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Articles 13231 - 13260 of 14899

Full-Text Articles in Medical Specialties

Sulfite Residues In Maraschino Cherries, Julie A. Nordlee, Laura B. Martin, Steve L. Taylor Jan 1985

Sulfite Residues In Maraschino Cherries, Julie A. Nordlee, Laura B. Martin, Steve L. Taylor

Department of Food Science and Technology: Faculty Publications

A survey of 53 samples of maraschino cherries from 14 different processors revealed that total sulfite residues averaged 52.3 ± 44.7 ppm. However, 58.5% of the samples had less than 40 ppm total SO2, while only 7.6% had greater than 120 ppm total SO2 indicating that the distribution was skewed in the direction of lower residue levels. Free sulfite residues in the 53 samples were considerably lower, averaging 14.2 ± 7.1 ppm. With free SO2 levels, 35.8% of the samples had less than 10 ppm free SO2, while only 5.7% had greater than 30 …

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Linkage Data Excluding A Locus For Multiple Endocrine Neoplasia Type 2 Syndromes From The Distal Part Of The Short Arm Of Chromosome 11, Kenneth K. Kidd, Susan D. Kruger, Daniela S. Gerhard, Judith R. Kidd, David Housman, Joseph M. Gertner Dec 1984

Linkage Data Excluding A Locus For Multiple Endocrine Neoplasia Type 2 Syndromes From The Distal Part Of The Short Arm Of Chromosome 11, Kenneth K. Kidd, Susan D. Kruger, Daniela S. Gerhard, Judith R. Kidd, David Housman, Joseph M. Gertner

Henry Ford Hospital Medical Journal

A study designed to identify the location of a gene for multiple endocrine neoplasia type 2 (MEN-2) is being performed using a single large family segregating for MEN-2A. Here we report our initial results using a set of DNA restriction fragment length polymorphisms spanning a 40 cM segment of the short arm of human chromosome 11. The locus for MEN-2 in this family is excluded from this entire region which includes an oncogene, c-Ha-ras-1, two hormone loci, insulin and parathyroid, and the five hemoglobin genes in the beta hemoglobin gene duster. This is the first exclusion of such a large …

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The First International Workshop On Multiple Endocrine Neoplasia Type 2 Syndromes, Charles E. Jackson Dec 1984

The First International Workshop On Multiple Endocrine Neoplasia Type 2 Syndromes, Charles E. Jackson

Henry Ford Hospital Medical Journal

No abstract provided.

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Impact Of Screening On Prognosis In The Multiple Endocrine Neoplasia Type 2 Syndromes: Natural History And Treatment Results In 105 Patients, Margareta Telenius-Berg, Bertel Berg, Bertil Hamberger, Sten Tibblin, Lars-Erik Tisell, Lars Ysander, Gunnar Welander Dec 1984

Impact Of Screening On Prognosis In The Multiple Endocrine Neoplasia Type 2 Syndromes: Natural History And Treatment Results In 105 Patients, Margareta Telenius-Berg, Bertel Berg, Bertil Hamberger, Sten Tibblin, Lars-Erik Tisell, Lars Ysander, Gunnar Welander

Henry Ford Hospital Medical Journal

We evaluated the effects of screening for multiple endocrine neoplasia type 2A (MEN-2A) in 12 families. Genealogical studies going back to 1730 show a common ancestry for seven Swedish families and one American family. The total number of patients included 105 individuals, 68 of whom were diagnosed by our screening program. Our screening methods for medullary carcinoma of the thyroid (MTC) had an optimal sensitivity and specificity. The frequency of gene carriers detected in MEN-2A families was 55%. Screening will lead to early diagnosis and early therapy, which in turn, will significantly decrease morbidity, incidence of surgical complications, and mortality …

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Central Registration Of Multiple Endocrine Neoplasia Type 2 Families In The Netherlands, C. J. M. Lips, E. Den Aantrekker, J. M. Jansen-Schillhorn Van Veen, R. A. Geerdink, G. Griffioen, E. A. Van Slooten Dec 1984

Central Registration Of Multiple Endocrine Neoplasia Type 2 Families In The Netherlands, C. J. M. Lips, E. Den Aantrekker, J. M. Jansen-Schillhorn Van Veen, R. A. Geerdink, G. Griffioen, E. A. Van Slooten

Henry Ford Hospital Medical Journal

No abstract provided.

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Chromosomes In Multiple Endocrine Neoplasia Type 2 Syndromes, Daniel L. Van Dyke, V. Ramesh Babu, Charles E. Jackson Dec 1984

Chromosomes In Multiple Endocrine Neoplasia Type 2 Syndromes, Daniel L. Van Dyke, V. Ramesh Babu, Charles E. Jackson

Henry Ford Hospital Medical Journal

In 19 patients from nine MEN-2A families, high-resolution C-banded chromosome studies have revealed a visible deletion within sub-band 20p12.2, yet no abnormality was observed in a 10th family. A deletion indistinguishable from that in MEN-2A was observed in five patients from three MEN-2B families but not in two other MEN-2B families. We found no abnormality in the entire karyotype of the four MEN-1 patients studied. These findings suggest that the mutation in most MEN-2 patients is a visible deletion in the short arm of chromosome 20.

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Research Vistas In The Multiple Endocrine Neoplasia Syndromes, John J. Mulvihill Dec 1984

Research Vistas In The Multiple Endocrine Neoplasia Syndromes, John J. Mulvihill

Henry Ford Hospital Medical Journal

Progress in understanding the single gene, cytogenetic, and multifactorial traits that predispose to human cancer suggests possible new directions for research in the multiple endocrine neoplasia (MEN) syndromes. Among the other 200 or so monogenic disorders associated with human neoplasia, advances have come from further delineation of syndromes by various clinical specialists, the recognition of subtypes of syndromes previously thought to be homogeneous, the search for in vitro manifestations of the mutant gene in fibroblasts, and the establishment of cell, tissue and patient registries and of voluntary lay organizations to serve as advocates for the disease. With regard to cytogenetics, …

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Book Review: Medical Meanings, Fred W. Whitehouse Dec 1984

Book Review: Medical Meanings, Fred W. Whitehouse

Henry Ford Hospital Medical Journal

No abstract provided.

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Front Matter Dec 1984

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

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Multiple Endocrine Neoplasia Type 2 Syndromes: Historical Perspectives, John H. Sipple Dec 1984

Multiple Endocrine Neoplasia Type 2 Syndromes: Historical Perspectives, John H. Sipple

Henry Ford Hospital Medical Journal

No abstract provided.

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The Calcitonin Assay And Multiple Endocrine Neoplasia Type 2 Syndromes: Historical Footnote, Kenneth E. W. Melvin Dec 1984

The Calcitonin Assay And Multiple Endocrine Neoplasia Type 2 Syndromes: Historical Footnote, Kenneth E. W. Melvin

Henry Ford Hospital Medical Journal

No abstract provided.

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Register Of Multiple Endocrine Neoplasia Type 2 Syndromes In The United Kingdom, Bruce A. J. Ponder Dec 1984

Register Of Multiple Endocrine Neoplasia Type 2 Syndromes In The United Kingdom, Bruce A. J. Ponder

Henry Ford Hospital Medical Journal

A collaborative group for the study of multiple endocrine neoplasia type 2 (MEN-2) syndromes comprised of clinicians and laboratory scientists has been set up in the United Kingdom. Its aims are 1) to provide a basis for collaborative work on MEN-2; 2) to establish a register of patients; 3) and specifically to conduct studies aimed at defining the best policy for screening the families of apparently sporadic patients, to establish radioimmunoassays for family screening, and to identify large kindreds for genetic linkage studies using DNA polymorphisms.

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Screening For Hereditary Medullary Cancer In Denmark, Kristian Emmertsen Dec 1984

Screening For Hereditary Medullary Cancer In Denmark, Kristian Emmertsen

Henry Ford Hospital Medical Journal

Screening of first-degree relatives of patients with medullary thyroid cancer (MTC) gave normal values of pentagastrin-stimulated serum calcitonin and 24-hour urinary catecholamine levels in the relatives of 18 of 22 patients. This result is considered to be valid evidence for sporadic MTC. Absence of C-cell hyperplasia maybe another indication of sporadic MTC. Four hereditary MTCs were represented by one fully expressed MEN-2B patient without affected relatives, one fully expressed MEN-2A case in one family, and two first cousins with MTC as the only MEN-2A lesion in another family. Fourteen relatives of the MEN-2A patients had elevated serum calcitonin levels, and …

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Familial Medullary Carcinoma Of The Thyroid: Clinical Studies In Northern New England, Walter W. Noll, L. Herbert Maurer, Victoria L. Herzberg, Paul J. Beisswenger, Brian M. Quinn, Charles C. Cate, Jane P. Bassick, Patricia A. Clark, Thomas A. Colacchio Dec 1984

Familial Medullary Carcinoma Of The Thyroid: Clinical Studies In Northern New England, Walter W. Noll, L. Herbert Maurer, Victoria L. Herzberg, Paul J. Beisswenger, Brian M. Quinn, Charles C. Cate, Jane P. Bassick, Patricia A. Clark, Thomas A. Colacchio

Henry Ford Hospital Medical Journal

No abstract provided.

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Multiple Endocrine Neoplasia Type 2 Syndromes In Japan, Shin-Ichiro Takai, Akira Miyauchi, Hideo Matsumoto, Tatsuro Ikeuchi, Tetsuro Miki, Kanji Kuma, Yuichi Kumahara Dec 1984

Multiple Endocrine Neoplasia Type 2 Syndromes In Japan, Shin-Ichiro Takai, Akira Miyauchi, Hideo Matsumoto, Tatsuro Ikeuchi, Tetsuro Miki, Kanji Kuma, Yuichi Kumahara

Henry Ford Hospital Medical Journal

Through nationwide surveys, we collected and analyzed 242 patients of medullary thyroid carcinoma (MTC). Included were 40 patients with multiple endocrine neoplasia type 2A (MEN-2A), six patients with MEN-2B, and 36 patients with only MTC having a positive family history (82 total patients in the hereditary group). Ten-year survival rates were 81.5% for all cases, and 97.5% and 76.1% for the hereditary and the sporadic group, respectively. Epinephrine/norepinephrine ratio in the urine was found to be a good indicator of the adrenomedullary hyperfunction in patients with hereditary MTC. At least one patient in each family with hereditary MTC had overt …

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A French Canadian Family With Multiple Endocrine Neoplasia Type 2 Syndromes, Maurice B. Verdy, Marcel Cadotte, Walter Schurch, William C. Sturtridge, Jacques Cantin, Andrée M. Weber, André Lacroix, Cynthia Forster-Gibson Dec 1984

A French Canadian Family With Multiple Endocrine Neoplasia Type 2 Syndromes, Maurice B. Verdy, Marcel Cadotte, Walter Schurch, William C. Sturtridge, Jacques Cantin, Andrée M. Weber, André Lacroix, Cynthia Forster-Gibson

Henry Ford Hospital Medical Journal

No abstract provided.

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Scintigraphy With 1-131 Mibg As An Aid To The Treatment Of Pheochromocytomas In Patients With The Multiple Endocrine Neoplasia Type 2 Syndromes, James C. Sisson, Brahm Shapiro, William H. Beierwaltes Dec 1984

Scintigraphy With 1-131 Mibg As An Aid To The Treatment Of Pheochromocytomas In Patients With The Multiple Endocrine Neoplasia Type 2 Syndromes, James C. Sisson, Brahm Shapiro, William H. Beierwaltes

Henry Ford Hospital Medical Journal

We reviewed the scintigraphic images made after injections of 1-131 metaiodobenzylguanidine (MIBG) or 1-123 MIBG in patients with multiple endocrine neoplasia (MEN) types 2A and 2B. The information we obtained was applied to three questions about the treatment of pheochromocytoma in patients affected with these syndromes. Our first question "When should adrenal gland(s) be removed?" was not directly answered. However, adrenalectomy generally should not be contemplated unless distinct abnormalities are present in the scintigraphic images. With experience it may be possible to approximate, from the stage of pheochromocytoma depicted by scintigraphy, how many years will elapse before symptoms or hypertension …

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The Molecular Basis Of Polypeptide Hormone Production By Medullary Thyroid Cancer, C. J. M. Lips, P. H. Steenbergh, J. W. M. Höppener, J. Zandberg, H. S. Jansz Dec 1984

The Molecular Basis Of Polypeptide Hormone Production By Medullary Thyroid Cancer, C. J. M. Lips, P. H. Steenbergh, J. W. M. Höppener, J. Zandberg, H. S. Jansz

Henry Ford Hospital Medical Journal

Using recombinant DNA techniques, we analyzed the structure of human calcitonin (CT)-encoding DNA. The sequence of nucleotides derived from the messenger RNA (mRNA) predict the amino acid sequence of the entire human CT precursor protein. The complete CT gene could be isolated from a DNA library of the human genome. The CT precursor encoding sequences (exons) as well as the noncoding intervening sequences (introns) could be identified. Another sequence, called human calcitonin gene-related peptide (hCCRP), could be located near this CT-encoding DNA. A genomic fragment encoding hCCRP was used as a probe to detect and isolate the corresponding mRNA in …

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Genetic Studies Of Multiple Endocrine Neoplasia Type 2 Syndromes: A Workshop Commentary, Nancy E. Simpson Dec 1984

Genetic Studies Of Multiple Endocrine Neoplasia Type 2 Syndromes: A Workshop Commentary, Nancy E. Simpson

Henry Ford Hospital Medical Journal

No abstract provided.

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Back Matter Dec 1984

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

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A Comparison Of Selected Nutrition Factors Of Personal Care Residents With Nutrition For The Elderly Residents., Jill Kay Costin Nov 1984

A Comparison Of Selected Nutrition Factors Of Personal Care Residents With Nutrition For The Elderly Residents., Jill Kay Costin

Masters Theses & Specialist Projects

Persons in the Nutrition for the Elderly program in Barren River Area Development District in Kentucky and personal care residents at Lakeview Nursing Home, Morgantown, Kentucky, and Glasgow Rest Home, Glasgow, Kentucky participated I this study on a voluntary basis. The population consisted of an intact sample of sixty-eight persons: forty-six personal care residents (PC residents) and twenty-two Nutrition for the Elderly participants (NE participants). The Ne participants and Pc residents were compared to determine which received the best nutritional care. Selected parameters of nutritional assessment were compared for the two groups be means of a t test. The groups …

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Genetics And Epidemiology Of Gallbladder Disease In New World Native Peoples, K M Weiss, R E Ferrell, C L Hanis, P N Styne Nov 1984

Genetics And Epidemiology Of Gallbladder Disease In New World Native Peoples, K M Weiss, R E Ferrell, C L Hanis, P N Styne

Faculty, Staff and Student Publications

Native peoples of the New World, including Amerindians and admixed Latin Americans such as Mexican-Americans, are highly susceptible to diseases of the gallbladder. These include cholesterol cholelithiasis (gallstones) and its complications, as well as cancer of the gallbladder. Although there is clearly some necessary dietary or other environmental risk factor involved, the pattern of disease prevalence is geographically associated with the distribution of genes of aboriginal Amerindian origin, and levels of risk generally correspond to the degree of Amerindian admixture. This pattern differs from that generally associated with Westernization, which suggests a gene-environment interaction, and that within an admixed population …

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Developing An Integrated Natural Language Database For Gastrointestinal Disease, Peter J. Feczko, Laurens V. Ackerman, Robert D. Halpert, Stuart M. Simms Sep 1984

Developing An Integrated Natural Language Database For Gastrointestinal Disease, Peter J. Feczko, Laurens V. Ackerman, Robert D. Halpert, Stuart M. Simms

Henry Ford Hospital Medical Journal

Using a mainframe computer connected to the Henry Ford Hospital computer network, we developed a database for gastrointestinal disease which includes data from radiologic and endoscopic gastrointestinal examinations, along with corresponding pathologic diagnosis. Because of the large volume of procedures in our practice, we developed several unique features for our system. The user enters data by responding to a series of question-and-answer sets constructed by the clinical staff, who do not have experience in computer programming. Data is stored in a hierarchical format using natural language. Boolean logic is used to retrieve data so that different procedures can be correlated …

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Front Matter Sep 1984

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

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Cooperation Between A Radiology Computer Consortium And A Computer Manufacturer In The Development Of A Radiology Information System, Matthew W. Burke, Laurens V. Ackerman Sep 1984

Cooperation Between A Radiology Computer Consortium And A Computer Manufacturer In The Development Of A Radiology Information System, Matthew W. Burke, Laurens V. Ackerman

Henry Ford Hospital Medical Journal

This article reports on the formation of a Radiology Information System Consortium (RISC) by 13 hospitals and medical centers in the United States, including Henry Ford Hospital in Detroit, and the cooperation between this consortium and a major manufacturer of computers and software. Digital Equipment Corporation (DEC), for the common goal of developing a state-of-the-art radiology information system.

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Computer-Assisted Methods For Design Optimization Of Cardiac Bioprosthetic Valves, Mohamed S. Hamid, Hani N. Sabbah, Paul D. Stein Sep 1984

Computer-Assisted Methods For Design Optimization Of Cardiac Bioprosthetic Valves, Mohamed S. Hamid, Hani N. Sabbah, Paul D. Stein

Henry Ford Hospital Medical Journal

Excessive mechanical stresses on valvular leaflets are considered an important factor in the degeneration of cardiac porcine bioprosthetic valves. This study describes a computer-assisted numerical model of a bioprosthetic valve which estimates the magnitude and distribution of leaflet stresses. The study also describes our initial attempts to determine the influence of stent height upon leaflet stresses. Whereas lowering stent heights has been suggested to improve hemodynamics in the bioprosthetic valve region, results indicate that an increase in leaflet stresses can accompany reductions of stent height.

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Automating The Expertise Of The Neuropsychologist, Kenneth M. Adams, Gregory G. Brown Sep 1984

Automating The Expertise Of The Neuropsychologist, Kenneth M. Adams, Gregory G. Brown

Henry Ford Hospital Medical Journal

No abstract provided.

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Distributed Computing In A Hospital Environment, Steven R. Lund, Laurens V. Ackerman, James B. Martin Sep 1984

Distributed Computing In A Hospital Environment, Steven R. Lund, Laurens V. Ackerman, James B. Martin

Henry Ford Hospital Medical Journal

Obtaining appropriate information in a timely fashion in medical practice has always been a burden for the practitioner. In a large hospital which undertakes major computer projects, this burden is intensified because information is not always available in a form directly usable by the physician or support personnel; it is now accumulated on diverse magnetic media where it is moved and processed as electronic pulses. This paper describes a solution which freely allows continued automation at different rates throughout a large hospital while expediting the movement of information where it is needed in a form understandable by the recipient.

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Intracerebral Hemorrhage After Carotid Endarterectomy, José Biller, Andrew C. Hayes, Fred N. Littooy, William H. Baker Sep 1984

Intracerebral Hemorrhage After Carotid Endarterectomy, José Biller, Andrew C. Hayes, Fred N. Littooy, William H. Baker

Henry Ford Hospital Medical Journal

Intracerebral hemorrhage (ICH) is a rare complication of carotid endarterectomy (CE). In our multicenter series of 1,180 CE (Baker-Littooy), three ICH occurred, of which two were fatal. One patient was receiving anticoagulants because ofa prosthetic aortic valve; another had rupture of a known ipsilateral intracranial aneurysm. Both occurred more than six weeks postoperatively. The third patient, who was hypertensive, had a nonfatal ipsilateral thalamic hemorrhage on the third postoperative day. Though these three patients represent only 0.25% of our series, they constitute 12% of our total strokes. ICH constitutes the largest percentage of nontechnically-related strokes and noncardiac deaths after CE.

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A Microcomputer Database In A Clinical Environment, Dennis R. Ownby, Thomas A. Burnett Sep 1984

A Microcomputer Database In A Clinical Environment, Dennis R. Ownby, Thomas A. Burnett

Henry Ford Hospital Medical Journal

No abstract provided.

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