Medical Specialties Commons^™

Medical Applications Of Computers In The Hospital, Laurens V. Ackerman, Michael E. Somand

Henry Ford Hospital Medical Journal

No abstract provided.

Computer Applications In The Vascular Registry Of Henry Ford Hospital: Use Of A Simplified Access Method, Joseph P. Elliott Jr., Kunwar Kapoor, John G. Hageman, D. Emerick Szilagyi, Roger F. Smith, Michalene Mcpharlin

Henry Ford Hospital Medical Journal

The Vascular Registry of Henry Ford Hospital was initiated by one of the authors in 1957 to provide a consistent and accurate method of documenting and correlating the clinical results of the treatment of occlusive and aneurysmal arterial diseases. Data collection for each patient includes demographic information, treatment of clinical problems, and followup observations. Initially, the system consisted of keypunch cards and eventually magnetic tape processing. By 1980, it was necessary to further update the system because of the increase in patient volume, the need to minimize manual manipulations, and the demand for research data. The present system uses institutional …

Development Of A Nephrology And Hypertension Information System, Francis Dumler, Gerard Zasuwa, Nathan W. Levin

Henry Ford Hospital Medical Journal

This article describes our experience in the development and implementation of a computerized information system specifically designed for a Division of Nephrology and Hypertension. Specific issues related to planning and implementation are discussed, and potential pitfalls in setting up such a system are addressed. The combination of a mainframe and a miniframe as integral parts of the system and the development of peripheral support in specific applications using a personal microcomputer are also described. The important area of user/computer interface and of user motivation is discussed in the light of the experience acquired while implementing the current system.

Cardiac Papillary Fibroelastoma: A Source Of Coronary Artery Emboli And Myocardial Infarction, Gerald Fine, Shoba R. Pai

Henry Ford Hospital Medical Journal

Cardiac papillary fibroelastomas, although generally small and asymptomatic, have been suspected of being responsible for cerebral accidents, angina, and sudden death. The diagnosis of tumor embolization, considered in a number of cases, has been based on circumstantial evidence in all instances except for one case of sudden death due to embolism to the left anterior descending coronary artery. In all other cases, angina and sudden death have been related to a ball valve-type obstruction of a coronary ostium by tumor. The present case documents tumor embolism to peripheral right coronary arteries with associated, clinically silent myocardial changes.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Age-Related Changes Of Neurites In Meissner Corpuscles Of Diabetic, Vicky R. Ras

Loma Linda University Electronic Theses, Dissertations & Projects

This thesis is based on a qualitative and quantitative study of the neural component of Meissner corpuscles of diabetic and non-diabetic mice. Age-related changes were also documented in these mechanoreceptors. Corpuscles from forty-six diabetic mice and forty-six non-diabetic mice ranging from 2.5 to 17 months old were studied. Forepaw index digital pads were formalin-fixed and frozen-sectioned parallel to each digit and perpendicular to the skin. Serial sections were then silver-impregnated to allow light microscopic examination of the neurites in the corpuscles.

Neurites became more coarse, tortuous, branched, varicose, and thus more complex until middle age. Corpuscle size appeared greatest at …

The Effects Of Tri-O-Cresyl Phosphate On 2',3'-Cyclicnucleotide-3'-Phosphohydrolase Activity In Neural And Non-Neural Tissue Of The Rat, Mark K. Schlager

Chemistry & Biochemistry Theses & Dissertations

A total of 44 Long-Evans rats received 5.7 g/kg tri-O-cresyl phosphate (TOCP) orally every 3 days for 6 days. A second group of 13 rats received 4.6 g/kg orally every 3 days for 6 days. Animals were administered atropine sulfate (10 mg/kg) intraperitoneally every 6 hours or as needed to alleviate cholinergic symptoms. Ten control animals were given corn oil orally. Eight rats (18%) survived the 5.7 g/kg dose regimen and 5 rats (38%) survived the 4.6 g/kg dose regimen. Surviving rats were killed at 30-33 days post-dose. Signs of delayed neuropathy included ataxia and motor impairment.

The CNP activity …

Influenza: Prevention And Therapy, William M. Valenti

Henry Ford Hospital Medical Journal

No abstract provided.

Immunology Of The Acquired Immunodeficiency Syndrome, Patrick W. Mclaughlin, Carl B. Lauter

Henry Ford Hospital Medical Journal

The Acquired Immunodeficiency Syndrome (AIDS) first recognized in 1981, has been extensively studied, and the most recent studies have demonstrated that its defects extend well beyond the apparent deficient cell-mediated immunity to include humoral immunity, autoimmunity, and abnormal immunoregulation. The recent discovery of a retrovirus, HTLV III, as a possible etiologic agent is discussed in relation to other viruses known to cause immunodeficiency. Simian AIDS, an animal model of virus-induced immunodeficiency, is also discussed. Recommendations are made regarding the interpretation and limitations of immune testing in AIDS, including a discussion of how apparently healthy homosexuals and groups at risk develop …

Medical Education In The United States: Some Current Problems And An Uncertain Future, Richard J. Reitemeier

Henry Ford Hospital Medical Journal

No abstract provided.

An Overview Of The Newer Antibiotics, Ramon Del Busto

Henry Ford Hospital Medical Journal

The introduction of a large number of new antibiotics has made selecting the one most appropriate for treatment a confusing task for the practicing physician. One problem is that the differences in pharmacokinetics, in vitro activity, and clinical indications between some of these agents may be relatively minor; this is especially true of the new cephalosporins. Another problem is that the generic names of the cephalosporins are so similar that it is impractical, even for the infectious diseases specialist, to be familiar with all of them. This review attempts to summarize the most important characteristics of these new antibiotics and …

Viral Hepatitis: Update On Prevention, Miriam J. Alter

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Infectious Diseases And The Persisting Microbial Challenge, Louis D. Saravolatz

Henry Ford Hospital Medical Journal

No abstract provided.

Prospects For The Medical Use Of Interferon In 1984, Bosko Postic, Julio C. Arroyo

Henry Ford Hospital Medical Journal

Interferon, a natural and wide spectrum antiviral polypeptide that was discovered in 1957, has been extensively described. In addition to its antiviral effect, interferon has been found to suppress tumor growth and modulate the immune response. Until 1980, interferon was primarily prepared for clinical trials in human leukocytes derived from the buffy coat of whole blood. A major breakthrough occurred in the late 1970s when human interferon was produced by DNA recombinant methods in such heterologous cells as bacteria (genetic engineering). Interferon is not commercially available in 1984, but it may, based on clinical trials in humans, become part of …

Congenital Seminal Vesicle Cyst: A Specific Diagnosis By Computed Tomography, Leo Drolshagen, Michael A. Sandler

Henry Ford Hospital Medical Journal

Computed tomography (CT) has been shown to be of great value in the assessment of the urinary tract. However, this modality has been primarily used in the evaluation of renal masses and the staging of urinary tract carcinomas. It may also be useful in less common abnormalities, such as mesonephric duct anomalies including congenital seminal vesicle cysts. These lesions are associated with renal agenesis and may produce urinary tract symptoms, or be discovered incidentally. We present a case of a congenital vesicle cyst associated with ipsilateral renal agenesis with characteristic CT findings allowing for a specific diagnosis.

A Case Of Ige Myeloma: Methodology And Review Of The Literature, Pat A. Allevato, Michael J. Deegan, Jau-Wen Chu, Mary B. Perry, Carolyn L. Barth

Henry Ford Hospital Medical Journal

A 56-year-old man presented with a one-year history of progressive weakness predominantly affecting his extremities and persistent low back pain. Ouchterlony immunodiffusion of the concentrated urine detected a marked increase in lambda light chains. A sternal bone marrow documented a diagnosis of multiple myeloma. Screening high resolution agarose gel electrophoresis revealed diffuse hypogammaglobulinemia and, retrospectively, an equivocal, faint band which migrated in the fast gamma region. By using a combination of Immunoelectrophoresis and immunofixation electrophoresis, this questionable band was determined to represent an IgE lambda monoclonal protein. Radioimmunoassay for IgE documented a serum concentration of 50.6 mg/dl. No intact IgE …

Rapidly Progressive Pancytopenia, Hepatomegaly, And Abnormal Lung Uptake Of Colloid In Systemic Lupus Erythematosus: Possible Saturation Of Reticuloendothelial System With Blood Elements, Tetsushi Sakurai, Kiyoshi Fukuda, Ichiro Kono, Teizo Kabashima, Kazuhide Yamane, Heihachiro Kashiwagi

Henry Ford Hospital Medical Journal

A patient with systemic lupus erythematosus developed severe abdominal pain and tender hepatomegaly associated with progressive pancytopenia and elevated serum levels of circulating immune complexes. Liver scintigram demonstrated extreme hepatomegaly with poor colloid uptake and splenomegaly with increased colloid uptake. An unusual accumulation of colloid in the lungs was also noted. Subsequent clinical and laboratory studies raised the possibility of saturation of the reticuloendothelial system in the liver by circulating immune complexes and blood cells, a condition demonstrated in experimental animals, but not hitherto well documented in the human immune complex disorder.

Tubal Lavage In The Management Of Ectopic Pregnancy, Samuel A. Motanya, William H. Pfeffer, Emile Sandelin, C. James Chuong

Henry Ford Hospital Medical Journal

No abstract provided.

Clinical Trials: I. Design And Ethical Issues, Barbara Tilley

Henry Ford Hospital Medical Journal

No abstract provided.

Editorial, Raymond C. Mellinger

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Screening Of Patients At High Risk For Cancer, Robert M. O'Bryan

Henry Ford Hospital Medical Journal

A cancer other than non-melanoma skin cancer will occur in one of every seven persons. Individuals with higher risks for cancer are those with increasing age, hereditary disorders, and a family history of cancer. Lifestyle, especially the use of tobacco and alcohol, diet, and perhaps behavioral patterns influence the risk. Less well understood but clearly pertinent risk factors include environmental and occupational exposures. The risk factors specific for breast cancer include a positive family history of breast cancer, history of mastopathy, age at first pregnancy greater than 35 years, early menarche with late menopause, and history of carcinoma of the …

Brief Communication: Streptokinase For Deep Venous Thrombosis, Barry Lesser, Maria A. Sawdyk

Henry Ford Hospital Medical Journal

No abstract provided.

Pericardial Tamponade In Acute Myeloid Leukemia, R. P. Warrier, K. R. Kini, R. Singh, K. Maeda, I. Barr, F. M. Jara

Henry Ford Hospital Medical Journal

We are reporting a case of acute myeloid leukemia in a child with pericardial effusion and cardiac tamponade, with a review of the literature. Morphologic and cytochemical evidence was used to diagnose acute myeloid leukemia, and radiologic, electrocardiographic, echocardiographic, cytologic, and histologic evidence confirmed the diagnosis of tamponade and pericardial leukemic involvement. Pericardiotomy and pericardial window drainage successfully relieved the tamponade, and conventional chemotherapy was used to induce a remission.

Cushing's Disease Due To Pituitary Carcinoma, M. Saeed Zafar, R. C. Mellinger, J. L. Chason

Henry Ford Hospital Medical Journal

Criteria for the diagnosis of pituitary carcinoma are subject to controversy. Some authors do not accept the demonstration of cellular anaplasia alone as sufficient to establish the diagnosis but require evidence of metastatic disease in order to label a pituitary tumor as malignant. However, pituitary tumors can metastasize even in the absence of anaplasia. The present case of Cushing's disease and pituitary carcinoma had no clinical evidence of metastases when first reported. Partial surgical removal of the tumor followed by irradiation resulted in clinical remission of the Cushing's syndrome, but two years later progressive uncontrollable recurrence of the disease ended …

Peritoneal Lavage Red Blood Cell And White Blood Cell Count: A Prospective Comparison Of Usefulness, Eugene Meyer, James C. Gruenberg

Henry Ford Hospital Medical Journal

Prospectively, 637 patients with blunt or penetrating trauma to the lower chest or abdomen had quantitative peritoneal lavage red blood cell (RBC) and white blood cell (WBC) counts as part of their initial diagnostic evaluation. Statistically, the lavage RBC count (error rate: 6.8%) was a superior test to the lavage WBC count (error rate: 9.7%) (chi sq=9.2564, p=0.0024). See Appendix. When the lavage RBC and WBC tests agreed, the predictive value was high: 94% (46/49) when both were positive and 95% (521/549) when both were negative. When the lavage RBC test was positive and the lavage WBC test was negative, …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Why Cancer?, Angelos A. Kambouris

Henry Ford Hospital Medical Journal

No abstract provided.

Family History As A Marker For Increased Risk Of Breast Cancer And Colon Cancer, Robert A. Norum

Henry Ford Hospital Medical Journal

Cancer of the breast and colon are well known to occur with high frequency in families with certain inherited cancer syndromes. These cancers also occur with increased frequency in families which do not have a recognizable genetic cancer syndrome. The fact of familial occurrence can be used to identify people with increased risk of cancer. In high-risk people methods for early detection can be developed which may reduce morbidity and mortality from these cancers, as has been done for certain inherited cancer syndromes.