional cell carcinoma (TCC) of the urinary bladder. This technique yielded high resolution of polypeptides in the urine of cancer patients. Urine was chosen as a source of tumor-associated components because the location of the tum or should release already solublized tum or substances in to the urine.

Urinary proteins were concentrated and then analyzed by the two - dimensional electrophoretic technique using isoelectric focusing in the first dimension and sodium dodecylsulfate - polyacrylamide gel electrophoresis in the second dimension. …

The Management Of Iatrogenic Chylous Ascites, Joseph W. Lewis, Edward H. Storer

Henry Ford Hospital Medical Journal

Iatrogenic chylous ascites, although extremely rare, appears to follow direct lymphatic injury during intra-abdominal surgery or to be due to specific postoperative complications such as pancreatitis. Statistically, truncal vagotomy has produced the largest number of cases. Any noticeable lymphatic injuries at the time of surgery should be controlled with appropriate sutures or clips. If iatrogenic chylous ascites develops postoperatively, a course of conservative treatment including multiple paracenteses should be tried for several weeks if reasonable nutritional balance can be maintained. If fluid volume does not diminish or the patient's nutritional status is jeopardized, early exploration should be undertaken. A lipophilic …

Percutaneous Transfemoral Renal Artery Occlusion In The Management Of Advanced Renal Carcinoma, Douglas E. Johnson

Henry Ford Hospital Medical Journal

This report describes renal artery occlusion as a therapeutic alternative to nephrectomy and chemotherapy in treating patients with metastatic renal carcinoma. Using a combination of Gelfoam and the Gianturco stainless steel coil, embolization was performed on 75 patients at the University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute with promising results. Its use is recommended 1) to facilitate surgical removal of large and difficult tumors, 2) to control local symptoms (pain, bleeding, etc), and 3) as part of a planned therapeutic program consisting of infarction, nephrectomy and progestins for patients with minimal to moderate metastatic disease.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Surgical Treatment For Renal Cell Carcinoma, Robert Di Loreto, Joseph C. Cerny

Henry Ford Hospital Medical Journal

Despite recent advances in chemotherapy, radiation therapy and immunology, renal cell carcinoma can best be treated by early detection and radical surgery. Today, radical nephrectomy is the standard surgery of choice for removing malignant renal tumors. Of the surgical procedures that have been used in the past, the transabdominal incision offers the best exposure of retroperitoneal structures at the diaphragmatic level and the contralateral renal vasculature. Occasionally, supraradical procedures are recommended if tumor size and location require this approach.

Bilateral Renal Cell Carcinoma: Two Case Reports, Riad N. Farah

Henry Ford Hospital Medical Journal

No abstract provided.