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Articles 31 - 49 of 49
Full-Text Articles in Medical Toxicology
Maternal Cocaine Administration In Mice Alters Dna Methylation And Gene Expression In Hippocampal Neurons Of Neonatal And Prepubertal Offspring, Svetlana I. Novikova, Fang He, Jie Bai, Nicholas J. Cutrufello, Michael S. Lidow, Ashiwel S. Undieh
Maternal Cocaine Administration In Mice Alters Dna Methylation And Gene Expression In Hippocampal Neurons Of Neonatal And Prepubertal Offspring, Svetlana I. Novikova, Fang He, Jie Bai, Nicholas J. Cutrufello, Michael S. Lidow, Ashiwel S. Undieh
College of Pharmacy Faculty Papers
Previous studies documented significant behavioral changes in the offspring of cocaine-exposed mothers. We now explore the hypothesis that maternal cocaine exposure could alter the fetal epigenetic machinery sufficiently to cause lasting neurochemical and functional changes in the offspring. Pregnant CD1 mice were administered either saline or 20 mg/kg cocaine twice daily on gestational days 8-19. Male pups from each of ten litters of the cocaine and control groups were analyzed at 3 (P3) or 30 (P30) days postnatum. Global DNA methylation, methylated DNA immunoprecipitation followed by CGI(2) microarray profiling and bisulfite sequencing, as well as quantitative real-time RT-PCR gene expression …
Diverse Antidepressants Increase Cdp-Diacylglycerol Production And Phosphatidylinositide Resynthesis In Depression-Relevant Regions Of The Rat Brain, Kimberly R. Tyeryar, Habiba O.U. Vongtau, Ashiwel S. Undieh
Diverse Antidepressants Increase Cdp-Diacylglycerol Production And Phosphatidylinositide Resynthesis In Depression-Relevant Regions Of The Rat Brain, Kimberly R. Tyeryar, Habiba O.U. Vongtau, Ashiwel S. Undieh
College of Pharmacy Faculty Papers
BACKGROUND: Major depression is a serious mood disorder affecting millions of adults and children worldwide. While the etiopathology of depression remains obscure, antidepressant medications increase synaptic levels of monoamine neurotransmitters in brain regions associated with the disease. Monoamine transmitters activate multiple signaling cascades some of which have been investigated as potential mediators of depression or antidepressant drug action. However, the diacylglycerol arm of phosphoinositide signaling cascades has not been systematically investigated, even though downstream targets of this cascade have been implicated in depression. With the ultimate goal of uncovering the primary postsynaptic actions that may initiate cellular antidepressive signaling, we …
Book Review: Drugs During Pregnancy And Lactation: Treatment Options And Risk Assessment, Robert L. Brent
Book Review: Drugs During Pregnancy And Lactation: Treatment Options And Risk Assessment, Robert L. Brent
The Selected Works of Robert Brent
No abstract provided.
Environmental Causes Of Human Congenital Malformations: The Physician's Role In Dealing With These Complex Clinical Problems Caused By Environmental And Genetic Factors., Robert L. Brent
The Selected Works of Robert Brent
No abstract provided.
Bio-Monitoring The Elimination Of Folic Acid-Preventable Spina Bifida And Anencephaly, Robert L. Brent
Bio-Monitoring The Elimination Of Folic Acid-Preventable Spina Bifida And Anencephaly, Robert L. Brent
The Selected Works of Robert Brent
No abstract provided.
Guest Perspective - Dr. Robert L. Brent, Robert L. Brent
Guest Perspective - Dr. Robert L. Brent, Robert L. Brent
The Selected Works of Robert Brent
No abstract provided.
Commentary: The Daubert Decision, Robert L. Brent
Commentary: The Daubert Decision, Robert L. Brent
The Selected Works of Robert Brent
No abstract provided.
Letter To The Editor: Further Efforts To Redce The Incidence Of Neural Tube Defects, Robert L. Brent
Letter To The Editor: Further Efforts To Redce The Incidence Of Neural Tube Defects, Robert L. Brent
The Selected Works of Robert Brent
No abstract provided.
Triumph And/Or Tragedy: The Present Food And Drug Administration Program Of Enriching Grains With Folic Acid., Robert L. Brent
Triumph And/Or Tragedy: The Present Food And Drug Administration Program Of Enriching Grains With Folic Acid., Robert L. Brent
The Selected Works of Robert Brent
No abstract provided.
Developmental Toxicology Drugs, And Fetal Teratogenesis, Robert L. Brent
Developmental Toxicology Drugs, And Fetal Teratogenesis, Robert L. Brent
The Selected Works of Robert Brent
No abstract provided.
Robert Warwick Miller: In Memoriam., Robert L. Brent
Robert Warwick Miller: In Memoriam., Robert L. Brent
The Selected Works of Robert Brent
No abstract provided.
How Does The Physician Avoid Prescribong Drugs And Medical Procedures That Have Reproductive And Developmental Risks?, Robert L. Brent
How Does The Physician Avoid Prescribong Drugs And Medical Procedures That Have Reproductive And Developmental Risks?, Robert L. Brent
The Selected Works of Robert Brent
No abstract provided.
The Folate Debate., Robert L. Brent
The Folate Debate., Robert L. Brent
The Selected Works of Robert Brent
No abstract provided.
Counseling Patients Exposed To Ionizing Radiation During Pregnancy, Robert L. Brent
Counseling Patients Exposed To Ionizing Radiation During Pregnancy, Robert L. Brent
The Selected Works of Robert Brent
Health physicists and knowledgeable clinicians have the responsibility to counsel women of reproductive age about the reproductive risks of ionizing radiation exposure before conception or during pregnancy. It is important to realize that lay individuals have many misconceptions about the reproductive risks of ionizing radiation. Many patients who have already had or will undergo some type of radiological test are apprehensive about the reproductive and developmental risks of diagnostic radiological procedures. Epidemiological studies and animal studies indicate that high exposures of ionizing radiation can cause miscarriage, congenital malformations, growth retardation, stillbirth, and cancer. With the exception of cancer, there are …
Trichloroethylene And Cardiac Malformations, Robert L. Brent
Trichloroethylene And Cardiac Malformations, Robert L. Brent
The Selected Works of Robert Brent
No abstract.
Commentary: Teratology In The 20th Century Environmental Causes Of Congenital Malformations In Humans And How They Were Established By Harold Kalter, Robert L. Brent
Commentary: Teratology In The 20th Century Environmental Causes Of Congenital Malformations In Humans And How They Were Established By Harold Kalter, Robert L. Brent
The Selected Works of Robert Brent
No abstract
Utilization Of Juvenile Animals Studies To Determine The Human Effects And Risks Of Environmental Toxicants During Postnatal Developmental Stages, Robert L. Brent
Utilization Of Juvenile Animals Studies To Determine The Human Effects And Risks Of Environmental Toxicants During Postnatal Developmental Stages, Robert L. Brent
The Selected Works of Robert Brent
Toxicology studies utilizing animals and in-vitro cellular or tissue preparations have been used to study the toxic effects and mechanism of action of drugs and chemicals and to determine the effective and safe dose of drugs in humans and the risk of toxicity from chemical exposures. Testing in animals could be improved if animal dosing using the mg/kg basis was abandoned and drugs and chemicals were administered to compare the effects of pharmacokinetically and toxicokinetically equivalent serum levels in the animal model and human. Since alert physicians or epidemiology studies, not animal studies have discovered most human teratogens and toxicities …
Medical, Social And Legal Implications Of Treating Nausea And Vomiting Of Pregnancy, Robert L. Brent
Medical, Social And Legal Implications Of Treating Nausea And Vomiting Of Pregnancy, Robert L. Brent
The Selected Works of Robert Brent
This article will deal with medical, social, and legal implications of treating nausea and vomiting of pregnancy (NVP). Clinical problems occur when the symptoms become exaggerated and result in debilitation, dehydration, and hospitalization. The treatment of NVP in its early stages has the implication that it will prevent the more serious complications, including hospitalization. Therapeutic modalities discussed in this conference that have been used or are being tested are primarily symptomatic treatments (antihistamines, Bendectin (Merrell Dow; Cincinatti, Ohio), phenothiazines, hyponosis, accupressure, relaxation behavioral modification, audiogenic feedback training, newer medications, diet, and nutritional support). Bendectin is probably the most studied medication …
Teratogen Update: Reproductive Risks Of Leflunomide (Arava); A Pyrimidine Synthesis Inhibitor: Counseling Women Taking Leflunomide Before Or During Pregnancy And Men Taking Leflunomide Who Are Contemplating Fathering A Child, Robert L. Brent
The Selected Works of Robert Brent
Arava™ (leflunomide) is a pyrimidine synthesis inhibitor used in the treatment of active rheumatoid arthritis (RA). The chemical name for leflunomide is N- (4’-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide. Because the drug has been successful in the treatment of rheumatoid arthritis (RA), it is being widely prescribed. In spite of the clear warning that the drug should not be prescribed for pregnant women, approximately 30 women have become pregnant while taking leflunomide as of December 1999. This commentary was prepared to aid teratology counselors and genetic counselors that might be contacted by physicians or patients about the risk of leflunomide exposure during pregnancy. Before the …